Good news for the ageing beta cell

Direct Autocrine Action of Insulin on  -Cells: Does It Make Physiological Sense?

(2013) C. J. Rhodes et al.   DIABETES

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human  -Cell Replication: A Revised Model of Human  -Cell G1/S Control

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

(2013) Seth J. Salpeter et al.   DIABETES

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?

(2012) Frans Schuit et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Adaptive changes of human islets to an obesogenic environment in the mouse

(2012) S. Gargani et al.   DIABETOLOGIA

PTEN at a glance

(2012) Y. Shi et al.   JOURNAL OF CELL SCIENCE

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Deletion of Pten in Pancreatic  -Cells Protects Against Deficient  -Cell Mass and Function in Mouse Models of Type 2 Diabetes

(2010) L. Wang et al.   DIABETES

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice

(2010) H. E. Levitt et al.   DIABETOLOGIA

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells

(2010) Chong Wee Liew et al.   JOURNAL OF CLINICAL INVESTIGATION

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

Pancreatic Endocrine Tumors: Expression Profiling Evidences a Role for AKT-mTOR Pathway

(2009) Edoardo Missiaglia et al.   JOURNAL OF CLINICAL ONCOLOGY

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES