Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Medicine, General & Internal
Maggie Wang, Samson S. Peter, Chi D. Chu, Delphine S. Tuot, Jonathan H. Chen
Summary: The findings of this study suggest that nearly half of patients with CKD at high risk of progressing to kidney failure do not have a nephrologist visit within 1 year of established risk.
Article
Endocrinology & Metabolism
Rohan Chakraborty, Rizwana Parveen, Prabhat Varshney, Prem Kapur, Saima Khatoon, Nilanjan Saha, Nidhi B. Agarwal
Summary: Inflammatory cytokines such as IL-36 alpha have been implicated in the pathogenesis of diabetic nephropathy, with levels significantly elevated in T2DM patients with DN. IL-36 alpha levels were found to correlate positively with urinary albumin excretion, HbA1c, and fasting plasma glucose, and negatively with glomerular filtration rate. Further extensive studies are recommended to evaluate this association.
MINERVA ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wataru Fujii, Shigeru Shibata
Summary: This article reviews the extensive research conducted over the past 80 years on the regulation and action of the mineralocorticoid receptor (MR). It highlights the role of MR and the steroid hormone aldosterone in integrating responses of tubular cells and maintaining fluid homeostasis, as well as their dysregulation in kidney diseases. Experimental studies have shown the pathological consequences of MR overactivity and the mechanisms of enhanced MR signaling, while clinical studies have demonstrated the renoprotective effects of MR blockade. The article also discusses future areas of investigation, including the use of non-steroidal MR antagonists in non-diabetic kidney disease patients and the search for downstream mediators of renoprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Tian-Shin Yeh, Lei Clifton, Jennifer A. Collister, Xiaonan Liu, David J. Hunter, Thomas J. Littlejohns
Summary: The study found that decreased kidney function and increased urine albumin to creatinine ratio were associated with a higher risk of dementia, and this association showed a dose-response relationship. Furthermore, the study also found that genetic risk factors played a role in modulating this association.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Hye-Yeon Kim, Sun-Seog Kweon, Young-Hoon Lee, So-Yeon Ryu, Hae-Sung Nam, Min-Ho Shin, Kyeong-Soo Park, Seong-Woo Choi
Summary: The study found independent associations between estimated glomerular filtration rate (eGFR) and albumin to creatinine ratio (ACR) with all-cause and cardiovascular mortality in Korean adults aged >= 50 years. When comparing eGFR performance, eGFR(cys) showed superior predictive accuracy for all-cause mortality compared to eGFR(MDRD) and eGFR(CKD-EPI).
Article
Engineering, Biomedical
Kang Zhang, Xiaohong Liu, Jie Xu, Jin Yuan, Wenjia Cai, Ting Chen, Kai Wang, Yuanxu Gao, Sheng Nie, Xiaodong Xu, Xiaoqi Qin, Yuandong Su, Wenqin Xu, Andrea Olvera, Kanmin Xue, Zhihuan Li, Meixia Zhang, Xiaoxi Zeng, Charlotte L. Zhang, Oulan Li, Edward E. Zhang, Jie Zhu, Yiming Xu, Daniel Kermany, Kaixin Zhou, Ying Pan, Shaoyun Li, Iat Fan Lai, Ying Chi, Changuang Wang, Michelle Pei, Guangxi Zang, Qi Zhang, Johnson Lau, Dennis Lam, Xiaoguang Zou, Aizezi Wumaier, Jianquan Wang, Yin Shen, Fan Fan Hou, Ping Zhang, Tao Xu, Yong Zhou, Guangyu Wang
Summary: Deep-learning models trained on retinal fundus images can accurately identify chronic kidney disease and type 2 diabetes, as well as predict disease progression risk. These models demonstrate high accuracy in training and validation, providing reliable predictions for blood glucose and glomerular filtration rate.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Environmental Sciences
Habyeong Kang, Jung Pyo Lee, Kyungho Choi
