Article
Cardiac & Cardiovascular Systems
Nico Hartmann, Lena Preuss, Belal A. Mohamed, Moritz Schnelle, Andre Renner, Gerd Hasenfuss, Karl Toischer
Summary: The study found that mechanical overload can activate specific signaling pathways in the heart muscle, leading to the phosphorylation of certain enzymes. This activation appears to be an intrinsic mechanism that is independent of endocrine signaling.
Article
Multidisciplinary Sciences
Moriz A. Habigt, Michelle Krieger, Jonas Gesenhues, Maike Ketelhut, Mare Mechelinck, Marc Hein
Summary: The linearity and shape of the ESPVR are influenced by different loading alterations. Increases in afterload lead to a biphasic change in ES-PV points, favoring bilinear ESPVRs, while preload reductions can be described by linear regression.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Mareomi Hamada, Akiyoshi Ogimoto, Takashi Otani, Kiyotaka Ohshima, Tamami Kono, Yuta Watanabe, Tatsuro Tasaka, Shuntaro Ikeda
Summary: The study found that the progression of LVH in hypertension did not lead to abnormal LV systolic function, but afterload mismatch was observed in patients with LVHF. Exhaustion of preload reserve led to afterload mismatch in group III.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Physiology
Jarrah M. Dowrick, Kenneth Tran, Amy S. Garrett, Alex Anderson, Poul M. F. Nielsen, Andrew J. Taberner, June-Chiew Han
Summary: This study investigates the Ca2+ handling in trabeculae undergoing work-loop contractions and reveals that reducing preload diminishes the influence of afterload on the decay phase of the cardiac Ca2+ transient. These findings reconcile inconsistencies in the literature regarding the influence of external loads on cardiac Ca2+ handling and highlight discrepancies between Ca2+ handling during isometric and work-loop contractions in cardiac trabeculae operating at their optimal length.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Brent J. Raiteri, Leon Lauret, Daniel Hahn
Summary: This study aimed to estimate the force-length relation of the tibialis anterior (TA) muscle. The results showed that TA produced its maximum active force at 15° dorsiflexion, and its force-length curve agreed with a sarcomere model within the muscle. These findings are important for predicting forces during movement.
Article
Medicine, General & Internal
Dorota Dlugosz, Andrzej Surdacki, Barbara Zawislak, Stanislaw Bartus, Bernadeta Chyrchel
Summary: The translation introduces a study on paradoxical low-flow/low-gradient aortic stenosis. The findings suggest that a smaller left ventricular end-diastolic diameter may be the cause of decreased left ventricular circumferential midwall systolic performance in patients with this condition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Marine Bossert, I. Trimaille, L. Cagnon, B. Chabaud, C. Gueneau, P. Spathis, P. E. Wolf, E. Rolley
Summary: We have studied the homogeneous cavitation in liquid nitrogen and normal liquid helium. The cavitation pressure threshold close to their critical point is in good agreement with the Classical Nucleation Theory (CNT), but at lower temperatures, deviations are observed due to a reduction in surface tension for smaller bubbles. For nitrogen, the nucleation rate was accurately measured as a function of the liquid pressure down to the triple point, and CNT still holds when considering the curvature dependence of the surface tension.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Borut Kirn, Mario Diedrich, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian V. V. Jansen
Summary: In this study, detection techniques for the preload and afterload in total artificial hearts (TAH) are developed and their reliability is evaluated across a range of cardiovascular system states. The results show that the preload estimation is reliable, especially for the left circulation, but further improvements are needed for afterload detection.
