HAPS HEPATITIS B VIRUS (HBV) CAPSID INHIBITORS PREVENT HBC INTERACTION WITH THE VIRAL MINICHROMOSOME AND SELECTED HOST CELL GENES TO INHIBITS TRANSCRIPTION AND AFFECT CCCDNA STABILITY
DIGESTIVE AND LIVER DISEASE (2014)
Journal
DIGESTIVE AND LIVER DISEASE
Volume 46, Issue -, Pages E9-E9Publisher
ELSEVIER SCIENCE INC
Keywords
Categories
Ask authors/readers for more resources
Authors
I am an author on this paper
Reviews
Recommended
IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver
Li-na Zhao, Hong-feng Yuan, Yu-fei Wang, Hao-lin Yun, Wei Zheng, Ying Yuan, Yu Geng, Man Zhao, Lian-yun Feng, Xiao-dong Zhang
ACTA PHARMACOLOGICA SINICA (2022)
Synthetic gRNA/Cas9 ribonucleoprotein targeting HBV DNA inhibits viral replication
Jinyu Zhang, Yi Zhang, Sushant Khanal, Dechao Cao, Juan Zhao, Xindi Dang, Nguyen Lam Ngoc Thao, Madison Schank, Xiao Y. Wu, Yong Jiang, Shunbin Ning, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Haitao Guo, Zhi Q. Yao
JOURNAL OF MEDICAL VIROLOGY (2023)
Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production
Julie Lucifora, Florentin Pastor, Emilie Charles, Caroline Pons, Heloise Auclair, Floriane Fusil, Michel Rivoire, Francois-Loic Cosset, David Durantel, Anna Salvetti
JHEP REPORTS (2021)
Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation
Megan A. Mendenhall, Xupeng Hong, Jianming Hu
VIRUSES-BASEL (2023)
PPIases Par14/Par17 Affect HBV Replication in Multiple Ways
Kyongmin Kim
VIRUSES-BASEL (2023)
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation
Dieudonne Buh Kum, Hannah Vanrusselt, Abel Acosta Sanchez, Valerio Taverniti, Eloi R. Verrier, Thomas F. Baumert, Cheng Liu, Jerome Deval, Nikky Corthout, Sebastian Munck, Leonid Beigelman, Lawrence M. Blatt, Julian A. Symons, Pierre Raboisson, Andreas Jekle, Sandrine Vendeville, Yannick Debing
HEPATOLOGY (2023)
The premise of capsid assembly modulators towards eliminating HBV persistence
Leda Bassit, Franck Amblard, Dharmeshkumar Patel, Nicolas Biteau, Zhe Chen, Mahesh Kasthuri, Shaoman Zhou, Raymond F. Schinazi
EXPERT OPINION ON DRUG DISCOVERY (2023)
Visualizing in situ viral replication across the natural history of chronic HBV infection
Hanyue Zhang, Miaoqu Zhang, Qiran Zhang, Yiqi Yu, Fan Zhang, Jing Wang, Mingzhe Zhou, Tong Yu, Chuan Shen, Shuili Yu, Yanfang Huang, Yuxian Huang, Jiming Zhang, Jie Jin, Chao Qiu, Guojun Li, Wenhong Zhang
HEPATOLOGY COMMUNICATIONS (2023)
The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly
Andrew G. Cole, Steven G. Kultgen, Nagraj Mani, Andrzej Ardzinski, Kristi Yi Fan, Emily P. Thi, Bruce D. Dorsey, Kim Stever, Tim Chiu, Sunny Tang, Owen Daly, Janet R. Phelps, Troy Harasym, Andrea Olland, Robert K. Suto, Michael J. Sofia
RSC MEDICINAL CHEMISTRY (2022)
The RNA Binding Proteins YTHDC1 and FMRP Regulate the Nuclear Export of N6-Methyladenosine-Modified Hepatitis B Virus Transcripts and Affect the Viral Life Cycle
Geon-Woo Kim, Hasan Imam, Aleem Siddiqui
JOURNAL OF VIROLOGY (2021)
Does Intrauterine Exposure of the Foetus to Immunosuppressive Drugs Used by the Mother-The Organ Recipient-Affect the Development of Post-Vaccination Immunity against Selected Viral Diseases in Children of These Mothers in Postnatal Life?