Summary: Exposure to consumer chemicals has been found to have inconsistent associations with estimated glomerular filtration rate (eGFR) when adjusted by different methods, but novel covariate-adjusted creatinine standardization revealed significant inverse associations. Phthalate metabolites, DEHP, and BPA were identified as major drivers of the association with eGFR or ACR in mixture exposure models using weighted quantile sum regression. The study suggests that exposure to specific chemicals may lead to declined eGFR and increased ACR in the general adult population.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Transplantation
Yuko Katayama, Jun Sugama, Tomohisa Suzuki, Yoshimasa Ishimura, Akihiro Kobayashi, Yusuke Moritoh, Masanori Watanabe
Summary: The study found that the enteropeptidase inhibitor SCO-792 had significant therapeutic effects on chronic kidney disease in rats, preventing declines in glomerular filtration rate, albuminuria, and kidney fibrosis. Furthermore, it increased hydrogen sulphide production capacity, suggesting potential for CKD treatment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Environmental Sciences
Maria Grau-Perez, Arce Domingo-Relloso, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Montserrat Leon-Latre, Belen Moreno-Franco, Martin Laclaustra, Eliseo Guallar, Ana Navas-Acien, Roberto Pastor-Barriuso, Josep Redon, Maria Tellez-Plaza
Summary: This study assessed the association between metal exposures and changes in renal endpoints, finding that zinc, arsenic, chromium, and tungsten may have nephrotoxic effects at low exposure levels, and other metals may also be associated with renal disease.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: This retrospective study reviewed the estimated glomerular filtration rates (eGFR) calculated by three equations and investigated the changes in prevalence of chronic kidney diseases. The study found that the prevalence of decreased eGFR increased with age and that the equation based on CKD-EPI 2021 had a lower prevalence compared to the other equations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zelai Xu, Pengtao Yue, James J. Feng
Summary: Albuminuria occurs when albumin leaks into the urine, and the mechanism behind it is not well understood. A gel-compression hypothesis suggests that compression of the glomerular basement membrane (GBM) acts as a barrier, but it fails to explain the reduction in filtration flux and thickening of the GBM. A second mechanism involving constriction of flow area at the slit diaphragm must also be considered. By combining these two mechanisms, the poroelastic model validates the hypothesis and explains the in vivo features of albuminuria.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Neurosciences
Erin L. Richard, Linda K. McEvoy, Eyal Oren, John E. Alcaraz, Gail A. Laughlin, Andrea Z. LaCroix, Rany M. Salem
Summary: In older men, albuminuria and hyperuricemia are associated with cognitive decline. However, no such associations were detected in women. eGFR showed no significant association with cognitive performance in either sex.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Antonia Schuster, Louisa Steines, Karolina Mueller, Florian Zeman, Peter Findeisen, Bernhard Banas, Tobias Bergler
Summary: Evidence of tubular atrophy and interstitial fibrosis is prognostically unfavorable and associated with a premature graft loss after kidney transplantation. Recently, Dickkopf 3 (DKK3), a profibrotic glycoprotein released by stressed tubular epithelial cells, has been identified to cause IF/TA by regulating the Wnt/beta-catenin signaling and seems to engage a T-cell response. The aim of our study was to determine if a correlation between DKK3 and graft function exists and if DKK3 could be a new indicator to identify patients at risk for a deterioration in graft function. Patients, transplanted between 2016 and 2018, were analyzed with regard to DKK3 in the urine and graft function (creatinine, eGFR, albuminuria). Multivariable analyzes were used including known factors influencing graft function (PRA, donor age) to stress robustness of DKK3. The 3 and 12 month DKK3 values were