Review
Biochemistry & Molecular Biology
Verena Petzer, Igor Theurl, Gunter Weiss, Dominik Wolf
Summary: Systemic iron overload in patients with MDS is multifactorial, mainly due to ineffective erythropoiesis and chronic red blood cell transfusion. Iron homeostasis varies among different MDS subtypes and its role in MDS is increasingly recognized. Genetic alterations, such as mutations in TET2, can lead to disturbances in iron homeostasis and hematopoiesis, highlighting the need for comprehensive understanding and development of future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Roya Shahidi, Muhajir Mohamed, Archana Sharma, Jessica Heenan, Julia Gardner, Sam Hitchins
Summary: This study aimed to evaluate the impact of azacitidine treatment on MDS patients with bone marrow fibrosis. The study found that patients with fibrotic marrow had shorter overall survival and event-free survival compared to patients without fibrosis. Bone marrow fibrosis was an independent factor affecting overall survival.
Review
Cell Biology
Xiaofang Chen, Ningyu Li, Jianyu Weng, Xin Du
Summary: Myelodysplastic syndrome (MDS) is a group of blood disorders related to dysfunction of hematopoietic stem and progenitor cells. Mesenchymal stem cells (MSCs) in the bone marrow microenvironment play a crucial role in normal hematopoiesis, but their aging and diminished regenerative capacities can contribute to disease progression. Recent studies have provided new insights into the role of MSCs in MDS, suggesting potential targets for treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Theodoros Karantanos, Patric Teodorescu, Brandy Perkins, Ilias Christodoulou, Christopher Esteb, Ravi Varadhan, Eric Helmenstine, Trivikram Rajkhowa, Bogdan C. Paun, Challice Bonifant, W. Brian Dalton, Lukasz P. Gondek, Alison R. Moliterno, Mark J. Levis, Gabriel Ghiaur, Richard J. Jones
Summary: In this study, it was found that CCRL2 is up-regulated in primitive cells from patients with MDS and sAML. Knockdown of CCRL2 inhibited cell growth and clonogenicity of MDS and sAML cells both in vitro and in vivo, and reduced the phosphorylation levels of JAK2/STAT3/STAT5. CCRL2 was also found to co-precipitate with JAK2 and enhance the JAK2-STAT interaction. These results indicate that CCRL2 plays a role in mediating the growth of MDS and sAML cells, partially through the JAK2/STAT signaling pathway.
Article
Oncology
Youshan Zhao, Juan Guo, Sida Zhao, Roujia Wang, Lei Shi, Ying Fang, Zheng Zhang, Luxi Song, Dong Wu, Chunkang Chang
Summary: The presence of bone marrow fibrosis in patients with myelodysplastic syndrome is associated with adverse prognostic characteristics, reduced overall survival, and higher frequency of TP53, U2AF1, and KMT2D mutations. Progression to moderate/severe fibrosis is observed in a subset of patients during follow-up, with similar clinical features, mutation landscape, and prognosis to those with fibrosis at diagnosis. These findings highlight the importance of considering bone marrow fibrosis in the prognosis and treatment selection for MDS patients.
