Article
Biochemistry & Molecular Biology
Ha-Hyeon Shin, Eun-Seok Jeon, Byung-Kwan Lim
Summary: In this study, the function of coxsackievirus and adenovirus receptor (CAR) in mouse macrophages during CVB3 infection was investigated. CAR expression was found to increase after infection and its deletion in macrophages led to increased inflammation and myocarditis. Furthermore, the expression of chemokine CXCL-11 was increased, leading to stimulation of CD4 and CD8 T cell activity. These findings highlight the importance of macrophage CAR in regulating inflammation during CVB3 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Koshiro Kanaoka, Kenji Onoue, Satoshi Terasaki, Tomoya Nakano, Michikazu Nakai, Yoko Sumita, Kinta Hatakeyama, Fumio Terasaki, Rika Kawakami, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Yoshihiko Saito
Summary: The study found that patients with fulminant myocarditis presentation are at higher risk of death or heart transplantation within 90 days. Factors associated with poorer prognosis include older age, non-sinus rhythm, low left ventricular wall motion, and ventricular tachycardia or fibrillation upon admission.
Article
Virology
Chengrui Niu, Wei Xu, Sidong Xiong
Summary: The appendix plays a role in regulating the composition of the intestinal microbiota and has an impact on cardiac infection and inflammation.
Article
Pharmacology & Pharmacy
Qiaoyu Wang, Qiongjun Zhu, Qiaofang Ye, Jiajun Wang, Qianqian Dong, Youran Chen, Minna Wang, Yu Fu, Rongzhou Wu, Tingting Wu
Summary: This study demonstrates that STAT3 plays a protective role in viral myocarditis by alleviating cardiomyocyte apoptosis. Activated STAT3 exerts anti-apoptotic effects by targeting survivin in the pathogenesis of viral myocarditis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Yun Im Lee, Suryeun Chung, Ji-Hyuk Yang, Kiick Sung, Darae Kim, Jin-Oh Choi, Eun-Seok Jeon, Jeong Hoon Yang, Yang Hyun Cho
Summary: The study aimed to evaluate the outcomes of patients with fulminant myocarditis and investigate factors associated with mortality, finding that ECMO can be an effective treatment option, with CK-MB and SOFA score being significant risk factors for in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Saurabh Rajpal, Rami Kahwash, Matthew S. Tong, Kelly Paschke, Anjali A. Satoskar, Beth Foreman, Larry A. Allen, Nicole M. Bhave, Ty J. Gluckman, Valentin Fuster
Summary: A 60-year-old woman with a history of asthma developed fulminant myocarditis 9 days after testing positive for SARS-CoV-2 and 16 days after developing symptoms consistent with COVID-19. She had a complicated hospital course but ultimately recovered and was discharged with normal left ventricular systolic function. However, she later developed symptomatic ventricular tachycardia and received treatment with an implantable cardioverter-defibrillator and antiarrhythmic drugs.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuxiao Hu, Jie Ren, Xueqi Dong, Di Zhang, Yi Qu, Chunxue Yang, Yang Sun, Jinghui Li, Fang Luo, Wei Wang, Huanhuan Wang, Ping Qing, Shihua Zhao, Jie Huang, Litian Yu, Yaxin Liu, Huiqiong Tan
Summary: This study compared the clinical characteristics, treatments, and outcomes in patients with fulminant giant cell myocarditis (FGCM) and fulminant lymphocytic myocarditis (FLM). The results showed that patients with FGCM had milder inflammatory responses and myocardial damage compared to those with FLM, but had poorer prognoses. hs-CRP levels could serve as a promising prognostic biomarker and an appropriate cutoff point for differentiating between FGCM and FLM patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yan Zhuang, Jin Wang, Huihui Li, Yanghui Chen, Chen Chen, Dao Wen Wang
Summary: The study identified plasma Siglec-5 and CD163 as valuable novel biomarkers for the early diagnosis of fulminant myocarditis (FM).