Article
Engineering, Biomedical
Hanno Steinke, Sascha Kurz, Benjamin Fischer, Sandra Schuberth, Constance Hobusch, Christoph-Eckhard Heyde
Summary: The objective of this study was to evaluate the intrinsic preload of the sacrotuberous ligament. Preload measurements and anatomical experiments were performed on 20 specimens from 10 human cadavers and assessed to consider the thesis of the ligamentous tension band system as a possible load distribution. The results showed that the sacrotuberous ligament has a higher preload force than expected, and this force is influenced by factors such as gender, body height, age, and elastin content.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Michael Haug, Paul Ritter, Mena Michael, Barbara Reischl, Sebastian Schuermann, Gerhard Proelss, Oliver Friedrich
Summary: Muscle biomechanics is determined by the spacing of individual sarcomeres within muscle fibers. The non-uniform distribution of sarcomere lengths may affect force production and elastic deformation. This study implemented live tracking of sarcomere length distributions and force assessments during axial stretch to analyze the impact of stretch on sarcomere lengths. The results showed a non-uniform distribution of sarcomere lengths and a minor change in distribution upon stretch. Additionally, there was almost no change in sarcomere length variability during elastic deformation. This study provides valuable insights into the contribution of serial elastic and force producing elements in muscle research.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Kaichun Li, Chengbin Du
Summary: This study presents a numerical framework to model the effect of surface tension on a flexoelectric energy harvesting system with liquid inclusions. The equivalent Young's modulus and Poisson's ratio of the liquid inclusions embedded in flexoelectric composites considering the surface tension are derived for the first time. The simulation results indicate that considering surface tension can significantly enhance the electromechanical coupling coefficient and energy conversion capability.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2024)
Article
Engineering, Electrical & Electronic
Xianwei Wang, Peng Han, Xusong Xu, Fei Xie, Zhaoliang Wang, Qinxian Jiang
Summary: This article investigates the preload variation of the CSMC preload structure under different load cases and proposes two strategies to decrease the preload difference. The analysis results demonstrate the feasibility of these schemes, providing helpful guidance for the design of the CFETR Central Solenoid.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2022)
Article
Chemistry, Physical
Z. Mitrinova, M. Chenkova, N. Denkov, S. Tcholakova
Summary: The effect of different types of surfactants with varying chain lengths on the surface properties of a mixed solution of SLES and CAPB was studied. It was found that the addition of longer cosurfactant chains decreases the surface tension of the solution. Nonionic surfactants showed a particularly deep minimum in dynamic surface tension. The addition of anionic surfactants did not affect the dynamic and equilibrium surface tensions of the solution. A strong correlation was established between the dynamic surface tension and the viscosity of the concentrated solution for nonionic surfactants.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Sport Sciences
Marie M. Moltubakk, Fabienne O. Villars, Melina M. Magulas, Stig P. Magnusson, Olivier R. Seynnes, Jens Bojsen-Moller
Summary: The study found that habitual stretching can increase joint range of motion, decrease passive torque, and alter muscle-tendon behavior with the potential to modify contractile function.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Geochemistry & Geophysics
Jeremy Rekier, Benjamin F. Chao, Jianli Chen, Veronique Dehant, Severine Rosat, Ping Zhu
Summary: The observation of variations in Earth's rotation reveals insights into its deep interior structure and dynamics, with a focus on polar motion, length of day variations, and nutations. While models can explain most observed signals, there are exceptions like the Markowitz wobble, suggesting a missing common interpretation related to deep interior dynamics. The interaction of geodetic, magnetic, and gravity observations provides valuable information on the Earth's core dynamics and their impact on nutations.
