Article
Infectious Diseases
Maria Anna Smolle, Hana Murtezai, Tobias Niedrist, Florian Amerstorfer, Nina Hoerlesberger, Lukas Leitner, Sebastian Martin Klim, Reingard Glehr, Raju Ahluwalia, Andreas Leithner, Mathias Glehr
Summary: This study analysed and compared the vancomycin elution kinetics of four biodegradable, osteoconductive antibiotic carriers used in clinical practice. The results showed different elution rates and antibiotic concentration patterns for each carrier. The carrier made of allogenic bone chips exhibited the highest elution rate, while the carrier with separately added vancomycin showed a more consistent antibiotic-releasing profile.
Article
Geosciences, Multidisciplinary
Yang Tang, Hailong Zhang, Jiang Xu, Seisuke Okubo, Xinrong Liu
Summary: This study conducted triaxial compression tests on four types of rocks to examine the loading rate dependence in both peak and postfailure regions. It was found that the increase in residual strength and peak strength with a tenfold increase in strain rate was approximately proportional to 4% of the respective strength. The obtained results can be easily applied to improve constitutive equations, and the effect mechanism of confining pressure on the loading rate dependence of rock strength was discussed.
FRONTIERS IN EARTH SCIENCE
(2021)
Article
Biochemical Research Methods
Weiqiang Hao, Bo Li, Yuying Deng, Qiang Chen, Lijuan Liu, Qiaoyin Shen
Summary: Analytical expressions for retention time and peak compression factor are deduced by assuming quadratic solvent strength model and multilinear gradient elution. A program for the optimization of multilinear gradient profile is written and applied to search for a gradient profile for the separation of twelve compounds that are degraded from lignin. Results show that a better separation of the compounds is achieved under an S-shaped multilinear gradient profile than that obtained under linear gradient profile.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Engineering, Multidisciplinary
Kuo Bao, Xian-feng Zhang, Gui-ji Wang, Jia-jie Deng, Tao Chong, Dan Han, Bing-qiang Luo, Meng-ting Tan
Summary: This study investigates the damage characteristics of YAG transparent ceramics through shock compression and shockless spalling experiments. The results show that YAG exhibits vertical split cracks with oblique fine cracks under compression, and horizontal transgranular cracks concentrated near the main spall surface under tension. At the microscale, the cracks generated by compression, tension, and shear stress extend in a similar tensile form. Additionally, higher loading rate and longer loading duration increase the percentage of transgranular fractures.
DEFENCE TECHNOLOGY
(2022)
Article
Construction & Building Technology
Prodip Kumar Sarkar, Nilanjan Mitra
Summary: This study investigates the stress-strain curve variations of Portlandite mineral under different compressive loading conditions, providing explanations from the perspective of molecular structure deformations. Changes in bond order and partial atomic charges were calculated and compared with the observed stress-strain curves.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
N. Cliche, S. Ringeval, E. Georges, J. Bellus, P. Petit, F. Cortial, J. -L. Heuze, A. -F. Gourgues-Lorenzon
Summary: This study investigated the effect of three high-temperature deformation modes on flow stress vs. strain curves, as well as on post-dynamic and static recrystallization of 316Nb austenitic stainless steel. The research found that the loading mode had minimal impact on recrystallization phenomena, with the amount of niobium atoms in solid solution potentially playing a key role in controlling recrystallization.
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Lizhou Wu, Jianting Zhou, Jun Yang, Jingzhou Xin, Hong Zhang, Bu Li
Summary: This study investigates the fracture propagation of single-crack concrete specimens under compressional loading and proposes a radial shear stress criterion to examine the stress intensity factor of the pre-crack specimens. Experimental and numerical results show that the existence of cracks considerably weakens the strength of the specimens, and the distribution and width of the cracks have a significant effect on the specimen strength.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Physical
Feiyan Zhang, Xiang Liu, Fang-Wen Ge, Chenxing Cui
Summary: Ductility-based structural design is currently the mainstream method. Corresponding experimental studies have been performed to analyze the ductility performance of concrete columns with high-strength steel reinforcements under eccentric compression. Numerical models were established and verified, and a parameter analysis was conducted to systematically discuss the ductility of the concrete column section. The results show that the ductility of the section increases with the strength of the concrete and eccentricity, and decreases with the reinforcement ratio. A simplified calculation formula capable of quantitatively evaluating the section ductility was proposed.
Article
Engineering, Chemical
Soham Teraiya, Swapnil Vyavahare, Shailendra Kumar
Summary: In this study, the influence of process parameters on the mechanical properties of tetra-anti-chiral auxetic structures manufactured by material extrusion technique of additive manufacturing is investigated. Experimental results show that all process parameters significantly affect the mechanical properties, and regression models are developed to predict these properties.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Construction & Building Technology
Bin Lei, Hongchen Yu, Yipu Guo, Wenkui Dong, Rui Liang, Xiaonan Wang, Xuqun Lin, Kejin Wang, Wengui Li
Summary: Multi-recycling of concrete waste is a promising solution for reutilization of construction and demolition wastes. This study investigates the combined effects of normal stress ratio (σ/fc) and number of recycling cycles (n) on the mechanical performance and damage evolution of Multi-RAC under compression-shear loading conditions. Both σ/fc and n significantly influence the failure mode, mechanical strength, stress-displacement relation, and damage evolution characteristics of Multi-RAC. The shear strength increases with increased σ/fc, but decreases with increased n. The proposed aggregate interlock model reveals the mechanism for the reduction of aggregate interlock strength with increasing n. The findings provide insights into the mechanical behaviors of Multi-RAC and can contribute to its application in structural concrete.
JOURNAL OF BUILDING ENGINEERING
(2023)
Article
Materials Science, Composites
Alok K. Srivastava, Aparna Singh
Summary: This study aims to investigate the effect of graphene nanoplatelets (GNPs) coating on the deformation modes of carbon fiber-reinforced polymer (CFRP) composites under flexural loading. The results showed that GNP-coated CFRPs had an increase in compressive modulus and failure strain, and the measured strains were higher. Nano-indentation tests also revealed a thicker interface region between the GNP coating and the fibers. Additionally, GNP-coated CFRPs exhibited improved flexural strength, flexural modulus, and strain distribution compared to uncoated CFRPs.
POLYMER COMPOSITES
(2023)
Article
Physics, Applied
Dun Wu, Yaxin Zhu, Lv Zhao, Minsheng Huang, Zhenhuan Li
Summary: The plastic deformation mechanism of tantalum under double shock loading is mainly influenced by the effects of the first shock, with twin-dislocation conversion dominating in certain crystal orientations and dislocation slipping dominating in others. Shock-induced amorphization and recrystallization occur in single shock-loaded tantalum models, resulting in lower flow strengths compared to double shock-loaded ones. These findings aid in understanding the complex relationship between dynamic strength and intrinsic deformation mechanisms in tantalum under multiple shock loadings.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Orthopedics
Wongthawat Liawrungrueang, Suwipa Ungphaiboon, Arnurai Jitsurong, Natnicha Ingviya, Boonsin Tangtrakulwanich, Varah Yuenyongviwat
Summary: This study aimed to compare the elution characteristics of gentamicin-impregnated PMMA made with lyophilized liquid gentamicin and PMMA made with gentamicin powder. Results showed that PMMA made with lyophilized liquid gentamicin had a higher rate of antibiotic elution compared to PMMA made with gentamicin powder.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Sebastian Philipp von Hertzberg-Boelch, Martin Luedemann, Maximilian Rudert, Andre F. Steinert
Summary: This literature review explores the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. It outlines the clinically relevant differences that need to be considered when using antibiotic loaded bone cements for long-term implant fixation or as spacers for treating periprosthetic joint infections. In vitro findings on antibiotic elution and material properties are summarized and their clinical applications are discussed.
Article
Engineering, Chemical
Xiaoju Li, Ze Ouyang, Zhanhui Li, Junxia Yu, Zhenyue Zhang, Xiaodi Li, Chunqiao Xiao, Ruan Chi
Summary: The study found that water-soluble ammonium in weathered crust elution-deposited rare earth tailings is easily adsorbed on clay mineral surface through weak forces and can migrate with rainwater, causing serious pollution. Therefore, studying the elution process of water-soluble ammonium is critical for remedying ammonium-leached rare earth tailings.