Tomasz Ginda, Karol Taradaj, Anna Stelmaszczyk-Emmel, Olga Tronina, Patrycja Kociolek, Oliver Jendro, Bozena Kociszewska-Najman
VACCINES (2023)
COMPLETE BLOCKAGE OF HBV VIRUS REPLICATION AND INHIBITION OF CCCDNA FORMATION BY CORE PROTEIN ALLOSTERIC MODIFIERS
P-C Li, E. Connelly, Y. Zong, Y. Zhou, S. Sun, A. Zlotnick, L. Arnold, U. Lopatin, Q. Huang
JOURNAL OF HEPATOLOGY (2016)
PRECLINICAL CHARACTERIZATION OF POTENT CORE PROTEIN ASSEMBLY MODULATORS FOR THE TREATMENT OF CHRONIC HEPATITIS B
Q. Huang, A. Mercier, Y. Zhou, K. Henne, G. Renuka Kumar, S. Sun, L. Guo, J. Liu, Y. Zong, T. Sun, K. Nabel, P. -C. Li, C. Mahon, G. Chen, M. Bures, L. Li, E. May, E. Connelly, J. Deer, S. Katen, S. Francis, W. W. Turner, A. Zlotnick, L. D. Arnold, U. Lopatin
JOURNAL OF HEPATOLOGY (2016)
US immigration order strikes against biotech
Jeremy M. Levin, Steven H. Holtzman, John Maraganore, Paul J. Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G. Aspinall, James E. Audia, Martin Babler, Peter Barrett, Zoe Barry, Nessan Bermingham, Stephen Blocha, Robert I. Blum, Paul B. Bolno, Michael W. Bonney, Bruce Booth, Daniel M. Bradbury, Steven K. Brauer, Brook Byers, Pablo J. Cagnoni, Brian M. Cali, Isaac Ciechanover, Chip Clark, Michael D. Clayman, Jeff L. Cleland, Paula Cobb, Ron Cooper, Mark G. Currie, John Diekman, Eric L. Dobmeier, Doug Doerfler, Elizabeth L. R. Donley, Deborah Dunsire, Matthew During, Jens W. Eckstein, Eric Elenko, Neil A. Exter, Jonathan J. Fleming, Gregory J. Flesher, Jean-Francois Formela, Robert Forrester, Cedric Francois, Heather Franklin, Mason W. Freemana, Howard Furst, Leonard Patrick Gage, Nicholas Galakatos, Brian M. Gallagher, James A. Geraghty, Simba Gill, David V. Goeddel, Mark A. Goldsmith, Maxine Gowen, Vikas Goyal, Tom Graney, David Grayzel, Barry Greene, Paul Grint, J. C. Gutierrez-Ramos, Bill Haney, Tuan Ha-Ngoc, Tim Harris, Faheem Hasnain, Yujiro Steve Hata, Peter Hecht, Leslie Henshaw, Rich Heyman, Herve Hoppenot, H. Robert Horvitz, Thomas E. Hughes, Wende S. Hutton, Stephen T. Isaacs, Annalisa Jenkins, Jeff Jonker, Jeff Kaplan, Perry Karsen, Jeb Keiper, Jean Kim, Jeff Kindler, Rachel King, Vanessa King, Nina Kjellson, Scott Koenig, Gerhard Koenig, Peter Kolchinsky, Paul Laikind, Robert (Bob) Langer, John J. Lee, Jonathan S. Leff, Bruce A. Leicher, Nick Leschly, Andrew Levin, Mark Levin, Arnold J. Levine, Alan Levy, David R. Liu, Harvey F. Lodish, Uri Lopatin, Ted W. Love, Guy Macdonald, Gail J. Maderis, Ankit Mahadevia, Nagesh K. Mahanthappa, Joel F. Martin, Alex Martin, W. Eddie Martucci, James G. McArthur, Corey M. McCann, Sean A. McCarthy, C. Geoffrey McDonough, John Mendlein, Larry Miller, Diego Miralles, Kenneth I. Moch, Bob More, Andrew G. Myers, Michael A. Narachi, Amir Nashat, Wendy Nelson, William