Article
Cardiac & Cardiovascular Systems
Florent Huang, Enrico Ammirati, Maharajah Ponnaiah, Santiago Montero, Victor Raimbault, Darryl Abrams, Guillaume Lebreton, Vincent Pellegrino, Joshua Ihle, Maurizio Bottiroli, Romain Persichini, Marisa Isabel Barrionuevo-Sanchez, Albert Ariza-Sole, Pauline Yeung Ng, Simon Wai Ching Sin, Raj Ayer, Hergen Buscher, Slimane Belaid, Clement Delmas, Rita Ferreira, Roberto Roncon Albuquerque Jr, Teresa Lopez-Sobrino, Jeroen J. H. Bunge, Christoph Fisser, Guillaume Franchineau, Jamie Mccanny, Shinichiro Ohshimo, Alessandro Sionis, Francisco Jose Hernandez-Perez, Eduardo Barge-Caballero, Martin Balik, Henrique Muglia, Sunghoon Park, Dirk W. Donker, Beatriz Porral, Nadia Aissaoui, Armand Mekontso Dessap, Virginia Burgos, Mathieu Lesouhaitier, Justin Fried, Jae-Seung Jung, Sandra Rosillo, Vincent Scherrer, Saad Nseir, Hadrien Winszewski, Pablo Jorge-Perez, Antoine Kimmoun, Rodrigo Diaz, Alain Combes, Matthieu Schmidt, FULLMOON Study Grp
Summary: This study aimed to investigate the clinical impact of the timing of endomyocardial biopsy (EMB) in adult patients with fulminant myocarditis. The results showed that early EMB was associated with a higher survival rate free of heart transplantation or left ventricular assist device at 1 year, highlighting its potential to improve patient prognosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Virology
Sandra Pinkert, Meike Kespohl, Nicolas Kelm, Ziya Kaya, Arnd Heuser, Karin Klingel, Antje Beling
Summary: The study demonstrates that the use of tramadol in the CVB3 myocarditis mouse model does not have disruptive effects on viral pathogenicity or immune response in the heart. This supports the consideration of the demonstrated protocol as a general analgesic strategy for CVB3 infection.
Article
Infectious Diseases
Daniele Colombo, Marco Albore, Franca Del Nonno, Giorgio Bolino, Mario D'Ambrosio, Alessandra Salvi, Camilla Cecannecchia, Laura Falasca
Summary: This report presents a fatal case of fulminant myocarditis and terminal liver involvement caused by HSV-2 infection, with a unique presentation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Plant Sciences
Bowen Sun, Lin Lin, Tian Yao, Jingchun Yao, Guimin Zhang, Yunlun Li, Chao Li
Summary: This study found that Jingfang Granules (JFG) significantly alleviated pathological damage in the cardiac tissues of coxsackievirus B3-induced viral myocarditis mice and attenuated the expression of inflammatory genes. JFG may exert its therapeutic effects by enhancing autophagy to suppress cell apoptosis, thereby reducing cell damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Immunology
Sichao Huang, Congcong Zhang, Jianing Li, Zongmao Dai, Jingjing Huang, Fengzhen Deng, Xumeng Wang, Xinxin Yue, Xinnan Hu, Yuxuan Li, Yushu Deng, Yanhang Wang, Wenran Zhao, Zhaohua Zhong, Yan Wang
Summary: In this study, a novel multi-epitope vaccine was designed using immunoinformatics methods to prevent CVB infection. By predicting and constructing conserved epitopes, optimizing the vaccine sequence, and performing molecular simulations, the vaccine showed potential safety and efficacy against CVB infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xinyue Zhang, Ruling Yang, Mengjie Ma, Siyu Chen, Kaiyin Guo, Li Zhang, Yingnan You, Hailin Jia, Bo Han
Summary: This study investigated the plasma exosome miRNA profile in pediatric fulminant myocarditis (FM) using small RNA microarray. Differential expression of 266 miRNAs was observed, including 197 upregulated and 69 downregulated candidate genes. Through analysis, FM-specific target genes related to inflammation and/or the immune system were identified. CeRNA networks between cardiomyocytes and peripheral blood mononuclear cells were established, and specific miRNAs were validated as potential biomarkers for FM diagnosis.
