Review
Gastroenterology & Hepatology
Babu P. Mohan, Gregory Toy, Lena L. Kassab, Suresh Ponnada, Saurabh Chandan, Sheeva Parbhu, Shaun Chandna, Douglas G. Adler
Summary: EBL showed excellent clinical outcomes in the treatment of GAVE with a treatment responder rate of 81% and minimal adverse events. The average number of treatment sessions required was 2.4, with an average of 15.1 bands used per patient.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Pharmacology & Pharmacy
Mengyuan Peng, Xiaozhong Guo, Fangfang Yi, Xiaodong Shao, Le Wang, Yanyan Wu, Chunmei Wang, Menghua Zhu, Ou Bian, Mostafa Ibrahim, Saurabh Chawla, Xingshun Qi
Summary: Gastric antral vascular ectasia (GAVE) is an uncommon cause of upper gastrointestinal bleeding. Pharmacotherapy, endoscopy, and surgery are the main treatment options, with endoscopy being the common choice. Different endoscopic approaches, including APC, RFA, and EBL, have varying success rates and recurrence rates. Follow-up endoscopy is important for managing the high recurrence of GAVE after endoscopic treatment.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Review
Gastroenterology & Hepatology
Jean M. Chalhoub, Jalaluddin Umar, Kevin Groudan, Nour Hamadeh, David J. Desilets, Yesenia Greeff
Summary: Compared to endoscopic thermal therapy, endoscopic band ligation for the management of bleeding gastric antral vascular ectasia led to significantly lower transfusion requirements, showed a trend toward more remarkable post-procedural hemoglobin elevation, and required fewer procedures. Adverse events did not differ significantly between the two treatments.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Gastroenterology & Hepatology
Cheng-Che Che, Sz-Iuan Shiu, Chung-Wang Ko, Yu-Kang Tu, Chung-Hsin Chang
Summary: A meta-analysis was conducted to compare three treatments for gastric antral vascular ectasia (GAVE), and the results showed that endoscopic band ligation (EBL) was superior to endoscopic thermal therapy (ETT) in terms of bleeding cessation, hemoglobin improvement, number of sessions, endoscopic improvement, hospitalization, and transfusion requirement. However, there were no significant differences in mortality and complication rate.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Anna Fabian, Renata Bor, Ella Szabo, Viktor Kardos, Anita Balint, Klaudia Farkas, Agnes Milassin, Mariann Rutka, Kata Szanto, Tamas Molnar, Monika Szucs, Katalin Lorinczy, Akos Orban-Szilagyi, Tibor Gyokeres, Gyorgy Gyimesi, Attila Szepes, Valeria Kovacs, Istvan Racz, Zoltan Szepes
Summary: This study retrospectively evaluated the efficacy of APC and EBL in treating GAVE in transfusion-dependent patients. Both methods were effective in increasing hemoglobin levels and decreasing the need for transfusion, but EBL required fewer treatment sessions. Further research with larger sample sizes and standardized settings is needed.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Medicine, General & Internal
Nimesh Lageju, Pratik Uprety, Durga Neupane, Satish Bastola, Suhel Lama, Sagar Panthi, Arun Gnawali
Summary: Gastric antral vascular ectasia (GAVE) is an uncommon cause of upper gastrointestinal bleeding in elderly patients, often misdiagnosed as gastritis. Endoscopy, including argon plasma coagulation, has become the first-line therapeutic option for diagnosis and treatment.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Medicine, General & Internal
Hyo Jin Kwon, Si Hyung Lee, Joon Hyun Cho
Summary: This study compared the clinical features and long-term outcomes of patients with gastric antral vascular ectasia (GAVE) based on endoscopic patterns and etiologies. The study found that punctate-type GAVE is strongly associated with liver cirrhosis, and patients without cirrhosis are more prone to overt bleeding. However, the presence of cirrhosis and endoscopic patterns did not influence the long-term clinical course or outcomes in cases of overt bleeding.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Medicine, Research & Experimental
Mengyuan Peng, Xiaozhong Guo, Fangfang Yi, Fernando Gomes Romeiro, Andrea Mancuso, Xingshun Qi
Summary: Treatment options for GAVE include endoscopic therapy, surgical resection, and pharmacotherapy, with limited evidence for the effectiveness of drug treatment mainly from scattered case reports or small case series.