J. Newell, Bernat Olle, John E. Osborn, Julia C. Owens, Atul Pande, Stelios Papadopoulos, H. Stewart Parker, Kush M. Parmara, Matthew R. Patterson, Steve M. Paul, Rob Perez, Matthew Perry, Cary G. Pfeffer, Mike Powell, Mark Pruzanski, Dennis J. Purcell, Amit Rakhit, Kartik Ramamoorthi, William Rastetter, Adrian (Ad) Rawcliffe, Laurence E. Reid, Ron C. Renaud, Jason P. Rhodes, William J. Rieflin, Chad Robins, Scott M. Rocklageb, Michael Rosenblatt, Jonathan G. Rosin, William J. Rutter, Saurabh Saha, Camille Samuels, Vicki L. Sato, George Scangos, John A. Scarlett, David Schenkein, Stuart L. Schreiber, Andrew Schwabb, Paul Sekhri, Rajeev Shah, Thomas Shenk, Clay B. Siegall, Nick J. Simon, Nancy Simonian, Jeff Stein, Michael Su, Mary T. Szela, Marco Taglietti, Nina Tandon, Henri Termeer, Nancy A. Thornberry, Martin Tolar, Richard Ulevitchc, Akshay K. Vaishnaw, Anne VanLent, Martin Varsavsky, George P. Vlasuk, Michel Vounatsos, Samuel G. Waksal, Neil Warma, Ryan J. Watts, Yaron Werber, Christoph Westphal, Wendell Wierenga, Doug E. Williams, Lewis (Rusty) Williams, Kleanthis G. Xanthopoulos, Daphne Zohar, Sandford (Sandy) Zweifach
NATURE BIOTECHNOLOGY (2017)
Interim safety, tolerability pharmacokinetics, and antiviral activity of ABI-H0731, a novel core protein allosteric modulator, in healthy volunteers and non-cirrhotic viremic subjects with chronic hepatitis B
M. -F. Yuen, K. Agarwal, E. Gane, C. Schwabe, W. Cheng, W. Sievert, D. J. Kim, S. H. Ahn, Y. -S. Lim, K. Visvanathan, E. Ruby, S. Liaw, R. Colonno, U. Lopatin
JOURNAL OF HEPATOLOGY (2018)
Biotech leaders call for free press
Ron Cohen, Steven Holtzman, Jeremy M. Levin, John M. Maraganore, Michael Aberman, Chris Adams, Julian Adams, Jeffrey Albers, Bonnie Anderson, Mara G. Aspinall, James E. Audia, Martin Babler, David Baltimore, Stephane Bancel, Peter Barrett, Zoe Barry, David Bartel, Jean-Jacques Bienaime, Burkhard Blank, Robert I. Blum, Daniel M. Bradbury, Eugene Braunwald, John P. Butler, Bruce Carter, Gustav Christensen, Isaac Ciechanover, Chip Clark, John K. Clarke, Michael Clayman, Jeffrey L. Cleland, David Clem, N. Anthony Coles, Charles L. Cooney, Robert K. Coughlin, Zoltan Csimma, Sally J. Curley, Bassi Dahiyat, Daniel A. de Boer, Elisabet de los Piuos, Ronald A. DePinho, Douglas Doerfler, Daniel Dornbusch, Richard H. Douglas, Deborah Dunsire, Neil Exter, Nina Farzan, Jean-Francois Formela, Robert Forrester, Maureen N. Franco, Cedric Francois, Heather Franklin, Scott Garland, Simba Gill, David V. Goeddel, Maxine Gowen, Kurt Graves, Mary Ann Gray, Barry Greene, David-Alexandre C. Gros, Faheem Hasnain, Michael Hammerschmidt, Elma S. Hawkins, Russell Herndon, Paul Hastings, Andrew Hindman, Annalisa Jenkins, Cigall Kadoch, Emil D. Kakkis, Johanne Kaplan, Laurie