Article
Nutrition & Dietetics
Sharmaine Reintar, Magdalena Poechhacker, Anna Obermayer, Katharina Eberhard, Andreas Zirlik, Nicolas Verheyen, Dirk von Lewinski, Daniel Scherr, Barbara Hutz, Christoph W. Haudum, Thomas R. Pieber, Harald Sourij, Barbara Obermayer-Pietsch
Summary: The urinary C-peptide-to-creatinine ratio (UCPCR) is a useful biomarker for predicting the risk of prediabetes. Higher UCPCR values in healthy individuals are associated with an increased likelihood of developing prediabetes. During follow-up, UCPCR values can predict the occurrence of prediabetes.
Article
Endocrinology & Metabolism
Wan Zhou, Jie Li, Xiaojing Yuan, Wei Wang, Huanran Zhou, Haoqiang Zhang, Shandong Ye
Summary: UCPCR can be used to evaluate islets beta Cell function in T2DM patients with different renal function status. Patients with eGFR>60 ml center dot min(-1)center dot 1.73 m(-2) showed increased levels of UCPCR, FCP, modified HOMA-IR(CP), and HOMA-islet (CP-DM), as well as decreased concentrations of HbA1C, FPG, and creatinine. It was found that UCPCR was positively correlated with FCP and HOMA-IR(CP) in T2DM patients with different levels of renal function, and a cut-off value of UCPCR <= 1.13 nmol/g had high sensitivity and specificity for identifying severe insulin deficiency in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lilian C. Mendoza, Martina Tashkova, Rosa Corcoy, Anne Dornhorst
Summary: This study examined the changes in urinary C-peptide creatinine ratio (UCPCR) during pregnancy and postpartum in women with Type 1 diabetes. The results showed that UCPCR concentration increases throughout pregnancy, especially in women with shorter diabetes duration.
Article
Neurosciences
Hui-Lian Guan, He Liu, Xiao-Yi Hu, Mannan Abdul, Ming-Sheng Dai, Xing Gao, Xue-Fen Chen, Yang Zhou, Xun Sun, Jian Zhou, Xiang Li, Qiu Zhao, Qian-Qian Zhang, Jun Wang, Yuan Han, Jun-Li Cao
Summary: This study identified a significant relationship between postoperative delirium and urinary albumin to creatinine ratio (UACR) in elderly patients, suggesting that elevated UACR levels before and after surgery may serve as a predictive factor for postoperative delirium.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Kaixi Chang, Yupei Li, Zheng Qin, Zhuyun Zhang, Liya Wang, Qinbo Yang, Baihai Su
Summary: This study aimed to quantify the relationship between alpha-Klotho and urinary albumin-to-creatinine ratio (ACR). The results showed a negative correlation between alpha-Klotho and ACR and revealed a nonlinear relationship between them. The study suggests that alpha-Klotho has potential as a serum marker and prophylactic or therapeutic agent.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yanai Wang, Xiantong Zou, Xiaoling Cai, Wei Liu, Ling Chen, Rui Zhang, Lingli Zhou, Siqian Gong, Ying Gao, Simin Li, Yingying Luo, Xueyao Han, Linong Ji
Summary: This study found that in patients with type 2 diabetes mellitus, UCPCR is positively correlated with insulin resistance, diabetic kidney disease, and coronary heart disease. Including UCPCR could help refine the classification of different subgroups within type 2 diabetes mellitus.
JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Yue Zhang, Binqi Li, Yang Liu, Wenxing Gao, Kang Chen, Anping Wang, Xulei Tang, Li Yan, Zuojie Luo, Guijun Qin, Lulu Chen, Qin Wan, Zhengnan Gao, Weiqing Wang, Guang Ning, Yiming Mu
Summary: This study analyzed the prevalence of different metabolic phenotypes and their relationship with urinary albumin-creatinine ratio (UACR) in Chinese community adults. The findings showed that increased albuminuria was associated with increased BMI whether metabolism was normal or not, and those with abnormal metabolism were at greater risk of increased albuminuria than those with normal metabolism.