Review
Biochemistry & Molecular Biology
Carla Felice, Arianna Dal Buono, Roberto Gabbiadini, Marcello Rattazzi, Alessandro Armuzzi
Summary: Spondyloarthritis and inflammatory bowel diseases are chronic immune disorders of the joints and the gut that often coexist in the same patient. The pathogenesis of both disorders involves genetic predisposition, environmental triggers, microbiome features, immune cell trafficking, and soluble factors such as cytokines. However, different cytokines may be involved in the tissue damage process, making it challenging to find an efficacious therapeutic plan that targets both inflammatory manifestations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rajiv Ranjan, Bhargab Kalita, Abhinav Singh, M. H. Yashavarddhan, Hridayesh Prakash, Manju Lata Gupta
Summary: The study demonstrates that G-003 M shows significant protective effects against radiation-induced mortality in mice, enhancing specific cell populations and colony-forming capabilities, while also reducing the levels of certain cytokines. Additionally, G-003 M promotes the expression of specific proteins, protects bone marrow vascularity and splenic colonies, contributing to hematopoietic recovery.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Chunxiu Yang, Shu-Yuan Xiao
Summary: COVID-19, caused by SARS-CoV-2, can lead to severe complications such as multiple organ failure, with most patients also experiencing gastrointestinal symptoms. Managing these symptoms presents challenges for patients with inflammatory bowel disease (IBD) due to potential interactions between the immune response to COVID-19 and dysregulated immunity associated with IBD.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhaolong Zeng, Xiangzheng Ma, Yifan Guo, Baodong Ye, Maosheng Xu, Wei Wang
Summary: IDEAL-IQ imaging can quantify fat fraction and iron content in bone marrow, aiding in distinguishing between patients with aplastic anemia and myelodysplastic syndrome.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Valentina Giudice, Antonio M. Risitano, Carmine Selleri
Summary: Acquired bone marrow failure (BMF) syndromes are considered immune-mediated disorders, with immune cells possibly playing a role in the development of BMF through chronic antigen exposure or cross-reactivity between viral particles and cellular components. The involvement of immunodominant T-cell clones associated with infectious diseases suggests a potential autoimmune response triggered by pathogens or a global immune dysregulation during BMF. These intracellular pathogens may not only be passengers in the development of marrow failure, but also play a central role in initiating an autoimmune response against hematopoietic stem cells.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
An Wu, Panpan Gao, Ningning Wu, Cong Shi, Zhenya Huang, Chunmeng Rong, Ye Sun, Lixia Sheng, Guifang Ouyang, Qitian Mu
Summary: The study found that PMMBM>6% was associated with inferior overall survival (OS), higher-risk IPSS-R, and higher frequency of IDH2 mutation. In addition, age, gender, neutrophil count, bone marrow blast percentage, karyotype, and elevated PMMBM were all independent adverse prognostic factors for OS in MDS.
Review
Biochemistry & Molecular Biology
Elena Crisa, Paola Boggione, Maura Nicolosi, Abdurraouf Mokhtar Mahmoud, Wael Al Essa, Bassel Awikeh, Anna Aspesi, Annalisa Andorno, Renzo Boldorini, Irma Dianzani, Gianluca Gaidano, Andrea Patriarca
Summary: Myelodysplastic syndromes (MDS) arising in the context of inherited bone marrow failure syndromes (IBMFS) present unique challenges in terms of prognosis and treatment, requiring early detection and hematopoietic stem cell transplantation to improve outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Konrad Lewandowski, Magdalena Kaniewska, Martyna Wiecek, Paulina Szwarc, Paulina Panufnik, Edyta Tulewicz-Marti, Magdalena Walicka, Edward Franek, Grazyna Rydzewska
Summary: This study assessed the frequency and risk factors of osteoporosis (OST) among patients with inflammatory bowel disease (IBD) compared to a group without IBD. It found that 7.3% of IBD patients suffered from OST. Factors such as male gender, ulcerative colitis, rare physical activity, past fractures, and abnormal levels of certain biomarkers were identified as risk factors for OST in IBD patients. The study highlights the importance of regular physical activity and the use of biomarkers in diagnosing and managing OST in IBD patients.
