Review
Health Care Sciences & Services
Kenichi Goda, Keiichiro Abe, Akira Kanamori, Masayuki Kondo, Shunsuke Kojimahara, Mimari Kanazawa, Takanao Tanaka, Kazunori Nagashima, Tsunehiro Suzuki, Akira Yamamiya, Koki Hoshi, Keiichi Tominaga, Yuichi Majima, Makoto Iijima, Atsushi Irisawa
Summary: This article introduces the application of advanced endoscopy techniques in the diagnosis of esophageal inflammatory diseases. Studies have shown that advanced endoscopy techniques can improve the diagnostic performance of white-light endoscopy in non-erosive reflux disease and eosinophilic esophagitis.
Article
Medicine, General & Internal
Yugo Suzuki, Toshiro Iizuka, Atsuko Hosoi, Daisuke Kikuchi, Takayuki Okamura, Yorinari Ochiai, Junnosuke Hayasaka, Nobuhiro Dan, Yutaka Mitsunaga, Masami Tanaka, Hiroyuki Odagiri, Kosuke Nomura, Satoshi Yamashita, Akira Matsui, Shu Hoteya
Summary: This study compared the clinicopathological features of asymptomatic esophageal eosinophilia (aEE) and symptomatic eosinophilic esophagitis (EoE). The results showed that there were no significant differences between the two groups in many aspects, suggesting that aEE and EoE may have similar characteristics.
Review
Gastroenterology & Hepatology
Rena Yadlapati, Elizabeth Hubscher, Corey Pelletier, Rinu Jacob, Allison Brackley, Shailja Shah
Summary: The efficacy of PPIs in treating EE is highest after 8 weeks of treatment, with over 80% of patients achieving endoscopic healing in most treatment groups, compared to lower efficacy (<80%) at 4 weeks. Rates of maintained healing with PPIs at 6 and 12 months were mostly lower than 80%, although the data were limited. Symptomatic patients and those with severe EE were less likely to achieve healing. Obese patients experienced similar healing rates as non-obese patients.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Jung Su Lee, Jihye Yun, Sungwon Ham, Hyunjung Park, Hyunsu Lee, Jeongseok Kim, Jeong-Sik Byeon, Hwoon-Yong Jung, Namkug Kim, Do Hoon Kim
Summary: A machine-learning-based AI system was developed to differentiate between HSV and CMV esophagitis, showing high accuracy in diagnosis. Through analysis of hundreds of endoscopic images, this system demonstrated excellent performance in differential diagnosis.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Nathalie Nguyen, Robert E. Kramer, Calies Menard-Katcher
Summary: Endoscopy and mucosal biopsies play essential roles in the diagnosis and management of EoE, confirming or excluding disease features and assessing treatment responses and complications. While these methods are currently key in assessing treatment response, less invasive strategies may provide alternative means to evaluate mucosal inflammation.
FRONTIERS IN PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Joel H. Rubenstein, Li Jiang, Jacob E. Kurlander, Joan Chen, Valbona Metko, Maryam Khodadost, Kimberly Nofz, Trivellore Raghunathan
Summary: The study found an association between incomplete response of GERD symptoms to PPI and psychological distress, but it is not a good predictor for endoscopic pathology. Patients with high psychological distress are less likely to have esophageal pathology such as erosive esophagitis or Barrett's esophagus.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Mengyu Zhang, Yinglian Xiao, Minhu Chen
Summary: This article reviews the role of vonoprazan in the management of erosive esophagitis, including mucosal healing, maintaining remission, and symptom relief. Vonoprazan, a novel potassium-competitive acid blocker, exhibits different pharmacological and pharmacokinetic profiles from conventional PPIs and has a rapid, potent, and sustained acid inhibitory effect. Safety concerns and cost-effectiveness analysis of vonoprazan were also mentioned.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sumeet Lal, Trinh Xuan Thi Nguyen, Abdul-Salam Sulemana, Mostafa Saidur Rahim Khan, Yoshihiko Kadoya
Summary: Financial literacy has no significant impact on health check-up behavior in Japan, but factors such as gender, age, marital status, and smoking are significantly related to health check-up behavior.
