Article
Neurosciences
Liam J. Peck, Ryan Patel, Paula Diaz, Yolanda M. Wintle, Anthony H. Dickenson, Andrew J. Todd, Margarita Calvo, David L. H. Bennett
Summary: The study looked at the expression of Kv1.6 in sensory neurons and its role in pain sensitivity, comparing two mouse models of constitutive Kv1.6 knock-out achieved by different methods. The results showed unexpected reductions in sensitivity to noxious heat stimuli in both mouse lines, with a more significant hyposensitivity in the gene trap model.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Rheumatology
M. Saitou, K. Noda, T. Matsushita, T. Ukichi, D. Kurosaka
Summary: This study aims to explore the prevalence, clinical characteristics, and association between central sensitisation syndrome (CSS) and neuropathic pain (NP)-like symptoms in rheumatoid arthritis (RA) patients. The findings suggest that NP-like symptoms might be one of the symptoms of CSS in longstanding RA patients. Detecting CSS using the central sensitisation inventory (CSI) may help to understand the pathogenesis of patients with disproportionately greater NP-like symptoms and/or widespread pain compared with the degree of inflammation.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Neurosciences
Nick J. Spencer, Tim Hibberd, Zili Xie, Hongzhen Hu
Summary: In recent years, there has been increasing interest in understanding the communication between the gut and the brain. New data suggests that the sensory nerve pathways between the two may have a more significant impact on health and disease than previously assumed. While sensory nerve endings in the skin have been extensively studied, there is a lack of knowledge about most types of visceral afferents, especially those that innervate abdominal organs like the gut. Recent studies have identified nerve endings of spinal afferents in visceral organs, emphasizing their role in pain perception from the gut to the brain. Surprisingly, the majority of these spinal afferent nerve endings in the gut express the TRPV1 ion channel, commonly associated with nociceptive neurons. Furthermore, these nerve endings are activated at low thresholds within the normal physiological range, suggesting a complex nature of visceral nociception. This highlights the need to redefine nociceptors in the gut, which may involve multiple morphological types of spinal afferent nerve endings.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Marcos Lisboa Neves, Jhenifer Karvat, Roli Rodrigues Simoes, Guilherme Fleury Fina Speretta, Renata Maria Lataro, Morgana Duarte da Silva, Adair Roberto Soares Santos
Summary: The study investigated the effects of ABVN stimulation on pain models in rats and found that stimulation on the left side could inhibit pain signaling, dependent on the activation of the vagus nerve and cholinergic receptors.
Article
Cell Biology
Moritz Moeller, Christine Moser, Ulrike Weiss, Ellen Niederberger
Summary: Alpha Synuclein is a synaptic protein associated with neurodegenerative diseases, particularly Parkinson's disease. Research suggests that inhibiting Alpha Synuclein may be beneficial in alleviating pain symptoms following nerve injury.
Article
Biochemistry & Molecular Biology
Zixuan Wang, Stefano Martellucci, Alicia Van Enoo, Dana Austin, Cohava Gelber, Wendy M. Campana
Summary: SP16, derived from AAT, is a bioactive peptide that can increase neurite length and regenerative gene expression in sensory neurons. It activates the Akt and ERK1/2 cell-signaling pathways in an LRP1-dependent manner. SP16 shows efficacy in attenuating nociceptive, inflammatory, and neuropathic pain in three different pain models, and also inhibits inflammatory cell recruitment and satellite cell activation.
Review
Pharmacology & Pharmacy
Alexandre da Silva, Sinda Lepetre-Mouelhi, Patrick Couvreur
Summary: Pain, which significantly affects quality of life, is currently treated with limited efficacy and potential side effects. Nanomedicine offers promising strategies to enhance drug distribution and targeting, improving bioavailability and reducing off-target toxicity.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Medicinal
Jakub Mlost, Marta Kedziora, Katarzyna Starowicz
Summary: The study focuses on the potential therapeutic effects of CBD on osteoarthritis by identifying molecular targets, notably the key role of PPAR gamma. It also highlights the potential heat hyperalgesia induced by CBD and the importance of bioinformatic tools in predicting its mechanism of action in different conditions. The findings pave the way for novel CBD-based therapies and encourage further research in this area.
