Article
Food Science & Technology
Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. Ward
Summary: Endothelial dysfunction may lead to atherosclerosis, while dietary nitrate/nitrite shows significant benefits on cardiovascular homeostasis. Research suggests that nitrate/nitrite may enhance eNOS activation by stimulating AMPK signaling pathway, potentially contributing to vascular protective effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cell Biology
Silvia Dragoni, Bruna Caridi, Eleni Karatsai, Thomas Burgoyne, Mosharraf H. Sarker, Patric Turowski
Summary: Neuronal and retinal disorders are often associated with pathological hyperpermeability of microvasculature. Using rodent retina explants, researchers studied acute neurovascular permeability and the role of AMP-activated protein kinase (AMPK). They found that AMPK plays a key role in regulating endothelial permeability through activation of eNOS and p38, providing a link between calcium transients and permeability regardless of the inducing factor.
JOURNAL OF CELL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xiang Gao, Kou Liu, Chengyang Hu, Keyang Chen, Zhengxuan Jiang
Summary: This study demonstrates that captopril alleviates oxidative damage in diabetic retinopathy by reducing reactive oxygen species (ROS) and nitric oxide (NO) levels, thereby reducing peroxynitrite formation. These findings provide new directions for research in diabetic retinopathy.
Article
Biochemistry & Molecular Biology
Huong Nguyen, Jia Yi Koh, Hainan Li, Argel Islas-Robles, Sai Pranathi Meda Venkata, Jie-Mei Wang, Terrence J. Monks
Summary: This study identified a novel pro-angiogenic agent IMZ that enhances angiogenesis by activating specific signaling pathways, providing a new mechanism for treating peripheral arterial disease.
Article
Chemistry, Multidisciplinary
Ken Mizoi, Vicente Rodriguez-Gonzalez, Mao Sasaki, Shoki Suzuki, Kaede Honda, Naoya Ishida, Norihiro Suzuki, Kazuyuki Kuchitsu, Takeshi Kondo, Makoto Yuasa, Akira Fujishima, Katsuya Teshima, Chiaki Terashima
Summary: Lightning strikes cause nitrogen to dissolve in water, forming reactive nitrogen and oxygen species that act as natural fertilizers. Plasma-activated water (PAW) has the potential to produce various dissolved reactive chemical species. The antialgal effect of PAW is influenced by ions such as NO2-, NO3-, and H2O2, as well as secondary reactive ions. The pH around the algal cells plays a significant role in the antialgal mechanism.
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Materials Science, Biomaterials
Ping Huang, Zihong Li, Li Nong, Jie Cheng, Weiying Lin
Summary: Aging is a natural process characterized by the decline of physiological functions in the body's organs and tissues. Oxidative stress, caused by active nitrogen substances like ONOO-, is considered to be the main cause of aging. Detecting changes in ONOO- in aging cells is important for studying senescence. In this study, we developed a fluorescent probe FLASN based on flavonol that can detect and treat ONOO- in cells. Our results showed that FLASN can effectively detect ONOO- in cells and reduce its production stimulated by metformin. This study provides a new perspective on the role of ONOO- in senescence and the potential therapeutic effect of flavonol.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Birandra K. Sinha, Erik J. Tokar, Carl D. Bortner
Summary: NCX4040 exhibits cytotoxicity against ovarian tumor cells and induces apoptosis and oxidative stress. Sensitivity to NCX4040 and DNA damage repair efficiency vary among different cell lines, and the cytotoxicity may be mediated by peroxynitrite.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Seyhan Taskin, Hakim Celik, Gokhan Cakirca, Vildan Manav, Abdullah Taskin
Summary: This study found that patients with alopecia areata are exposed to potent nitrosative stress. Specifically, peroxynitrite, acting as a bridge between reactive oxygen species and reactive nitrogen species, triggers the expansion of oxidative stress cascade. Nitrosative stress may play a role in the pathogenesis of alopecia areata. Nitrosative stress parameters, particularly NOS activity, may be potential markers for alopecia areata.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Takafumi Yamashita, Toshihito Fujii, Ichiro Yamauchi, Yohei Ueda, Keisho Hirota, Yugo Kanai, Akihiro Yasoda, Nobuya Inagaki