MINERALS ENGINEERING
(2023)
Article
Infectious Diseases
Syed Iqbal Haider, Naeem Akhtar, Muhammad Saleem, Sheraz Ahmed, Shiza Nadeem, Maham Amjad, Faiz Ul Haq
Summary: This study aimed to compare the diagnostic potential of Raman spectroscopy with rapid urease test and histopathology in diagnosing H. pylori infection. The results showed that Raman spectroscopy had higher sensitivity, accuracy, and specificity compared to the rapid urease test and histopathology. This study demonstrates the applicability of Raman spectroscopy as an innovative detection tool for molecular diagnosis of H. pylori infection in gastritis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Editorial Material
Infectious Diseases
Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane, Pallavi Vidhate, Partha Rakshit, Preeti Madan, Hema Gogia, Priya Abraham, Sandhya Kabra, Ekta Gupta
Summary: The present study aimed to determine the diagnostic performance of dried blood spot (DBS) for HBsAg and anti-HCV detection using CLIA in three different laboratories across India. DBS can be a simple and convenient alternative to plasma or serum for HBsAg detection, but site-specific validation of the assay is necessary for anti-HCV detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Somayeh Yazdanpanah, Maryam Rahbarmah, Marjan Motamedi, Hossein Khodadadi
Summary: This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Or Kriger, Natasha Belausov, Shiraz Gefen-Halevi, Nadezda Savieva, Sharon Amit
Summary: This study demonstrates that the usage of preservative-containing urine tubes may inhibit pathogens in low-volume pediatric urine samples, resulting in false-negative results. We advocate for large-scale validations by regulators to ensure result consistency.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Sibra R. M. Shihab, Bushran N. Iqbal, Shiyamalee Arunasalam, Faseeha Noordeen
Summary: This study investigated the effect of sample-based RNA quality on COVID-19 real-time RT-PCR results. The purity of the extracts and concentration of RNA were found to impact test interpretations. The presence of impurities led to inconclusive test results.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Nouf K. Almaghlouth, Panagiotis Arvanitis, Kendra Vieira, Abby London, Dimitrios Farmakiotis
Summary: This study evaluated the performance of the Viracor CMV-T-cell immunity Panel (TCIP) in predicting CMV events. The results showed that CMV-specific CD4+ and CD8(+)T-cells were significantly lower in those with CMV events, and the TCIP could be a useful adjunct tool in individualized management of CMV infection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Linzhen Zhu, Haoting Zhang, Haibo Gu, Jianying Zhou
Summary: This case report describes a 70-year-old male patient with previously unknown immunodeficiency. Multiple pulmonary nodular shadows were observed on radiography. Fungal infection was detected in various samples, and the patient was ultimately diagnosed with disseminated Talaromyces marneffei infection and B-cell non-Hodgkin's lymphoma. The main significance of this study is to emphasize the importance for clinicians to obtain comprehensive specimens from patients presenting with multiple masses in order to ensure accurate clinical diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ming Chang, Sambasivan Venkatasubramanian, Holly Barrett, Kevin B. Urdahl, Kris M. Weigel, Gerard A. Cangelosi, Javeed A. Shah, Aparajita Saha, Libing Feng, Kristin N. Adams, David R. Sherman, Nahum Smith, Chetan Seshadri, Sean C. Murphy, James G. Kublin
Summary: Efforts are being made globally to develop vaccines and drugs against M. tuberculosis. This study developed a real-time RT-PCR assay to detect pre-rRNA as a biomarker for bacterial viability. The assay showed promising results in mouse models, indicating its potential in future clinical studies for tuberculosis drugs and vaccines.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Letter
Infectious Diseases
Temi Lampejo, Fadia Alsheikh, Declan Crilly, Martin Brown
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Yao Li, Pengfei Shi, Rong Zhu
Summary: This study successfully diagnosed a case of lung abscess caused by Porphyromonas endodontalis using mNGS technology, highlighting the importance of considering inhalation diseases caused by oral pathogens in patients with periodontal diseases and respiratory symptoms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Mariana Quaresma de Souza, Dienefer Venske Bierhals, Ana Julia Reis, Erica Chimara, Julia Silveira Vianna, Andrea von Groll, Pedro Almeida da Silva, Ivy Bastos Ramis
Summary: This study proposed and evaluated a drug susceptibility testing method using 2,3,5-triphenyl tetrazolium chloride (TTC) as a colorimetric indicator for the clinical relevant non-tuberculous mycobacteria (Mycobacterium abscessus complex (MABC), M. avium complex (MAC), and M. kansasii). The results showed high agreement between TTC assay and the recommended broth microdilution method, indicating the potential of TTC as a promising indicator in drug susceptibility testing for NTM.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Shanshan Zhang, Mingyuan Duan, Shuang Li, Jie Hou, Ting Qin, Zhanwei Teng, Jianhe Hu, Huihui Zhang, Xiaojing Xia
Summary: Rapid detection of pathogenic microorganisms is crucial for epidemiologic identification, prevention, and control in public health. PCR-based methods have limitations in resource-limited areas due to the need for precise temperature control. Recombinase polymerase amplification (RPA) is a new nucleic acid amplification technology that can amplify DNA or RNA at a constant temperature, offering simplicity, high specificity and sensitivity, and short detection time. Microfluidic technology combined with RPA enables rapid detection of pathogenic microorganisms by integrating nucleic acid extraction, amplification, and detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Piyush Agrawal, Aditya Upadhyay, Awanish Kumar
Summary: Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. During infection, the expression of host microRNAs changes, which could be potential biomarkers for early detection of tuberculosis. Further research is needed to identify potential microRNA biomarkers, but momentum is gaining in this field and microRNAs are expected to become routine approaches for reliable diagnosis and specific therapeutic interventions.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)