Journal
DIGESTIVE AND LIVER DISEASE
Volume 42, Issue 10, Pages 685-691Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2010.03.004
Keywords
Celiac disease; Gluten-free diet; Outcome research; Quality of life; Serology
Categories
Funding
- Consejo de Investigacion en Salud, Ministerio de Salud
- Gobierno de la Ciudad de Buenos Aires
- AEDEI
Ask authors/readers for more resources
Background: Deterioration of quality of life in the long term has been suggested for celiac disease patients on a gluten-free diet. Aims: To determine long-term quality of life of celiac disease patients and to assess the benefits of gluten-free diet compliance. Patients: We prospectively evaluated 53 newly diagnosed adult celiac disease patients. Methods: The Short Form 36 Health Survey, the Gastrointestinal Symptoms Rating Scale and the Beck Depression Inventory were employed at the time of diagnosis, 1 year, and beyond 4 years (median: 53 months) on treatment. Results: At 1 year, a significant improvement from baseline in quality of life indicators was observed (p < 0.001 to p < 0.0001) with comparable scores to healthy subjects. At 4 years, the Short Form 36 Health Survey scores (p < 0.002 to p < 0.0002) and Beck Depression Inventory score (p < 0.002) show significant deterioration compare with 1 year. Most scores remained significantly better than those at diagnosis (p < 0.03 to p < 0.0005). No changes were detected in the Gastrointestinal Symptoms Rating Scale scores. The long-term impairment of quality of life was attributable to the deterioration of most dimensions in patients who were not strictly compliant with the gluten-free diet (p < 0.05 to p < 0.001). Conclusions: Long-term deterioration of quality of life outcomes after the first year of gluten-free diet was associated with the lack of strict compliance with the diet. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available