Article
Endocrinology & Metabolism
Hiroki Kobayashi, Yoshihiro Nakamura, Masanori Abe, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Yoshiyu Takeda, Takashi Yoneda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Ryuichi Sakamoto, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Tetsuya Yamada, Ryuji Okamoto, Yuichi Matsuda, Megumi Fujita, Minemori Watanabe, Kouichi Tamura, Akiyo Tanabe, Mitsuhide Naruse
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Medicine, General & Internal
Masato Takeuchi, Masahito Ogura, Takaaki Minoura, Nobuya Inagaki, Koji Kawakami
MAYO CLINIC PROCEEDINGS
(2020)
Article
Neurosciences
Tingting Guo, Tomohiro Tanaka, Mami Matsumoto, Kentaro Kaneko, Tomo Unzai, Yohei Ogino, Daisuke Aotani, Toru Kusakabe, Hiroshi Iwakura, Takashi Miyazawa, Kazunobu Sawamoto, Yasuhiko Minokoshi, Hiroaki Masuzaki, Nobuya Inagaki, Kazuwa Nakao
NEUROSCIENCE LETTERS
(2020)
Article
Multidisciplinary Sciences
Hiroto Minamino, Masao Katsushima, Tamami Yoshida, Motomu Hashimoto, Yoshihito Fujita, Mirei Shirakashi, Wataru Yamamoto, Kosaku Murakami, Koichi Murata, Kohei Nishitani, Masao Tanaka, Hiromu Ito, Nobuya Inagaki, Shuichi Matsuda
Article
Endocrinology & Metabolism
Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, Nobuya Inagaki
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Toshihiro Nakamura, Junji Fujikura, Takayuki Anazawa, Ryo Ito, Masahito Ogura, Hideaki Okajima, Hirofumi Noguchi, Shinji Uemoto, Nobuya Inagaki
JOURNAL OF DIABETES INVESTIGATION
(2020)
Article
Neurosciences
Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N. Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Raj N. Kalaria, Nobuya Inagaki, Ryosuke Takahashi, Mariko Harada-Shiba, Masafumi Ihara, Haruhisa Inoue
Article
Oncology
Yuki Yamauchi, Yuzo Kodama, Masahiro Shiokawa, Nobuyuki Kakiuchi, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Teruko Tomono, Atsushi Mima, Toshihiro Morita, Tomoaki Matsumori, Tatsuki Ueda, Motoyuki Tsuda, Yoshihiro Nishikawa, Katsutoshi Kuriyama, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Atsuhiro Masuda, Hisato Tatsuoka, Daisuke Yabe, Sachiko Minamiguchi, Toshihiko Masui, Nobuya Inagaki, Shinji Uemoto, Tsutomu Chiba, Hiroshi Seno
Article
Endocrinology & Metabolism
Shinsuke Tokumoto, Daisuke Yabe, Hisato Tatsuoka, Ryota Usui, Muhammad Fauzi, Ainur Botagarova, Hisanori Goto, Pedro Luis Herrera, Masahito Ogura, Nobuya Inagaki
Article
Peripheral Vascular Disease
Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Akiyuki Kawashima, Yoshiyu Takeda, Takashi Yoneda, Isao Kurihara, Hiroshi Itoh, Mika Tsuiki, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Ryuichi Sakamoto, Yoshihiro Ogawa, Takanobu Yoshimoto, Tetsuya Yamada, Junji Kawashima, Yuichi Matsuda, Hiroki Kobayashi, Kohei Kamemura, Koichi Yamamoto, Michio Otsuki, Shintaro Okamura, Shoichiro Izawa, Ryuji Okamoto, Kouichi Tamura, Akiyo Tanabe, Mitsuhide Naruse
Article
Endocrinology & Metabolism
Takaaki Murakami, Hiroyuki Fujimoto, Naotaka Fujita, Keita Hamamatsu, Daisuke Yabe, Nobuya Inagaki
JOURNAL OF DIABETES INVESTIGATION
(2020)
Editorial Material
Endocrinology & Metabolism
Toshihiro Nakamura, Junji Fujikura, Nobuya Inagaki
Summary: The translation mentions pancreas transplantation and islet transplantation as established treatments for IDDM, and suggests that stem cell-derived cell transplantation therapy may be an alternative to the limited supply of donor islets in the future. It also summarizes recent developments in transplantation therapy for diabetes and research on using stem cells for diabetes complications.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Takumi Mikawa, Eri Shibata, Midori Shimada, Ken Ito, Tomiko Ito, Hiroaki Kanda, Keiyo Takubo, Matilde E. Lleonart, Nobuya Inagaki, Masayuki Yokode, Hiroshi Kondoh
Article
Urology & Nephrology
Yusuke Kobayashi, Tatsuya Haze, Yuichiro Yano, Kouichi Tamura, Isao Kurihara, Takamasa Ichijo, Takashi Yoneda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Tetsuya Yamada, Ryuji Okamoto, Megumi Fujita, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Akiyo Tanabe, Mitsuhide Naruse
KIDNEY INTERNATIONAL REPORTS
(2020)