☆ 4.6 Article

A Multicenter Study on Childhood Constipation and Fecal Incontinence: Effects on Quality of Life

JOURNAL OF PEDIATRICS (2015)

Journal

JOURNAL OF PEDIATRICS

Volume 166, Issue 6, Pages 1482-+

Publisher

MOSBY-ELSEVIER

DOI: 10.1016/j.jpeds.2015.03.016

Keywords

Funding

Takeda Pharmaceutical Inc [08-014LUB]

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Protocol

Community support

Reagent

Community support

Abstract

Objective To describe the effects of childhood functional constipation compared with functional constipation plus fecal incontinence on quality of life, evaluating effects on physical, psychosocial, and family functioning. Study design This prospective, multicenter study collected data from 5 regional children's hospitals. Children meeting Rome III criteria for functional constipation were included. Parents completed the following 5 instruments: Pediatric Quality of Life Inventory (PedsQL), PedsQL-Family Impact Module, Functional Disability Inventory-Parent Version, Pediatric Inventory for Parents (PIP), and Pediatric Symptom Checklist-Parent Report. Results Families of 410 children aged 2-18 years (mean [SD], 7.8 [3.5] years; 52% male) were included. Children with functional constipation + fecal incontinence had worse quality of life than children with functional constipation alone (PedsQL Total Score, P <= .03). Older children with functional constipation + fecal incontinence had lower quality of life than their younger counterparts (PedsQL Total Score, P <= .047). Children with functional constipation + fecal incontinence had worse family functioning (PedsQL-Family Impact Module Total Score, P <= .012), greater parental stress (PIP-F Total Score, P <= .016; PIP-D Total Score, P <= .013), and poorer psychosocial functioning (Pediatric Symptom Checklist Total Score, P <= .003). There were no statistically significant between-group differences in physical functioning based on the functional Disability Inventory. Conclusion Fecal incontinence significantly decreases quality of life compared with functional constipation alone in children. Older children with functional constipation + fecal incontinence may be at particular risk. Strategies for early identification and treatment of constipation along with diagnosis and treatment of related adjustment difficulties may mitigate the negative impact of this highly prevalent condition.

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A multicenter study of anorectal pressures and rectal sensation measured with portable manometry in healthy women and men

Mayank Sharma, Ann C. Lowry, Satish S. Rao, William E. Whitehead, Lawrence A. Szarka, Frank A. Hamilton, Adil E. Bharucha

Summary: The study aimed to generate reference values for anorectal pressures, examining the effects of gender and age. Results showed that anal and rectal pressures measured using diagnostic and biofeedback catheters were correlated and not significantly different, with pressures found to be influenced by age and sex. Specific pressures during different activities varied among different gender and age groups, providing valuable reference values for clinicians.

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