Article
Medicine, General & Internal
Songyi Park, Dong-Yeop Shin, Junseo Steve Park, Hee Sue Park, Soo Young Moon, Sung-Soo Yoon, Dong-Soon Lee
Summary: This study retrospectively investigated the cellular proliferative and apoptotic activity in patients with myelodysplastic syndrome (MDS). The results showed that apoptotic activity gradually increased from healthy controls to MDS patients and was associated with better MDS patient prognostic scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Minzhi Gan, Yong Peng, Mengya Zhu, Ying Ying
Summary: This study analyzed the factors affecting the treatment response of primary Sjogren's syndrome (pSS) patients with thrombocytopenia, and established an individualized nomogram to predict the treatment response of patients. Accurate prediction of therapeutic response is significant for improving the prognosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Noriyo Yamashiki, Hironori Haga, Yoshihide Ueda, Takashi Ito, Shintaro Yagi, Naoko Kamo, Koichiro Hata, Akira Mori, Toshimi Kaido, Hideaki Okajima, Shinji Uemoto
HEPATOLOGY RESEARCH
(2020)
Article
Multidisciplinary Sciences
Taiki Yamashita, Haruhiko Takeda, Atsushi Takai, Soichi Arasawa, Fumiyasu Nakamura, Yoichi Mashimo, Miyuki Hozan, Shigeru Ohtsuru, Hiroshi Seno, Yoshihide Ueda, Akihiro Sekine
SCIENTIFIC REPORTS
(2020)
Article
Medicine, General & Internal
Kenji Sawada, Atsushi Takai, Tomoyo Yamada, Osamu Araki, Yuki Yamauchi, Yuji Eso, Ken Takahashi, Takero Shindo, Takaki Sakurai, Yoshihide Ueda, Hiroshi Seno
Article
Oncology
Haruhiko Takeda, Atsushi Takai, Ken Kumagai, Eriko Iguchi, Soichi Arasawa, Yuji Eso, Takahiro Shimizu, Yoshihide Ueda, Kojiro Taura, Shinji Uemoto, Ryuichi Kita, Hironori Haga, Hiroyuki Marusawa, Akihiro Fujimoto, Hiroshi Seno
JOURNAL OF PATHOLOGY
(2020)
Article
Oncology
Atsushi Yamamoto, Yoshihiko Yano, Yoshihide Ueda, Eiichiro Yasutomi, Yuri Hatazawa, Hiroki Hayashi, Ryutaro Yoshida, Naoki Asaji, Yuuki Shiomi, Kazutoshi Tobimatsu, Arata Sakai, Yuzo Kodama
Summary: This study found that immune-mediated hepatotoxicity occurred in 9.5% of patients treated with immune checkpoint inhibitors, with appropriate therapeutic interventions and accurate diagnosis being crucial for prognosis. The frequency of immune-mediated hepatotoxicity varied according to the type of cancer and the drug used, and was significantly higher in patients with malignant melanoma and in patients given ipilimumab-nivolumab combination therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Eriko Iguchi, Atsushi Takai, Haruhiko Takeda, Ken Kumagai, Soichi Arasawa, Yuji Eso, Takahiro Shimizu, Yoshihide Ueda, Hiroyuki Marusawa, Hiroshi Seno
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Haruhiko Takeda, Atsushi Takai, Eriko Iguchi, Masako Mishima, Soichi Arasawa, Ken Kumagai, Yuji Eso, Takahiro Shimizu, Ken Takahashi, Yoshihide Ueda, Kojiro Taura, Etsuro Hatano, Hiroko Iijima, Haruyo Aoyagi, Hideki Aizaki, Hiroyuki Marusawa, Takaji Wakita, Hiroshi Seno
Summary: This study revealed that some oncogenic transcriptomic profiles persist in liver tissues after hepatitis C virus eradication, which may serve as a molecular basis for liver cancer development even after viral clearance. Among them, up-regulated CYR61 could potentially be a biomarker for hepatocellular carcinoma after sustained virologic response.
Meeting Abstract
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Vincenzo Ronca, Maryam Ebadi, Bettina Hansen, Gideon Hirschfield, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz, Maciej K. Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Cumali Efe, Ali Riza Caliskan, Murat Harputluoglu, Gokhan Kabacam, Debora Raquel Terrabuio, Fernanda Onofrio, Albert Pares, Laura Patricia Llovet, Murat Akyildiz, Cigdem Arikan, Michael P. Manns, Richard Taubert, Anna-Lena Weber, Thomas Schiano, Brandy Hayde, Piotr Czubkowski, Piotr Socha, Natalia Oldak, Nobuhisa Akamatsu, Atsushi Tanaka, Cynthia Levy, Eric F. Martin, Aparna Goel, Mai Sedki, Irena Jankowska, Toru Ikegami, Maria Rodriguez, Martina Sterneck, Christina Weiler-Normann, Christoph Schramm, Maria Francesca Donato, Ansgar W. Lohse, Raul J. Andrade, Alan Bonder, Vilas Patwardhan, Bart Van Hoek, Maaike Biewenga, Andreas E. Kremer, Yoshihide Ueda, Mark Deneau, Mark Pedersen, Marlyn J. Mayo, Annarosa Floreani, Patrizia Burra, Maria Francesca Secchi, Benedetta Terziroli Beretta-Piccoli, Marco Sciveres, Giuseppe Maggiore, Syed-Mohammed Jafri, Dominique Debray, Muriel Girard, Florence Lacaille, Ellina Lytvyak, Andrew L. Mason, Michael Heneghan, Ye Htun Oo
