Article
Biochemistry & Molecular Biology
Qingwen Zhao
Summary: Mutations in IDH1 are frequently found in intrahepatic cholangiocarcinoma and have been shown to affect hepatic lipid metabolism by regulating a molecular network associated with hepatic lipid embolism. The mutant IDH1 produces 2-HG, which stabilizes PTEN mRNA and activates the Akt-SEBP1c signaling pathway, leading to lipogenesis defect.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Justyna Maczynska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek
Summary: The study demonstrates that targeted photoimmunotherapy can accurately visualize EGFR-positive brain tumors and destroy tumor cells after conjugate irradiation, turning an immunosuppressive tumor environment into an immune-vulnerable one. In vitro and in vivo experiments show that the photodynamic treatment promotes immunogenic cell death and activates T cell response, leading to reduced cell proliferation and tumor necrosis. These findings highlight the potential of photoimmunotherapy as a multimodal treatment approach for glioblastoma.
Article
Cell Biology
Luning Wang, Xiaohong Zhang, Junxiu Sheng, Lei Chen, Lili Zhi, Yangfan Qi, Qianqian Zheng, Linlin Wang, Jinrui Zhang, Jinyao Zhao, Yang Wang, Shu-Xin Liu, Ming-Zhong Sun, Wenjing Zhang
Summary: Cellular senescence is a powerful mechanism for inhibiting the proliferation of cancer cells, and RNA-binding proteins (RBPs) play important roles in regulating senescence. This study discovered that the RBP RBM4 contributes to cellular senescence and its depletion induces senescence in various cell types, including cancer cells. Furthermore, the depletion of RBM4 inhibits cancer cell progression and is mediated by the regulation of SERPINE1 through miR-1244.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Aimee L. Dowling, Stuart Walbridge, Celine Ertekin, Sriya Namagiri, Krystal Camacho, Ashis Chowdhury, Jean-Paul Bryant, Eric Kohut, John D. Heiss, Desmond A. Brown, Sangamesh G. Kumbar, Yeshavanth Kumar Banasavadi-Siddegowda
Summary: FKBP38 expression is upregulated in glioblastoma and plays a crucial role in cell survival and self-renewal. It negatively regulates autophagy through the JNK/C-Jun-PTEN-AKT pathway. Targeting FKBP38 could be a potential therapeutic strategy for glioblastoma.
Article
Oncology
Stefaan W. Van Gool, Jennifer Makalowski, Peter van de Vliet, Stefanie Van Gool, Tobias Sprenger, Volker Schirrmacher, Wilfried Stuecker
Summary: The standard treatment for primary glioblastoma multiforme includes neurosurgery, radiochemotherapy, and maintenance chemotherapy. This study added individualized multimodal immunotherapy to the treatment, which resulted in improved overall survival compared to published data. The addition of immunotherapy takes into account dynamic changes in tumor biology and tumor-host interaction, providing a new perspective for clinical trials.
Article
Medicine, Research & Experimental
Minwei He, Xing Wang, Wei Chen, Jianzhi Zhang, Ying Xiong, Lulu Cao, Liyi Zhang, Ning Zhao, Yue Yang, Lu Wang
Summary: PTPIP51 is downregulated in non-small cell lung cancer (NSCLC), but its overexpression inhibits EGFR signaling pathway and promotes apoptosis, acting as a tumor suppressor in NSCLC.
Article
Biochemistry & Molecular Biology
Jian-Hua Luo, Silvia Liu, Junyan Tao, Bao-Guo Ren, Katherine Luo, Zhang-Hui Chen, Michael Nalesnik, Kathleen Cieply, Tianzhou Ma, Shi-Yuan Cheng, Qi Chen, George K. Michalopoulos, Joel B. Nelson, Rohit Bhargava, Jun Zhang, Deqin Ma, David Jarrard, Arjun Pennathur, James D. Luketich, Donald B. DeFranco, Satdarshan Paul Monga, George Tseng, Yan-Ping Yu
Summary: The fusion gene Pten-NOLC1, derived from Pten gene, is a driver for human cancers as it promotes cancer proliferation, growth, invasion, and metastasis. Its presence in primary cancer samples and cancer cell lines from different organs suggests its significance in oncogenesis.
Article
Pharmacology & Pharmacy
Kunyan He, Guang-Xing Wang, Li-Nan Zhao, Xiao-Fang Cui, Xian-Bin Su, Yi Shi, Tian-Pei Xie, Shang-Wei Hou, Ze-Guang Han
Summary: The compound cinobufagin extracted from Traditional Chinese Medicine showed potent inhibitory effects on the proliferation of cancer cells with EGFR amplification, leading to suppression of tumor growth in vivo. This discovery provides a new therapeutic option for treating malignant glioma and other human cancers expressing EGFR.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guowen Ren, Eun Ju Yang, Shishi Tao, Pui Kei Mou, Yue Pu, Li-Jie Chen, Joong Sup Shim
Summary: This study found that PTEN-deficient colorectal cancer (CRC) is susceptible to MDM2 inhibition, which selectively inhibits the growth of PTEN-deficient CRC both in vitro and in mice models. The synthetic lethal effect of MDM2 inhibitor in PTEN-deficient cells is largely dependent on p53, as p53 silenced cells or cells lacking p53 failed to exhibit synthetic lethality. MDM2 inhibition activates p53 and reverses the Bcl2-Bax ratio, leading to mitochondria-mediated apoptotic cell death in PTEN-deficient CRC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Xiaomei Wu, Lu Ren, Qianqian Yang, Hui Song, Qiaoli Tang, Mingchao Zhang, Jiong Zhang, Zheng Tang, Shaolin Shi
Summary: Glucocorticoids exert therapeutic effects on anti-GBM crescentic glomerulonephritis by inhibiting podocyte EGFR/STAT3 signaling and the downstream pathway that leads to PEC proliferation and crescent formation.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chen-Yi Liao, Shun-Fa Yang, Ting-Jian Wu, Han Chang, Chi-Ying F. Huang, Yu-Fan Liu, Chi-Hsiang Wang, Jhong-Chio Liou, Shih-Lan Hsu, Huei Lee, Gwo-Tarng Sheu, Jinghua Tsai Chang
Summary: This study reveals that lung cancer risk is associated with PERP genotypes, with individuals carrying PERP-428CC having the highest risk. PERP-428C can modulate the expression of antioxidant enzymes via regulating p53 protein stability, thus affecting redox status and increasing the risk of lung cancer.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Sara Lazaro, Corina Lorz, Ana Belen Enguita, Ivan Seller, Jesus M. Paramio, Mirentxu Santos
Summary: Lung cancer is a leading cause of cancer death worldwide. This study investigates the impact of deleting tumor suppressor genes in adult mice's lungs and identifies a new mouse model for pulmonary sarcomatoid carcinoma (PSC). PSC is rare and lacks effective treatment and preclinical models, making this discovery significant for further research and understanding the relationship between different types of non-small cell lung cancer.
Article
Medicine, Research & Experimental
Jin Woo Shin, Se-Hee Kim, Jin Young Yoon
Summary: The study suggests that downregulation of PTEN induces apoptosis and decreases proliferation in cervical cancer cells, indicating that PTEN inhibition may represent a promising strategy for the treatment of cervical cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jyh-Der Leu, Shih-Ting Lin, Chiung-Tong Chen, C-Allen Chang, Yi-Jang Lee
Summary: BPR0C261 demonstrates dose-dependent cytotoxicity on A549 and H1299 cells, inducing maximum G2/M phase arrest and apoptosis in both cell lines. The combination of low concentration of BPR0C261 and X-rays shows a synergistic radiosensitizing effect on NSCLC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Esther Kaplun, Yijun Gao, HuiYong Zhao, Arnaud Da Cruz Paula, Yingjie Zhu, Almudena Chaves Perez, Kalyani Chadalavada, Edison Tse, Sudhir Chowdhry, Sydney Bowker, Qing Chang, Besnik Qeriqi, Britta Weigelt, Gouri J. Nanjangud, Michael F. Berger, Hirak Der-Torossian, Kenna Anderes, Nicholas D. Socci, Jinru Shia, Yonina R. Murciano-Goroff, Bob Li, James G. Christensen, Jorge S. Reis-Filho, David B. Solit, Elisa de Stanchina, Scott W. Lowe, Neal Rosen, Sandra Misale
Summary: Combining KRASG12C and EGFR inhibitors is an effective treatment for colorectal cancer. However, secondary resistance can reduce its efficacy. Our study found that resistance alterations preventing inhibition of ERK signaling are detected at a low frequency, except for KRASG12C amplification, which increases over time. Upon drug withdrawal, resistant cells undergo senescence, but mTOR signaling remains elevated. Targeting the senescence response may be a potential therapeutic vulnerability to overcome acquired resistance.
Article
Oncology
Omkar S. Vinchure, Vikas Sharma, Saba Tabasum, Sourabh Ghosh, Rana P. Singh, Chitra Sarkar, Ritu Kulshreshtha
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Kavneet Kaur, Prerana Jha, Pankaj Pathak, Vaishali Suri, Mehar Chand Sharma, Ajay Garg, Ashish Suri, Chitra Sarkar
JOURNAL OF NEURO-ONCOLOGY
(2019)
Meeting Abstract
Oncology
K. Kaur, P. Jha, P. Pathak, V. Suri, M. C. Sharma, A. Garg, A. Suri, C. Sarkar
Article
Endocrinology & Metabolism
Pankaj Kumar, Michael Traurig, Leslie J. Baier
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Meeting Abstract
Clinical Neurology
P. Pathak, Y. Blech-Hermoni, K. Subedi, J. Mpamugo, C. Obeng-Nyarko, A. Mankodi
NEUROMUSCULAR DISORDERS
(2019)
Article
Pathology
Kalpana Kumari, Mehar C. Sharma, Aanchal Kakkar, Prit B. Malgulwar, Pankaj Pathak, Vaishali Suri, Chitra Sarkar, Sarat P. Chandra, Mohammed Faruq
ANNALS OF DIAGNOSTIC PATHOLOGY
(2020)
Article
Endocrinology & Metabolism
Paolo Piaggi, Cigdem Koroglu, Anup K. Nair, Jeff Sutherland, Yunhua L. Muller, Pankaj Kumar, Wen-Chi Hsueh, Sayuko Kobes, Alan R. Shuldiner, Hye In Kim, Nehal Gosalia, Cristopher V. Van Hout, Marcus Jones, William C. Knowler, Jonathan Krakoff, Robert L. Hanson, Clifton Bogardus, Leslie J. Baier
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Oncology
Sonam Takkar, Vikas Sharma, Sourabh Ghosh, Ashish Suri, Chitra Sarkar, Ritu Kulshreshtha
Summary: This study identified miR-196a as a hypoxia-inducible and hypoxia-inducible factor (HIF)-regulated miRNA that plays an oncogenic role in GBM. It was significantly up-regulated in TCGA-GBM, CGGA glioma and Indian GBM patient cohorts. miR-196a overexpression promoted cellular proliferation, migration, spheroid and colony formation, and inhibited apoptosis, while inhibition of miR-196a yielded opposite results, suggesting an oncogenic role.
Article
Biology
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi
Summary: This research demonstrates that the LDB3 protein regulates mechanical stress signaling through interactions with filamin C, HSPA8, and PKC alpha. Mutations in LDB3 lead to early aggregation of filamin C and its chaperones at the muscle Z-disc, ultimately causing protein aggregation myopathy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Srishti Srivastava, Hima Makala, Vikas Sharma, Vaishali Suri, Chitra Sarkar, Ritu Kulshreshtha
Summary: This study reveals the overexpression of a subunit of the mediator complex, MED12, in glioblastoma and shows its role in promoting tumor cell proliferation, migration, and inhibiting apoptosis. The study also identifies MED12 as an important mediator of the VDR signaling pathway and highlights its potential as a therapeutic target for glioblastoma.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, General & Internal
Shivangi Attri, Vikas Sharma, Amit Kumar, Chaitenya Verma, Suresh Kumar Gahlawat
Summary: The study investigated the potential pathogenic mechanisms of the V727M mutation in hereditary inclusion body myopathy, finding that the mutation may have detrimental effects on GNE protein stability and interactions, affecting MYC transcription factor interactions and gene expression regulation. Understanding these effects could lead to the development of effective therapies against HIBM.
Article
Clinical Neurology
Pankaj Pathak, Mehar Chand Sharma, Pankaj Jha, Chitra Sarkar, Mohammed Faruq, Prerana Jha, Vaishali Suri, Rohit Bhatia, Sumit Singh, Sheffali Gulati, Mohammad Husain
Summary: LGMDR1, previously known as LGMD2A, is a genetic disorder characterized by inactivating mutations in the CAPN3 gene. A systematic study was conducted to characterize the genetic framework of LGMDR1 in the Indian population, with preliminary calpain-3 immunoblot screening proving effective for genetic testing. The identification of key exons in CAPN3 could facilitate targeted sequencing panels for genetic diagnosis, carrier testing, counseling, and clinical trials in LGMDR1 patients in India.
JOURNAL OF NEUROMUSCULAR DISEASES
(2021)
Article
Neurosciences
Prit B. Malgulwar, Aanchal Kakkar, Mehar C. Sharma, Ranajoy Ghosh, Pankaj Pathak, Chitra Sarkar, Vaishali Suri, Manmohan Singh, Shashank S. Kale, Mohammed Faruq
Meeting Abstract
Clinical Neurology
Yotam Blech-Hermoni, Pankaj Pathak, Kalpana Subedi, Charissa Obeng-Nyarko, Jessica Mpamugo, Ami Mankodi
Meeting Abstract
Clinical Neurology
Chitra Sarkar, Kavneet Kaur, Anupam Kumar, Pankaj Pathak, Vaishali Suri, Mehar Chand Sharma, Ajay Garg, Ashish Suri