Article
Cardiac & Cardiovascular Systems
Guanglin Cui, Rui Li, Chunxia Zhao, Dao Wen Wang
Summary: This is the first report of two cases of fulminant myocarditis (FM) occurring after administration of the currently available inactivated SARS-CoV-2 vaccine. Cardiac magnetic resonance imaging revealed myocardial edema and necrosis, while pathological evaluation showed inflammatory cell infiltration, myocyte necrosis, and fibrosis. The patients recovered and were discharged after comprehensive treatment. These findings highlight the importance of paying more attention to the rare but lethal complications of COVID-19 vaccination.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Raja Ramachandran, Neeraj Inamdar, Joyita Bharati, Ashok K. Yadav, Ashwani Kumar, Gaurav Prakash, Ritambhra Nada, Manish Rathi, Harbir Singh Kohli, Krishan L. Gupta, Vivekanand Jha
Letter
Urology & Nephrology
Raja Ramachandran, Ashok Kumar Yadav, Vinod Kumar, Ashwani Varma, Sunil Taneja, Ritambhra Nada, Krishan Lal Gupta, Vivekanand Jha
Article
Pediatrics
Karalanglin Tiewsoh, Ankur Kumar Jindal, Dhrubajyoti Sharma, Sunil Arora, Ranjana W. Minz, Parimal Agrawal, Ritambhra Nada, Deepti Suri
PAEDIATRICS AND INTERNATIONAL CHILD HEALTH
(2018)
Editorial Material
Ophthalmology
Jitender Jinagal, Gaurav Gupta, Faisal Thattaruthody, Ritambhra Nada, Jagat Ram
INDIAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Rheumatology
R. K. Pilania, A. K. Jindal, G. Sandesh, P. Vignesh, D. Suri, R. Nada, S. Singh
Article
Urology & Nephrology
Raja Ramachandran, Joyita Bharati, Indu Rao, Ahmed W. Kashif, Ritambhra Nada, Ranjana Minz, Krishan L. Gupta, Harbir S. Kohli
Article
Transplantation
K. L. Gupta, Navin Pattanashetti, Raja Ramachandran, Ritambhra Nada, Ritu Aggarwal, Ashsish Sharma
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2019)
Letter
Urology & Nephrology
Navin Pattanashetti, Raja Ramachandran, Manish Rathi, Ritambhra Nada, Krishan L. Gupta
Article
Urology & Nephrology
Parimal Agrawal, Ashwani Kumar, Amber Parwaiz, Amit Rawat, Karalanglin Tiewsoh, Ritambhra Nada
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2019)
Article
Urology & Nephrology
P. Agrawal, R. Nada, R. Ramachandran, C. S. Rayat, A. Kumar, H. S. Kohli
INDIAN JOURNAL OF NEPHROLOGY
(2019)
Article
Urology & Nephrology
Raja Ramachandran, Saurabh Nayak, Hari P. Anakutti, Ashok K. Yadav, Ritambhra Nada, Vanita Jain, Krishan L. Gupta, Vivekanand Jha
KIDNEY INTERNATIONAL REPORTS
(2019)
Letter
Urology & Nephrology
Jasmine Sethi, Raja Ramachandran, Vivek Kumar, Manish Rathi, H. S. Kohli, Ritambhra Nada, Ashish Sharma, Krishan Lal Gupta
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2019)
Article
Urology & Nephrology
Lesa Dawman, Aravind Sekar, Tandra Harish Varma, Ritambhra Nada, Karalanglin Tiewsoh
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2019)
Article
Urology & Nephrology
P. Agrawal, V. Kumar, A. Kumar, M. U. S. Sachdeva, P. Malhotra, R. Nada
INDIAN JOURNAL OF NEPHROLOGY
(2019)
Review
Respiratory System
Richa Singh Chauhan, Kushaljit Singh Sodhi, Ritambhara Nada, Ramandeep Virk, Joseph Mathew
Article
Infectious Diseases
Syed Iqbal Haider, Naeem Akhtar, Muhammad Saleem, Sheraz Ahmed, Shiza Nadeem, Maham Amjad, Faiz Ul Haq
Summary: This study aimed to compare the diagnostic potential of Raman spectroscopy with rapid urease test and histopathology in diagnosing H. pylori infection. The results showed that Raman spectroscopy had higher sensitivity, accuracy, and specificity compared to the rapid urease test and histopathology. This study demonstrates the applicability of Raman spectroscopy as an innovative detection tool for molecular diagnosis of H. pylori infection in gastritis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Editorial Material
Infectious Diseases
Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane, Pallavi Vidhate, Partha Rakshit, Preeti Madan, Hema Gogia, Priya Abraham, Sandhya Kabra, Ekta Gupta
Summary: The present study aimed to determine the diagnostic performance of dried blood spot (DBS) for HBsAg and anti-HCV detection using CLIA in three different laboratories across India. DBS can be a simple and convenient alternative to plasma or serum for HBsAg detection, but site-specific validation of the assay is necessary for anti-HCV detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Somayeh Yazdanpanah, Maryam Rahbarmah, Marjan Motamedi, Hossein Khodadadi
Summary: This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Or Kriger, Natasha Belausov, Shiraz Gefen-Halevi, Nadezda Savieva, Sharon Amit
Summary: This study demonstrates that the usage of preservative-containing urine tubes may inhibit pathogens in low-volume pediatric urine samples, resulting in false-negative results. We advocate for large-scale validations by regulators to ensure result consistency.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Sibra R. M. Shihab, Bushran N. Iqbal, Shiyamalee Arunasalam, Faseeha Noordeen