significant predictors for subsequent graft function up to 36 months. An increase of DKK3 from month 3 to 12 of >= 25% showed a higher risk of an impaired graft function, with, e.g., a reduction in eGFR of about 9-10 ml/min in contrast to patients without intensified DKK3 increase. Induction therapy has an influence on DKK3 as patients induced with a T-cell depleting therapy showed a trend toward lower DKK3 values. In summary, our study is the first investigation of DKK3 in kidney transplant recipients and was able to show that DKK3 could forecast graft function. It is recommended to investigate the potential of DKK3 as a predictor of kidney function after transplantation in further studies.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Erin L. Richard, Linda K. McEvoy, Steven Y. Cao, Eyal Oren, John E. Alcaraz, Andrea Z. LaCroix, Rany M. Salem
Summary: This study does not provide evidence for causal effects of serum uric acid, eGFR based on serum creatinine, or eGFR based on serum cystatin C on cognitive performance. However, genetically increased urine albumin to creatinine ratio was associated with slower processing speed and worse visual memory, but more research is needed for confirmation in independent samples.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Nursing
Piyanee Klainin-Yobas, Jeanette Ignacio, Hong-Gu He, Ying Lau, Bi Xia Ngooi, Soo Quee David Koh
BIOLOGICAL RESEARCH FOR NURSING
(2016)
Review
Public, Environmental & Occupational Health
K. W. To, A. Lai, K. C. K. Lee, D. Koh, S. S. Lee
JOURNAL OF HOSPITAL INFECTION
(2016)
Article
Public, Environmental & Occupational Health
Falk Muller-Riemenschneider, Sheryl Hui Xian Ng, David Koh, Anne Hin Yee Chu
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2016)
Review
Endocrinology & Metabolism
A. H. Y. Chu, S. H. X. Ng, C. S. Tan, A. M. Win, D. Koh, F. Mueller-Riemenschneider
Article
Behavioral Sciences
Smrithi Prasad, Jayanth Narayanan, Vivien K. G. Lim, Gerald C. H. Koh, David S. Q. Koh, Pranjal H. Mehta
HORMONES AND BEHAVIOR
(2017)
Article
Chemistry, Analytical
Mohammad Rizwan, David Koh, Marsilea Adela Booth, Minhaz Uddin Ahmed
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Multidisciplinary Sciences
Anne H. Y. Chu, Sheryl H. X. Ng, Mahsa Paknezhad, Alvaro Gauterin, David Koh, Michael S. Brown, Falk Muller-Riemenschneider
Article
Chemistry, Analytical
Juthi Adhikari, Mohammad Rizwan, David Koh, Natasha Ann Keasberry, Minhaz Uddin Ahmed
CURRENT ANALYTICAL CHEMISTRY
(2020)
Article
Public, Environmental & Occupational Health
David Koh
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Wee Hoe Gan, David Koh
Summary: Singapore's construction sector employs over 450,000 workers, with a disproportionately high impact from the pandemic. Through multilevel safe management measures, including government interventions, the sector saw a significant decline in COVID-19 incidence rates, enabling phased reopening of construction worksites from July onwards.
SAFETY AND HEALTH AT WORK
(2021)
Editorial Material
Public, Environmental & Occupational Health
David Koh, Alvin Tan
SAFETY AND HEALTH AT WORK
(2022)
Article
Medicine, General & Internal
Ayako Kohno, Maznah Dahlui, David Koh, Inge Dhamanti, Hanif Rahman, Takeo Nakayama
Summary: This qualitative study aimed to explore factors influencing healthcare-seeking behaviors and experiences of Muslims from Southeast Asian countries (Indonesia and Malaysia) living in Japan. Findings indicated that language barrier is one of the main challenges faced by Muslims in accessing healthcare services in Japan.
Review
Dentistry, Oral Surgery & Medicine
Adi Idris, Sumaira Z. Hasnain, Lu Z. Huat, David Koh
ORAL SCIENCE INTERNATIONAL
(2017)
Article
Education & Educational Research
Mee Lian Wong, Junice Y. S. Ng, Roy K. W. Chan, Martin T. W. Chio, Raymond B. T. Lim, David Koh
HEALTH EDUCATION RESEARCH
(2017)
Article
Public, Environmental & Occupational Health
David Koh, Hui Poh Goh
JOURNAL OF OCCUPATIONAL HEALTH
(2020)