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tomonori Wada, Yoshihiko Yano, Atsushi Yamamoto, Masato Kinoshita, Eiichiro Yasutomi, Yuri Hatazawa, Hiroki Hayashi, Yuuki Shiomi, Kimihiro Yamashita, Yoshihide Ueda, Yuzo Kodama
Summary: An 80-year-old male with myelofibrosis and chronic renal disease was admitted to the hospital due to severe anemia and gastrointestinal bleeding. After surgery to resect the small intestine, it was confirmed that the patient had variceal rupture in the small intestine, which stopped the bleeding and improved the anemia. This is the first reported case of ectopic jejunal varices in a patient with myelofibrosis.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ryosuke Ishida, Yoshihiko Yano, Atsushi Yamamoto, Eiichiro Yasutomi, Yuri Hatazawa, Hiroki Hayashi, Yuuki Shiomi, Hidetoshi Gon, Satoshi Omiya, Maki Kanzawa, Tomoo Itoh, Yoshihide Ueda, Yuzo Kodama
Summary: For beta-catenin-activated hepatocellular adenoma, needle aspiration biopsy and immunohistochemistry are useful for histological diagnosis and treatment decisions. Surgical resection is crucial for patients at risk of malignant transformation.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Eiichiro Yasutomi, Yoshihide Ueda, Naoki Asaji, Atsushi Yamamoto, Ryutaro Yoshida, Yuri Hatazawa, Hiroki Hayashi, Yuuki Shiomi, Yoshihiko Yano, Yuzo Kodama
Summary: A 72-year-old man developed a rare liver abscess after undergoing TACE for hepatocellular carcinoma, caused by Cutibacterium namnetense, which was successfully treated leading to discharge on day 19.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Kentaro Iwaki, Yoshihide Ueda, Masako Mishima, Syoko Narukami, Masahiro Shiokawa, Kenji Sawada, Junya Kanda, Ken Takahashi, Hiroshi Seno
Summary: This case report presents a patient with extensive portal vein thrombosis caused by essential thrombocythemia accompanied by limited cutaneous systemic sclerosis. High level of serum platelet-derived growth factor, possibly linked to high platelet count due to essential thrombocythemia, suggests a causal relationship between the two conditions.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Noriyo Yamashiki, Yoshihide Ueda, Shun'Ichi Noma, Toshimi Kaido, Shinji Uemoto
Meeting Abstract
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Maryam Ebadi, Bettina E. Hansen, Gideon Hirschfield, Andrew L. Mason, Piotr Milkiewicz, Maciej Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Albert Pares, Laura Patricia Llovet, Debora Terrabuio, Murat Akyildiz, Cigdem Arikan, Rodrigo Liberal, Nanda Kerkar, Ynte S. Boer, Ansgar W. Lohse, Joost P. H. Drenth, Annarosa Floreani, Piotr Czubkowski, Piotr Socha, Natalia Oldak, Raul Jesus Andrade Bellido, Patrizia Burra, Maria Francesca Secchi, Ellina Lytvyak, Irena Jankowska, Maria Rodriguez, Martina Sterneck, Christina Weiler-Normann, Christoph Schramm, Benedetta Terziroli, Thomas D. Schiano, Brandy Haydel, Dominique Debray, Muriel Girand, Florence Lacaille, Maria Francesca Donato, Nobuhisa Akamatsu, Atsushi Tanaka, Toru Ikegami, Yoshihide Ueda, Diego Vergani, Michael A. Heneghan
Meeting Abstract
Gastroenterology & Hepatology
Kojiro Taura, Kenji Yoshino, Yoshinobu Ikeno, Yumi Umeya, Tomoko Ishibashi, Yasuko Kojitani, Yusuke Kimura, Nguyen Hai Nam, Yusuke Uemoto, Ken Fukumitsu, Takashi Ito, Shintaro Yagi, Naoko Kamo, Koichiro Hata, Noriyo Yamashiki, Yoshihide Ueda, Toshimi Kaido, Shinji Uemoto