Article
Immunology
Francisco Callejas-Hernandez, Alfonso Herreros-Cabello, Javier del Moral-Salmoral, Manuel Fresno, Nuria Girones
Summary: This study analyzed the complete repertoire of maxicircle and minicircle sequences of different T. cruzi strains, revealing structural differences in minicircles and maxicircles among strains. Understanding the mitochondrial genome of Trypanosomatids is crucial for coordinating the expression of nuclear and mitochondrial genes involved in oxidative phosphorylation, and the heterogeneity observed in minicircles and maxicircles suggests a more complex organization than previously described.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Virginia Ramirez-Montoya, Danielle Garcia-Olivares, Hector Acosta, Ascanio Rojas
Summary: Trypanosoma rangeli is the most similar organism to Trypanosoma cruzi, but they have key differences, such as the latter being the etiological agent of a disease. A single copy gene called LYT1 in T. cruzi plays an important role in infectiveness and serves as a potential vaccine target.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Microbiology
Fanny E. Eberhard, Sven Klimpel, Alessandra A. Guarneri, Nicholas J. Tobias
Summary: The study reveals the interactions between the parasites and microbiota in the intestinal tract of triatomine vectors, shedding light on important aspects of the transmission of Chagas disease by triatomine vectors.
Article
Mathematics, Applied
Xiaotian Wu, Daozhou Gao, Zilong Song, Jianhong Wu
Summary: A mathematical model is developed to investigate the impact of Trypanosoma cruzi and Trypanosoma rangeli co-infection and Trypanosoma rangeli-induced pathogenicity on the spread of Chagas disease. The presence of Trypanosoma rangeli infection is found to reduce the risk of Chagas disease infection. These findings are beneficial for the prevention and control of Chagas disease.
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B
(2023)
Article
Ecology
Vanessa J. Pineda, Kadir A. Gonzalez, Milixa Perea, Chystrie Rigg, Jose E. Calzada, Luis F. Chaves, Vanessa Vasquez, Franklyn Samudio, Nicole Gottdenker, Azael Saldana
Summary: Didelphis marsupialis, a competent reservoir for trypanosomatid parasites, showed high rates of T. cruzi infection in Chagas disease endemic regions of Panama. The study provided important information for improved surveillance and management of Chagas disease in the area.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE
(2022)
Article
Plant Sciences
Barbara Verena Dias Galvao, Carlos Fernando Araujo-Lima, Monica Cristine Pereira dos Santos, Mariana Pulmar Seljan, Eduardo Kennedy Carrao-Dantas, Claudia Alessandra Fortes Aiub, Luiz Claudio Cameron, Mariana Simoes Larraz Ferreira, Edira Castello Branco de Andrade Goncalves, Israel Felzenszwalb
Summary: The study identified 14 phenolic compounds in Plinia cauliflora leaf extract, showing certain anti-Trypanosoma cruzi activity but also cytotoxic effects on liver cell lines.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Veterinary Sciences
Gaetano Cammilleri, Stefano D'Amelio, Vincenzo Ferrantelli, Antonella Costa, Maria Drussilla Buscemi, Annamaria Castello, Emanuela Bacchi, Elisa Goffredo, Maria Emanuela Mancini, Serena Cavallero
Summary: Four dead Phalacrocorax carbo sinensis specimens from Southern Italy coasts were examined for the presence of Contracaecum sp. A total of 181 Contracaecum specimens, including larvae and adults, were found in the examined specimens. Contracaecum rudolphii A and B were detected, with a co-infestation of both in one of the specimens from Leporano Bay. This study provides the first report of Contracaecum sp. presence in P. carbo sinensis from Southern Italy.
