Article
Medicine, General & Internal
Adriana Molder, Daniel Vasile Balaban, Cristian-Constantin Molder, Mariana Jinga, Antonin Robin
Summary: For the diagnosis of adult CD, an alternative biopsy-avoiding strategy has been proposed, using machine learning and deep learning algorithms to detect endoscopic markers of villous atrophy in duodenal images during routine endoscopy examinations. In this pilot study, a highly accurate algorithm was developed for the automated detection of mucosal changes associated with villous atrophy in CD patients compared to non-CD controls, using histology as a reference.
Review
Gastroenterology & Hepatology
Giuseppe Losurdo, Milena Di Leo, Edoardo Santamato, Monica Arena, Maria Rendina, Carmelo Luigiano, Enzo Ierardi, Alfredo Di Leo
Summary: The European Society of Pediatric Gastroenterology, Hepatology, and Nutrition has approved new criteria for diagnosing celiac disease in children, allowing for biopsy avoidance in specific antibody value and positivity cases, while adults still require histological biopsy for diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
V. Seitz, K. Gennermann, S. Elezkurtaj, D. Groth, S. Schaper, A. Droege, N. Lachmann, E. Berg, D. Lenze, A. A. Kuehl, C. Husemann, D. Horst, K. Kleo, V. Lennerz, S. Hennig, M. Hummel, M. Schumann
Summary: Celiac disease is an autoimmune disorder characterized by immune response involving gluten-specific CD4(+) T cells and gluten-triggered CD8(+) T cells. This study found that T cell receptors (TCRs) of gluten-triggered CD8(+) T cells were significantly enriched in the duodenal tissue of celiac disease patients, especially in refractory celiac disease. Sequence alignments suggest that these TCRs may recognize microbial, viral, and autoantigens.
CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Serena Vitale, Mariantonia Maglio, Stefania Picascia, Ilaria Mottola, Erasmo Miele, Riccardo Troncone, Renata Auricchio, Carmen Gianfrani
Summary: Celiac disease is a chronic intestinal inflammation caused by gluten ingestion in genetically predisposed individuals. Overt-CD and potential-CD are two main forms with varying degrees of intestinal mucosa lesion and clinical management. Patients with overt-CD require a gluten-free diet, while dietary therapy is recommended for potential-CD only in symptomatic subjects.
Article
Medicine, General & Internal
Giuseppe Losurdo, Milena Di Leo, Edoardo Santamato, Antonio Giangaspero, Maria Rendina, Carmelo Luigiano, Enzo Ierardi, Alfredo Di Leo
Summary: The study suggests that diagnostic criteria for celiac disease and villous atrophy based solely on serological markers are not reliable in adults. While high TGA levels are linked to villous atrophy, the sensitivity and specificity of this relationship are limited in adult patients.
MEDICINA-LITHUANIA
(2021)
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Review
Gastroenterology & Hepatology
Knut E. A. Lundin, Ciaran P. Kelly, David S. Sanders, Kristina Chen, Sheena Kayaniyil, Sisi Wang, Rajvi J. Wani, Caitlin Barrett, Shakira Yoosuf, Ellen S. Pettersen, Robert Sambrook, Daniel A. Leffler
Summary: This study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology and symptoms after diagnosis. Patterns of monitoring varied between sites, with biopsies more frequently conducted in Norway and patients in the United States having a longer follow-up duration.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Pediatrics
Diyora Abdukhakimova, Kuanysh Dossybayeva, Dimitri Poddighe
Summary: This study aimed to summarize the main characteristics of the gut microbiota in pediatric CD. The authors conducted a systematic review and found no specific celiac signature in the fecal and/or duodenal microbiota of CD children. However, certain components of the fecal microbiota, such as Bifidobacterium spp., may warrant further research for their potential value in probiotic therapy and diagnostic/prognostic biomarkers.
FRONTIERS IN PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Shubham Mehta, Ankit Agarwal, Aditya Vikram Pachisia, Alka Singh, Sana Dang, Dwarakanathan Vignesh, Anam Ahmed, Bodhisattya Roy Chaudhari, Shubham Prasad, Ritik Mahaveer Goyal, Amitkumar Chavan, Aagamjit Singh, Sanjay Kumar, Divya Sharma, Ashish Chauhan, Mahendra Singh Rajput, Sachin Rajput, Prasenjit Das, Sushil Falodia, Saroj Kant Sinha, Rakesh Kochhar, Vineet Ahuja, Govind K. Makharia
Summary: Delayed diagnosis of celiac disease leads to increased severity of symptoms, highlighting the need for increased sensitivity in diagnosing celiac disease in appropriate clinical settings.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Juha Taavela, Keijo Viiri, Anna Valimaki, Jani Sarin, Kristiina Salonoja, Markku Maki, Jorma Isola
Summary: The use of APOA4 staining improves the reliability and reproducibility of morphometrical VH:CrD readings, aiding in a more accurate assessment of small intestinal mucosal damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Nicole M. Ralbovsky, Igor K. Lednev
Summary: This study utilized Raman hyperspectroscopy to identify celiac disease in red blood cells, aiming to develop a noninvasive, cost-effective, accurate, and reliable diagnostic method. Through partial least squares discriminant analysis (PLS-DA) and ROC curve analysis, the method achieved 100% successful external validation at the individual donor level.
