Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, R. Maurizio Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-esophageal reflux (GER) symptoms are associated with an increased odds of Barrett's esophagus (BE), especially when the symptoms occur weekly. However, GER symptoms have low sensitivity and specificity for predicting BE, except for a strong association with long segment BE. Screening individuals with weekly GER symptoms may be beneficial to rule out long segment BE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka
Summary: Existing Barrett's esophagus screening guidelines have limitations in detecting prevalent esophageal adenocarcinoma. An optimized approach is needed to identify individuals most suitable for esophageal adenocarcinoma screening, particularly one that does not rely on chronic reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Sung-Goo Kang, Hyun Jee Hwang, Youngwoo Kim, Junseak Lee, Jung Hwan Oh, Jinsu Kim, Chul-Hyun Lim, Seung Bae Youn, Sung Hoon Jung
Summary: The study evaluated the association between reflux esophagitis and fatigue, finding no statistically significant association between reflux esophagitis and daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, being women, anxiety, and depression. Further research is needed to clarify the relationship between fatigue and reflux esophagitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Article
Surgery
Mohammad Kermansaravi, Bassem Amr, Ali Kabir, Amir Zare, Seidamir Pasha Tabaeian, Foolad Eghbali, Abdolreza Pazouki, Radwan Kassir
Summary: This study aimed to evaluate the occurrence of gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) in patients who underwent sleeve gastrectomy (SG). The results showed that after 5 years, 29.5% of patients developed reflux esophagitis and the incidence of BE was 5.7%.
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jan Bilski, Monika Pinkas, Dagmara Wojcik-Grzybek, Marcin Magierowski, Edyta Korbut, Agnieszka Mazur-Bialy, Gracjana Krzysiek-Maczka, Slawomir Kwiecien, Katarzyna Magierowska, Tomasz Brzozowski
Summary: Both obesity and esophageal adenocarcinoma (EAC) rates have seen a significant increase in recent years in the United States and Western Europe. Obesity plays a key role in the development of EAC, with increased body mass index correlating with higher risk. Pathologically altered visceral fat in obesity is believed to contribute to this process. Visceral obesity may promote EAC through direct effects on gastroesophageal reflux disease and Barrett's esophagus (BE), as well as through the release of pro-inflammatory adipokines and insulin resistance. Disrupted adipokine production, such as the imbalance of leptin and adiponectin, is implicated in the pathogenesis of BE and EAC. This review discusses the epidemiology, pathophysiology, and molecular alterations associated with obesity in BE and EAC, with a focus on the potential role of adipokines and myokines. The review also highlights the possible crosstalk of adipokines and myokines during exercise and suggests lifestyle interventions, specifically regular physical activity, as a promising strategy for preventing the development of BE and EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Roger Scherer, Philipp Schreiner, Jean-Benoit Rossel, Thomas Greuter, Emanuel Burri, Catherine Saner, Christoph Schlag, Ekaterina Safroneeva, Alain Schoepfer, Alex Straumann, Luc Biedermann
Summary: There is a complex interrelationship between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE), with Barrett's Esophagus (BE) being a defining factor for the diagnosis of GERD. This study analyzed data from EoE patients to determine the prevalence of BE and found that it is twice as frequent in EoE patients compared to the general population. EoE patients with Barrett's esophagus had more severe remodeling in their esophagus.
DIGESTIVE DISEASES
(2023)
Article
Medicine, General & Internal
Ahmed Gouda, Mohamed El-Kassas
Summary: This case highlights the importance of upper endoscopy screening for Barrett's esophagus in patients with eating disorders.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Immunology
Ikenna C. Okereke, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy Krill, Clark R. Andersen, Richard B. Pyles
Summary: The microbial community structures differ between patients with and without Barrett's esophagus, with certain organisms less likely to be detected as the severity of Barrett's esophagus worsens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Surgery
J. Veziant, S. Benhalima, G. Piessen, K. Slim
Summary: Sleeve gastrectomy is a commonly performed surgery for morbid obesity, but it may lead to gastro-esophageal reflux disease and its complications. Roux-en-Y gastric bypass is considered the preferred treatment for pre-existing gastro-esophageal reflux disease. Strict endoscopic surveillance and revisional surgery may be necessary after sleeve gastrectomy.
