Editorial Material
Medicine, General & Internal
N. Greco, A. Meacci, B. Mora, A. Vestri, A. Picarelli
Summary: This study examined the clinical status, psychological effects, and management of the gluten-free diet in coeliac patients during the COVID-19 pandemic. The results showed that most patients did not consider themselves vulnerable to COVID-19 and had no difficulties in managing the gluten-free diet. The study also suggested that the HLA DQ2 and/or DQ8 haplotype may play a protective role against SARS-CoV-2 infection.
ANNALS OF MEDICINE
(2022)
Review
Immunology
Jordan Voisine, Valerie Abadie
Summary: Celiac disease is influenced by various factors like gluten antigen, HLA molecules, TG2 enzyme, and interactions between different types of T cells. These factors together lead to changes in immune pathways in specific gut compartments, ultimately resulting in the development of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, David S. Sanders, Paola Baiardi, Giacomo Caio, Carolina Ciacci, Katri Kaukinen, Benjamin Lebwohl, Daniel Leffler, Georgia Malamut, Joseph A. Murray, Kamran Rostami, Alberto Rubio-Tapia, Umberto Volta, Federico Biagi
Summary: This study achieved a consensus on the definitions and diagnostic criteria for seronegative coeliac disease and chronic non-coeliac enteropathies in adults through the Delphi process.
Article
Gastroenterology & Hepatology
Carolin Schneider, Moritz Kleinjans, Malin Fromme, Kai Markus Schneider, Pavel Strnad
Summary: Patients with coeliac disease have higher overall mortality compared to controls, and they are more prone to developing and dying from cancer, respiratory, and cardiovascular diseases. Those with 2 HLA-DQ2/DQ8 risk alleles are more likely to die from lymphoproliferative diseases.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Immunology
Bushra Al Hadra, Tsvetelin Lukanov, Milena I. Ivanova
Summary: This study analyzed the allelic polymorphism of MICA and MICB genes and haplotype associations with HLA-B locus in the Bulgarian population, revealing significant global linkage disequilibrium and contributing to a better understanding of genetic heterogeneity in this population.
Article
Immunology
Karen Toledo-Stuardo, Carolina H. Ribeiro, Andrea Canals, Marcela Morales, Valentina Garate, Jose Rodriguez-Siza, Samantha Tello, Marco Bustamante, Ricardo Armisen, Douglas J. Matthies, Gerald Zapata-Torres, Patricio Gonzalez-Hormazabal, Maria Carmen Molina
Summary: This study revealed the association between MICA gene polymorphisms and susceptibility and prognosis of gastric cancer. Different MICA alleles were found to be significantly correlated with the risk and survival rates of gastric cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Flavia Persechino, Gloria Galli, Severino Persechino, Francesco Valitutti, Letizia Zenzeri, Angela Mauro, Vito Domenico Corleto, Pasquale Parisi, Chiara Ziparo, Melania Evangelisti, Giovanna Quatrale, Giovanni Di Nardo
Summary: Celiac disease is an immune-mediated enteropathy caused by gluten ingestion, affecting approximately 1% of the worldwide population. Extraintestinal symptoms, such as dermatitis herpetiformis, may be the first signs of CD. The role of a gluten-free diet is crucial for improving symptoms associated with CD, including skin manifestations.
Article
Gastroenterology & Hepatology
Anais Levescot, Georgia Malamut, Nadine Cerf-Bensussan
Summary: Coeliac disease is an immune enteropathy induced by genetic and environmental factors. The antigluten immune response and epithelial damage are key events in its pathogenesis, with the JAK/STAT pathway playing a crucial role. However, there are still many unanswered questions and challenges, such as the variability of the disease and improving the patients' quality of life.
Article
Medicine, General & Internal
Anupam Rej, David S. Sanders
Summary: Coeliac disease is a common autoimmune-mediated gastrointestinal disorder with a prevalence of around 1%, but many cases remain undiagnosed. The cornerstone of management is strict adherence to a gluten-free diet with support and education from a gastrointestinal dietitian, sometimes requiring re-evaluation of symptoms and repeat biopsies. Refractory CD affects a small subset of individuals and requires specialist intervention.
