Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsin-Yu Fang, Stefan Stangl, Sabrina Marcazzan, Marcos J. Braz Carvalho, Theresa Baumeister, Akanksha Anand, Julia Strangmann, Julia Slotta Huspenina, Timothy C. Wang, Roland M. Schmid, Marcus Feith, Helmut Friess, Vasilis Ntziachristos, Gabriele Multhoff, Dimitris Gorpas, Michael Quante
Summary: This study evaluated the use of a highly specific Hsp70-specific contrast agent in guided fluorescence molecular endoscopy biopsy, showing promising potential to improve tumor surveillance in BE patients, especially in cases with dysplasia and EAC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Gastroenterology & Hepatology
Elissa M. Ozanne, Elisabeth R. Silver, Sameer D. Saini, Joel H. Rubenstein, Iris Lansdorp-Vogelaar, Nicole Bowers, Sarah Xinhui Tan, John M. Inadomi, Chin Hur
Summary: Physicians' recommendations for BE surveillance cessation vary based on patient age, comorbidities, and BE length, with age showing the most significant variation in decisions. It appears that age and comorbidities influence BE surveillance cessation decisions, but with differences among clinicians. Clear guidelines balancing the risks and benefits of BE surveillance cessation are needed.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lu
Summary: This article briefly describes the etiology and clinical significance of intestinal metaplasia in Barrett's esophagus, as well as its impact on diagnosis, monitoring, and treatment according to different guidelines. The basis for endoscopic diagnosis and identification techniques of goblet cells in Barrett's esophagus are explored, along with current treatment methods related to the condition.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Marco Spadaccini, Edoardo Vespa, Viveksandeep Thoguluva Chandrasekar, Madhav Desai, Harsh K. Patel, Roberta Maselli, Alessandro Fugazza, Silvia Carrara, Andrea Anderloni, Gianluca Franchellucci, Alessandro De Marco, Cesare Hassan, Pradeep Bhandari, Prateek Sharma, Alessandro Repici
Summary: This paper summarizes the current evidence, recent research advancements, and future perspectives regarding advanced imaging technology and artificial intelligence (AI) in Barrett's esophagus (BE). It stresses the importance of comprehensive endoscopic assessment and computer-aided diagnosis in improving diagnostic outcomes.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Blake Jones, J. Lucas Williams, Srinadh Komanduri, V. Raman Muthusamy, Nicholas J. Shaheen, Sachin Wani
Summary: Black patients with Barrett's esophagus have lower diagnosis rates, are less likely to be recommended appropriate surveillance intervals, and are less likely to follow the Seattle biopsy protocol compared to white patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarmed S. Sami, James P. Moriarty, Jordan K. Rosedahl, Bijan J. Borah, David A. Katzka, Kenneth K. Wang, John B. Kisiel, Krish Ragunath, Joel H. Rubenstein, Prasad G. Iyer
Summary: In GERD-independent scenarios, most non-sEGD BE screening tests were cost-effective, with swallowable esophageal cell collection devices with biomarkers being the optimal choice. However, exhaled volatile organic compounds had the highest ICERs in all scenarios.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Elisa Marabotto, Gaia Pellegatta, Afscin Djahandideh Sheijani, Sebastiano Ziola, Patrizia Zentilin, Maria Giulia De Marzo, Edoardo Giovanni Giannini, Matteo Ghisa, Brigida Barberio, Marco Scarpa, Imerio Angriman, Matteo Fassan, Vincenzo Savarino, Edoardo Savarino
Summary: In the last decades, there has been a rapid increase in the incidence and prevalence of esophageal cancer worldwide, with low rates of early detection and poor prognosis. The main forms are esophageal squamous cell carcinoma and esophageal adenocarcinoma, prevalent in different regions. International scientific societies have proposed various preventive strategies aimed at early detection and improving outcomes.