SURVEYS IN GEOPHYSICS
(2022)
Article
Gastroenterology & Hepatology
Moeen Ud-Din, Bassam Karout, Wiktoria M. Torbe, Johan Lunding, Anne-Marie Wegeberg, Asbjorn M. Drewes, Christina Brock, Per M. Hellstrom
Summary: The study aims to develop a clinical decision-support tool to differentiate the underlying disease in gastrointestinal symptoms of diabetes patients. By collecting basic characteristics and patient reported outcomes, using statistical analysis and machine learning techniques, and searching for biomarkers for autonomic neuropathy, the study hopes to provide better healthcare for diabetes patients.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Reem A. Alharbi, Hossam Elfeki, Katrine J. Emmertsen, Alexander R. Mortensen, Asbjorn M. Drewes, Peter Christensen, Soren Laurberg, Therese Juul
Summary: The chronic pain score (CP score) has been translated and validated in a cohort of colon cancer patients. The score demonstrated good convergent and discriminative validity, and was able to differentiate between different genders and age groups. It also showed the ability to identify patients with a major impact on quality of life.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Davide Bertoli, Esben Bolvig Mark, Donghua Liao, Christina Brock, Jens Brondum Frokjaer, Asbjorn Mohr Drewes
Summary: This study developed a detailed three-dimensional MRI model of the stomach to describe gastric volumes, surface areas, wall tension distribution, and interobserver agreement. The model provides a tool for evaluating gastric function and has important implications for the diagnosis and treatment of diseases such as diabetic gastroparesis.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Tiago Bouca-Machado, Stefan A. W. Bouwense, Martin Brand, Ihsan Ekin Demir, Jens Brondum Frokjaer, Pramod Garg, Peter Hegyi, J. -Matthias Lohr, Enrique de-Madaria, Soren Schou Olesen, Sanjay Pandanaboyana, Jan Bech Pedersen, Vinciane Rebours, Andrea Sheel, Vikesh Singh, Martin Smith, John A. Windsor, Dhiraj Yadav, Asbjorn Mohr Drewes
Summary: Acute on chronic pancreatitis (ACP) is a common condition, but there are significant gaps in our knowledge about it. Through a systematic review and expert consensus, a new definition of ACP was reached. Despite the poor evidence base, this position statement provides a foundation for the management of ACP.
Article
Gastroenterology & Hepatology
Mikael Parhiala, Anne Waage, Povilas Ignatavicus, Jakob L. Poulsen, Engjom Trond, Georg Dimcevski, Ingrid Nordaas, Amer Hadi, Evangelos Kalaitzakis, Asbjorn M. Drewes, Camilla Nojgaard, Johanna Laukkarinen
Summary: This study aimed to determine the surgical treatment strategies for chronic pancreatitis (CP) in the Scandinavian and Baltic countries. The results showed that only 7% of CP patients underwent pancreatic surgery, with 51% of them undergoing surgery for chronic pain. After surgery, 47% of the patients were pain-free and half of the patients reported no pain.
Article
Biotechnology & Applied Microbiology
Donghua Liao, Rasmus B. Nedergaard, Misbah Unnisa, Soumya J. Mahapatra, Mahya Faghih, Anna E. Phillips, Dhiraj Yadav, Vikesh K. Singh, Soren S. Olesen, Rupjyoti Talukdar, Pramod K. Garg, Imran K. Niazi, Christina Brock, Asbjorn M. Drewes
Summary: This study used a custom-designed wearable device to record ECG and ECG-based cardiac function biomarkers in healthy volunteers during tonic pain. The results showed that during exposure to tonic pain, the periodic repolarization dynamics increased significantly, indicating enhancement of sympathetic nervous activity. The custom-designed wearable device can potentially be useful as a new telemetry technology in healthcare.
BIOENGINEERING-BASEL
(2023)
Article
Substance Abuse
Ulrik Becker, Amalie Timmermann, Ola Ekholm, Morten Gronbaek, Asbjorn Mohr Drewes, Srdan Novovic, Camilla Nojgaard, Soren Schou Olesen, Janne Schurmann Tolstrup
Summary: This study analyzed the effects of drinking pattern and type of alcohol on the risk of acute and chronic pancreatitis. The results showed that increased alcohol intake was associated with increased development of pancreatitis. Frequent binge drinking and long-term drinking (daily drinking) were associated with the development of pancreatitis. The intake of large amounts of spirits and beer was associated with the development of acute and chronic pancreatitis, while the consumption of wine was not associated with the development of pancreatitis.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Pharmacology & Pharmacy
Tina Okdahl, Esben Bolvig Mark, Rasmus Bach Nedergaard, Cecilie Siggaard Knoph, Mathias Ellgaard Cook, Klaus Krogh, Asbjorn Mohr Drewes
Summary: Opium tincture, traditionally used for chronic diarrhea, has been found to decrease bowel movements and increase stool consistency without causing sedation. This controlled trial demonstrates that opium tincture has anti-propulsive properties in the healthy gut, making it a relevant and safe treatment option for chronic diarrhea.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kar Man Lo, Daming Sun, Ssu-Chi Chen, Wing Wa Leung, Cherry Wong, Tony Mak, Simon Ng, Kaori Futaba, Hans Gregersen
Summary: This study assessed the repeatability of anorectal data obtained with the Fecobionics device. The results showed that the data from normal subjects were within the normal range and the bias for most parameters were within acceptable limits. The study also found that the intra-individual variability was lower than the inter-individual variability.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, Research & Experimental
Mathias E. Cook, Cecilie S. Knoph, Camilla A. Fjelsted, Jens B. Frokjaer, Anders E. Bilgrau, Srdan Novovic, Maiken Thyregod Jorgensen, Michael B. Mortensen, Liv B. J. Nielsen, Amer Hadi, Mark Berner-Hansen, Wiktor Rutkowski, Miroslav Vujasinovic, Matthias Lohr, Asbjorn M. Drewes, Soren S. Olesen
Summary: This study aims to investigate whether naldemedine can alter the natural course of pancreatitis in patients with recurrent acute pancreatitis and improve patient outcomes.
