Article
Agriculture, Multidisciplinary
Jiaying Wu, Shumao Cui, Xin Tang, Qiuxiang Zhang, Yan Jin, Jianxin Zhao, Bingyong Mao, Hao Zhang
Summary: This study screened probiotics with the ability to metabolize glucoraphanin and investigated the effects of a combination of B. longum CCFM1206 and BSE on colitis induced by DSS in mice. The results showed that the combination treatment could alleviate colitis symptoms, reduce inflammatory reactions and oxidative stress, and protect the intestinal barrier. Furthermore, the combination increased the production of sulforaphane compounds in the colon and activated genes related to the Nrf2 signaling pathway. These findings suggest that probiotics can enhance the bioactivity of dietary phytochemicals in vivo and have potential therapeutic implications for colitis treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yinhua Ni, Yi Zhang, Liujie Zheng, Nianke Rong, Yuru Yang, Ping Gong, Yi Yang, Xuerong Siwu, Chenyang Zhang, Linxi Zhu, Zhengwei Fu
Summary: The effects of probiotic strains BL986 and LC122 on intestinal barrier function and gut microbiota in IBD zebrafish were investigated. The results showed that both probiotics improved intestinal mucosal barrier function and altered the composition and function of the microbiota in different IBD models. The impact of probiotics on IBD was influenced by the subtypes of IBD and the age of the zebrafish.
Article
Agriculture, Multidisciplinary
Qingyu Cui, Zhe Zhang, Xiaoying Tian, Xi Liang, Youyou Lu, Yixin Shi, Malina Kuerman, Rui Wang, Yu Zhou, Pimin Gong, Kai Lin, Huaxi Yi, Jiadong Li, Tongjie Liu, Lanwei Zhang
Summary: This study investigated the effects and mechanisms of Bifidobacterium bifidum FL-276.1 and B. bifidum FL-228.1 in alleviating dextran sulfate sodium (DSS)-induced colitis. Both strains significantly alleviated colitis, whether administered throughout the experiment or after DSS induction began. Activation of the Aryl hydrocarbon receptor (AHR) and the nuclear factor erythroid 2-related factor 2 (NRF2) pathways, as well as downregulation of the NLR family pyrin domain containing 3 (NLRP3) protein, were observed. The AHR ligand, indole-3-lactic acid, produced by FL-276.1 and FL-228.1, regulated the AHR/NRF2/NLRP3 pathway, upregulated tight junction proteins, and protected the integrity of the epithelial barrier. These findings support the promotion of clinical trials and product development of probiotics for colitis alleviation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qing-yu Cui, Xiao-ying Tian, Xi Liang, Zhe Zhang, Rui Wang, Yu Zhou, Hua-xi Yi, Pi-min Gong, Kai Lin, Tong-jie Liu, Lan-wei Zhang
Summary: This study aimed to identify probiotics with the potential to alleviate inflammatory bowel disease and elucidate their mechanism of action. Two strains of Bifidobacterium bifidum, FL-276.1 and FL-228.1, were found to be the most effective in improving body weight loss, colon shortening, and intestinal barrier disruption in mice. It was further discovered that these strains activated the aryl hydrocarbon receptor (AhR) in the intestine, potentially contributing to their anti-inflammatory properties.
Review
Microbiology
Cuilan Huang, Wujuan Hao, Xuyang Wang, Renmin Zhou, Qiong Lin
Summary: Ulcerative colitis (UC) is a global public health problem with increasing prevalence among children. Dysbiosis of the gut microbiota is considered the main cause of chronic intestinal inflammation. This review focuses on the therapeutic effects of probiotics on UC and their potential mechanisms of action. Animal studies have shown that probiotics can alleviate symptoms of UC and restore intestinal microecological homeostasis, improve gut barrier function, modulate the immune response, and attenuate intestinal inflammation. However, more research is needed to understand the specific mechanisms and clinical trials are lacking for validation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jana Stofilova, Monika Kvakova, Anna Kamlarova, Emilia Hijova, Izabela Bertkova, Zuzana Gul'asova
Summary: There is a need for new therapies for ulcerative colitis, as many patients are unresponsive to available treatments. Strategies targeting dysbiosis of gut microbiota have been tested, but the effectiveness of conventional probiotics varies. New candidates for next-generation probiotics could provide more targeted treatment options.
