Review
Pharmacology & Pharmacy
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee
Summary: Cancer, a disease of inappropriate cell proliferation, is closely linked to the cell cycle, with multiple genetic alterations leading to cancer development. Both oncogenes and tumor suppressor genes regulate the cell cycle and play key roles in breast cancer progression. These components are tightly controlled in normal breast epithelial cells, but following mitogenic stimuli, their deregulation promotes neoplastic transformation. Numerous clinical studies have revealed prognostic significance in screening for these components, impacting patient outcomes and treatment responses. The review aims to summarize the roles of oncogenic and tumor-suppressive components in breast cancer progression and prognosis.
Article
Cell Biology
Weicai Huang, Zhen Han, Zepang Sun, Hao Feng, Liying Zhao, Qingyu Yuan, Chuanli Chen, Shitong Yu, Yanfeng Hu, Jiang Yu, Hao Liu, Guoxin Li, Yuming Jiang
Summary: The study identifies PAK6 as an important regulator of the DNA damage response (DDR) and chemoresistance in gastric cancer (GC). PAK6 enhances homologous recombination (HR) to facilitate DNA double-strand break repair, leading to chemoresistance. These findings provide insights for reversing chemoresistance in clinical decision-making.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Hong-Yue Jiang, Ying-Ling Chen, Xing-Xing Xu, Chuan-Yin Li, Yun Chen, Dong-Ping Li, Xiao-Qing Zeng, Hong Gao
Summary: Cyclin C plays a crucial role in the regulation of cisplatin resistance in gastric cancer. The ubiquitylation of cyclin C by HACE1 facilitates mitochondrial fission and ROS production, leading to cell apoptosis. This finding provides new insight into the understanding of cisplatin resistance and its potential therapeutic targets in gastric cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jiahui Yuan, Xiaomei Li, Gongye Zhang, Weipeng Cheng, Weiwei Wang, Yongbin Lei, Qiujuan Ma, Gang Song
Summary: USP39 is frequently overexpressed in colon cancer, and its knockdown inhibits the growth of colon cancer cells by stabilizing p21. It regulates the proliferation of colon cancer cells through the p53/p21/CDC2/cyclin B1 axis in a p21-dependent manner, suggesting it as a novel potential target for colon cancer therapy.
MOLECULAR CARCINOGENESIS
(2021)
Article
Surgery
Cansu Karakas, Ashleigh M. Francis, Min Jin Ha, Hannah F. Wingate, Richard A. Meena, Min Yi, Komal S. Rasaputra, Angelica M. Gutierrez Barrera, Banu Arun, Kim-Anh Do, Aysegul Sahin, Khandan Keyomarsi, Kelly K. Hunt
Summary: The presence of cytoplasmic cyclin E expression in breast cancer patients is associated with a lower rate of pathologic complete response to neoadjuvant chemotherapy and poorer long-term outcomes, making it a potential predictor for treatment response.
Article
Biochemistry & Molecular Biology
Weiwei Chen, Kundong Zhang, Yuhan Yang, Zengya Guo, Xiaofeng Wang, Buwei Teng, Qian Zhao, Chen Huang, Zhengjun Qiu
Summary: This study found significantly downregulated HCP5 expression in gastric cancer tissues, and depletion of HCP5 facilitated cell proliferation, migration, and invasion. Moreover, MEF2A-mediated HCP5 exerted an anti-tumor effect in gastric cancer development through the miR-106b-5p/p21 axis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Peng Gu, Minhao Zhang, Jin Zhu, Xiaoliang He, Dongrong Yang
Summary: Dysregulation of CDCA3 expression in prostate cancer is associated with poor prognosis. Knockdown of CDCA3 reduces cell proliferation and increases apoptosis, and affects the cell cycle through NF-κB signaling pathway. Therefore, CDCA3 knockdown may have therapeutic potential for prostate cancer.