Summary: This study investigated the effect of sample-based RNA quality on COVID-19 real-time RT-PCR results. The purity of the extracts and concentration of RNA were found to impact test interpretations. The presence of impurities led to inconclusive test results.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Nouf K. Almaghlouth, Panagiotis Arvanitis, Kendra Vieira, Abby London, Dimitrios Farmakiotis
Summary: This study evaluated the performance of the Viracor CMV-T-cell immunity Panel (TCIP) in predicting CMV events. The results showed that CMV-specific CD4+ and CD8(+)T-cells were significantly lower in those with CMV events, and the TCIP could be a useful adjunct tool in individualized management of CMV infection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Linzhen Zhu, Haoting Zhang, Haibo Gu, Jianying Zhou
Summary: This case report describes a 70-year-old male patient with previously unknown immunodeficiency. Multiple pulmonary nodular shadows were observed on radiography. Fungal infection was detected in various samples, and the patient was ultimately diagnosed with disseminated Talaromyces marneffei infection and B-cell non-Hodgkin's lymphoma. The main significance of this study is to emphasize the importance for clinicians to obtain comprehensive specimens from patients presenting with multiple masses in order to ensure accurate clinical diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ming Chang, Sambasivan Venkatasubramanian, Holly Barrett, Kevin B. Urdahl, Kris M. Weigel, Gerard A. Cangelosi, Javeed A. Shah, Aparajita Saha, Libing Feng, Kristin N. Adams, David R. Sherman, Nahum Smith, Chetan Seshadri, Sean C. Murphy, James G. Kublin
Summary: Efforts are being made globally to develop vaccines and drugs against M. tuberculosis. This study developed a real-time RT-PCR assay to detect pre-rRNA as a biomarker for bacterial viability. The assay showed promising results in mouse models, indicating its potential in future clinical studies for tuberculosis drugs and vaccines.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Letter
Infectious Diseases
Temi Lampejo, Fadia Alsheikh, Declan Crilly, Martin Brown
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Yao Li, Pengfei Shi, Rong Zhu
Summary: This study successfully diagnosed a case of lung abscess caused by Porphyromonas endodontalis using mNGS technology, highlighting the importance of considering inhalation diseases caused by oral pathogens in patients with periodontal diseases and respiratory symptoms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Mariana Quaresma de Souza, Dienefer Venske Bierhals, Ana Julia Reis, Erica Chimara, Julia Silveira Vianna, Andrea von Groll, Pedro Almeida da Silva, Ivy Bastos Ramis
Summary: This study proposed and evaluated a drug susceptibility testing method using 2,3,5-triphenyl tetrazolium chloride (TTC) as a colorimetric indicator for the clinical relevant non-tuberculous mycobacteria (Mycobacterium abscessus complex (MABC), M. avium complex (MAC), and M. kansasii). The results showed high agreement between TTC assay and the recommended broth microdilution method, indicating the potential of TTC as a promising indicator in drug susceptibility testing for NTM.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Shanshan Zhang, Mingyuan Duan, Shuang Li, Jie Hou, Ting Qin, Zhanwei Teng, Jianhe Hu, Huihui Zhang, Xiaojing Xia
Summary: Rapid detection of pathogenic microorganisms is crucial for epidemiologic identification, prevention, and control in public health. PCR-based methods have limitations in resource-limited areas due to the need for precise temperature control. Recombinase polymerase amplification (RPA) is a new nucleic acid amplification technology that can amplify DNA or RNA at a constant temperature, offering simplicity, high specificity and sensitivity, and short detection time. Microfluidic technology combined with RPA enables rapid detection of pathogenic microorganisms by integrating nucleic acid extraction, amplification, and detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Piyush Agrawal, Aditya Upadhyay, Awanish Kumar
Summary: Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. During infection, the expression of host microRNAs changes, which could be potential biomarkers for early detection of tuberculosis. Further research is needed to identify potential microRNA biomarkers, but momentum is gaining in this field and microRNAs are expected to become routine approaches for reliable diagnosis and specific therapeutic interventions.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
