Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function

Adiponectin Increases Skeletal Muscle Mitochondrial Biogenesis by Suppressing Mitogen-Activated Protein Kinase Phosphatase-1

(2012) L. Qiao et al.   DIABETES

Maintenance of redox state and pancreatic beta-cell function: Role of leptin and adiponectin

(2012) Moria Chetboun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of AMPK in pancreatic beta cell function

(2012) Accalia Fu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

APPL1 potentiates insulin secretion in pancreatic   cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

(2012) K. K. Y. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: Differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses

(2011) Ling Tian et al.   ATHEROSCLEROSIS

Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking

(2011) Jae-Rin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

(2011) Yi Wang et al.   DIABETES

Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss

(2011) R. Marinho et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway

(2011) M E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

(2011) Maki Koyanagi et al.   PLoS One

Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells

(2010) Luan Wen et al.   DEVELOPMENTAL DYNAMICS

Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

(2010) G. Sun et al.   DIABETOLOGIA

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

(2010) Masato Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion

(2010) Nadeeja Wijesekara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus

(2010) Z. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

(2009) Kenneth K.Y. Cheng et al.   Cell Metabolism

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

(2009) Changhua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APPL1: role in adiponectin signaling and beyond

(2008) Sathyaseelan S. Deepa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

The AMP-regulated kinase family: Enigmatic targets for diabetes therapy

(2008) G RUTTER et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY