Journal
DIGESTIVE AND LIVER DISEASE
Volume 43, Issue 5, Pages 345-351Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2010.10.006
Keywords
Chronic anaemia; Cirrhosis; Gastrointestinal bleeding; Gastropathy; Vascular ectasia
Categories
Funding
- Yale Liver Center NIH [P30 DK34989]
- Instituto de Salud de Carlos III (ISCIII)
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Portal hypertensive gastropathy and gastric antral vascular ectasia are gastric mucosal lesions that can cause chronic gastrointestinal haemorrhage and, consequently, chronic anaemia, in patients with cirrhosis. Although chronic anaemia is the most common clinical manifestation, these entities may also lead to acute gastrointestinal bleeding. Despite similar clinical manifestations, their pathophysiology and management are entirely different. Their diagnosis is endoscopic and although generally each of them has a characteristic endoscopic appearance and distribution, there are cases in which the differential is difficult and must rely on histology. This review focuses on the management of both entities. The mainstay of management of portal hypertensive gastropathy is based on portal-hypotensive pharmacological treatment whilst gastric antral vascular ectasia benefits from endoscopic therapy. More invasive options should be reserved for refractory cases. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.
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