JOURNAL OF DIABETES
(2022)
Article
Endocrinology & Metabolism
Yumeng Shi, Huan Hu, Zuxiang Wu, Ji Wu, Zhiqiang Chen, Ping Li
Summary: This study found a significant positive association between urinary albumin-to-creatinine ratio (uACR) and diabetes, and that sex can modify this relationship.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Veterinary Sciences
Federica Cagnasso, Barbara Bruno, Claudio Bellino, Antonio Borrelli, Ilaria Lippi, Barbara Miniscalco, Silvia Roncone, Alberto Valazza, Renato Zanatta, Paola Gianella
Summary: This study aimed to investigate the effects of intravenous iodinated contrast medium on serum biochemical and urinary parameters in 22 dogs. Significant differences were found in serum total protein, albumin, chloride, calcium, and phosphorus concentrations, as well as urine protein to creatinine ratio and urine specific gravity within one week of IVIC administration. However, these changes were not considered clinically significant.
VETERINARY SCIENCES
(2021)
Article
Nutrition & Dietetics
Shanshan Shi, Yizhou Jiang, Weihua Chen, Kaihong Chen, Ying Liao, Kun Huang
Summary: Cr/CysC performs well in identifying non-sarcopenia cases, especially when based on FNIH diagnostic criteria, and also reveals a positive association with higher risk of mortality. The optimal cut-off values for Cr/CysC were <1.0 in males and <0.8 in females. Expanding the use of Cr/CysC would allow for early and targeted treatment of sarcopenia.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Kakuya Niihata, Hiroki Nishiwaki, Maki Kinoshita, Kentaro Kurosawa, Yui Sakuramachi, Satoshi Matsunaga, Shintaro Okamura, Satoru Tsujii, Yasuaki Hayashino, Noriaki Kurita
Summary: This cohort study aimed to evaluate the association between urinary levels of C-megalin and kidney dysfunction progression in individuals with diabetes, and its dependence on the urinary albumin-creatinine ratio (UACR). The results showed that high urinary C-megalin levels were associated with progressive kidney dysfunction in individuals with diabetes, and this association was attenuated by high UACRs.
ACTA DIABETOLOGICA
(2023)
Article
Environmental Sciences
Ram B. Jain
Summary: The study investigated the relationship between urinary bisphenol A (BPA) concentrations and urinary albumin creatinine ratio (UACR) across various stages of renal function (RF) using data from the National Health and Nutrition Examination Survey for US adults aged 20 years and above. It was found that severe kidney dysfunction was associated with significantly higher concentrations of BPA in urine, and the shape of BPA concentration curves across RF stages was influenced by age and concentration. Additionally, the associations between BPA and UACR varied across different RF stages, with both negative and positive correlations observed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, General & Internal
Natsumi Matsuoka-Uchiyama, Kenji Tsuji, Kensaku Takahashi, Kazuhiko Fukushima, Hidemi Takeuchi, Shinji Kitamura, Kenichi Inagaki, Haruhito A. A. Uchida, Jun Wada
Summary: This study examined the association between urinary creatinine excretion rate (CER) and hypothyroidism. The results showed that hypothyroidism was not independently associated with CER, and estimated glomerular filtration rate calculated using serum creatinine (eGFRcre) is a useful marker for evaluating kidney function regardless of hypothyroidism.
Article
Pediatrics
Amelia Peris Vidal, Susana Ferrando Monleon, Juan Marin Serra, Carmen Quinones-Torrelo, Aurelio Hervas Andres, Jaime Fons Moreno, Roberto Hernandez Marco
Summary: This study updated the reference values for solute/creatinine ratios of calcium, phosphate, magnesium, and uric acid in the urine of infants and young children. It found that breastfed infants had higher calcium/creatinine ratios and lower phosphate/creatinine ratios. New cutoff values for diagnosing hypercalciuria in infants based on the type of lactation were proposed.