Article
Food Science & Technology
Menglin Chen, Hong Yao, Huizi Tan, Wenqi Huang, Quanyong Wu, Shaoping Nie
Summary: This study investigated the intervention effects of Bifidobacterium longum NSP001 on DSS-induced colitis in mice colonized with either native or humanized microbiota. The results showed that B. longum NSP001 improved disease activity index, colon morphology and histology, intestinal permeability, and the secretion of inflammatory markers. In humanized microbiota, B. longum NSP001 also improved abnormal thymus index and colonic production of certain substances. The beneficial effects of B. longum NSP001 were likely explained by the regulation of metabolites and metabolic pathways in the gut microbiome. These findings highlight the necessity of including humanized microbiota in investigating potential therapeutic strategies based on rodent models.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Microbiology
Cristiano Pagnini, Maria Carla Di Paolo, Riccardo Urgesi, Lorella Pallotta, Gianfranco Fanello, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: This study aimed to investigate the clinical efficacy and safety of LGG administration in UC patients with mild-moderate disease activity. The results showed that monotherapy with LGG is safe and effective for inducing remission in UC patients.
Article
Biochemistry & Molecular Biology
Mingjie Li, Jiuhong Ding, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Bo Yang, Wei Chen
Summary: In this study, it was found that B. longum subsp. infantis FJSYZ1M3 could alleviate DSS-induced colitis through various mechanisms, including maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying the gut microbiota.
Article
Chemistry, Medicinal
Xing-Wei Xiang, Rui Wang, Li-Wen Yao, Yu-Fang Zhou, Pei-Long Sun, Bin Zheng, Yu-Feng Chen
Summary: MP demonstrates promising effects in anti-inflammatory responses and protection against ulcerative colitis in mice, while also regulating the richness and diversity of intestinal microbial communities.
Article
Microbiology
Taotao Han, Xiaomin Hu, Kemin Li, Di Zhang, Yan Zhang, Jingnan Li
Summary: Probiotic strain Bifidobacterium infantis shows efficacy in maintaining remission of ulcerative colitis (UC) by acting as a key predisposing factor for host genome stability. Studies reveal that B. infantis administration can alleviate DSS-induced colitis and decrease DNA double strand breaks (DSBs) levels in both colitis and inflammatory bowel disease models, suggesting its potential in clinical management of UC patients.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wenqin Jin, Huangping Ai, Qingqing Huang, Chuncai Li, Xiang He, Zhao Jin, Yuling Zuo
Summary: The imbalance of gastrointestinal microbial composition is the main factor of chronic inflammatory diseases, and the specific mechanism of probiotics on the microbial composition of the human gastrointestinal tract is still unknown. This study aims to compare the mechanism of different probiotics on ulcerative colitis. The results showed that probiotics can improve ulcerative colitis by improving histopathological manifestations, reducing inflammatory reaction, and repairing the mucosal barrier, and different probiotics showed different effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Lingyun Xu, Yingchao Li, Yingli He
Summary: Anxiety and depression still exist in UC patients even in the remission period. This study found that the composition of intestinal microbiota differs between UC patients with anxiety and depression and those without, with a decrease in probiotics and an increase in pathogens in the former group. These findings may provide new insights into the recurrence of UC caused by impaired psychological function and offer potential treatment strategies for UC patients with psychological issues.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Qianqian Liu, Wenwen Jian, Lu Wang, Shenglin Yang, Yutian Niu, ShuaiJing Xie, Kim Hayer, Kun Chen, Yi Zhang, Yanan Guo, Zeng Tu
Summary: In this study, Lactobacillus acidophilus C4 with high acid and bile salt resistance was evaluated for its beneficial effect on DSS-induced colitis in mice. The results showed that oral administration of L. acidophilus C4 alleviated colitis symptoms and minimized colon tissue damage. Further investigation revealed that L. acidophilus C4 repaired the mucosal barrier and maintained the intestinal microecological balance, suggesting its potential for colitis therapy.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianjue Hu, Leilei Yu, Qixiao Zhai, Jianxin Zhao, Fengwei Tian
Summary: This study evaluated the probiotic characteristics of four yeast strains and their ability to alleviate DSS-induced colitis. The results showed that S. cerevisiae QHNLD8L1 effectively protected mice from colitis, with increased body weight, colon length, histological injury relief, decreased gut inflammation markers, and intestinal barrier restoration. Additionally, S. cerevisiae QHNLD8L1 reduced the abundance of pathogenic bacteria and increased the abundance of beneficial bacteria, as well as enhanced carbon metabolism and fatty acid biosynthesis function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
