Do post-translational beta cell protein modifications trigger type 1 diabetes?

Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes?

(2013) Åke Lernmark   DIABETOLOGIA

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

(2013) P. Marrack et al.   Cold Spring Harbor Perspectives in Medicine

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A

(2012) T. Delong et al.   DIABETES

Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?

(2012) J. L. Dunne et al.   DIABETES

HLA-dependent autoantibodies against post-translationally modified collagen type II in type 1 diabetes mellitus

(2012) R. Strollo et al.   DIABETOLOGIA

Novel autoantigens for diabetogenic CD4 T cells in autoimmune diabetes

(2012) Thomas Delong et al.   IMMUNOLOGIC RESEARCH

Type 1 diabetes: primary antigen/peptide/register/trimolecular complex

(2012) Tomasz Sosinowski et al.   IMMUNOLOGIC RESEARCH

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Zinc Transporter 8 (ZnT8) Expression Is Reduced by Ischemic Insults: A Potential Therapeutic Target to Prevent Ischemic Retinopathy

(2012) Michael DeNiro et al.   PLoS One

T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives

(2011) Roberto Mallone et al.   Clinical & Developmental Immunology

Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders

(2011) Ludvig M Sollid et al.   CURRENT OPINION IN IMMUNOLOGY

Autoantigenesis: the evolution of protein modifications in autoimmune disease

(2011) Hester A Doyle et al.   CURRENT OPINION IN IMMUNOLOGY

Antigen presentation events in autoimmune diabetes

(2011) Boris Calderon et al.   CURRENT OPINION IN IMMUNOLOGY

How Does Type 1 Diabetes Develop?: The Notion of Homicide or  -Cell Suicide Revisited

(2011) M. A. Atkinson et al.   DIABETES

Immune Cell Populations in Nonhuman Primate Islets

(2010) Lane C. K. Coffey et al.   CELL TRANSPLANTATION

Autoimmune Markers in Diabetes

(2010) W. E. Winter et al.   CLINICAL CHEMISTRY

Shaping the T-cell repertoire in the periphery

(2010) Stacey Allen et al.   IMMUNOLOGY AND CELL BIOLOGY

Islets and their antioxidant defense

(2010) Jhankar D. Acharya et al.   Islets

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

(2009) Natalia Wegner et al.   IMMUNOLOGICAL REVIEWS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Characterization of hydroxyl radical modified GAD65: A potential autoantigen in type 1 diabetes

(2008) Mohd Wajid A. Khan et al.   AUTOIMMUNITY

Autoimmunity and oxidatively modified autoantigens

(2008) Biji T. Kurien et al.   AUTOIMMUNITY REVIEWS

Infusion of UVB-treated splenic stromal cells induces suppression of β cell antigen-specific T cell responses in NOD mice

(2008) Chang-Qing Xia et al.   JOURNAL OF AUTOIMMUNITY

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY

Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands

(2008) C. Murgia et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES