Journal
DIFFERENTIATION
Volume 81, Issue 3, Pages 142-152Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2011.01.008
Keywords
Embryonic stem cells ESC; Non-human Primate; Self-renewal; Neural differentiation; Neural stem cells
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Non-human primate (NHP) embryonic stem (ES) cells show unlimited proliferative capacities and a great potential to generate multiple cell lineages. These properties make them an ideal resource both for investigating early developmental processes and for assessing their therapeutic potential in numerous models of degenerative diseases. They share the same markers and the same properties with human ES cells, and thus provide an invaluable transitional model that can be used to address the safety issues related to the clinical use of human ES cells. Here, we review the available information on the derivation and the specific features of monkey ES cells. We comment on the capacity of primate ES cells to differentiate into neural lineages and the current protocols to generate self-renewing neural stem cells. We also highlight the signalling pathways involved in the maintenance of these neural cell types. Finally, we discuss the potential of monkey ES cells for neuronal differentiation. (C) 2011 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.
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