Article
Pharmacology & Pharmacy
Jinhao Zeng, Xiao Ma, Ziyi Zhao, Yu Chen, Jundong Wang, Yanwei Hao, Junrong Yu, Zhongzhen Zeng, Nianzhi Chen, Maoyuan Zhao, Jianyuan Tang, Daoyin Gong
Summary: GRb1 has been found to reverse intestinal metaplasia and a portion of dysplasia in MNNG-induced GPL rats, possibly by reducing protein expression and nuclear translocation of beta-catenin, interfering with beta-catenin/TCF4 interaction to prevent the occurrence and progression of GPL.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
M. Blanca Piazuelo, Luis E. Bravo, Robertino M. Mera, M. Constanza Camargo, Juan C. Bravo, Alberto G. Delgado, M. Kay Washington, Alicia Rosero, Luz S. Garcia, Jose L. Realpe, Sandra P. Cifuentes, Douglas R. Morgan, Richard M. Peek, Pelayo Correa, Keith T. Wilson
Summary: In a Hispanic population at high risk of gastric cancer, anti-H pylori therapy had a long-term beneficial effect against histologic progression. Incomplete IM is a strong predictor of GC risk.
Article
Immunology
Xinmei Zhang, Chao Li, Weijun Cao, Zhenyu Zhang
Summary: Microbial infections are known to contribute to gastric carcinogenesis, and changes in gastric microbiota may aid in early diagnosis of gastric cancer. This study aimed to characterize microbial changes and identify taxonomic biomarkers across stages of gastric carcinogenesis. The results showed that the richness and diversity of gastric microbiota did not show a gradual changing trend, with certain oral bacteria continuously enriching from superficial gastritis to gastric cancer. Patients with gastric cancer had enrichments of both oral and environmental bacteria, while those with gastric intraepithelial neoplasia had an enrichment of intestinal commensals. Gastric cardia cancer and non-cardia cancer patients had significantly different microbiota profiles, with a higher abundance of Helicobacter in the cardia cancer patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuan Li, Tao Li, Jiena Chen, Haocheng Zheng, Yicong Li, Fuhao Chu, Sici Wang, Ping Li, Jie Lin, Zeqi Su, Xia Ding
Summary: Manpixiao decoction (MPX), a traditional Chinese medicine formula, has shown protective effects against precancerous lesion of gastric cancer (PLGC) through inhibiting epithelial-mesenchymal transition process mediated by EGFR-PI3K-AKT pathway. MPX improved the pathological condition of gastric mucosa in PLGC rats and reduced the incidence of gastric cancer. The efficacy of MPX in the treatment of PLGC might be associated with its effects on inflammation, immune responses, and angiogenesis. These findings suggest the potential of MPX as an alternative therapy for preventing the progression of PLGC to gastric cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Dehua Liu, Si Chen, Yawen Gou, Wenyong Yu, Hangcheng Zhou, Rutong Zhang, Jinghao Wang, Fei Ye, Yingling Liu, Baolin Sun, Kaiguang Zhang
Summary: This study identified associations between gastric precancerous lesions and gastric microbiota, as well as changes in intestinal microbiota, and explored their potential value in the prediction of gastric precancerous lesions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xin Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben, Linghua Wang, Junya Fujimoto, Jian Carrot-Zhang, Nicholas McGranahan, Lisha Ying, Junya Fukuoka, Chi-Wan Chow, Hoa H. N. Pham, Myrna C. B. Godoy, Brett W. Carter, Carmen Behrens, Jianhua Zhang, Mara B. Antonoff, Boris Sepesi, Yue Lu, Harvey Pass, Humam Kadara, Paul Scheet, Ara A. Vaporciyan, John Heymach, Ignacio I. Wistuba, J. Jack Lee, P. Andrew Futreal, Dan Su, Jean-Pierre J. Issa, Jianjun Zhang
Summary: This study reveals that DNA methylation alterations accompany the evolution of pre-cancerous lesions in early carcinogenesis of lung adenocarcinomas, with global hypomethylation correlating with immune infiltration, mutational burden, and copy number alterations.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang, Yunfeng Gao, Ran Yang, Shiwen Yan, Wen Zhang, Bingbing Lu, Feifei Liu, Ran Zhao, Wenting Liu, Zihan Zhang, Kangdong Liu, Xiang Li, Zigang Dong
Summary: Spatial transcriptomics analysis revealed expression changes in TAGLN2 and CRNN during the progression from esophageal squamous precancerous lesions (ESPL) to esophageal squamous cell carcinoma (ESCC). TAGLN2 expression significantly increased, while CRNN expression decreased along with ESCC progression. These findings suggest that TAGLN2 and CRNN can serve as candidate indicators for predicting the risk of ESCC at the ESPL stage.