Article
Environmental Sciences
Sanjay Kumar, Paul B. Tchounwou
Summary: Arsenic trioxide (ATO) affects cell signaling pathways through various mechanisms, leading to reduced proliferation and growth of acute promyelocytic leukemia (APL) cells by regulating key signaling molecules. Its novel mode of action in APL cells has potential for the development of new APL drugs.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Xiao-Kun Wang, Ya-Wei Zhang, Chun-Ming Wang, Bo Li, Tian-Zhi Zhang, Wen-Jie Zhou, Lyu-jia Cheng, Ming-Yu Huo, Chang-Hua Zhang, Yu-Long He
Summary: The study showed that METTL16 was highly expressed in gastric cancer and associated with prognosis. In vitro and in vivo experiments confirmed that METTL16 promoted proliferation of GC cells and tumor growth. Furthermore, METTL16 was found to enhance proliferation of GC cells by regulating the expression of cyclin D1.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Genetics & Heredity
Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Hikaru Murakawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita, Kiyoshi Ohtani
Summary: Transcription factor E2F, the main target of the tumor suppressor pRB, plays essential roles in cell proliferation and tumor suppression. In almost all cancers, pRB is inactivated, leading to enhanced E2F activity. Trials have been conducted to suppress enhanced E2F activity for targeted cancer therapy, but it may also affect normal growing cells due to the shared mechanism of growth stimulation.
Article
Veterinary Sciences
Giorgia Tura, Barbara Brunetti, Elena Brigandi, Riccardo Rinnovati, Giuseppe Sarli, Giancarlo Avallone, Luisa Vera Muscatello, Roberto Marcello La Ragione, Andy E. Durham, Barbara Bacci
Summary: Expression of cell-cycle regulatory proteins pRB, Cyclin D1, and p53 is not associated with recurrence rates of equine sarcoids, different from human papillomavirus.
VETERINARY SCIENCES
(2022)
Article
Oncology
Takako Sakamoto, Keiji Tanimoto, Hidetaka Eguchi, Shunta Sasaki, Kouki Tsuboi, Shin-ichi Hayashi, Sahoko Ichihara
Summary: This study found that resveratrol (RSV) can suppress the metastatic capacity of triple-negative breast cancer (TNBC) and enhance the cytotoxic activity of ABT263 in TNBC cells. Through regulating the expression and histone acetylation levels of CDH1 and CDKN1A, RSV can up-regulate these two genes via epigenetic mechanisms, thereby repressing TNBC metastasis and enhancing the cytotoxic activity of ABT263.
Article
Pharmacology & Pharmacy
N. S. Helal, M. M. Moussa, T. Aboushousha, M. A. Aboul-Ezz, M. Magdy
Summary: This study suggests that both MT and p21 may play important roles in the development and progression of intestinal-type gastric cancer, and could be potential indicators for selecting personalized targeted therapy for gastric cancer patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Yi Zeng, Gang Ma, Fenglin Cai, Pengliang Wang, Han Liang, Rupeng Zhang, Jingyu Deng, Yong Liu
Summary: SMYD3 is highly expressed in gastric cancer tissues and is associated with aggressive clinical characteristics and poor prognosis. Inhibition of SMYD3 expression significantly reduces the proliferation of gastric cancer cells and Akt signaling pathway activity. SMYD3 epigenetically represses the expression of EMP1 through H4K20me3-dependent mechanisms.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Alexander M. M. Minikes, Yu Song, Yan Feng, Changhwan Yoon, Sam S. S. Yoon, Xuejun Jiang
Summary: Gastric cancer, particularly the aggressive subtype diffuse-type gastric cancer (DGC), is difficult to detect and treat. In this study, it was found that DGC cells with loss-of-function mutation of E-cadherin are more sensitive to ferroptosis, a non-apoptotic, iron-dependent form of cell death. E-cadherin suppresses ferroptosis through activation of the Hippo pathway. Mutations in E-cadherin that reduce its homophilic binding capacity reverse its ability to suppress ferroptosis. Additionally, circulating DGC cells lacking E-cadherin have lower metastatic ability due to their susceptibility to ferroptosis. This study suggests E-cadherin as a biomarker for predicting ferroptosis sensitivity in DGC cells and guiding future therapeutic usage.