PEDIATRIC NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Li Ming, Duan Wang, Yong Zhu
Summary: Recently, it has been suggested that urine albumin-to-creatinine ratio (uACR) can be associated with hypertension, even within the normal range. This study used data from the National Health and Nutrition Examination Survey to determine the association between normal range uACR and the prevalence of hypertension. The findings showed that even subtle elevations in uACR within the normal range were associated with an increased prevalence of hypertension in the USA general population, and this association may be stronger in individuals with low BMI.
CLINICAL CARDIOLOGY
(2023)
Letter
Endocrinology & Metabolism
Beatrice Pieri, Harshal Deshmukh, Emma G. Wilmot, Pratik Choudhary, Najeeb Shah, Robert Gregory, Dennis Barnes, Simon Saunders, Jane Patmore, Chris Walton, Robert E. J. Ryder, Thozhukat Sathyapalan
DIABETES OBESITY & METABOLISM
(2023)
Article
Genetics & Heredity
Stuart Cannon, Rhian Clissold, Kittiya Sukcharoen, Marcus Tuke, Gareth Hawkes, Robin N. Beaumont, Andrew R. Wood, Mark Gilchrist, Andrew T. Hattersley, Richard A. Oram, Kashyap Patel, Caroline Wright, Michael N. Weedon
Summary: 17q12 microdeletion and microduplication syndromes are complex disorders with overlapping phenotypes, including diabetes, renal disease, and neurocognitive traits.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Endocrinology & Metabolism
Katherine G. Young, Andrew P. McGovern, Ines Barroso, Andrew T. Hattersley, Angus G. Jones, Beverley M. Shields, Nicholas J. Thomas, John M. Dennis
Summary: This population-based study demonstrates that HbA(1c) screening in adults aged 40-70 years can reduce the time to diabetes diagnosis by a median of 2.2 years compared with routine clinical care.
Article
Medicine, Research & Experimental
Luke A. Perera, Andrew T. Hattersley, Heather P. Harding, Matthew N. Wakeling, Sarah E. Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Summary: Mutation in the FICD gene leads to dysfunction of the endoplasmic reticulum, resulting in cell loss and diabetes mellitus. The study suggests that regulating the activity of FICD may provide therapeutic benefits for treating related diseases.
EMBO MOLECULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Nicholas J. Thomas, Andrew McGovern, Katherine G. Young, Seth A. Sharp, Michael N. Weedon, Andrew T. Hattersley, John Dennis, Angus G. Jones
Summary: This study aimed to compare the performance of different approaches for classifying insulin-treated diabetes without measured classification biomarkers. The results showed that combining early insulin requirement with a T1D probability model and interview-reported diabetes type achieved the highest accuracy.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Immunology
Rebecca C. Wyatt, Sven Olek, Elisa De Franco, Bjoern Samans, Kashyap Patel, Jayne Houghton, Steffi Walter, Janika Schulze, Rosa Bacchetta, Andrew T. Hattersley, Sarah E. Flanagan, Matthew B. Johnson
Summary: By studying a large cohort of patients diagnosed with IPEX and using TSDR analysis, it was found that diagnosing IPEX at presentation with isolated diabetes can effectively monitor disease progression and predict the course of the disease. This method can aid in the classification and diagnosis of FOXP3 variants and allow for immune modulatory treatment to be initiated before the onset of severe enteropathy.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan Hong, Petra B. Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe Muilwijk, Marieke T. Blom, Leen M. T. Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
Summary: The application of multiple omics technologies in biomedical cohorts can reveal patient-level disease characteristics and individualized response to treatment. We developed a deep-learning-based framework, MOVE, to integrate and analyze multi-omics data from a cohort of newly diagnosed type 2 diabetes patients. By using in silico perturbations, we identified drug-omics associations in the multi-modal datasets with higher sensitivity than univariate statistical tests.