Article
Gastroenterology & Hepatology
Claire A. Beveridge, Chetan Mittal, V. Raman Muthusamy, Amit Rastogi, Vladimir Kushnir, Mariah Wood, Sachin Wani, Srinadh Komanduri
Summary: This study aimed to assess the rate of visible lesion (VL) detection by academic and community endoscopists using high-definition white-light endoscopy (HD-WLE) and narrow-band imaging (NBI). Participants identified VLs using HD-WLE and NBI, and the results showed that 28% and 31% of VLs were not identified using HD-WLE and NBI respectively. The study also found that the rate of VL detection was associated with the endoscopist's experience and the number of surveillance endoscopies performed each month.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Robert D. Odze, John Goldblum, Vivek Kaul
Summary: Barrett's esophagus (BE) is a premalignant condition that can be effectively monitored and managed using the Wide-area transepithelial sampling with computer-assisted three-dimensional analysis (WATS(3D)) technique, which has shown to significantly increase detection rates of dysplasia and intestinal metaplasia in BE patients.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eszter Becskehazi, Marietta Margareta Korsos, Eleonora Gal, Laszlo Tiszlavicz, Zsofia Hoyk, Maria A. Deli, Zoltan Marton Kohler, Aniko Keller-Pinter, Attila Horvath, Kata Cseko, Zsuzsanna Helyes, Peter Hegyi, Viktoria Venglovecz
Summary: The study suggests that smoking affects the function of ion transporters, playing a role in the development of smoking-induced esophageal diseases. In metaplastic cells, CSE treatment increased the activity and protein expression of NHE-1, reducing proliferation in a NHE-1-dependent manner. Contrarily, in normal cells, the expression and activity of NHE-1 decreased due to smoke exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Aaron P. Thrift, Massimo Rugge, Hashem B. El-Serag
Summary: This study examined the prevalence of Barrett's esophagus in a previously unscreened primary care population and evaluated the performance of various BE screening guidelines. The findings suggest that guidelines requiring GERD symptoms have low sensitivity, while those not requiring GERD have low specificity. The study proposes a screening guideline with better utilization of known risk factors.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Article
Emergency Medicine
Elhaam Mesghali, Scott Fitter, Khaled Bahjri, Kayvan Moussavi
JOURNAL OF EMERGENCY MEDICINE
(2019)
Article
Rehabilitation
Mastour S. Alshaharani, Everett B. Lohman, Khaled Bahjri, Travis Harp, Mansoor Alameri, Hatem Jaber, Noha S. Daher
JOURNAL OF SPORT REHABILITATION
(2020)
Article
Pharmacology & Pharmacy
Lily Yam, Khaled Bahjri, Van Geslani, Adrian Cotton, Lisa Hong
Article
Nursing
Dorothy Forde, Douglas D. Deming, John C. Tan, Raylene M. Phillips, Eileen K. Fry-Bowers, Mary K. Barger, Khaled Bahjri, Danilyn M. Angeles, Danilo S. Boskovic
BIOLOGICAL RESEARCH FOR NURSING
(2020)
Article
Hematology
Soo Min Jang, Khaled Bahjri, Joanna Lee, Sanaz Nabavi, Amir Abdipour
Summary: This study aimed to determine whether the use of ACE inhibitors increases the risk of adverse drug reactions in patients undergoing therapeutic plasma exchange with a conventional centrifuge-based apheresis system. The results showed that there was no significant association between ACEi use and adverse events in these patients. More randomized controlled prospective trials may be needed for further investigation.
THERAPEUTIC APHERESIS AND DIALYSIS
(2021)
Article
Medicine, General & Internal
Ammar Qureshi, Joline De Castro, Adewale B. Ajumobi
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Substance Abuse
Majed M. Ramadan, Jim E. Banta, Khaled Bahjri, Susanne B. Montgomery
JOURNAL OF ADDICTIVE DISEASES
(2020)
Article
Nursing
Elizabeth Johnston Taylor, Carla Gober-Park, Kathy Schoonover-Shoffner, Iris Mamier, Chintan K. Somaiya, Khaled Bahjri
JOURNAL OF CHRISTIAN NURSING
(2019)
Article
Nursing
Elizabeth Johnston Taylor, Carla Gober-Park, Kathy Schoonover-Shoffner, Iris Mamier, Chintan K. Somaiya, Khaled Bahjri
CLINICAL NURSING RESEARCH
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Fnu Versha, Roy Young, Adewale Ajumobi
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Oncology
Brice Jabo, Matthew J. Selleck, John W. Morgan, Sharon S. Lum, Khaled Bahjri, Mayada Aljehani, Carlos A. Garberoglio, Mark E. Reeves, Jukes P. Namm, Naveenraj L. Solomon, Fabrizio Luca, Gary Yang, Maheswari Senthil
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Edelweiss Ramal, Andrea Champlin, Khaled Bahjri
AMERICAN JOURNAL OF HEALTH PROMOTION
(2018)
Article
Oncology
Brice Jabo, Matthew J. Selleck, John W. Morgan, Sharon S. Lum, Khaled A. Bahjri, Mayada Aljehani, Carlos A. Garberoglio, Mark E. Reeves, Jukes P. Namm, Naveenraj L. Solomon, Fabrizio Luca, Crickett Dyke, Maheswari Senthil
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2018)
Article
Pharmacology & Pharmacy
Soo Min Jang, Khaled Bahjri, Huyentran Tran
Article
Dentistry, Oral Surgery & Medicine
Thomas C. Maveli, Montry Suprono, Mathew T. Kattadiyil, Khaled Bahjri
JOURNAL OF PROSTHETIC DENTISTRY
(2018)