Article
Dentistry, Oral Surgery & Medicine
Dipti Sharma, Sagar N. Pawar, Prasad Sulkshane, Rohit Waghole, Mohd Yasser, Sushil S. Pawar, Sadhana Kannan, Nazia Chaudhary, Anjali Kalwar, Rahul Patil, Sudhir Nair, Sorab N. Dalal, Tanuja Teni
Summary: This study reveals the important role of Translationally controlled tumour protein (TCTP) in oral carcinogenesis and prognosis. TCTP is significantly overexpressed in oral tumours and is associated with poor patient outcomes. The co-expression of TCTP and MCL1 further worsens the prognosis. Additionally, TCTP knockdown inhibits the survival and invasion of oral cancer cells. In conclusion, TCTP may serve as a potential prognostic marker and therapeutic target in oral cancers.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nicolas Fischer, Ean-Jeong Seo, Anette Klinger, Edmond Fleischer, Thomas Efferth
Summary: The study identified AMG900 as a novel inhibitor of TCTP, which disrupted the interaction between TCTP and p53, inducing G0/G1 arrest in cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Plant Sciences
Brenda Beatriz Xoconostle-Moran, Beatriz Xoconostle-Cazares, Brenda Yazmin Vargas-Hernandez, Leandro Alberto Nunez-Munoz, Berenice Calderon-Perez, Roberto Ruiz-Medrano
Summary: Long-distance signaling molecules, such as TCTP mRNA, are important in plant development and responses to the environment. TCTP regulates cell cycle progression, programmed cell death, and has various other functions. In this study, the role of TCTP in tuber development and vegetative propagation was investigated by analyzing its overexpression in a solanaceous plant model. The results showed that the overexpression of StTCTP led to larger sprouts and early tuber formation, indicating its involvement in vegetative propagation and asexual reproduction.
Review
Biochemistry & Molecular Biology
Jeehye Maeng, Kyunglim Lee
Summary: Translationally controlled tumor protein (TCTP) is a multifunctional protein that plays various roles in physiological and pathological processes, including inhibiting Na,K-ATPase. Overexpression of TCTP and inhibition of Na,K-ATPase increase cytoplasmic Ca2+ levels, leading to increased vascular contractility and hypertension. TCTP-induced hypertension also worsens the severity of atherosclerotic lesions.
Article
Medicine, Research & Experimental
Eun-Hwa Jang, Hae-Duck Bae, Yejin Jeon, Dong Hae Shin, Soosung Kang, Kyunglim Lee
Summary: In this study, we investigated nine compounds known to interact with mTCTP for their ability to suppress the activity of extracellular dTCTP. Meclizine, a piperazine-derivative antihistamine, was found to significantly reduce IL-8 release and suppress the NF-kappa B pathway. The direct interaction of meclizine with dTCTP was confirmed by surface plasmon resonance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Haejun Pyun, Joo-Won Nam, Hyunsoo Cho, Jiyoung Park, Eun Kyoung Seo, Kyunglim Lee
Summary: The study demonstrated that cardamonin can exert anti-allergic and anti-inflammatory effects by interacting with dTCTP, reducing secretion of IL-8, inhibiting cell migration and IgE production, as well as reducing bronchial remodeling. Cardamonin also showed potential in therapy of allergic diseases by inhibiting NF-kappa B activity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Dae-Wook Yang, Jung-Wan Mok, Stephanie B. Telerman, Robert Amson, Adam Telerman, Kwang-Wook Choi
Summary: The study reveals the critical importance of mutual regulation of Tctp and Top2 protein levels for cell survival during organ development in Drosophila.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Atenea A. Perez-Serna, Reinaldo S. Dos Santos, Cristina Ripoll, Angel Nadal, Decio L. Eizirik, Laura Marroqui
Summary: Diabetes is a chronic disease that affects glucose metabolism, either by autoimmune-driven beta-cell loss or by the progressive loss of beta-cell function. BCL-XL, an anti-apoptotic protein, plays a dual role in beta-cells, participating in cellular processes and fostering survival against pro-apoptotic insults. Overexpression of BCL-XL can partially protect beta-cells from cytokine- and palmitate-induced apoptosis, and the protection is more significant in human beta-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hae-Duck Bae, Minyoung Cho, Hyeran Seo, In Kyoon Lyoo, Kyunglim Lee