Article
Gastroenterology & Hepatology
Alaa El-Hussuna
COLORECTAL DISEASE
(2018)
Article
Gastroenterology & Hepatology
Sanjary Chaudhri
COLORECTAL DISEASE
(2018)
Editorial Material
Hematology
Chrissa Sioka, Konstantinos Sakelariou, Alexandra Papoudou-Bai, Christos Tolis, Jihand Al-Boucharali, Andreas Fotopoulos
TURKISH JOURNAL OF HEMATOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aristeidis H. Katsanos, George A. Alexiou, Andreas D. Fotopoulos, Pascal Jabbour, Athanasios P. Kyritsis, Chrissa Sioka
CLINICAL NUCLEAR MEDICINE
(2019)
Letter
Oncology
Chrissa Sioka, Georgia Karpathiou, Alexandra Papoudou-Bai, Anastasia Zikou, Elpida Tsina, Vanesa Bellou, Vasilios Ragos, Maria I. Argyropoulou, Andreas Fotopoulos, Athanasios Konstantinidis
Editorial Material
Cardiac & Cardiovascular Systems
Chrissa Sioka, Konstantinos Papadimitropoulos, Lampros Michalis, Konstantinos Pappas, Lampros Lakkas, Andreas Fotopoulos, Evangelia Dounousi
CARDIOLOGY JOURNAL
(2019)
Review
Clinical Neurology
Pavlos Texakalidis, Ahmad Sweid, Nikolaos Mouchtouris, Eric C. Peterson, Chrissa Sioka, Leonardo Rangel-Castilla, John Reavey-Cantwell, Pascal Jabbour
WORLD NEUROSURGERY
(2019)
Review
Biochemistry & Molecular Biology
Konstantinos C. Siaravas, Christos S. Katsouras, Chrissa Sioka
Summary: Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment, and it has various mechanisms of radiation-induced cardiac toxicities. This systematic review summarizes the known mechanisms, dosage values, and timeline of cardiovascular toxicities after radiation therapy. The findings can be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Vasiliki Zoi, Maria Giannakopoulou, George A. Alexiou, Penelope Bouziotis, Savvas Thalasselis, Andreas G. Tzakos, Andreas Fotopoulos, Athanassios N. Papadopoulos, Athanassios P. Kyritsis, Chrissa Sioka
Summary: Cancer theragnostics is an innovative approach that combines diagnostic imaging and radionuclide therapy for early diagnosis and targeted treatment of cancer. It uses a pair of radiopharmaceuticals, one for imaging and the other for damaging cancer cells. The advantages of this approach include simplified procedures, reduced adverse effects, and personalized patient care.
Article
Oncology
George A. Alexiou, Georgios S. Markopoulos, Evrysthenis Vartholomatos, Anna C. Goussia, Lefkothea Dova, Savvas Dimitriadis, Stefania Mantziou, Vasiliki Zoi, Anastasios Nasios, Chrissa Sioka, Athanasios P. Kyritsis, Spyridon Voulgaris, George Vartholomatos
Summary: This study investigated the role of intraoperative flow cytometry in differentiating low-grade (grade 1) from high-grade (grade 2-3) meningiomas. Intraoperative flow cytometry analysis using the 'Ioannina Protocol' was performed on 59 patients. The results showed that high-grade meningiomas had higher S-phase fraction, mitosis fraction, and tumor index, while low-grade meningiomas had lower G0/G1 phase fraction. ROC analysis identified a tumor index cutoff value of 11.4% for discriminating between low- and high-grade meningiomas.
Article
Medicine, General & Internal
Chrissa Sioka, Paraskevi Zotou, Michail Papafaklis, Aris Bechlioulis, Konstantinos Sakellariou, Aidonis Rammos, Evangelia Gkika, Lampros Lakkas, Sotiria Alexiou, Pavlos Kekiopoulos, Katerina K. Naka, Christos Katsouras
Summary: This study found that BMI was an independent predictor of myocardial ischemia, and in women, both BMI and waist circumference were significantly associated with myocardial ischemia.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Christina Batsi, Evangelia Gkika, Loukas Astrakas, Athanassios Papadopoulos, Ioannis Iakovou, Alexandros Dogoritis, Andreas Fotopoulos, Chrissa Sioka
Summary: This study found that low levels of vitamin D may represent a risk factor for myocardial ischemia, with patients deficient or insufficient in vitamin D more likely to have abnormal myocardial perfusion imaging results.
MEDICINA-LITHUANIA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Fotopoulos, Chrissa Sioka, Konstantinos Papadimitropoulos, Tzihad Al Boucharali, John Kalef Ezra
NUCLEAR MEDICINE REVIEW
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
C. Sioka, G. Georgiou, A. Karampas, P. Petrikis, A. Papadopoulos, S. Tsiouris, A. Fotopoulos
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Fotopoulos, Konstantinos Papadimitropoulos, Athanasios Papadopoulos, Labros Lakkas, Maria Spiliotopoulou, Tzimis-Dimitrios Kotrotsios, Konstantinos Pappas, Athanasios Notopoulos, Chrissa Sioka
NUCLEAR MEDICINE REVIEW
(2019)