Review
Gastroenterology & Hepatology
Kazushige Uchida, Kazuichi Okazaki
Summary: The concept of autoimmune pancreatitis (AIP) was first proposed by Yoshida et al. in 1995. AIP has been accepted as a new pancreatic inflammatory disease and is now divided into two subtypes: type 1, which is associated with immunoglobulin G4 (IgG4) and IgG4-related disease, and type 2, characterized by neutrophil infiltration and granulocytic epithelial lesions (GEL). Recent research has provided more knowledge about type 1 AIP, which is more prevalent among the Japanese population compared to type 2. However, many details regarding the pathogenesis and progression of this disease remain unclear.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medical Laboratory Technology
Keiichi Nakano, Junichi Sugita, Masanori Seimiya, Keiko Yasuda, Chiaki Watanabe, Takanori Teshima
Summary: This study found that the formation frequency of IgG4-IgE complex was significantly higher in patients with IgG4-RD compared to those without IgG4-RD. There were no significant differences in clinical characteristics and laboratory data between the groups, but the IgG4-IgE complex-positive group had a significantly higher frequency of pancreatic lesions and a significantly lower rate of retroperitoneal fiber/periarterial lesions compared to the IgG4-IgE complex-negative group.
CLINICA CHIMICA ACTA
(2022)
Editorial Material
Medicine, General & Internal
Stephanie V. Sherman, Yi-Min Huang, Pei-Hsuan Lin
Summary: A 67-year-old man presented with swollen eyelids and proptosis in the ophthalmology clinic. Biopsy of the right lacrimal gland revealed a lymphoplasmacytic infiltrate with IgG4-positive plasma cells.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Taotao Zhou, Henrike Lenzen, Leona Dold, Bennet Bundgens, Heiner Wedemeyer, Michael P. Manns, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Tobias J. Weismuller
Summary: Patients with PSC and elevated sIgG4 should be considered as a distinct subgroup, characterized by different clinical and cholangiographical features and are associated with an inferior outcome.
LIVER INTERNATIONAL
(2021)
Article
Medical Laboratory Technology
Keiichi Nakano, Junichi Sugita, Masanori Seimiya, Keiko Yasuda, Chiaki Watanabe, Takanori Teshima
Summary: This study reported a case of IgG4-IgE complex in a patient with IgG4-RD, leading to discrepancies in IgE concentrations among measuring reagents.
CLINICA CHIMICA ACTA
(2022)
Article
Allergy
Jeffrey M. Wilson, Behnam Keshavarz, Hayley R. James, Maya K. C. Retterer, Alexander J. Schuyler, Alice Knoedler, Lisa J. Workman, Lucy Ng'ang'a, Martha E. Chico, Eva Ronmark, Peter W. Heymann, Matthew S. Perzanowski, Thomas A. E. Platts-Mills, Philip J. Cooper
Summary: The study found that alpha-Gal sensitization is common in children from Ecuador and Kenya, associated with Ascaris exposure, and characterized by a low percentage of specific/total IgE compared to children with meat allergy in the United States.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Immaculate Mutisya, Evelyn Muthoni, Raphael O. Ondondo, Jacques Muthusi, Lennah Omoto, Charlotte Pahe, Abraham Katana, Evelyn Ngugi, Kenneth Masamaro, Leonard Kingwara, Trudy Dobbs, Megan Bronson, Hetal K. Patel, Nicholas Sewe, Doris Naitore, Kevin De Cock, Catherine Ngugi, Lucy Nganga
Summary: By analyzing data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), we estimated the burden and prevalence of pediatric HIV infection, identified associated factors, and described the clinical cascade among children aged < 15 years in Kenya. The survey confirmed a substantial HIV burden among children in Kenya, especially among orphans.