Keating, Rachel King, Vanessa King, Scott Koenig, Peter Kokhinsky, Daphne Koller, Marc Kozin, Paul Laikind, Robert Langer, Donna L. La Voie, John J. Lees, Jonathan Leff's, Alan Levy, Judy Lieberman, Christine Lindenboom, David R. Liu, Uri Lopatin, Ted W. Love, David N. Low, Nagesh K. Malianthappa, Tiny Martignetti, W. Eddie Martucci, Kiran Mazitindar-Shaw, Tracey L. McCain, Corey M. McCann, David J. McLachlan, David Meeker, Ravi Mehrotra, Steven I. Mentos, Rachel Meyers, Gregory Miller, Ken Mills, Kenneth I. Moch, Michael M. Morrissey, Robert Mulroy, Hnran Nasrullah, William J. Newell, John F. Neylan, Bernat Olle, Eric T. Olson, Douglas E. Onsi, John E. Osborn, Julia C. Owens, Stelios Papadopoulos, Steve Pau, Brian J. G. Pereira, Doris Peterkin, Cary Pfeffer, Mark. Pruzanski, Gerald F. Quirk, Michael Raab, Paula Ragan, Amit Rakhit, Bill Rastetter, Ron Renaud, Jason P. Rhodes, Scott M. Rocklage, Michael Rosenblatt, William J. Rutter, Camille Samuels, James Sapirstein, Amax Sawhney, David Scadden, George Scangos, John A. Scarlett, Stuart L. Schreiber, Paul J. Sekhri, Eric Shaff, Bennett Shapiro, Thomas Shenk, Nancy Simonian, William Slattery, Erika R. Smith, Bruce Steel, Harald Stock, Clifford J. Stocks, Michael Su, Tim Surgenor, Jean-Christophe Tellier, Charles Theuer, Martin Tolar, Eric Tipol, Beth Trehu, Akshay K. Vaishnaw, Christi van Heek, Michael J. Vasconcelles, George P. Vlasuk, Michel Vounatsos, Christopher T. Walsh, Jane Wasman, Andrew Weisenfeld, Yaron Werber, Christoph Westphal, Wendell Wierenga, Thrry Winters, Eugene Williams, Chuck Witson, Peter Wirth, Kleanthis Xanthopoulos, Sanford (Sandy) Zweifach
NATURE BIOTECHNOLOGY (2018)
Drugs in the Pipeline for HBV
Uri Lopatin
CLINICS IN LIVER DISEASE (2019)
Interim safety and efficacy results of the ABI-H0731 phase 2a program exploring the combination of ABI-H0731 with Nuc therapy in treatment-naive and treatment-suppressed chronic hepatitis B patients
Xiaoli Ma, Jacob Lalezari, Tuan Nguyen, Ho Bae, Eugene R. Schiff, Scott Fung, Man-Fung Yuen, Tarek Hassanein, Hie-Won Hann, Magdy Elkhashab, Douglas Dieterich, Mark Sulkowski, Paul Kwo, Ronald Nahass, Kosh Agarwal, Alnoor Ramji, James Park, Natarajan Ravendhran, Sing Chan, Frank Weilert, Steven-Huy Han, Walid Ayoub, Edward Gane, Ira Jacobson, Michael Bennett, Qi Huang, Ran Yan, Vivian Huey, Eric Ruby, Sandy Liaw, Richard Colonno, Uri Lopatin
JOURNAL OF HEPATOLOGY (2019)
Phase 1a Study of the Safety, Tolerability and Pharmacokinetics of ABI-H2158, a Novel Second-Generation HBV Core Inhibitor, in Healthy Volunteers
Edward Gane, Christian Schwabe, Marc Evanhcik, Eric Ruby, Sandy Liaw, Katia Alves, Richard Colonno, Uri Lopatin
JOURNAL OF HEPATOLOGY (2019)
Chinese scientists and US leadership in the life sciences