Summary: In this study, the production of anti-TCTP monoclonal antibodies was demonstrated. The anti-TCTP mAb JEW-M449 showed the ability to inhibit dTCTP-induced secretion of IL-8 and exhibited therapeutic effects in a murine model of OVA-induced airway inflammation. Specifically targeting the flexible loop of TCTP was found to be a potent strategy for treating airway inflammatory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Kai Zhang, Yijian Zhang, Cheng Chen, Yuexing Yuan, Xiaotian Jiang, Xiangjiang Yuan, Yao Wang
Summary: The study showed that high fatty acids reduce insulin secretion in pancreatic beta-cells by increasing miR-139-5p, which in turn targets NPTX1. Knockdown of miR-139-5p reversed the insulin secretion defects induced by high fatty acids, indicating that impaired NPTX1 expression is involved in this process.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Plant Sciences
Ravindra Bansal, Gagan Deep Gupta, Prasun K. Mukherjee
Summary: Translationally controlled tumour proteins (TCTPs) are widely present in eukaryotes and play crucial physiological roles. This study focused on the function of a TCTP orthologue (Tcp1) in the plant beneficial fungus Trichoderma virens, revealing its multiple roles in growth, conidiation, and antagonistic ability within the fungus strain.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2021)
Article
Parasitology
Haoran Zhong, Yuqi Ren, Fanglin Qin, Xiaochun Li, Ling Hou, Shaopeng Gu, Yamei Jin
Summary: Schistosomiasis is a globally important parasitic disease, and understanding the reproductive mechanism of schistosomes can contribute to the development of new drugs and vaccines for its control. This study identified SjTCTP as a critical protein involved in the reproduction of female worms and a potential candidate antigen for immune protection.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeehye Maeng, Kyunglim Lee
Summary: It has been discovered that translationally controlled tumor protein (TCTP) exhibits cytokine-like activities associated with allergic responses after forming dimers (dTCTP). Inhibitors targeting dTCTP can block the development of allergic reactions and serve as potential drugs for allergic diseases. Peptides and antibodies that specifically inhibit the interactions between dTCTP and its receptor or immunoglobulins show significant efficacy as anti-inflammatory agents in murine models of allergic inflammatory diseases. This review focuses on the development of dTCTP inhibitors and discusses their effects on the pathophysiological processes of allergic and inflammatory diseases in animal models, providing new perspectives on anti-allergic drug discovery.
Article
Endocrinology & Metabolism
David Cottet-Dumoulin, Laura Mar Fonseca, Juliette Bignard, Reine Hanna, Geraldine Parnaud, Fanny Lebreton, Kevin Bellofatto, Ekaterine Berishvili, Thierry Berney, Domenico Bosco
Summary: This study investigated the protein synthesis of pancreatic islets after short exposure to palmitate using mass spectrometry. The results showed that this exposure increased the synthesis of ribosomal proteins and proteins of the cytoskeleton, as well as the secretion of proteins involved in insulin synthesis and insulin secretion. These findings provide valuable insights into the effects of palmitate on pancreatic islets and their implications for islet dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
Kiriko Watanabe, Moritake Higa, Yoshimasa Hasegawa, Akihiro Kudo, Richard C. Allsopp, Bradley J. Willcox, Donald C. Willcox, Masataka Sata, Hiroaki Masuzaki, Michio Shimabukuro
Summary: Regional differences in insulin response and sensitivity were observed in Japanese participants, with insulin secretion correlating positively with fat intake and negatively with fish, carbohydrates, and dietary fiber intake. This suggests that nutritional factors may play a role in these variations independently of body size/adiposity.