Article
Medicine, General & Internal
Shu Pan, Na Yan, Yuanyuan Zhao, Zhiwen Li
Summary: This study found that marital status has a significant impact on the prognosis of malignant pleural mesothelioma (MPM). Married patients have higher cancer-specific survival and overall survival rates compared to unmarried patients. The poor prognosis in unmarried patients may be attributed to inadequate treatment and socioeconomic and psychosocial factors.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Rui Liu, Jinjin Wang, Nan Wang, Jing Li, Xin Ge, Jingxue Zhang, Jianmin Ma
Summary: By comparing the clinical characteristics and prognoses of IgG4-positive and IgG4-negative lacrimal lymphomas, significant differences were found in certain clinical indicators between the two groups, but no significant differences were observed in laboratory indicators and event-free cumulative percentages.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Christina Schroder, Dorothee Gramatzki, Erwin Vu, Matthias Guckenberger, Nicolaus Andratschke, Michael Weller, Caroline Hertler
Summary: This retrospective analysis of 93 glioblastoma patients with poor performance status found that radiotherapy improved overall survival, especially in patients amendable to neurosurgical resection. Factors influencing survival included extent of resection and administration of radiotherapy with or without systemic treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jingxuan Zhao, Xuesong Han, Leticia Nogueira, Stacey A. Fedewa, Ahmedin Jemal, Michael T. Halpern, K. Robin Yabroff
Summary: Previous studies have shown that uninsured patients in the United States are more likely to be diagnosed with late-stage cancer and have worse survival rates. This report provides comprehensive data on the association between health insurance coverage type and stage at diagnosis and long-term survival in individuals diagnosed with common cancers between 2010 and 2013.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Medicine, General & Internal
Gordon S. Huggins, Daniel D. Kinnamon, Garrie J. Haas, Elizabeth Jordan, Mark Hofmeyer, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Keith D. Aaronson, Daniel P. Fishbein, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Jonathan O. Mead, Hanyu Ni, Wylie Burke, Ray E. Hershberger
Summary: In a US cross-sectional study, the estimated prevalence of familial dilated cardiomyopathy (DCM) among probands was high, and there were differences in the risk of DCM among first-degree relatives across different races and ethnicities, with higher risk observed in first-degree relatives of non-Hispanic Black probands.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Rheumatology
Zachary S. Wallace, Gandarvaka Miles, Ekaterina Smolkina, Natalia Petruski-Ivleva, Duane Madziva, Claire Cook, Xiaoqing Fu, Yuqing Zhang, John H. Stone, Hyon K. Choi
Summary: This study describes the epidemiology of IgG4-related disease (IgG4-RD) in the USA, finding that the incidence and prevalence of IgG4-RD are increasing, and patients with IgG4-RD have a higher risk of death.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Hai Wang, Chunling Wang, Qin Wan, Li Li
Summary: Elevated serum IgG4 level is commonly observed in IgG4-RD and other diseases, especially in chronic diseases of various organs. Serum IgG4 and IgG4/IgG have significant value for the diagnosis and treatment evaluation of IgG4-RD.
CLINICAL RHEUMATOLOGY
(2023)
Article
Pediatrics
Mariaclaudia Meli, Marta Arrabito, Lucia Salvatorelli, Rachele Soma, Santiago Presti, Maria Licciardello, Vito Miraglia, Maria Grazia Scuderi, Giuseppe Belfiore, Gaetano Magro, Giovanna Russo, Andrea Di Cataldo
Summary: IgG4-related disease is an uncommon immune-mediated fibroinflammatory condition that can involve multiple organs and induce cancer-like lesions and organ damage. In children, it often presents as lymph node enlargement, which can be hard to differentiate from other diseases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mats Andersson, Oscar Jalnefjord, Mikael Montelius, Magnus Rizell, Malin Sternby Eilard, Maria Ljungberg
Summary: This study evaluated the response to intratumoral injections with the immune primer, ilixadencel, in hepatocellular carcinoma (HCC) using diffusion-weighted magnetic resonance imaging (DW-MRI) and intravoxel incoherent motion (IVIM) with histogram analysis. The results showed significant reductions in the perfusion-related parameter D* after ilixadencel injections, as well as correlations between baseline D values and tumor size change at three months. Further research is needed to confirm these findings and explore the treatment effect on HCC.