VETERINARY SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Jorge Vasconez-Gonzalez, Juan S. Izquierdo-Condoy, Raul Fernandez-Naranjo, Esteban Gamez-Rivera, Andrea Tello-De-la-Torre, Galo S. Guerrero-Castillo, Carlos Ruiz-Sosa, Esteban Ortiz-Prado
Summary: Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi, transmitted through contact with triatomine insect feces and urine. It infects approximately 6-7 million people worldwide, causing at least 14,000 deaths annually. In Ecuador, it has been reported in 20 out of 24 provinces, with El Oro, Guayas, and Loja being the most affected.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Parasitology
Davi Alvarenga Lima, Leilane Oliveira Goncalves, Joao Luis Reis-Cunha, Paul Anderson Souza Guimaraes, Jeronimo Conceicao Ruiz, Daniel Barbosa Liarte, Silvane Maria Fonseca Murta
Summary: This study performed comparative transcriptomic analysis of wildtype and benznidazole-resistant T. cruzi populations, revealing metabolic pathways related to clinical drug resistance and identifying promising molecular targets for the development of new drugs for Chagas disease.
PARASITES & VECTORS
(2023)
Article
Immunology
Pablo Smircich, Leticia Perez-Diaz, Fabricio Hernandez, Maria Ana Duhagon, Beatriz Garat
Summary: Trypanosoma cruzi is a parasite that causes Chagas disease, and its life cycle involves alternating between a blood-sucking insect and a mammalian host. The parasite undergoes different stages of development in the insect gut, leading to the formation of infective forms that are transmitted through feces. Starvation in the insect host affects the parasite population and leads to the emergence of transitional forms. Understanding the molecular changes during nutritional restrictions can provide insights into the parasite's adaptation in the insect vector.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Parasitology
Djamila Boushaki, Julie Wallis, Frederik Van den Broeck, Achim Schnaufer
Summary: The study confirmed recent Trypanosoma infections in camels in Southern Algeria were caused by T. b. evansi type A, and introduced a newly designed PCR assay specific for this type, which is expected to be useful for diagnostic purposes in the community.
ACTA PARASITOLOGICA
(2022)
Article
Parasitology
Lilian Pinto, Alejandro G. Schijman, Julio Alonso-Padilla, Daniel Lozano, Mary Cruz Torrico, Pietro Gamba, Margarita Torrez, Vania Lozada, Karina Cartagena, Jareth Sanchez, Faustino Torrico, Joaquim Gascon
Summary: This study developed a method to detect the presence and quantify the load of Trypanosoma cruzi parasite in dysfunctional tissue segments of patients with Chagas disease. The study found that qPCR analysis using a new quantification methodology was able to detect the presence of the parasite and showed a correlation between parasite load and disease severity.
Article
Multidisciplinary Sciences
Bushra A. Kanaan, Mushtak T. S. Al-Ouqaili, Rafal M. Murshid
Summary: This study aimed to establish the frequency and pattern of chromosomal abnormalities in women with primary and secondary amenorrhea and detect genetic changes in specific genotypes. The results highlighted the importance of cytogenetic analysis for determining the genetic basis of amenorrhea and suggested genotyping for women with normal karyotype and high FSH serum levels for accurate diagnosis and appropriate management.
Article
Plant Sciences
Catarina G. Pereira, Carolina Borsoi Moraes, Caio H. Franco, Clarissa Feltrin, Raphael Grougnet, Euzebio Guimaraes Barbosa, Michele Panciera, Carlos Roque D. Correia, Maria Joao Rodrigues, Luisa Custodio
Summary: Marine halophytes are a valuable source of natural products with potential anti-infectious properties, among which sea fennel flower decoction showed significant anti-Trypanosoma cruzi activity. This suggests sea fennel as a promising candidate for the treatment of Chagas disease.
Article
Parasitology
Alicia Majeau, Erin Cloherty, A. Nikki Anderson, Susanne C. Straif-Bourgeois, Eric Dumonteil, Claudia Herrera
Summary: Raccoons in Louisiana serve as an important reservoir for Trypanosoma cruzi, the causative agent of Chagas disease. Assessing the genetic diversity of T. cruzi in raccoons is crucial to evaluate the risk to human health. The study revealed previously unreported DTU types and a significant association between DTU distribution and ecoregions in Louisiana, highlighting the need for ongoing surveillance and targeted interventions to mitigate human health risk.
