Journal
DIGESTIVE DISEASES
Volume 30, Issue -, Pages 32-38Publisher
KARGER
DOI: 10.1159/000341122
Keywords
Primary sclerosing cholangitis; Genome-wide association studies; Genetics
Categories
Ask authors/readers for more resources
As a result of international collaborations and application of genome-wide association studies (GWAS), a number of susceptibility genes for primary sclerosing cholangitis (PSC) have been detected over the recent years. The genetic architecture of PSC resembles prototypical HLA-associated autoimmune diseases almost as much as that of inflammatory bowel disease. All susceptibility loci reported have previously been detected in other phenotypes in accordance with a paradigm where risk loci detected by GWAS are likely to represent broad phenotypic features like inflammation rather than disease-specific affections. The risk loci have opened up for mechanistic studies in relevant model systems that are likely to enhance understanding of PSC pathogenesis. This review aims to summarize the status and thinking on genetics of PSC as drawn from present data and a series of recent review articles. A particular emphasis will be put on future opportunities related to the incorporation of metagenomic data in the analysis. Copyright (C) 2012 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available