ADVANCES IN THERAPY
(2021)
Article
Medicine, General & Internal
Bruno Salomao Hirsch, Igor Braga Ribeiro, Mateus Pereira Funari, Vitor Massaro Takamatsu Sagae, Fabio Catache Mancini, Guilherme Henrique Peixoto de Oliveira, Eduardo Guimaraes Hourneaux de Moura, Wanderley Marques Bernardo
Summary: The Guidelines Project aims to combine medical information, standardize physician conduct, and assist in reasoning and decision-making.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
Article
Oncology
Colin Y. C. Lee, Adriaan Olivier, Judith Honing, Anne-Marie Lydon, Susan Richardson, Maria O'Donovan, Marc Tischkowitz, Rebecca C. Fitzgerald, Massimiliano di Pietro
Summary: Hereditary diffuse gastric cancer, caused by CDH1 gene mutations, is characterized by early-onset signet ring cell carcinoma. Prophylactic total gastrectomy is the recommended treatment. This study assessed different sampling strategies for detecting signet ring cell carcinoma and identified criteria for characterizing endoscopic lesions in hereditary diffuse gastric cancer.
Review
Gastroenterology & Hepatology
Gwang Ha Kim
Summary: Subepithelial tumors (SETs) are commonly encountered during upper gastrointestinal endoscopy in Korea, with concerns about benign or malignant nature. Routine endoscopic biopsy is often inconclusive, making a systematic and meticulous approach to differential diagnosis important.
Article
Medicine, General & Internal
Kazuhiro Ota, Yosuke Mori, Hironori Tanaka, Takahiro Murata, Taro Iwatsubo, Shimpei Kawaguchi, Yuichi Kojima, Noriyuki Nakajima, Akitoshi Hakoda, Noriaki Sugawara, Toshihisa Takeuchi, Kazuhide Higuchi
Summary: In this case report, an 80-year-old male patient presented with exertional fatigue and was diagnosed with severe anemia. Gastroscopy revealed gastric antral vascular ectasia (GAVE) and autoimmune gastritis, suggesting that GAVE is triggered by autoimmune gastritis, possibly related to hypergastrinemia. This rare case may contribute to our understanding of the unknown cause of GAVE.
Article
Gastroenterology & Hepatology
Katsunori Matsueda, Noriya Uedo, Masanori Kitamura, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Yoji Takeuchi, Koji Higashino, Ryu Ishihara, Tomoki Michida, Seiji Kawano, Yoshiro Kawahara
Summary: The endoscopic features of gastric neuroendocrine carcinoma (G-NEC) were investigated and compared with clinicopathological findings. Submucosal tumor-like marginal elevation (87%), adherent white coat (67%), and ulceration with a distinct border (60%) were characteristic endoscopic findings in white-light images. Magnifying narrow-band imaging endoscopy revealed an absent microsurface (MS) pattern plus disrupted irregular microvessel (MV) in the majority of cases.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Gwang Ha Kim
Summary: Early gastric cancers (EGCs) are defined as gastric cancers confined to the mucosa or submucosa, regardless of regional lymph node metastasis. The shift from surgical resection to endoscopic resection for selected EGCs is accelerating due to increased screening endoscopy. Successful endoscopic resection of EGCs requires early detection and accurate prediction of histological type, depth of invasion, and horizontal margins.
Review
Polymer Science
Youli Chen, Xinyan Zhao, Dongke Wang, Xinghuang Liu, Jie Chen, Jun Song, Tao Bai, Xiaohua Hou
Summary: New endoscopic approaches for preventing delayed bleeding after gastric endoscopic submucosal dissection (ESD) have emerged, with the use of biodegradable polymers showing promising results for ulcer hemostasis and coverage. However, the comparative efficacy of these techniques is still uncertain.
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Vivien Dolby, Tanya Clark, Veronica Hall, Suzanne Tattersall, Francesca Fairhurst, Catherine Kenneth, Rachael Walker, Karen Kemp, Simon Borg-Bartolo, Jimmy K. Limdi, Jo Taylor, Tristan Townsend, Sree Subramanian, Daniel Storey, Arash Assadsangabi, Catherine Stansfield, Paul Smith, Debra Byrne, Annalisa De Silvestri, Christian P. Selinger
Summary: The study showed that ustekinumab was more effective than vedolizumab at 14 weeks in CD patients, but there was no significant difference between the two at 52 weeks. Ustekinumab was found to be effective and well tolerated in this real-world cohort.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Elizabeth Ratcliffe, James Britton, Shaheen Hamdy, John McLaughlin, Yeng Ang
Summary: This review explores the emerging role of dedicated services for patients with Barrett's oesophagus (BO). The research indicates that dedicated services can improve guideline adherence and increase dysplasia detection rates. Additionally, patients report high levels of cancer worry and poor disease-specific knowledge.