Review
Medicine, General & Internal
Carlo Catassi, Elena F. Verdu, Julio Cesar Bai, Elena Lionetti
Summary: Coeliac disease is an autoimmune disorder primarily affecting the small intestine and caused by the ingestion of gluten. It has a complex immune response mechanism. The disease has diverse clinical symptoms, including gastrointestinal symptoms, extraintestinal manifestations, and subclinical cases. Diagnosis involves serological testing and small-intestinal biopsy, and treatment includes a gluten-free diet.
Article
Multidisciplinary Sciences
Moritz Kleinjans, Carolin Schneider, Tony Bruns, Pavel Strnad
Summary: Coeliac disease (CeD) shares similarities in morbidity and mortality with Crohn's disease (CD) and ulcerative colitis (UC), while the specific conditions of CeD may be driven by both inherited and acquired factors.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Michal Kori, Yonatan Zamir, Sami Or Yermiyahu, Inessa Ainbinder, Svetlana Daichman, Gavriel David Pinto, Yiska Loewenberg Weisband, Shira Greenfeld, Revital Kariv, Natan Lederman, Eran Matz, Raanan Shamir, Iris Dotan, Dan Turner
Summary: This study found that the prevalence of coeliac disease (CeD) and coeliac autoimmunity (CeA) is higher in patients with inflammatory bowel diseases (IBD), especially in paediatric-onset IBD and Crohn's disease (CD). The diagnosis of CeD usually precedes the diagnosis of IBD, and patients with both IBD and CeD receive more intensified treatment for IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Pilvi Laurikka, Laura Kivela, Kalle Kurppa, Katri Kaukinen
Summary: The systemic consequences of coeliac disease have a significant impact on the overall health of patients, affecting multiple organ systems including skeletal, reproductive, cardiovascular, and neurological systems. Early diagnosis and treatment with a gluten-free diet are beneficial for most conditions, but potential negative metabolic and psychosocial effects should be considered.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Laia Closa, Francisco Vidal, Maria J. Herrero, Jose L. Caro
Summary: This study analyzed the allele frequencies of HLA-G, HLA-F, MICA, and MICB genes in a population of blood donors in Catalonia, Spain using high-throughput next generation sequencing. The most frequent alleles were identified for each gene, providing important information for further research on the functional role of these genes in different populations and diseases. Strong linkage disequilibrium was observed between MICA and HLA-B, indicating potential genetic associations between these genes.
Article
Gastroenterology & Hepatology
Antonio Rispo, Nicola Imperatore, Maria Guarino, Raffaella Tortora, Anna Alisi, Valentina Cossiga, Anna Testa, Simona Ricciolino, Andrea Fiorentino, Filomena Morisco
Summary: The study found that coeliac disease patients are at high risk of developing non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) after commencing a gluten-free diet. MAFLD patients showed worse outcomes in insulin resistance, liver function, and lipid metabolism, while PNPLA3 gene polymorphisms were associated with the development of NAFLD.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Gaetano Bergamaschi, Fabiana Castiglione, Renata D'Inca, Marco Astegiano, Walter Fries, Monica Milla, Carolina Ciacci, Fernando Rizzello, Simone Saibeni, Rachele Ciccocioppo, Ambrogio Orlando, Fabrizio Bossa, Mariabeatrice Principi, Piero Vernia, Chiara Ricci, Maria L. Scribano, Giorgia Bodini, Dario Mazzucco, Gabrio Bassotti, Gabriele Riegler, Andrea Buda, Matteo Neri, Flavio Caprioli, Fabio Monica, Aldo Manca, Erica Villa, Gionata Fiorino, Michele Comberlato, Nicola Aronico, Cristina Della Corte, Roberta Caccaro, Paolo Gionchetti, Paolo Giuffrida, Paola Iovino, Marco Lenti, Caterina Mengoli, Lucienne Pellegrini, Alberto Pieraccini, Davide Ribaldone, Anna Testa, Cristina Ubezio, Anna Viola, Maurizio Vecchi, Catherine Klersy, Antonio Di Sabatino
Summary: The prevalence of anemia in Italian IBD patients is lower than previously reported, with the majority being caused by iron deficiency and leading to fatigue and decreased quality of life. However, a large proportion of patients with iron and/or vitamin deficiencies remain untreated.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Sport Sciences
Andrea Buonsenso, Arianna Murri, Marco Centorbi, Giulia Di Martino, Giuseppe Calcagno, Alessandra di Cagno, Giovanni Fiorilli, Enzo Iuliano, Giuseppe Musumeci
Summary: The COVID-19 pandemic has had a significant impact on sports and athletes, affecting their performance and psychological well-being. Female athletes are more likely to experience post-COVID-19 symptoms and exhibit greater levels of fatigue. Specific training programs and continuous medical checks and monitoring are necessary for athletes at different levels.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Carolina Ciacci, Francesco Valitutti
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Nutrition & Dietetics
Najla Hajji, Ilaria Russo, Jessica Bianco, Ornella Piazza, Paola Iovino, Antonella Santonicola, Carolina Ciacci
Summary: This study aims to investigate the effects of Globularia alypum L. in patients with ulcerative colitis and normal controls. The results showed that this plant has significant effects on most studied markers and enzymes in both UC patients and normal controls.