JOURNAL OF VISCERAL SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Samer Elkassem
Summary: This study found that 3 to 4 years after sleeve gastrectomy, patients had a total weight loss percentage of 23%, with increased rates of GERD, esophagitis, and formation of Barrett's esophagus. The majority of patients with GERD pre-op had stable or improved disease post-op.
Article
Biology
Mariana Floria, Diana-Elena Iov, Daniela Maria Tanase, Oana Bogdana Barboi, Genoveva Livia Baroi, Alexandru Burlacu, Mihaela Grecu, Radu Andy Sascau, Cristian Statescu, Catalina Mihai, Vasile Liviu Drug
Summary: Patients undergoing atrial fibrillation ablation may not be at a higher risk of developing symptomatic gastroesophageal reflux disease three months after the procedure, according to a small prospective study.
Review
Gastroenterology & Hepatology
Bashar J. Qumseya, Yazan Qumsiyeh, Sandeep A. Ponniah, David Estores, Dennis Yang, Crystal N. Johnson-Mann, Jeffrey Friedman, Alexander Ayzengart, Peter V. Draganov
Summary: After analyzing 10 studies, it was found that the prevalence of BE is high in patients undergoing EGD after SG, with no significant correlation with postoperative GERD symptoms. Most cases of BE were observed after 3 years.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Pathology
Federica Grillo, Luca Carlin, Andrea Remo, Matteo Fassan, Claudia Mescoli, Michela Campora, Luigi Caserta, Fabrizio Mazza, Luca Mastracci
Summary: Dasatinib-induced colitis may present histological features similar to Crohn's disease, including microgranulomas and active inflammation, and complete remission can be achieved after treatment interruption.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Pathology
Michela Campora, Michele Paudice, Alessandro Gambella, Danila Comandini, Paola Parente, Marta Sbaraglia, Angelo Paolo Dei Tos, Federica Grillo, Luca Mastracci
Summary: Mitotic count is an important prognostic indicator in gastrointestinal stromal tumours. The study found that many pathologists still use 50 high-power fields instead of 5 mm^2 for mitotic count evaluation, leading to non-standardized assessment and risk stratification errors.
Letter
Gastroenterology & Hepatology
Paola Parente, Stefano Ascani, Brigida Anna Maiorano, Magda Zanelli, Davide Ciardiello
Summary: This article is linked to papers by Dahl et al. To access these articles, please visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Margarita Kirienko, Giovanni Centonze, Giovanna Sabella, Mauro Sollai, Martina Sollini, Xiaoli Lan, Haojun Chen, Luigi Terracciano, Ettore Seregni, Massimo Milione
Summary: This study discovered the expression of FAP in alpha cells of the Langerhans islets in the pancreas, which has implications for the use of radioligands.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cell Biology
F. Grillo, M. Paudice, A. Gambella, S. Bozzano, S. Sciallero, A. Puccini, S. Lastraioli, M. Dono, P. Parente, A. Vanoli, V. Angerilli, M. Fassan, L. Mastracci
Summary: This study aims to identify the advantages, disadvantages, and potential pitfalls of MMR evaluation on biopsy tissue for colorectal cancer. The results show that biopsy specimens often have indeterminate stains, particularly for MLH1. However, this issue can be solved by reducing primary incubation times, allowing for accurate assessment of MMR status.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Editorial Material
Cell Biology
Magda Zanelli, Maria Elena Nizzoli, Francesca Sanguedolce, Andrea Palicelli, Maurizio Zizzo, Giuseppe Broggi, Rosario Caltabiano, Paola Parente, Stefano Ascani
Letter
Cell Biology
Andrea Remo, Federica Grillo, Alessandro Vanoli, Paola Parente, Luca Mastracci, Valentina Angerilli, Emanuele Damiano Urso, Francesca Bergamo, Matteo Fassan
Review
Medicine, General & Internal
Alessandro Vanoli, Paola Parente, Matteo Fassan, Luca Mastracci, Federica Grillo
Summary: Gut inflammation disrupts gastrointestinal homeostasis and is associated with cancerogenesis. Various chronic inflammatory disorders of the tubular gastrointestinal tract have been linked to an increased risk of neoplasms, including epithelial tumors (esophageal, gastric, small bowel, and colorectal) and lymphomas. Studies have investigated the mechanisms and changes in the microenvironment and microbiome that lead to genetic and/or epigenetic alterations and eventually tumorigenesis, typically following an inflammation-dysplasia-carcinoma sequence.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Genetics & Heredity
Anna Ferrari, Roberto Fiocca, Elena Bonora, Chiara Domizio, Eugenio Fonzi, Davide Angeli, Gian Domenico Raulli, Sandro Mattioli, Giovanni Martinelli, Chiara Molinari
Summary: This study conducted genomic analysis on a neoadjuvant chemotherapy-resistant gastroesophageal tumor and identified a novel gene fusion, MSI2-C17orf64, that has never been reported before. This finding highlights the potential of MSI2 as a therapeutic target.