Article
Parasitology
Paola Garcia-Huertas, Francisco Olmo, Manuel Sanchez-Moreno, Jorge Dominguez, Rachid Chahboun, Omar Triana-Chavez
EXPERIMENTAL PARASITOLOGY
(2018)
Article
Infectious Diseases
Jeiczon Jaimes-Duenez, Omar Triana-Chavez, Ana M. Mejia-Jaramillo
TICKS AND TICK-BORNE DISEASES
(2018)
Article
Veterinary Sciences
Jeiczon Jaimes-Duenez, Carolina Zapata-Zapata, Omar Triana-Chavez, Ana M. Mejia-Jaramillo
PREVENTIVE VETERINARY MEDICINE
(2019)
Article
Entomology
Andrea Arevalo-Cortes, Ana M. Mejia-Jaramillo, Yurany Granada, Heather Coatsworth, Carl Lowenberger, Omar Triana-Chavez
Article
Veterinary Sciences
Jeiczon Jaimes-Duenez, Edgar Mogollon-Waltero, Norberto Arias-Landazabal, David Rangel-Pachon, Angela Jimenez-Leano, Ana Mejia-Jaramillo, Omar Triana-Chavez
Summary: In South America, Colombia ranks as the third-largest livestock producer with approximately 28.8 million cattle, where Colombian Creole cattle represent around 1% of the livestock population. Animal Trypanosomiasis (AT) is a critical problem in the livestock industry, reducing production by about 30%. This study reports the molecular prevalence and clinical traits associated with Trypanosoma spp. infection in three Colombian Creole cattle breeds. The study found significant variations in prevalence and clinical signs associated with the infection, suggesting different levels of trypanotolerance in the breeds and potential effects of environmental variables on prevalence and clinical characteristics.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Infectious Diseases
Omar Cantillo-Barraza, Manuel Medina, Sara Zuluaga, Maria Isabel Blanco, Rodrigo Caro, Jeiczon Jaimes-Duenez, Virgilio Beltran, Samanta C. C. Xavier, Omar Triana-Chavez
Summary: This study highlights the distribution of synanthropic triatomine bugs in Boyaca, Colombia, with T. dimidiata becoming the most prevalent vector after successful control programs targeting R. prolixus. T. venosa, P. geniculatus, and P. rufotuberculatus also increase the risk of Chagas disease transmission in the region, suggesting the need for ongoing surveillance and control measures. The presence of residual R. prolixus populations poses a threat to the progress made in eliminating intradomiciliary transmission of T. cruzi.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Yurany Granada, Ana Maria Mejia-Jaramillo, Sara Zuluaga, Omar Triana-Chavez
Summary: The study found that Aedes aegypti mosquitoes in different Colombian cities have developed resistance to some pyrethroid insecticides due to allelic substitutions on the voltage-gated sodium channel gene known as kdr mutations. While kdr mutations play a role in conferring low levels of resistance, other mechanisms such as metabolic enzymes also contribute to the resistance. The findings suggest that genetic surveillance of mosquito populations is essential for monitoring resistance emergence and improving disease control measures.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Lidia Gual-Gonzalez, Catalina Arango-Ferreira, Laura Camila Lopera-Restrepo, Omar Cantillo-Barraza, Daniela Velasquez Marin, Natalia Restrepo Bustamante, Omar Triana-Chavez, Melissa S. Nolan
Summary: Chagas disease, caused by Trypanosoma cruzi infection, is a major cause of heart failure in Latin America. Early diagnosis and treatment are crucial to prevent irreversible myocardial damage. However, in Colombia, less than 1% of cases are treated due to various barriers. This study presents two cases of pediatric oral transmission of Chagas disease in an area of Colombia where this mode of transmission was previously unreported.
Article
Entomology
Andrea Arevalo-Cortes, Yurany Granada, David Torres, Omar Triana-Chavez
Summary: This study analyzed the characteristics of Aedes aegypti populations from different cities in Colombia, including lifespan, fecundity, and mortality. The study found that each population had unique features and patterns, which are important for determining the timing of insecticide application and surveillance.
Article
Virology
Andrea Arevalo-Cortes, Ashish Damania, Yurany Granada, Sara Zuluaga, Rojelio Mejia, Omar Triana-Chavez
Summary: This study identified high Zika virus infection rates in Ae. aegypti females from Colombian rural municipalities with deficient water supply. Differences in diversity were observed between infective and non-infective forms in the presence of natural Zika infection. Bacteria associated with Zika virus infection and lambda-cyhalothrin resistance were detected, suggesting a potential role in virus entry and insecticide bioremediation.