Review
Medicine, General & Internal
Herbert Wieser, Massimo Amato, Mario Caggiano, Carolina Ciacci
Summary: This review summarizes recent investigations on dental manifestations in celiac disease, including delayed dental eruption and maturity, dental enamel defects, molar incisor hypomineralization, dental caries, dental plaque, and periodontitis. Studies have shown a higher frequency of delayed dental eruption and maturation in children, and dental enamel defects in individuals with celiac disease compared to healthy individuals. Malabsorption of micronutrients and impaired immunity are considered the main causes. Early diagnosis and a gluten-free diet can prevent the development of these conditions. Dentists can play a significant role in identifying unrecognized celiac disease and preventing long-term complications. Research on dental caries, plaque, and periodontitis in celiac disease is lacking and inconsistent, requiring further examination.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Sport Sciences
Andrea Buonsenso, Marco Centorbi, Enzo Iuliano, Giulia Di Martino, Carlo Della Valle, Giovanni Fiorilli, Giuseppe Calcagno, Alessandra di Cagno
Summary: The systematic review examined the effectiveness of flywheel training, which replicates specific sports movements, in improving sports performance. The review analyzed 21 RCTs involving various sports and found that flywheel training is a beneficial strategy with potential for improving strength, power, sprinting, jumping, and change of direction. However, further studies are needed to establish guidelines for training modalities and parameters. Additionally, the application of flywheel devices in multidirectional movements at different joint angles warrants more research due to limitations such as cost and individual training.
Article
Cardiac & Cardiovascular Systems
Alessandra di Cagno, Giovanni Fiorilli, Andrea Buonsenso, Giulia Di Martino, Marco Centorbi, Antonella Angiolillo, Giuseppe Calcagno, Klara Komici, Alfonso Di Costanzo
Summary: A two-year physical activity program can reduce the medication dosage of antihypertensive drugs for older adults with essential hypertension. The study found that the experimental group had significantly lower drug load at 18 and 24 months compared to the control group.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Nutrition & Dietetics
Fabiana Zingone, Luisa Bertin, Daria Maniero, Michela Palo, Greta Lorenzon, Brigida Barberio, Carolina Ciacci, Edoardo Vincenzo Savarino
Summary: Most adverse reactions to food are self-reported by patients and not validated by tests. Our study aims to clarify the myths and reality of common food intolerances, providing clinicians with guidance for diagnosis and treatment. The review finds that many food intolerances lack sufficient evidence and lead to unnecessary dietary restrictions for patients.