Article
Chemistry, Multidisciplinary
He-ling Niu, Ya-ni Liu, Deng-qi Xue, Li-ying Dong, Hui-jie Liu, Jing Wang, Yi-lin Zheng, An-ruo Zou, Li-ming Shao, KeWei Wang
Summary: QLS-81, a novel Nav1.7 channel inhibitor, demonstrated efficacy in alleviating chronic pain in mice, indicating potential for pain therapy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Paola Pacifico, James S. Coy-Dibley, Richard J. Miller, Daniela M. Menichella
Summary: This article reviews new approaches for treating peripheral neuropathic pain, including disease modifying therapies and advanced techniques for uncovering novel mechanisms. It also highlights the potential of drug treatment applied topically and the role of non-neuronal cells and communication between the skin and sensory afferents. Lastly, it discusses the current challenges in developing new therapies and improving the translation of research findings from animal models to the clinic.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Medicine, Research & Experimental
Andreia Carona, Joana Bicker, Rui Silva, Carla Fonseca, Amilcar Falcao, Ana Fortuna
Summary: Epilepsy is a common brain disorder affecting millions worldwide, with the third-generation anti-seizure drug, lacosamide, showing good efficacy and safety in treating various types of seizures. Therapeutic drug monitoring can help control variability in treatment and promote personalized therapy, especially in special populations.
Review
Neurosciences
Francesco Ferrini, Chiara Salio, Elena M. Boggio, Adalberto Merighi
Summary: This review summarizes the role of BDNF and GDNF as modulators of synaptic transmission in the mature CNS, with a focus on their interaction in the regulation of nociceptive neurotransmission. BDNF is identified as a key player in pain modulation, whereas the full role of GDNF remains to be elucidated. These neurotrophic factors hold potential as targets for investigating and addressing chronic pain.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Siavash Parvardeh, Sheida Koohsari, Saeed Haji Aghajani, Ramin Pouriran, Leila Alipour Vaezi
Summary: Cuminic alcohol exhibits significant analgesic effects and can alleviate nociceptive and neuropathic pain through multiple pathways, including involvement of opioid receptors, the L-arginine/NO/cGMP pathway, and anti-inflammatory functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Ingrid Schuttert, Hans Timmerman, Gerbrand J. Groen, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Andre P. Wolff
Summary: This study aims to identify the presence of central sensitisation in patients with chronic low back pain radiating to the leg, and to determine its association with the effect of selective nerve root blocks and compare outcomes with healthy volunteers. The primary study parameters are quantitative sensory testing (QST) and the Central Sensitisation Inventory. The results of this study will be disseminated through publications and conferences.