Article
Biochemistry & Molecular Biology
Elisa Gnodi, Clara Mancuso, Luca Elli, Elisa Ballarini, Raffaella Meneveri, Jean Francois Beaulieu, Donatella Barisani
Summary: The study found that in patients with celiac disease, the expression of NEAT1 and TUG1 is downregulated at diagnosis, but increases in patients' intestinal biopsies after exposure to gluten on a gluten-free diet. Through gel shift assays, it was demonstrated that the increase in NEAT1 expression after gluten exposure is mediated by IL-15 and STAT3 activation, binding to the NEAT1 promoter. NEAT1 is primarily localized in the nucleus and can regulate gene expression by sequestering transcription factors, and has been implicated in immune regulation and control of cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Johannes Virta, Markus Hannula, Katri Lindfors, Ilmari Tamminen, Juha Taavela, Heini Huhtala, Katri Kaukinen, Paeivi Saavalainen, Jari Hyttinen, Kalle Kurppa
Summary: This study validated the use of micro-CT imaging method for accurate evaluation of duodenal histomorphometry and mucosal surface areas. The method showed excellent accuracy and reproducibility, making it a powerful tool for diagnosing celiac disease and conducting clinical and pharmacological studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Kazuma Kishi, Masaki Kuwatani, Yuki Ohnishi, Yasuhiro Kumaki, Hiroyuki Kumeta, Hajime Hirata, Yunosuke Takishin, Ryutaro Furukawa, Kosuke Nagai, Hiroki Yonemura, Shunichiro Nozawa, Ryo Sugiura, Kazumichi Kawakubo, Tomoyasu Aizawa, Naoya Sakamoto
Summary: A metabolomic analysis of duodenal juice was performed to identify differences between malignant and benign biliary diseases, demonstrating the potential of duodenal juice metabolomics as a diagnostic biomarker for biliary diseases.
Review
Pharmacology & Pharmacy
Harrison A. Besser, Chaitan Khosla
Summary: This review summarizes the pathogenesis of celiac disease, focusing on the interactions between three molecular families and the potential for pharmacological targeting.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
B. Zanini, C. Ricci, A. Lanzini
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2015)
Article
Gastroenterology & Hepatology
B. Zanini, R. Basche, A. Ferraresi, C. Ricci, F. Lanzarotto, M. Marullo, V. Villanacci, A. Hidalgo, A. Lanzini
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2015)
Article
Nutrition & Dietetics
Barbara Zanini, Vincenzo Villanacci, Luigina De Leo, Alberto Lanzini
EUROPEAN JOURNAL OF NUTRITION
(2015)
Letter
Gastroenterology & Hepatology
B. Zanini, M. Marullo, C. Ricci, A. Lanzini
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2016)
Article
Nutrition & Dietetics
Barbara Zanini, Monica Marullo, Vincenzo Villanacci, Marianna Salemme, Francesco Lanzarotto, Chiara Ricci, Alberto Lanzini
Letter
Pathology
Barbara Zanini, Vincenzo Villanacci, Monica Marullo, Moris Cadei, Francesco Lanzarotto, Anna Bozzola, Chiara Ricci
Article
Pathology
Barbara Zanini, Vincenzo Villanacci, Monica Marullo, Moris Cadei, Francesco Lanzarotto, Anna Bozzola, Chiara Ricci
Article
Gastroenterology & Hepatology
Barbara Zanini, Beatrice Petroboni, Tarcisio Not, Nicola Di Toro, Vincenzo Villanacci, Francesco Lanzarotto, Norberto Pogna, Chiara Ricci, Alberto Lanzini
BMC GASTROENTEROLOGY
(2013)
Article
Gastroenterology & Hepatology
Barbara Zanini, Francesca Caselani, Alberto Magni, Daniele Turini, Alice Ferraresi, Francesco Lanzarotto, Vincenzo Villanacci, Nice Carabellese, Chiara Ricci, Alberto Lanzini
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2013)
Article
Gastroenterology & Hepatology
Barbara Zanini, Roberta Basche, Alice Ferraresi, Marie Graciella Pigozzi, Chiara Ricci, Francesco Lanzarotto, Vincenzo Villanacci, Alberto Lanzini
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2014)
Article
Gastroenterology & Hepatology
Barbara Zanini, Francesco Lanzarotto, Vincenzo Villanacci, Nice Carabellese, Chiara Ricci, Alberto Lanzini
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2014)
Letter
Pathology
Barbara Zanini, Anna Bozzola, Vincenzo Villanacci
Review
Nutrition & Dietetics
Barbara Zanini, Anna Simonetto, Matilde Zubani, Maurizio Castellano, Gianni Gilioli
Article
Nutrition & Dietetics
Silvia Marconi, Loredana Covolo, Monica Marullo, Barbara Zanini, Gaia Claudia Viviana Viola, Umberto Gelatti, Roberto Maroldi, Nicola Latronico, Maurizio Castellano
Summary: Good cooking skills are associated with better nutrition knowledge and healthier eating habits, including lower consumption of ultra-processed foods. Adolescents with higher culinary abilities showed lower intake of ultra-processed foods and higher eating habit index scores.
Article
Medicine, General & Internal
Emirena Garrafa, Agnese Segala, Marika Vezzoli, Emanuela Bottani, Barbara Zanini, Alice Vetturi, Renata Bracale, Chiara Ricci, Alessandra Valerio
Summary: Non-alcoholic fatty liver disease (NAFLD) is a global health emergency due to its high prevalence and lack of specific therapies. This study found that mitochondrial dysfunction in peripheral blood mononuclear cells (PBMCs) is associated with NAFLD, as indicated by reduced basal respiration, ATP-linked respiration, maximal respiration, and spare respiratory capacity in NAFLD patients compared to control subjects. These mitochondrial respiratory parameters were correlated with triglycerides, fasting insulin levels, IL-6 levels, HDL-cholesterol level, and fatty liver index, suggesting their potential as predictive biomarkers for NAFLD.