Article
Oncology
Arianna Orsini, Luca Mastracci, Isotta Bozzarelli, Anna Ferrari, Federica Isidori, Roberto Fiocca, Marialuisa Lugaresi, Antonietta D'Errico, Deborah Malvi, Erica Cataldi-Stagetti, Paola Spaggiari, Anna Tomezzoli, Luca Albarello, Ari Ristimaki, Luca Bottiglieri, Kausilia K. Krishnadath, Riccardo Rosati, Uberto Fumagalli Romario, Giovanni De Manzoni, Jari Rasanen, Giovanni Martinelli, Sandro Mattioli, Elena Bonora
Summary: Esophageal adenocarcinoma (EAC) is a severe malignancy with increasing incidence, poorly understood pathogenesis, and low survival rates. TP53 gene alterations, especially missense mutations, negatively affect cancer-specific survival in EAC. HNF1alpha gene disruption is associated with other gene alterations and is identified as a new EAC-mutated gene.
Article
Multidisciplinary Sciences
Luigi Cerulo, Nunziana Pezzella, Francesca Pia Caruso, Paola Parente, Andrea Remo, Guido Giordano, Nicola Forte, Johan Busselez, Federico Boschi, Mirco Galie, Brunella Franco, Massimo Pancione
Summary: Ribonucleoprotein (RNP) condensates play a crucial role in controlling RNA metabolism and splicing events in animal cells. By using spatial proteomics and transcriptomics, researchers have identified the RNP interaction networks at the centrosome, which is the main microtubule-organizing center in animal cells. They found that specific cell-type centrosome-associated spliceosome interactions are localized in subcellular structures involved in nuclear division and ciliogenesis. This research provides insights into the functions of cytoplasmic condensates in defining cell identity and the origin of rare diseases.
Article
Cell Biology
Paola Parente, Maria C. Macciomei, Anna M. Buccoliero, Luisa Santoro, Barbara Cafferata, Delfina Bifano, Jacopo Ferro, Alessandro Vanoli, Matteo Fassan, Valentina Angerilli, Rita Alaggio, Luca Mastracci, Maria D'Armiento, Federica Grillo, Paola Francalanci
Summary: Very early-onset inflammatory bowel disease (VEO-IBD) refers to IBD-like symptoms in children before the age of 6 years, including both 'pure' IBD and monogenic diseases (MDs). MD patients may have histological features similar to IBD, making diagnosis challenging.
Article
Pathology
Luca Carlin, Michele Paudice, Marta Ingaliso, Simona Pigozzi, Lucia Trevisan, Stefania Sciallero, Alessandro Pastorino, Nataniele Piol, Federica Grillo, Luca Mastracci
Summary: This study aimed to evaluate the MMR status of synchronous and metachronous CRCs, and found that there were cases with discordant MMR status and metastatic nodal deposits, which is important for patient management.
Editorial Material
Oncology
Paola Parente
FRONTIERS IN ONCOLOGY
(2023)
Letter
Medicine, General & Internal
Edoardo G. Giannini, Tommaso Testa, Federica Grillo, Luca Mastracci, Serena Arrigo, Piero Cai, Sabrina Paolino, Martina Burlando, Livia Pisciotta, Elena Formisano, Giuseppe Cittadini, Francesco Copello, Sabrina Tuo, Giorgia Bodini
Summary: The establishment of an interdisciplinary IBD center is associated with improved healthcare utilization, including a decrease in hospitalizations per patient/year, a decrease in length of hospitalization, and an increase in patients on biologics.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