BMJ OPEN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
A. Barney Hawthorne, Jackie Glatter, Jonathan Blackwell, Rachel Ainley, Ian Arnott, Kevin J. Barrett, Graham Bell, Matthew J. Brookes, Melissa Fletcher, Rafeeq Muhammed, Alan M. Nevill, Jonathan Segal, Christian P. Selinger, Anja St Clair Jones, Lisa Younge, Christopher A. Lamb
Summary: This study assessed patients' experience of IBD and the healthcare they received, aiming to identify factors associated with perceived high-quality care. The results showed that the perceived quality of care varied with age, gender, and time since diagnosis. Factors associated with patient-reported high-quality care included being in a tertiary center, availability of patient information, shared decision-making, rapid response to advice, access to urgent review, joint medical/surgical clinics, and access to research. The presence of IBD nurse specialists was strongly associated with regular reviews, self-management confidence, and high-quality care.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Letter
Gastroenterology & Hepatology
Christian P. Selinger, Marco Vincenzo Lenti, Annalisa De Silvestri
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Letter
Gastroenterology & Hepatology
Charlie W. Lees, Tariq Ahmad, Christopher Andrew Lamb, Nick Powell, Shahida Din, Rachel Cooney, Nicholas A. Kennedy, Rachel Ainley, Ruth Wakeman, Christian Philipp Selinger
Article
Biology
Alvin Wei Tian Ng, Gianmarco Contino, Sarah Killcoyne, Ginny Devonshire, Ray Hsu, Sujath Abbas, Jing Su, Aisling M. Redmond, Jamie M. J. Weaver, Matthew D. Eldridge, Simon Tavare, Paul A. W. Edwards, Rebecca C. Fitzgerald
Summary: This study categorizes genomic structural variants (SVs) in 383 cases of oesophageal cancer, uncovering mutational patterns and new disease drivers. Identification of SV events in OAC is crucial for targeted therapies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Surgery
Ajith K. Siriwardena
Summary: This study provides a global overview of the management of patients with acute cholecystitis during the early phase of the COVID-19 pandemic. The pandemic led to a decrease in surgical workforce and operating facilities, worse severity of disease, and increased use of conservative management. While the number of patients undergoing cholecystectomy decreased, there was no increase in post-operative mortality.
Article
Pharmacology & Pharmacy
Marc Ferrante, Peter M. Irving, Christian P. Selinger, Geert D'Haens, Tanja Kuehbacher, Ursula Seidler, Savion Gropper, Thomas Haeufel, Sebastiano Forgia, Silvio Danese, Jochen Klaus, Brian G. Feagan
Summary: This study reported the safety, immunogenicity, and efficacy data of intravenous Spesolimab in ulcerative colitis. Spesolimab was well tolerated without unexpected safety concerns, and the safety data were consistent with studies in other inflammatory diseases.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Gastroenterology & Hepatology
Eleanor Liu, Robyn Laube, Rupert W. Leong, Aileen Fraser, Christian Selinger, Jimmy K. Limdi
Summary: Objective assessment shows that gastroenterology health care professionals have good knowledge of pregnancy-specific IBD, but there is inconsistency in applying this knowledge in decision-making. Further education for clinicians is needed to provide optimal standardized care for IBD in pregnancy.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Antonia M. D. Churchhouse, Victoria E. L. Moffat, Christian P. Selinger, Christopher A. Lamb, Michelle J. Thornton, Ian Penman, Shahida Din
Review
Medicine, General & Internal
Konstantina Rosiou, Christian P. Selinger
Summary: Crohn's disease can affect fertility in women, and there are concerns about the impact of pregnancy on the disease and the potential effects of medication on the fetus. International guidelines provide evidence-based advice on reproduction for women with Crohn's disease. This review article focuses on obstetric considerations beyond medication safety and covers factors such as fertility, pregnancy outcomes, complications, mode of delivery, intestinal stoma management, and breastfeeding.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Robyn Laube, Christian P. Selinger, Cynthia H. Seow, Britt Christensen, Emma Flanagan, Debra Kennedy, Reme Mountifield, Sean Seeho, Antonia Shand, Astrid-Jane Williams, Rupert W. Leong
Summary: This study aimed to update consensus statements that guide the clinical management of pregnancy in patients with inflammatory bowel disease (IBD). Through a multidisciplinary working group's discussion and voting, consensus agreements were reached. It is crucial to achieve and maintain IBD remission and engage in a multidisciplinary approach to optimize pregnancy outcomes.
Article
Gastroenterology & Hepatology
Isabel Carbery, Gemma Burdge, Tanya Clark, Giacomo Broglio, Dan Greer, Alaa Alakkari, Christian Philipp Selinger
Summary: Our study shows that switching patients from intravenous to subcutaneous CT-P13 is cost neutral, as it results in a decrease in indirect costs and allows for more efficient use of infusion units.
BMJ OPEN GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Christian P. Selinger, Helen Steed, Satvinder Purewal, Rebecca Homer, Matthew Brookes, NIHR BioResource
Summary: Women with Inflammatory Bowel Diseases (IBD) have lower fertility rates and family planning choices are not fully understood.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Christian P. Selinger, Robyn Laube, Helen Steed, Matthew Brookes, Rupert W. L. NIHR BioResource, Rupert W. L. Leong
Summary: In female IBD patients, planning to conceive within the next year is associated with better medication adherence and greater disease-related knowledge.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)