Review
Medicine, General & Internal
Herbert Wieser, Carolina Ciacci, Carolina Gizzi, Antonella Santonicola
Summary: Celiac disease is a chronic gluten-sensitive immune-mediated enteropathy that is characterized by various signs and symptoms. While otorhinolaryngological complaints in Celiac disease are relatively rare, recent studies have shown an increased prevalence of certain mouth and throat conditions in Celiac patients. The association between Celiac disease and other oral manifestations and esophageal disorders requires further investigation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Antonio Rispo, Oriana Olmo, Benedetta Toro, Nicola Mattia Cantisani, Nicola Imperatore, Simona Ricciolino, Alessia Dalila Guarino, Roberto de Sire, Giulio Calabrese, Carolina Ciacci
Meeting Abstract
Gastroenterology & Hepatology
A. Rispo, O. Olmo, B. Toro, N. M. Cantisani, N. Imperatore, S. Ricciolino, L. Limansky, R. Caso, M. Giaquinto, C. Ciacci
DIGESTIVE AND LIVER DISEASE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
P. Bianchi, A. Vanoli, M. Lenti, C. Guerini, G. Arpa, E. Quaquarini, N. Aronico, F. Grillo, G. Nesi, D. Furlan, G. Latella, F. Sessa, C. Mescoli, M. Rugge, S. Ferrero, M. C. Macciomei, D. Santini, U. Volta, R. De Giorgio, G. Caio, A. Calabro, C. Ciacci, M. D'Armiento, V. Villanacci, R. Cannizzaro, V Canzonieri, A. M. Florena, A. Ciardi, L. Elli, M. Vecchi, F. Zingone, Reggiani L. Bonetti, M. Astegiano, G. Sandri, M. Silano, P. Usai, V Perfetti, A. G. Giannone, V Barresi, R. Ciccocioppo, E. Biletta, G. R. Corazza, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
E. S. Corazziari, A. Gasbarrini, L. D'Alba, V. D'Ovidio, O. Riggio, S. Passaretti, B. Annibale, M. Cicala, A. Repici, G. Bassotti, C. Ciacci, A. Di Sabatino, M. Neri, M. C. Bragazzi, E. Ribichini, G. Radocchia, M. Marazzato, S. Schippa, D. Badiali
DIGESTIVE AND LIVER DISEASE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
C. Guerini, P. Bianchi, L. Libera, A. Vanoli, G. Arpa, N. Aronico, D. Furlan, F. Grillo, G. Nesi, G. Sampietro, S. Ardizzone, P. Fociani, R. Fiocca, G. Latella, F. Sessa, A. D'Errico, D. Malvi, C. Mescoli, M. Rugge, S. Ferrero, G. Poggioli, F. Rizzello, M. C. Macciomei, D. Santini, U. Volta, R. De Giorgio, G. Caio, A. Calabro, C. Ciacci, M. D'Armiento, A. Rizzo, G. Solina, F. Tonelli, V. Villanacci, R. Cannizzaro, V Canzonieri, A. M. Florena, L. Biancone, G. Monteleone, R. Caronna, A. Ciardi, L. Elli, F. Caprioli, M. Vecchi, R. D'Inca, F. Zingone, A. D'Odorico, B. Oreggia, Reggiani Bonetti, M. Astegiano, L. Cantoro, C. Papi, G. Sandri, M. Silano, P. Usai, V Perfetti, E. Quaquarini, A. G. Giannone, A. Orlandi, V Barresi, R. Ciccocioppo, G. Amodeo, E. Biletta, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. A. Latorre, P. I. Bianchi, M. V. Lenti, Aronico N., C. Petrucci, C. C. D'Agate, M. Neri, U. Volta, M. G. Mumolo, M. Astegiano, A. S. Calabro, F. Zingone, G. Latella, A. Di Sario, A. Carroccio, C. Ciacci, F. Luzza, C. Bagnato, M. C. Fantini, L. Elli, G. Cammarota, A. Gasbarrini, P. Portincasa, C. Quatraccioni, C. Iannelli, N. Vecchione, G. Broglio, G. Ianiro, I. Marsilio, S. Bibbo, B. Marinoni, D. Tomaselli, L. Abenavoli, R. Pilia, G. Santacroce, E. Lynch, A. Carrieri, P. Mansueto, M. Gabba, G. Alunno, C. Rossi, F. Onnis, K. Efthymakis, N. Cesaro, M. Vernero, Baiano F. Svizzero, M. Silano, C. Klersy, G. R. Corazza, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2023)