Article
Gastroenterology & Hepatology
Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler
Summary: This study found that vonoprazan, a potassium-competitive acid blocker, was noninferior and superior to the PPI lansoprazole in healing and maintenance of erosive esophagitis, particularly in patients with more severe cases.
Article
Gastroenterology & Hepatology
Evan S. Dellon, Paneez Khoury, Amanda B. Muir, Chris A. Liacouras, Ekaterina Safroneeva, Dan Atkins, Margaret H. Collins, Nirmala Gonsalves, Gary W. Falk, Jonathan M. Spergel, Ikuo Hirano, Mirna Chehade, Alain M. Schoepfer, Calies Menard-Katcher, David A. Katzka, Peter A. Bonis, Albert J. Bredenoord, Bob Geng, Elizabeth T. Jensen, Robert D. Pesek, Paul Feuerstadt, Sandeep K. Gupta, Alfredo J. Lucendo, Robert M. Genta, Girish Hiremath, Emily C. McGowan, Fouad J. Moawad, Kathryn A. Peterson, Marc E. Rothenberg, Alex Straumann, Glenn T. Furuta, Seema S. Aceves
Summary: This study aimed to create an international consensus severity scoring index for eosinophilic esophagitis (EoE). A multidisciplinary team of experts successfully created a clinically usable scoring system, called I-SEE, which can help standardize the assessment of disease severity and guide EoE management.
Review
Medicine, General & Internal
Jakub Wasik, Ewa Malecka-Wojciesko
Summary: Eosinophilic esophagitis is a Th-2 antigen-mediated disease that causes inflammation in the esophagus with an influx of eosinophils. It leads to esophageal remodeling and difficulties in swallowing. While the disease has a relatively short history, its incidenc e and prevalence are increasing rapidly, especially in Western countries. The diagnosis requires the presence of at least 15 eosinophils per high-power field in esophageal biopsies, along with relevant symptoms and exclusion of other causes of esophageal eosinophilia. Treatment options for eosinophilic esophagitis are challenging, but the combination of proton pump inhibitors, topical corticosteroids, elimination diet, and biological treatment has shown promise. New methods for disease diagnosis and clinical assessment are also available.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hye-Rin Kang, Ye Jin Lee, Ha Youn Lee, Tae Yun Park, Jung-Kyu Lee, Eun Young Heo, Hee Soon Chung, Seung Ho Choi, Deog Kyeom Kim
Summary: In patients with normal lung function, the presence of erosive reflux esophagitis did not affect the annual declines in FEV1 or FVC.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Pathology
Meredith E. Pittman
Summary: This review summarizes the current understanding of lymphocytic esophagitis (LE), a novel form of chronic esophagitis that incorporates distinctive histologic, clinical, and endoscopic features.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Computer Science, Cybernetics
Zhongzhi Xu, Weibin Cheng, Zhen Li, Gary Tse, Fengshi Jing, Wanmin Lian, Junzhang Tian, Qingpeng Zhang
Summary: This study aimed to develop a scoring system for mass screening of low bone density in women aged 50 years or older using basic body check-up items as variables. Age, BMI, SBP, glucose, and TCL were significantly associated with the risk of LBD, and the proposed scoring system had precision, recall, c-statistic, and F1-score of 0.66, 0.83, 0.73, and 0.74 respectively. Artificial neural networks showed better performance in all measurements.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Medicine, General & Internal
Shinsuke Yahata, Minoru Tamura, Atsushi Yamaoka, Yoshihide Fujioka, Masanobu Okayama
Summary: The Yoitoko check-up is a novel health check-up for older adults that provides positive feedback and aims to promote health through short-term behavioral changes. Four check-ups conducted at 3-month intervals showed that some participants experienced improvements in functional capacity scores.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Environmental Sciences
Chung-Yao Hsu, Yao-Chung Chuang, Fang-Chia Chang, Hung-Yi Chuang, Terry Ting-Yu Chiou, Chien-Te Lee
Summary: Chronic lead exposure disrupts the sleep-wake cycle in rats, particularly disrupting sleep homeostasis. This disturbance is associated with toxic effects on clock gene expression in the hypothalamus.