Article
Neurosciences
Rubina Aktar, Madusha Peiris, Asma Fikree, Simon Eaton, Stamatiki Kritas, Stephen J. Kentish, Eduardo J. A. Araujo, Cristiano Bacarin, Amanda J. Page, Nicol C. Voermans, Qasim Aziz, L. Ashley Blackshaw
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Neurosciences
James K. Ruffle, Anya Patel, Vincent Giampietro, Matthew A. Howard, Gareth J. Sanger, Paul L. R. Andrews, Steven C. R. Williams, Qasim Aziz, Adam D. Farmer
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Gastroenterology & Hepatology
Fabienne G. M. Smeets, Daniel Keszthelyi, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Jose M. Conchillo, Joanna W. Kruimel, Jim Van Os, A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Review
Anesthesiology
Rolf-Detlef Treede, Winfried Rief, Antonia Barke, Qasim Aziz, Michael Bennett, Rafael Benoliel, Milton Cohen, Stefan Evers, Nanna B. Finnerup, Michael B. First, Maria Adele Giamberardino, Stein Kaasa, Beatrice Korwisi, Eva Kosek, Patricia Lavand'homme, Michael Nicholas, Serge Perrot, Joachim Scholz, Stephan Schug, Blair H. Smith, Peter Svensson, Johan W. S. Vlaeyen, Shuu-Jiun Wang
Biographical-Item
Gastroenterology & Hepatology
Qasim Aziz
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Gastroenterology & Hepatology
Kenichiro Nakagawa, Ken Hara, Asma Fikree, Shahab Siddiqi, Philip Woodland, Atsushi Masamune, Qasim Aziz, Daniel Sifrim, Etsuro Yazaki
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Medicine, Research & Experimental
David Gunn, Ron Fried, Rabia Lalani, Amanda Farrin, Ivana Holloway, Tom Morris, Catherine Olivier, Rachael Kearns, Maura Corsetti, Mark Scott, Adam Farmer, Anton Emmanuel, Peter Whorwell, Yan Yiannakou, David Sanders, John Mclaughlin, Kapil Kapur, Maria Eugenicos, Ayesha Akbar, Nigel Trudgill, Lesley Houghton, Phil G. Dinning, Alexander C. Ford, Qasim Aziz, Robin Spiller
Article
Gastroenterology & Hepatology
Adam D. Farmer, Ahmed Albusoda, Gehanjali Amarasinghe, James K. Ruffle, Heather E. Fitzke, Ruqaya Idrees, Ron Fried, Christina Brock, Qasim Aziz
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Florencia Carbone, Nick Goelen, Asma Fikree, Qasim Aziz, Jan Tack
Summary: Functional dyspepsia (FD) often co-exists with joint hypermobility syndrome (JHS), characterized by decreased gastric accommodation and lower nutrient tolerance compared to FD patients with JHS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Tim Klaassen, Fabienne G. M. Smeets, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Joanna W. Kruimel, Jose M. Conchillo, Carsten Leue, Adrian A. M. Masclee, Daniel Keszthelyi
Summary: This study demonstrated the good validity and reliability of a novel ESM-based PROM for assessing gastrointestinal symptoms in FD patients. The novel PROM allows evaluation of individual symptom patterns and interactions between symptoms and environmental/contextual factors. ESM has the potential to increase patients' disease insight, provide tools for self-management, and improve shared decision making, aiding in the transition toward personalized health care for FD patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study did not support the hypothesis that adding an inspiratory load to slow, deep breathing enhances its hypoalgesic effects. While pain intensity was slightly lower during SDB with load compared to normal-frequency controlled breathing, the difference was minimal. Heart rate variability was higher during SDB, but emotional responses were less favorable when using load.
Article
Anesthesiology
Abraham B. Beckers, Lukas van Oudenhove, Zsa Zsa R. M. Weerts, Heidi I. L. Jacobs, Nikos Priovoulos, Benedikt A. Poser, Dimo Ivanov, Ali Gholamrezaei, Qasim Aziz, Sigrid Elsenbruch, Ad A. M. Masclee, Daniel Keszthelyi
Summary: The study found that subjects with abdominal pain had more pronounced brain activation during infusion, while activation at the NTS level was independent of subjective pain ratings. These findings contribute to understanding the fundamental mechanism necessary for developing novel therapies aimed at correcting disturbances in visceral afferent pain processing.
Review
Gastroenterology & Hepatology
Christopher Roberts, Ahmed Albusoda, Adam D. Farmer, Qasim Aziz
Summary: This study aimed to determine whether individuals with irritable bowel syndrome (IBS) have lower pain thresholds compared to healthy individuals. The results showed that reduced rectal pain threshold is more common in IBS patients than in healthy controls. Further research is needed to understand the pathophysiological and therapeutic implications of rectal sensitivity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: This study compared four deep breathing techniques and found that loaded breathing was associated with better cardiovascular effects, while pursed-lips breathing had better emotional responses. The findings suggest that different deep breathing techniques may have varying impacts on physiological and emotional states.