Article
Multidisciplinary Sciences
Mohammad Reza Hatamnejad, Marzieh Shirvani, Mohamad Amin Pourhoseingholi, Hedieh Balaii, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Amirhosein Koolaeian, Makan Cheraghpour
Summary: This study evaluates the psychometric properties of the Persian version of the Inflammatory bowel disease-fatigue (IBD-F) questionnaire. The questionnaire was translated and validated through face, content, and construct validity. The Persian version of the IBD-F questionnaire was found to be valid and reliable, providing a suitable scale to measure fatigue severity, frequency, and impact on daily activities.
Review
Nursing
Parichat Thapwong, Christine Norton, Emma Rowland, Noora Farah, Wladyslawa Czuber-Dochan
Summary: This review examines the impact of Inflammatory Bowel Disease (IBD) on family members. It found that IBD negatively affects family members' well-being in various aspects, and they employ both adaptive and maladaptive coping strategies. Family members also expressed the need for better information, support groups, and access to counseling services.
JOURNAL OF CLINICAL NURSING
(2023)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Review
Medicine, General & Internal
Emese Mihaly, Arpad Patai, Zsolt Tulassay
Summary: Microscopic colitis (MC) is increasingly recognized, but there are still many unanswered questions regarding its pathogenesis, diagnosis, and therapy. The relationship between microbiome changes, different subtypes of the disease, and the effectiveness of treatments like budesonide and biologics remain unclear, highlighting the need for further research in the future.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Mirae Lee, Eugene B. Chang
Summary: Inflammatory bowel diseases (IBD) result from the interaction of environmental, microbial, immunological, and genetic factors, with alterations in the gut microbiota playing a role in their development and progression. The use of microbiome-based therapies can potentially prevent, manage, and cure IBD, bridging the gap between basic sciences and clinical application through research findings.
Editorial Material
Gastroenterology & Hepatology
Chung Sang Tse, Melissa G. Hunt, Lily A. Brown, James D. Lewis
Summary: The diagnosis of IBD brings about significant changes in the lives of most adults. Despite advancements in treatment options, medical and surgical intervention alone may not be enough to completely restore health and prevent long-term disability due to the incurable nature of IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Casper Steenholdt, Ruben Due Lorentsen, Pernille Norgaard Petersen, Jorn Brynskov
Summary: Improvement in health-related quality of life (QoL) and fatigue is observed in patients with inflammatory bowel disease (IBD) receiving vedolizumab therapy. The improvement in QoL is rapid, while the improvement in fatigue is slow.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Hamed Khalili, Jordan E. Axelrad, Bjorn Roelstraete, Ola Olen, Mauro D'Amato, Jonas F. Ludvigsson
Summary: The study reveals that gastrointestinal infections are associated with an increased risk of microscopic colitis, especially Clostridioides difficile. The association between gastrointestinal infections and risk of MC is stronger for the collagenous subtype.
Article
Biology
Istvan Fedor, Eva Zold, Zsolt Barta
Summary: The prevalence of autoimmune diseases is higher in patients with colonic involvement in inflammatory bowel diseases than in those with ileal involvement. Crohn's disease patients have a higher rate of gluten-related disorders compared to ulcerative colitis and microscopic colitis patients. Ulcerative colitis patients may have laboratory markers of autoimmunity without fulfilling the diagnostic criteria for definite autoimmune disorders.
Article
Health Care Sciences & Services
Serena Barello, Elena Guida, Salvatore Leone, Enrica Previtali, Guendalina Graffigna
Summary: Patients diagnosed with inflammatory bowel disease often face unpredictability and poorer health-related quality of life. Patient engagement has been shown to be related to HRQoL among chronic patients. This study found that patient engagement significantly impacts HRQoL, particularly in systemic symptoms, bowel symptoms, social and psycho-emotional functioning.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Pathology
Zhiyan Fu, Michel Kmeid, Soe Htet Arker, Georgi Lukose, Edward C. Lee, Gregory Y. Lauwers, Hwajeong Lee
Summary: This study aimed to identify histologic features of diverted colon segments in IBD patients and found that severe inflammatory activity, mucosal atrophy, and transmural inflammation were significantly greater in IBD patients compared to non-IBD cases. The inflammatory activity, presence of ulcer(s), IMLAs, TMLAs, and transmural inflammation in diverted colon segments of IBD patients may reflect the severity of underlying IBD.
Review
Pathology
Lin Yuan, Tsung-Teh Wu, Lizhi Zhang
Summary: Microscopic colitis (MC) is a chronic inflammatory disease of the colon characterized by chronic, watery, nonbloody diarrhea and normal or almost normal endoscopic findings. Two main subtypes of MC, lymphocytic colitis (LC) and collagenous colitis (CC), are identified through microscopic examination on colon biopsy. The pathogenesis of MC is still unclear, but it has been associated with various risk factors and other diseases such as celiac disease, inflammatory bowel disease, and medication use. This paper aims to provide a systematic introduction to the clinicopathologic features of MC, focusing on unusual features and associations with other conditions.
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Article
Chemistry, Multidisciplinary
Qiong Huang, Yuqi Yang, Yan Zhu, Qiaohui Chen, Tianjiao Zhao, Zuoxiu Xiao, Mingyuan Wang, Xiangping Song, Yitian Jiang, Yunrong Yang, Jinping Zhang, Yang Xiao, Yayun Nan, Wei Wu, Kelong Ai
Summary: Oral antioxidant nanozymes show promise for treating inflammatory bowel disease (IBD). Metal-free melanin nanozymes (MeNPs) are proposed as a favorable therapy for IBD, offering excellent gastrointestinal stability, biocompatibility, and targeting abilities. MeNPs can alleviate the major pathological features of IBD and have potential for clinical use in treating inflammatory diseases.