Article
Environmental Sciences
Chen-Cheng Yang, Chia-Yen Dai, Kuei-Hau Luo, Kuo-Wei Lee, Cheng-Hang Wu, Chih-Hsing Hung, Hung-Yi Chuang, Chao-Hung Kuo
Summary: This study found a negative association between lead exposure and high-density lipoprotein cholesterol (HDL-C) levels. Two specific SNPs were significantly associated with HDL-C in lead-exposed workers, and an interaction between one of the SNPs (rs150813626) and lead exposure had a positive influence on HDL-C. The TWIST gene may play a role in lead deposition in bones and calcium metabolism.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ting-Hao Chen, Chen-Cheng Yang, Kuei-Hau Luo, Chia-Yen Dai, Yao-Chung Chuang, Hung-Yi Chuang
Summary: This study utilized whole genomic genotypes from the Taiwan Biobank to explore the association between Al concentrations in plasma and renal function, identifying a link between DPP6 SNPs, plasma Al concentrations, and eGFR. Further longitudinal studies and research on mechanism are needed to validate these findings. This analysis represents the first study to investigate the impact of DPP6, SNPs, and Al in plasma on eGFR.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Chih-Wei Wu, Hung-Yi Chuang, Dong-Lin Tsai, Tzu-Yu Kuo, Chen-Cheng Yang, Huang-Chi Chen, Chao-Hung Kuo
Summary: The meta-analysis revealed a significant and positive association between asbestos exposure and esophageal cancer, especially with chrysotile. It is recommended that patients undergo cancer follow-up for over ten years, considering the long latency period.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Genetics & Heredity
Chun-Ting Lin, Ting-Hao Chen, Chen-Cheng Yang, Kuei-Hau Luo, Tzu-Hua Chen, Hung-Yi Chuang
Summary: The study investigated the impact of cadmium exposure on human kidney health and found that EGFR gene polymorphisms could modify Cd kidney toxicity, with certain genotypes potentially having a protective effect, while interactions between cadmium and specific genes could affect kidney function.
Article
Medicine, General & Internal
Chi-Di Hung, Chen-Cheng Yang, Chun-Ying Lee, Stephen Chu-Sung Hu, Szu-Chia Chen, Chih-Hsing Hung, Hung-Yi Chuang, Ching-Yu Chen, Chao-Hung Kuo
Summary: This study investigated the association between frailty and polypharmacy using three screening tools, finding a link between polypharmacy and frailty among older adults. Future research is needed to further explore the risk of frailty in older populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Sebastian Yu, Chung-Yao Hsu, Hung-Yi Chuang, Chen-Cheng Yang, Chiou-Lian Lai, Hsin-Su Yu
Summary: This study found that there were differences in baseline cutaneous perfusion between patients with Alzheimer's disease (AD) and chronic insomnia disorder (CID), and red light therapy significantly increased cutaneous finger perfusion in AD patients but decreased it in CID patients. These results suggest that cutaneous perfusion can be used as a tool to detect sympathetic dysfunction in CID and AD patients, and red light therapy may be a potential therapeutic intervention for improving sympathetic function in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Bo-Lin Pan, Chia-Pei Chou, Kun-Siang Huang, Pin-Jie Bin, Kuei-Hau Luo, Hung-Yi Chuang
Summary: This cohort study investigated the relationship between different HbA1C trajectories and the risk of herpes zoster infection among newly diagnosed type 2 diabetes patients. The study found that patients with poor glycemic control had a higher risk of herpes zoster infection, while patients who initially had high blood sugar levels and then reached optimal control had a lower risk of infection.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Yi-Jen Fang, Kuan-Lin Lin, Jyuhn-Hsiarn Lee, Kuei-Hau Luo, Tzu-Hua Chen, Chen-Cheng Yang, Hung-Yi Chuang
Summary: This study investigated the interaction between arsenic exposure, TNF-alpha gene SNPs, and eGFR, revealing that certain SNPs of the TNF-alpha gene may have a protective effect against the decrease in eGFR caused by arsenic exposure. Further research is needed to confirm the regulatory mechanism of these SNPs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Yi-Jen Fang, Lukas Jyuhn-Hsiarn Lee, Kuei-Hau Luo, Po-Sheng Fang, Chen-Cheng Yang, Hung-Yi Chuang
Summary: The study found a significant relationship between short-term exposure to air pollutants ozone and carbon monoxide and serum CEA concentration, although the mechanism is still unclear. Moreover, further evaluation is needed regarding the long-term exposure to air pollution and changes in CEA concentration.