NATURE COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Andreia Albuquerque, Mayura Nathan, Carmelina Cappello, Mario Dinis-Ribeiro
Summary: Anal squamous cell carcinoma, associated with anal HPV infection, is increasing in incidence and common in specific population groups. Screening aims to detect precancerous lesions for prevention, with various treatment options available for high-grade lesions. Gastroenterologists should be aware of these conditions for early detection in high-risk patients.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Medicine, Research & Experimental
Weichao Xu, Bolin Li, Miaochan Xu, Tianxiao Yang, Xinyu Hao
Summary: The article discusses the treatment of gastric precancerous lesions (PLGC) stage, proving the effectiveness of traditional Chinese medicine in treating and preventing such diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Kohei Yamakawa, Noriko Inomata, Atsuhiro Masuda, Mamoru Takenaka, Hirochika Toyama, Keitaro Sofue, Arata Sakai, Takashi Kobayashi, Takeshi Tanaka, Masahiro Tsujimae, Shigeto Ashina, Masanori Gonda, Shohei Abe, Shigeto Masuda, Hisahiro Uemura, Shinya Kohashi, Kae Nagao, Yoshiyuki Harada, Mika Miki, Yosuke Irie, Noriko Juri, Hideyuki Shiomi, Maki Kanzawa, Tomoo Itoh, Takumi Fukumoto, Yuzo Kodama
Summary: Pancreatic cancer primarily arises from precancerous lesions such as PanIN and ADM. This study aimed to investigate the relationship between EUS findings and these lesions. The results showed that abnormal EUS findings were significantly associated with a higher frequency of PanIN and ADM, and lobularity may be a predictor of increased precancerous lesions.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Raquel Ron, Alfonso Cabello, Maria Jose Gosalbes, Matilde Sanchez-Conde, Alba Talavera-Rodriguez, Javier Zamora, Begona Monge-Maillo, Daniel Jimenez, Javier Martinez-Sanz, Yolanda Lopez, Clara Crespillo, Tamara Velasco, Santiago Moreno, Jose A. Perez-Molina, Sergio Serrano-Villar
Summary: This study identified specific anal-associated bacteria indicative of a higher risk of precancerous anal lesions, with a combination showing high diagnostic specificity as a potential complementary diagnostic tool to overcome limitations of current anal cancer screening strategies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Integrative & Complementary Medicine
Ping Wang, Peng Li, Yingxuan Chen, Li Li, Yuanyuan Lu, Weixun Zhou, Liqun Bian, Beihua Zhang, Xiaolan Yin, Junxiang Li, Jie Chen, Shutian Zhang, Yongquan Shi, Xudong Tang
Summary: This guideline, created by 5 traditional Chinese medicine and Western medicine associations, provides specific key points and strategies for the diagnosis and treatment of gastric precancerous conditions and lesions, aiming to achieve effective secondary prevention of gastric cancer.
Article
Biochemistry & Molecular Biology
Aneta Popiel-Kopaczyk, Aleksandra Piotrowska, Patrycja Sputa-Grzegrzolka, Beata Smolarz, Hanna Romanowicz, Piotr Dziegiel, Marzenna Podhorska-Okolow, Christopher Kobierzycki
Summary: During the epithelial-mesenchymal transition (EMT) process, cells undergo changes in phenotype, which can be observed in the metastatic phase of neoplastic diseases like cervical cancer. This study aimed to determine the localization and associations of TWIST, SNAIL, and SLUG proteins, which are markers of EMT, in precancerous lesions and cervical cancer. The immunohistochemical (IHC) analysis showed higher expressions of EMT markers in precancerous lesions and cervical cancer compared to the control group. Additionally, the expression of TWIST, SNAIL, and SLUG varied significantly between different grades of cervical intraepithelial neoplasia and cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zong-Chao Liu, Wen-Hui Wu, Sha Huang, Zhong-Wu Li, Xue Li, Guang-Hou Shui, Sin Man Lam, Bo-Wen Li, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li
Summary: This study identified lipidomic signatures associated with the risk of gastric lesion progression and gastric cancer occurrence, with translational implications for gastric cancer prevention.
Article
Medicine, General & Internal
Xue Li, Nai-Ren Zheng, Lin-Heng Wang, Zhong-Wu Li, Zong-Chao Liu, Hua Fan, Yi Wang, Jin Dai, Xiao-Tian Ni, Xin Wei, Ming-Wei Liu, Kai Li, Zhe-Xuan Li, Tong Zhou, Yang Zhang, Jing-Ying Zhang, Gaohaer Kadeerhan, Sha Huang, Wen-Hui Wu, Wei-Dong Liu, Xiu-Zhen Wu, Lan-Fu Zhang, Jian-Ming Xu, Markus Gerhard, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li, Jun Qin
Summary: By analyzing the proteomic landscape, we identified protein signatures associated with the progression of gastric lesions and the risk of early gastric cancer. These findings have important implications for identifying high-risk populations and early detection of gastric cancer.