Article
Polymer Science
Nicolas Montoya-Escobar, Daniel Ospina-Acero, Jorge Andres Velasquez-Cock, Catalina Gomez-Hoyos, Angelica Serpa Guerra, Piedad Felisinda Ganan Rojo, Lina Maria Velez Acosta, Juan Pablo Escobar, Natalia Correa-Hincapie, Omar Triana-Chavez, Robin Zuluaga Gallego, Pablo M. Stefani
Summary: In this study, the crystallinity of three different types of cellulose was investigated using FTIR and XRD methods. A deconvolution method was developed to accurately estimate the crystallinity index. The effect of milling time on crystallinity was observed.
Article
Entomology
Lidia Gual-Gonzalez, Manuel Medina, Cesar Valverde-Castro, Virgilio Beltran, Rodrigo Caro, Omar Triana-Chavez, Melissa S. Nolan, Omar Cantillo-Barraza
Summary: This study evaluated the feasibility and effectiveness of micro-encapsulated insecticide paints in controlling vector species in a rural community in Colombia. The results showed the potential of this approach to prevent colonization and reduce the risk of disease transmission. The complementary use of insecticide spraying and micro-encapsulated paints could enhance public health efforts and reduce costs.
Article
Plant Sciences
Cesil Solis-Medina, Sara Zuluaga Aguirre, Omar Triana-Chavez, Omar Cantillo-Barraza
Summary: The study provides an update on the infection status of P. geniculatus and the presence of infected P. lignarius in the Guainia region in Colombia, highlighting the importance of continuous search and characterization of triatomine bugs for Chagas disease surveillance programs.
ACTA BIOLOGICA COLOMBIANA
(2021)
Article
Public, Environmental & Occupational Health
Omar Cantillo-Barraza, Manuel Medina, Yurany Granada, Camilo Munoz, Cesar Valverde, Fernando Cely, Paola Gonzalez, Yovanny Mendoza, Sara Zuluaga, Omar Triana-Chavez
ANNALS OF GLOBAL HEALTH
(2020)
Article
Public, Environmental & Occupational Health
Victor Hugo Pena-Garcia, Irma Sanchez-Vargas, Rebecca Christofferson, William C. Black, Sair Arboleda, Omar Triana-Chavez
ANNALS OF GLOBAL HEALTH
(2019)
Article
Infectious Diseases
Syed Iqbal Haider, Naeem Akhtar, Muhammad Saleem, Sheraz Ahmed, Shiza Nadeem, Maham Amjad, Faiz Ul Haq
Summary: This study aimed to compare the diagnostic potential of Raman spectroscopy with rapid urease test and histopathology in diagnosing H. pylori infection. The results showed that Raman spectroscopy had higher sensitivity, accuracy, and specificity compared to the rapid urease test and histopathology. This study demonstrates the applicability of Raman spectroscopy as an innovative detection tool for molecular diagnosis of H. pylori infection in gastritis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Editorial Material
Infectious Diseases
Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane, Pallavi Vidhate, Partha Rakshit, Preeti Madan, Hema Gogia, Priya Abraham, Sandhya Kabra, Ekta Gupta
Summary: The present study aimed to determine the diagnostic performance of dried blood spot (DBS) for HBsAg and anti-HCV detection using CLIA in three different laboratories across India. DBS can be a simple and convenient alternative to plasma or serum for HBsAg detection, but site-specific validation of the assay is necessary for anti-HCV detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Somayeh Yazdanpanah, Maryam Rahbarmah, Marjan Motamedi, Hossein Khodadadi
Summary: This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Or Kriger, Natasha Belausov, Shiraz Gefen-Halevi, Nadezda Savieva, Sharon Amit
Summary: This study demonstrates that the usage of preservative-containing urine tubes may inhibit pathogens in low-volume pediatric urine samples, resulting in false-negative results. We advocate for large-scale validations by regulators to ensure result consistency.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Sibra R. M. Shihab, Bushran N. Iqbal, Shiyamalee Arunasalam, Faseeha Noordeen
Summary: This study investigated the effect of sample-based RNA quality on COVID-19 real-time RT-PCR results. The purity of the extracts and concentration of RNA were found to impact test interpretations. The presence of impurities led to inconclusive test results.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Nouf K. Almaghlouth, Panagiotis Arvanitis, Kendra Vieira, Abby London, Dimitrios Farmakiotis
