Article
Immunology
Yichen Liang, Zhenhua Xian, Dehua Fu, Shuang Liu, Yang Yao, Yuebo Jin, Chun Gao, Long Shen, Guixiu Shi, Jing He
Summary: This study evaluated the potential of IL-14 alpha as a biomarker for dry eye in primary Sjogren's syndrome and its correlation with BAFF in different patient groups. The results indicated that IL-14 alpha and BAFF could serve as critical cytokine biomarkers for the stratification of dry eye in pSS, providing insights for non-invasive diagnosis methods.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaomao Luo, Huiling Zhang, Xiaorui Cao, Ding Yang, Yi Yan, Jiayin Lu, Xiaonan Wang, Haidong Wang
Summary: Endurance training increases Fgf21 levels, promotes fiber-type conversion in skeletal muscle, and improves muscle health and reduces fatigue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yoko Ogawa, Tsutomu Takeuchi, Kazuo Tsubota
Summary: Autoimmune epithelitis and chronic inflammation are characteristic features of the immune pathogenesis of Sjogren's syndrome (SS)-related dry eye disease, affecting the secretion of tear fluid and mucin. Dysfunction of ocular surface epithelium can lead to dry eye disease, with potential targets for treatment including various molecules in tear film, cornea, conjunctiva, lacrimal glands, and meibomian glands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ji Sue Baik, You Na Seo, Young-Choon Lee, Joo Mi Yi, Man Hee Rhee, Moon-Taek Park, Sung Dae Kim
Summary: This study demonstrates that ionizing radiation activates the p38 MAPK-NLRC4-caspase-1 pathway in macrophages, leading to increased IL-1 beta production in response to lipopolysaccharide treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hyunmin Ahn, Yong Woo Ji, Ikhyun Jun, Tae-im Kim, Hyung Keun Lee, Kyoung Yul Seo
Summary: This study evaluated the effectiveness of different treatment modalities for dry eye in primary Sjogren's syndrome and found that the treatment outcome is closely related to the presence of ocular surface inflammation. Punctal plug insertion is the mainstay of the treatment for dry eye in primary Sjogren's syndrome, primarily targeting aqueous deficiency. Steroid eye drops significantly improve corneal staining scores in the presence of ocular surface inflammation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Evan Michaelov, Caroline McKenna, Pierre Ibrahim, Manav Nayeni, Arpit Dang, Rookaya Mather
Summary: Sjogren's syndrome-related dry eye disease (SS-DED) causes more severe symptoms compared to non-SS dry eye disease (DED). Patients with SS-DED have difficulty with visual tasks and experience reduced enjoyment in daily activities. Many patients worry about a reduced quality of life and fear blindness due to DED. Non-adherence to treatment is often due to high therapy costs and forgetting to use eye drops.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yanbo Wang, Yanling Yu, Wanjing Yu, Xun Bian, Linxia Gong
Summary: IL-35 inhibits cell pyroptosis and reduces asthma injury by suppressing the p38 MAPK pathway.
Article
Biochemistry & Molecular Biology
Junjue Chen, Huimin Zhong, Huan Yu, Jun Sun, Bingqiao Shen, Xing Xu, Shouyue Huang, Ping Huang, Yisheng Zhong
Summary: IL-17A plays a significant role in the regulation of retinal immune response and retinal ganglion cell death in glaucoma by promoting retinal microglial activation via p38 MAPK signaling pathway. Suppression of IL-17A contributes to alleviate glaucoma neuropathy.
Article
Ophthalmology
Spandita Pal, Gorati Vani, Pragnya Rao Donthineni, Sayan Basu, Kotakonda Arunasri
Summary: This study examined the bacterial microbiome changes in tears of patients with Sjogren's syndrome (SS) and non-Sjogren's syndrome (NSS) compared to healthy individuals. The results showed significant changes in the phyla and genera between SS and NSS samples compared to healthy samples. Network analysis also predicted a possible association of the pro-inflammatory bacterium Prevotella with both SS and NSS.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Microbiology
Pengbo Guo, Juan Xu, Hao Liang, Li Xu, Wanying Gao, Ziman Chen, Yuan Gao, Maojun Zhang, Guangfu Yu, Zhujun Shao
Summary: This study reveals the protective role of estrogen in Neisseria meningitidis infection and its mechanism in regulating inflammatory cytokine release. The results suggest that estrogen receptor beta (ER beta) may be involved in the modulation of the inflammatory response in N. meningitidis infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Summary: Research suggests that the accumulation of amyloid beta (Aβ) plaques in the brain is a key factor in the development of Alzheimer's disease (AD). This study found that Aβ(1-40) oligomers stimulate the expression of IL-6 in human microglial cells. The activation of p38 MAPK is associated with this increase in IL-6. Inhibition of p38 MAPK can prevent Aβ-induced IL-6 production. These findings indicate that targeting p38 MAPK could be a potential approach to reduce neuroinflammation caused by Aβ accumulation in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Yanan Huo, Qi Wan, Xinzhu Hou, Zhiyong Zhang, Jinchuan Zhao, Zhiyi Wu, Xiuming Jin
Summary: This study evaluates the efficacy and safety of intense pulsed light (IPL) and meibomian gland expression (MGX) as polytherapy for Sjogren's Syndrome-related dry eye. The results show that this combined treatment significantly improves subjective and objective characteristics, representing a promising treatment strategy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Plant Sciences
Xin Guo, Yun-Da Yao, Jun-Li Kang, Fu-Kang Luo, Xi-Jun Mu, Yan-Yu Zhang, Ming-Tai Chen, Meng-Nan Liu, Chi-Chou Lao, Zi-Hao Tan, Yu-Feng Huang, You-Hua Xu, Ying Xie, Peng Wu, Hua Zhou
Summary: This study isolated an active compound, IT24, from Iris tectorum and demonstrated its anti-inflammatory effects. IT24 exerts its anti-inflammatory effects by inhibiting mPGES-1 and the p38/JNK pathway, and has potential as an mPGES-1 inhibitor for the prevention and treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Qi Tan, Limin Duan, Qi Huang, Wenjuan Chen, Zimo Yang, Jiangbin Chen, Yang Jin
Summary: The study revealed that IL-1 beta promotes glycolysis of LUAD cells through the p38 signaling pathway, enhancing tumor-cell migration and invasion. Targeting IL-1 beta and the glycolysis pathway may be a potential therapeutic strategy for lung cancer.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jenq-Lin Yang, Weng-Ling Lin, Shun-Ban Tai, Yi-Siang Ciou, Chih-Ling Chung, Jih-Jung Chen, Pei-Feng Liu, Ming-Wei Lin, Chun-Lin Chen
Summary: Sinulariolide (SC-1), a natural extract from Sinularia flexibilis, has anti-inflammatory, anti-proliferative, and anti-migratory effects. The molecular pathway behind its anti-inflammatory effects remains unclear. In this study, we investigated the effects of SC-1 on TGF beta-induced IL-6 release. We found that SC-1 inhibited TGF beta-induced IL-6 secretion through the suppression of p38 MAPK signaling and subsequent inhibition of NF-kappa B nuclear translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)