Steven H. Holtzman, Ron Cohen, Jeremy M. Levin, John Maraganore, Jeff Albers, Joseph E. Aoun, James E. Audia, Michael P. Bailey, Peter Barrett, David Bartel, Jean-Jacques Bienamie, Robert I. Blum, Joshua Boger, Jim Bollenbacher, Michael W. Bonney, Bruce Booth, Daniel M. Bradbury, Olivier Brandicourt, Eugene Braunwald, Anne E. Carpenter, Henry E. Chang, Pavan Cheruvu, Gustav Christensen, George Church, Michael D. Clayman, Charles L. Cooney, Gerald F. Cox, Sally J. Curley, Bassil Dahiyat, Ronald A. DePinho, John Diekman, Douglas Doerfler, Daniel Dornbusch, Richard H. Douglas, Deborah Dunsire, Richard H. Ebright, Wayne Eskridge, Gregory J. Flesher, Kenneth Fong, Jean-Francois Formela, Kaye Foster-Cheek, Cedric Francois, Michael P. Franken, Heather Franklin, Yang-Xin Fu, L. Patrick Gage, Phyllis Gardner, Jason Gardner, Mohamed Genead, James A. Geraghty, Leo Gerweck, Simba Gill, Steven Gillis, David V. Goeddel, Mark Goldsmith, Kurt Graves, Mary Ann Gray, David Grayzel, Barry Greene, Richard J. Gregory, Carol A. Greve-Philips, David-Alexandre Gros, Margaret A. Hamburg, Michael Hammerschmidt, Yuan Hao, Haro Hartounian, Faheem Hasnain, Paul J. Hastings, Elma S. Hawkins, Wei-Wu He, Wei He, Alan Hirzel, Zhi Hong, Herve Hoppenot, William Jia, Johanne Kaplan, Jeb Keiper, Vanessa King, Peter Kolchinsky, Daphne Koller, Paul Laikind, Eric S. Lander, Robert S. Langer, Donna L. LaVoie, Alison Lawton, John J. Lee, Jonathan S. Leff, John Lepore, Nick Leschly, Qingsheng Li, Matthew H. Liang, Judy Lieberman, Johnathan Lim, Martin Lindenberg, Stephen J. Lippard, David R. Liu, Yan Liu, Shan-Lu Liu, Harvey Lodish, Brad Loncar, Uri Lopatin, Ted W. Love, Derek Lowe, Israel Lowy, Hongbo Lu, Liqun Luo, Nagesh K. Mahanthappa, Paul W. Martin, Ann Martini, W. Eddie Martucci, James McArthur, Corey M. McCann, Sean McCarthy, David McLachlan, Craig Mello, Steven J. Mento, James Meyers, Rachel Meyers, Ken Mills, Kenneth I. Moch, Walter H. Moos, Michael Narachi, Amir Nashat, William J. Newell, Oleg Nodelman, Bernat Olle, John E. Osborn, John V. Oyler, William Pao, Neil Patel, Rob Perez, Doris Peterkin, Alice Pompino, Mark Pruzanski, Dan Quinn, Amina Ann Qutub, Michael G. Raab, Massimo Radaelli, Amit Rakhit, Kartik Ramamoorthi, William Rastetter, John C. Reed, Harald Reinhart, Jason P. Rhodes, William J. Rieflin, Lijun Rong, Daniel E. Rosan, Michael Rosenblatt, William J. Rutter, Ismael Samudio, Camille Samuels, Vicki L. Sato, Brent Saunders, David Scadden, George Scangos, John A. Scarlett, Marc Schegerin, Paul Schimmel, Stuart L. Schreiber, Christian R. Schubert, Amy Schulman, Eric Shaff, Robert Shaffer, Phillip A. Sharp, Morgan Sheng, Guojun Sheng, Thomas Shenk, Fuxin Shi, Ada Silos-Santiago, Nancy Simonian, William Slattery, Julie A. Smith, Clifford Stocks, Markus Stoffel, Michael