FRONTIERS IN NUTRITION
(2021)
Article
Neurosciences
Shavanthi Rajatileka, David Odd, Matthew T. Robinson, Alexandra C. Spittle, Louis Dwomoh, Maggie Williams, David Harding, Miles Wagstaff, Marie Owen, Charlene Crosby, Jared Ching, Elek Molnar, Karen Luyt, Aniko Varadi
MOLECULAR NEUROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Caroline L. Scholefield, Palmi T. Atlason, David E. Jane, Elek Molnar
NEUROCHEMICAL RESEARCH
(2019)
Editorial Material
Biochemistry & Molecular Biology
Elek Molnar
NEUROCHEMICAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Lavinia Gambelli, Benjamin H. Meyer, Mathew McLaren, Kelly Sanders, Tessa E. F. Quax, Vicki A. M. Gold, Sonja-Verena Albers, Bertram Daum
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Alexander Neuhaus, Muniyandi Selvaraj, Ralf Salzer, Julian D. Langer, Kerstin Kruse, Lennart Kirchner, Kelly Sanders, Bertram Daum, Beate Averhoff, Vicki A. M. Gold
NATURE COMMUNICATIONS
(2020)
Review
Cell Biology
Ulrich-Axel Bommer, Adam Telerman
Article
Geriatrics & Gerontology
Alejandro Martin-Belmonte, Carolina Aguado, Rocio Alfaro-Ruiz, Makoto Itakura, Ana Esther Moreno-Martinez, Luis de la Ossa, Elek Molnar, Yugo Fukazawa, Rafael Lujan
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Biographical-Item
Cell Biology
Alkis Togias, Marshall Plaut, Jackie Langdon, Ulrich-Axel Bommer, Adam Telerman
Editorial Material
Cell Biology
Ulrich-Axel Bommer, Toshiaki Kawakami
Article
Neurosciences
Jeffrey C. Watkins, Richard H. Evans, Alex Bayes, Sam A. Booker, Alasdair Gibb, Angela M. Mabb, Mark Mayer, Jack R. Mellor, Elek Molnar, Li Niu, Arturo Ortega, Yuriy Pankratov, David Ramos-Vicente, Ada Rodriguez-Campuzano, Antonio Rodriguez-Moreno, Lu-Yang Wang, Yu Tian Wang, Lonnie Wollmuth, David J. A. Wyllie, Min Zhuo, Bruno G. Frenguelli
Summary: The excerpt discusses a seminal review written by Jeff Watkins and Dick Evans in 1981 on excitatory amino acids and their receptors, providing compelling evidence for the role of EAAs as neurotransmitters in the nervous system. The research on EAAs has continued to thrive into the 21st Century, with EAAs and their receptors flourishing in various disciplines and clinical conditions.
Article
Multidisciplinary Sciences
Rebecca Conners, Mathew McLaren, Urszula Lapinska, Kelly Sanders, M. Rhia L. Stone, Mark A. T. Blaskovich, Stefano Pagliara, Bertram Daum, Jasna Rakonjac, Vicki A. M. Gold
Summary: The study reveals the structure of the pIV channel from f1 filamentous bacteriophage and suggests its potential as an adjuvant to enhance antibiotic uptake and efficacy. The pIV forms a gated channel in the bacterial outer membrane, aiding in the egress of phages.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Neurosciences
Elek Molnar
Article
Neurosciences
Astrid Rollenhagen, Max Anstoetz, Kerstin Zimmermann, Yu Kasugai, Kurt Saetzler, Elek Molnar, Francesco Ferraguti, Joachim H. R. Luebke
Summary: AMPA and NMDA glutamate receptors play essential roles in synaptic transmission and plasticity in the neocortex. The study reveals their layer- and target-specific distribution patterns in the adult rat neocortex, which contribute to the observed functional differences in synaptic transmission and plasticity.
Article
Clinical Neurology
Benjamin Clennell, Tom G. J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnar, Bruce W. Drinkwater, Daniel J. Whitcomb
Summary: This study reveals the regulation of neuronal excitability and synaptic function by ultrasound stimulation. Ultrasound stimulation can increase whole-cell potassium currents and excitatory synaptic transmission. Activation of ionotropic glutamate receptors is required for ultrasound-induced modulation of neuronal potassium currents. These findings have important implications for the application of ultrasound stimulation in experimental and therapeutic settings, but further research is needed to understand the underlying molecular mechanisms.
Article
Chemistry, Organic
Lisa-Maria Recnik, Robert J. Thatcher, Shahida Mallah, Craig P. Butts, Graham L. Collingridge, Elek Molnar, David E. Jane, Christine L. Willis
Summary: (-)-Arctigenin and new analogues showed antagonist activity at both AMPA and kainate receptors, with spirocyclic analogue 6c acting as a non-competitive antagonist. Molecular docking studies suggest they bind in a similar manner to known AMPA receptor antagonists, indicating potential as novel leads for epilepsy treatment drug development.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)