Article
Oncology
Annette Boesen Braeuner, Nicolas Avellaneda, Peter Christensen, Asbjorn Mohr Drewes, Katrine Jossing Emmertsen, Klaus Krogh, Soren Laurberg, Michael Bodker Lauritzen, Uffe Schou Love, Ole Thorlacius-Ussing, Therese Juul
Summary: This study examined changes in bowel function and quality of life after colon cancer surgery and found that some symptoms worsened in the right-sided colon resection group while improving in the left-sided colon resection group. At 12 months, both groups still experienced bowel dysfunction and impaired quality of life, highlighting the need for systematic screening and early treatment of symptoms.
Article
Clinical Neurology
Rasmus Bach Nedergaard, Matthew Scott, Anne-Marie Wegeberg, Tina Okdahl, Joachim Starling, Birgitte Brock, Asbjarn Mohr Drewes, Christina Brock
Summary: This study used supervised machine learning to classify the severity of cardiovascular autonomic neuropathy (CAN). The results showed that beat-to-beat measures, inflammation markers, disease-duration, and age were the most important features for characterizing CAN. It was suggested that monitoring cardiac reflex responses closely and targeting systemic low-grade inflammation could help diagnose and prevent the development of CAN.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Thomas Arendt Nielsen, Soren Lundbye-Christensen, Yoanna Krasimirova Dimitrova, Sam Riahi, Birgitte Brock, Asbjorn Mohr Drewes, Christina Brock
Summary: Heart rate variability during tonic cold pain can potentially reveal cardiac autonomic neuropathy in individuals with type 1 diabetes mellitus. Compared to healthy controls, patients with type 1 diabetes mellitus have lower heart rate variability, which is further diminished during exposure to cold pain.
SCIENTIFIC REPORTS
(2023)
Review
Gastroenterology & Hepatology
Tina Okdahl, Anton Emmanuel, Bart Morlion, Adam Farmer, Giustino Varrassi, Asbjorn Mohr Drewes
Summary: Despite the standard treatment for opioid-induced constipation, escalation of treatment is often necessary. Previous guidelines have not been used enough, leading to insufficient management. Simplified recommendations are proposed to improve the management of this condition.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mikael Parhiala, Camilla Nojgaard, Andreas Bartholdy, Anne Waage, Povilas Ignatavicius, Trond Engjom, Georg Dimcevski, Ingrid Kvale Nordaas, Evangelos Kalaitzakis, Asbjorn M. Drewes, Amer Hadi, Soren S. Olesen, Jakob L. Poulsen, Johanna Laukkarinen, Scandinavian Baltic Pancreatic Club
Summary: This study aimed to determine the frequency of endoscopic procedures (EP) in chronic pancreatitis (CP) patients and analyze their pain and quality of life (QoL) after the procedures. The study found that 20% of CP patients underwent EP, and these patients had higher QoL scores and improved symptoms. Patients who had pancreatic stenting had similar pain patterns to the reference population.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