Su, Lishan Su, Nina Tandon, C. M. Tang, Alison Taunton-Rigby, Nikolaos Tezapsidis, Charles Theuer, Nancy A. Thornberry, Martin Tolar, Eric Topol, Wanda Tormos, Anna Trask, Samantha Truex, Thomas Tuschl, Harold E. Varmus, Michael J. Vasconcelles, Michel Vounatsos, Timothy P. Walbert, Christopher T. Walsh, Jason Wang, Jie Wang, Nan Wang, Christoph Westphal, Wendell Wierenga, Douglas E. Williams, Lewis T. Williams, Rick E. Winningham, Peter Wirth, Ryan Witt, Charles Wood, David J. Woodhouse, Rob Wright, Yuntao Wu, Kleanthis G. Xanthopoulos, Charlie Xiao, Tsan Sam Xiao, Jingwu Xie, Yan Xu, Zao C. Xu, Gerald J. Yakatan, Lijuan Yuan, W. K. Alfred Yung, Phillip D. Zamore, Mark Zaydman, Xian-Ming Zeng, Elias Zerhouni, Feng Zhang, Qing Zhang, Shuguang Zhang
NATURE BIOTECHNOLOGY (2019)
Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial
Man-Fung Yuen, Kosh Agarwal, Edward J. Gane, Christian Schwabe, Sang Hoon Ahn, Dong Joon Kim, Young-Suk Lim, Wendy Cheng, William Sievert, Kumar Visvanathan, Eric Ruby, Sandy Liaw, Ran Yan, Qi Huang, Richard Colonno, Uri Lopatin
LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)
Final Results of a Phase 1b 28-Day Study of ABI-H0731, a Novel Core Inhibitor, in Non-Cirrhotic Viremic Subjects with Chronic Hepatitis B
Man-Fung Yuen, Kosh Agarwal, Edward J. Gane, Christian Schwabe, Sang Hoon Ahn, Dong Joon Kim, Young-Suk Lim, Wendy Cheng, William Sievert, Kumar Visvanathan, Eric Ruby, Sandy Liaw, Ran Yan, Emily Connelly, Dawei Cai, Qi Huang, Richard Colonno, Uri A. Lopatin
HEPATOLOGY (2018)
Rapid Turnover of cccDNA in Chronic Hepatitis B Patients Who Have Failed Nucleoside Treatment Due to Emerging Resistance
Qi Huang, Bin Zhou, Yuhua Zong, Dawei Cai, Yaobo Wu, Haitao Guo, Uri A. Lopatin, Jian Sun, Jinlin Hou, Richard Colonno
HEPATOLOGY (2017)
Phase 1a Safety and Pharmacokinetics (PK) of ABI-H0731, a Novel Core Protein Allosteric Modifier (CpAM) For The Treatment of Chronic HBV Infection
Edward J. Gane, Christian Schwabe, Sandy Liaw, Eric Ruby, Leping Li, Kelvin Chan, Kashyap Patel, Patrick Smith, Richard Colonno, Uri A. Lopatin
HEPATOLOGY (2017)
Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients
Louis Jansen, Matthijs R. A. Welkers, Karel A. van Dort, R. Bart Takkenberg, Uri Lopatin, Hans L. Zaaijer, Menno D. de Jong, Hendrik W. Reesink, Neeltje A. Kootstra
ANTIVIRAL RESEARCH (2017)
Blockage of HBV Virus Replication and Inhibition of cccDNA Establishment by Core Protein Allosteric Modifiers (CpAMs)
Qi Huang, Yuhua Zong, Alex Mercier, Renuka Kumar, Cathal Mahon, Yi Zhou, Pao-Chen Li, Lida Guo, Emily Connelly, Shawn Sun, Geoffrey Chen, Katherine Nobel, Lee D. Arnold, William Turner, Leping Li, Simon Haydar, Uri Lopatin, Richard Colonno
HEPATOLOGY (2016)
Export Citation
Share Paper