NATURE BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Beverley M. Shields, Catherine D. Angwin, Maggie H. Shepherd, Nicky Britten, Angus G. Jones, Naveed Sattar, Rury Holman, Ewan R. Pearson, Andrew T. Hattersley
Summary: Patient preference plays a crucial role in medication selection for chronic medical conditions like type 2 diabetes. Balancing potential efficacy and side effects, patient preference can inform treatment decisions based on personal experience with alternative medications. A recent study on type 2 diabetes patients compared three different glucose-lowering drugs and found that allocating therapy based on individual drug preference resulted in better glycemic control and fewer side effects compared to prescribing the overall most preferred drug.
Article
Biochemistry & Molecular Biology
Beverley M. M. Shields, John M. M. Dennis, Catherine D. D. Angwin, Fiona Warren, William E. E. Henley, Andrew J. J. Farmer, Naveed Sattar, Rury R. R. Holman, Angus G. G. Jones, Ewan R. R. Pearson, Andrew T. T. Hattersley
Summary: Precision medicine in type 2 diabetes aims to treat patients based on their clinical characteristics. This study examines the differential drug response in relation to body mass index (BMI) and estimated glomerular filtration rate (eGFR). The findings suggest that in obese patients, thiazolidinediones may be more effective in lowering glucose levels compared to DPP4 inhibitors, while in patients with eGFR of 60-90 ml/min/1.73 m², DPP4 inhibitors may be more effective than SGLT2 inhibitors in lowering glucose levels.
Article
Gastroenterology & Hepatology
Zhigang Liu, Kaixing Le, Xin Zhou, James L. Alexander, Simeng Lin, Claire Bewshea, Neil Chanchlani, Rachel Nice, Timothy J. McDonald, Christopher A. Lamb, Shaji Sebastian, Klaartje Kok, Charlie W. Lees, Ailsa L. Hart, Richard C. Pollok, Rosemary J. Boyton, Daniel M. Altmann, Katrina M. Pollock, James R. Goodhand, Nicholas A. Kennedy, Tariq Ahmad, Nick Powell, C. L. A. R. I. T. Y. study investigators CLARITY Study Investigators
Summary: This study aimed to determine the impact of the anti-TNF drug infliximab and the anti-integrin drug vedolizumab on vaccine-induced neutralising antibodies against the omicron variant of SARS-CoV-2. The results showed that patients treated with infliximab had significantly lower antibody levels after three doses of vaccine compared to those treated with vedolizumab, and they also had a higher risk of breakthrough infection.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Jean Claude Katte, Timothy J. McDonald, Eugene Sobngwi, Angus G. Jones
Summary: The phenotype of type 1 diabetes in Africa, especially sub-Saharan Africa, is poorly understood. Previous studies have suggested differences in phenotype from the classical form of the disease described in western literature. Accurate diagnosis is challenging due to atypical diabetes forms and limited resources. The age of onset seems to be later in sub-Saharan Africa.
FRONTIERS IN PUBLIC HEALTH
(2023)
Correction
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Cristina Leal Rodriguez, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan B. Hong, Petra Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe T. Muilwijk, Marieke M. Blom, Leen 't Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian N. Forgie, Giuseppe Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil W. Dermitzakis, Paul M. Franks, Jochen Schwenk, Jerzy I. Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
NATURE BIOTECHNOLOGY
(2023)
Editorial Material
Medical Laboratory Technology
Andrew T. Hattersley
CLINICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Adem Y. Dawed, Andrea Mari, Andrew Brown, Timothy J. McDonald, Lin Li, Shuaicheng Wang, Mun-Gwan Hong, Sapna Sharma, Neil R. Robertson, Anubha Mahajan, Xuan Wang, Mark Walker, Stephen Gough, Leen M. 't Hart, Kaixin Zhou, Ian Forgie, Hartmut Ruetten, Imre Pavo, Pallav Bhatnagar, Angus G. Jones, Ewan R. Pearson, for the D. I. R. E. C. T. consortium DIRECT consortium
Summary: This study identified genetic variants associated with the response to GLP-1 receptor agonist treatment in patients with type 2 diabetes, which provides valuable insights for clinical decision making and personalized medicine.
LANCET DIABETES & ENDOCRINOLOGY
(2023)