Summary: This study evaluated the performance of the Viracor CMV-T-cell immunity Panel (TCIP) in predicting CMV events. The results showed that CMV-specific CD4+ and CD8(+)T-cells were significantly lower in those with CMV events, and the TCIP could be a useful adjunct tool in individualized management of CMV infection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Linzhen Zhu, Haoting Zhang, Haibo Gu, Jianying Zhou
Summary: This case report describes a 70-year-old male patient with previously unknown immunodeficiency. Multiple pulmonary nodular shadows were observed on radiography. Fungal infection was detected in various samples, and the patient was ultimately diagnosed with disseminated Talaromyces marneffei infection and B-cell non-Hodgkin's lymphoma. The main significance of this study is to emphasize the importance for clinicians to obtain comprehensive specimens from patients presenting with multiple masses in order to ensure accurate clinical diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Ming Chang, Sambasivan Venkatasubramanian, Holly Barrett, Kevin B. Urdahl, Kris M. Weigel, Gerard A. Cangelosi, Javeed A. Shah, Aparajita Saha, Libing Feng, Kristin N. Adams, David R. Sherman, Nahum Smith, Chetan Seshadri, Sean C. Murphy, James G. Kublin
Summary: Efforts are being made globally to develop vaccines and drugs against M. tuberculosis. This study developed a real-time RT-PCR assay to detect pre-rRNA as a biomarker for bacterial viability. The assay showed promising results in mouse models, indicating its potential in future clinical studies for tuberculosis drugs and vaccines.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Letter
Infectious Diseases
Temi Lampejo, Fadia Alsheikh, Declan Crilly, Martin Brown
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Yao Li, Pengfei Shi, Rong Zhu
Summary: This study successfully diagnosed a case of lung abscess caused by Porphyromonas endodontalis using mNGS technology, highlighting the importance of considering inhalation diseases caused by oral pathogens in patients with periodontal diseases and respiratory symptoms.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Infectious Diseases
Mariana Quaresma de Souza, Dienefer Venske Bierhals, Ana Julia Reis, Erica Chimara, Julia Silveira Vianna, Andrea von Groll, Pedro Almeida da Silva, Ivy Bastos Ramis
Summary: This study proposed and evaluated a drug susceptibility testing method using 2,3,5-triphenyl tetrazolium chloride (TTC) as a colorimetric indicator for the clinical relevant non-tuberculous mycobacteria (Mycobacterium abscessus complex (MABC), M. avium complex (MAC), and M. kansasii). The results showed high agreement between TTC assay and the recommended broth microdilution method, indicating the potential of TTC as a promising indicator in drug susceptibility testing for NTM.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Shanshan Zhang, Mingyuan Duan, Shuang Li, Jie Hou, Ting Qin, Zhanwei Teng, Jianhe Hu, Huihui Zhang, Xiaojing Xia
Summary: Rapid detection of pathogenic microorganisms is crucial for epidemiologic identification, prevention, and control in public health. PCR-based methods have limitations in resource-limited areas due to the need for precise temperature control. Recombinase polymerase amplification (RPA) is a new nucleic acid amplification technology that can amplify DNA or RNA at a constant temperature, offering simplicity, high specificity and sensitivity, and short detection time. Microfluidic technology combined with RPA enables rapid detection of pathogenic microorganisms by integrating nucleic acid extraction, amplification, and detection.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Review
Infectious Diseases
Piyush Agrawal, Aditya Upadhyay, Awanish Kumar
Summary: Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. During infection, the expression of host microRNAs changes, which could be potential biomarkers for early detection of tuberculosis. Further research is needed to identify potential microRNA biomarkers, but momentum is gaining in this field and microRNAs are expected to become routine approaches for reliable diagnosis and specific therapeutic interventions.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
