Journal
DIFFERENTIATION
Volume 88, Issue 1, Pages 29-32Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2014.09.001
Keywords
Somatic cell nuclear transfer; Induced pluripotent stem cells; Epigenetic memory; Nuclear reprogramming; Embryonic stem cells; Cloning
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Funding
- Silvia and Charles Viertel Senior Medical Research Fellowship
- NHMRC project grant [APP1051117]
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Six decades ago, seminal work conducted by John Gurdon on genome conservation resulted in major advancements towards nuclear reprogramming technologies such as somatic cell nuclear transfer (SCNT), cell fusion and transcription factor mediated reprogramming. This revolutionized our views regarding cell fate conversion and development. These technologies also shed light On the role of the epigenome in cellular identity, and how the memory of the cell of origin affects the reprogrammed cell. This review will discuss recent work on epigenetic memory retained in pluripotent cells derived by SCNT and transcription factor mediated reprogramming, and the challenges attached to it (C) 2014 international Society of Differentiation. Published by Elsevier B.V. All rights reserved.
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