Article
Immunology
Sylvia M. Brakenhoff, Margo J. H. van Campenhout, Annemiek A. van der Eijk, Willem P. Brouwer, Florian van Bommel, Bettina E. Hansen, Thomas Berg, Harry L. A. Janssen, Robert A. de Man, Milan J. Sonneveld
Summary: The study aimed to investigate the relationship between off-treatment ALT flares and virological outcomes, as well as to explore whether serum levels of novel biomarkers at the end of treatment can predict flares. The results showed that ALT flares were associated with decreased sustained response rates, and higher levels of HBsAg, HBV RNA, and HBcrAg were associated with an increased risk of flares.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Gastroenterology & Hepatology
Philipp K. Haber, Florian Castet, Miguel Torres-Martin, Carmen Andreu-Oller, Marc Puigvehi, Maeda Miho, Pompilia Radu, Jean-Francois Dufour, Chris Verslype, Carolin Zimpel, Jens U. Marquardt, Peter R. Galle, Arndt Vogel, Melanie Bathon, Tim Meyer, Ismail Labgaa, Antonia Digklia, Lewis R. Roberts, Mohamed A. Mohamed Ali, Beatriz Minguez, Davide Citterio, Vincenzo Mazzaferro, Fabian Finkelmeier, Joerg Trojan, Burcin Ozdirik, Tobias Mueller, Moritz Schmelzle, Anthony Bejjani, Max W. Sung, Myron E. Schwartz, Richard S. Finn, Swan Thung, Augusto Villanueva, Daniela Sia, Josep M. Llovet
Summary: This study analyzed tumor samples from patients with advanced hepatocellular carcinoma (aHCC) treated with anti-PD1 and identified interferon signaling and major histocompatibility complex-related genes as key molecular features of HCCs responding to anti-PD1. The researchers developed an 11-gene signature that can predict treatment response and survival in frontline aHCC patients.
Article
Gastroenterology & Hepatology
Julia Dietz, Beat Muellhaupt, Peter Buggisch, Christiana Graf, Kai-Henrik Peiffer, Katrin Matschenz, Joern M. Schattenberg, Christoph Antoni, Stefan Mauss, Claus Niederau, Thomas Discher, Janina Trauth, Georg Dultz, Julian Schulze zur Wiesch, Felix Piecha, Hartwig Klinker, Tobias Mueller, Thomas Berg, Christoph Neumann-Haefelin, Christoph P. Berg, Stefan Zeuzem, Christoph Sarrazin
Summary: This study evaluated the long-term persistence of resistance-associated substitutions (RASs) in HCV patients treated with DAAs. Low-to medium-level RASs were found to persist over time, while high-level resistant RASs gradually disappeared. Different patterns of RAS persistence according to HCV subtype could have implications for retreatment with first-generation DAAs and for global HCV elimination goals.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Victoria Therese Muecke, Janett Fischer, Marcus Maximilian Muecke, Alexander Teumer, Alexander Koch, Johannes Vermehren, Malin Fromme, Stefan Zeuzem, Christian Trautwein, Christoph Sarrazin, Thomas Berg, Biaohuan Zhou, Karim Hamesch
Summary: This study found that the heterozygous Pi*Z allele is not a clinically relevant disease modifier in chronic hepatitis C infection, based on analysis of two cohorts. Further validation in larger cohorts with longitudinal follow-up is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Raik Otto, Katharina M. Detjen, Pamela Riemer, Melanie Fattohi, Carsten Groetzinger, Guido Rindi, Bertram Wiedenmann, Christine Sers, Ulf Leser
Summary: Machine learning approaches can improve the classification accuracy of neuroendocrine neoplasms (NEN), but usually require large amounts of training data. This study used machine learning-aided classification based on the similarity between NEN and non-transformed pancreatic cell types to predict patient survival time, neoplastic grading, and carcinoma versus tumor subclassification, providing additional criteria for confident classification of ambiguous cases.