Article
Environmental Sciences
Kuei-Hau Luo, Hung-Pin Tu, Cheng-Hong Yang, Chen-Cheng Yang, Tzu-Hua Chen, Hung-Yi Chuang
Summary: Exposure to heavy metals can have negative health effects due to oxidative reactions or inflammation. This study explores the association between arsenic, cadmium, lead, zinc, selenium, and TNF-alpha as well as kidney function.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Chung-Ying Yang, Fong-Ching Chang, Ru Rutherford, Wen-Yu Chen, Chiung-Hui Chiu, Ping-Hung Chen, Jeng-Tung Chiang, Nae-Fang Miao, Hung-Yi Chuang, Chie-Chien Tseng
Summary: This study examined the impact of excessive online gaming and exposure to online marketing of energy drinks and alcohol on adolescents. The findings suggest that excessive gaming and higher levels of online energy-drink marketing are positively associated with energy-drink consumption, while marketing-affective literacy can mitigate the effects of such advertising.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
I-Cheng Lu, Chen-Cheng Yang, Chi-Hsien Huang, Szu-Ying Chen, Chi-Wei Lin, Chia-Hsiang Lin, Hung-Yi Chuang
Summary: Workers in high-temperature workplaces with inadequate water supply are at increased risk of chronic dehydration and nephrolithiasis. This study found that heat exposure and age were major risk factors for radiolucent stone formation among workers. Younger workers with heat exposure had a higher odds ratio of radiolucent stones compared to those without heat exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Ho-Ming Chen, Po-Yao Huang, Hung-Yi Chuang, Chao-Ling Wang, Chen-Cheng Yang, Peng-Ju Huang, Chi-Kung Ho
Summary: This meta-analysis aimed to determine the association between shift work and low back pain (LBP). The analysis of 40 studies found a significant association between shift work and LBP. Subgroup analysis showed that night shift was associated with LBP, while rotating shift was not. Additionally, healthcare workers had a higher risk of LBP compared to non-healthcare workers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Psychology, Multidisciplinary
Chun-Yin Hou, Tzu-Fu Huang, Fong-Ching Chang, Tsu-En Yu, Tai-Yu Chen, Chiung-Hui Chiu, Ping-Hung Chen, Jeng-Tung Chiang, Nae-Fang Miao, Hung-Yi Chuang
Summary: This study investigated the influence of influencer marketing and non-alcoholic beer consumption on the intentions of adolescents to purchase and consume alcohol. A questionnaire was completed by 3121 high-school students in Taiwan during the COVID-19 pandemic in 2022. The results showed that exposure to influencer marketing positively correlated with the purchase and consumption of non-alcoholic beer among adolescents. When combined with lower levels of parental restrictive mediation, exposure to influencer marketing of non-alcoholic beer increased the odds of purchasing and consuming alcohol. Furthermore, both exposure to influencer marketing and consumption of non-alcoholic beer were associated with intentions to purchase and consume alcohol in the future among individuals who had not previously purchased or consumed alcohol.
BEHAVIORAL SCIENCES
(2023)