Article
Microbiology
Janett Fischer, Shuang Long, Eleni Koukoulioti, Tobias Mueller, Balazs Fueloep, Renate Heyne, Mohammed Eslam, Jacob George, Fabian Finkelmeier, Oliver Waidmann, Thomas Berg, Florian van Boemmel
Summary: This study found that three common IL-1 beta SNPs are associated with HBV-related HCC in Caucasian patients, with rs1143627 TT and rs16944 CC genotypes being more frequent in HCC patients.
Article
Oncology
Wiebke Werner, Katharina Detjen, Alix Bruneau, Isabella Lurje, Natalie Nestel, Henning Jann, Frank Tacke, Bertram Wiedenmann, Christoph Roderburg, Linda Hammerich
Summary: In a retrospective study on neuroendocrine tumors, the levels of FLT3LG mRNA were found to be correlated with the abundance of immune cells cDC and T cells, which also predicted disease-specific survival. The combination of FLT3LG and T cell counts improved this prediction, suggesting their potential as prognostic markers.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Evelyn Kidess, Yvonne Giesecke, Ines Eichhorn, Raphael Mohr, Henning Jann, Christian Fischer, Bertram Wiedenmann, Christoph Roderburg, Frank Tacke, Michael Sigal
Summary: The study aimed to analyze plasma concentrations of OPN in patients with NEN and explore its diagnostic and prognostic value. The results showed that OPN levels were significantly higher in NEN patients compared to healthy controls, with the highest levels in high-grade tumors (grade 3). In addition, patients with initial OPN levels above 200 ng/ml had a poor prognosis in terms of shorter progression-free survival, both in the overall NEN patient group and within the subgroup of well-differentiated G1/G2 tumors. Therefore, OPN can serve as a surrogate prognostic biomarker in NEN patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Thomas Berg, Aleksander Krag
JOURNAL OF HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Jessica Ryhlander, Gisela Ringstrom, Bjorn Lindkvist, Viktor Tasselius, Per Hedenstrom
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Oncology
Frederico Costa, Bertram Wiedenmann, Christoph Roderburg, Raphael Mohr, Ghassan K. Abou-Alfa
Summary: Hepatocellular carcinoma (HCC) is a leading cause of death in liver cirrhosis patients. Immuno-oncology has revolutionized the treatment for advanced HCC, but most trials exclude patients with moderate liver dysfunction. Patients with HCC and moderate liver dysfunction have a low overall survival rate with sorafenib treatment, indicating the need for improved treatment strategies.
Article
Health Care Sciences & Services
Maria Beatriz Walter Costa, Christiane Gaertner, Maria Schmidt, Thomas Berg, Daniel Seehofer, Thorsten Kaiser
Summary: The MELD scoring system used in prioritizing liver transplantation in Germany is biased against women. By substituting female patients' creatinine levels with male equivalents, we identified a potential solution to reduce gender inequality in patient prioritization for liver transplantation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Max Seidensticker, Osman Oecal, Kerstin Schuette, Peter Malfertheiner, Thomas Berg, Christian Loewe, Heinz Josef Kluempen, Otto van Delden, Muzaffer Reha Uemuetlue, Najib Ben Khaled, Enrico Narciso de Toni, Ricarda Seidensticker, Ali Aghdassi, Albert Tran, Jean-Pierre Bronowicki, Bora Peynircioglu, Bruno Sangro, Maciej Pech, Jens Ricke
Summary: This study aimed to evaluate the efficacy and safety of adjuvant sorafenib treatment compared with placebo in hepatocellular carcinoma patients who underwent local ablation. The results showed that adjuvant sorafenib did not improve time-to-recurrence or local control rate in patients with hepatocellular carcinoma after local ablation.
Letter
Gastroenterology & Hepatology
Tobias Boettler, Aleksander Krag, Thomas Berg
JOURNAL OF HEPATOLOGY
(2023)