Review
Endocrinology & Metabolism
Zhen Zhang, Jianyun Sun, Meng Guo, Xuemin Yuan
Summary: Organ transplantation is an effective treatment for end-stage organ failure, but post transplantation diabetes mellitus (PTDM) is a severe complication that affects the survival of recipients. However, PTDM is often overlooked or poorly managed in its early stage. This article provides an overview of the incidence, pathogenesis, and risk factors for PTDM, aiming to improve the quality of life of recipients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Sun H. Kim, Ipsa Arora, Daniel S. Hsia, William C. Knowler, Erin LeBlanc, Eleftherios Mylonakis, Richard Pratley, Anastassios G. Pittas
Summary: There is evidence suggesting that infection with SARS-CoV-2 can lead to long-term sequelae, including diabetes. This mini-review examines the evolving literature on new-onset diabetes after COVID-19 (NODAC). Current evidence suggests that COVID-19 increases the risk of developing diabetes, but the exact causality is uncertain due to study limitations and the evolving nature of the pandemic. COVID-19 may have direct and indirect effects on pancreatic beta-cell function and insulin sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Genetics & Heredity
Soha Azadi, Negar Azarpira, Jamshid Roozbeh, Shahrokh Ezzatzadegan-Jahromi, Ghanbar Ali Raees-Jalali, Farzaneh Foroughinia, Iman Karimzadeh
Summary: This study aimed to evaluate the association between three functional polymorphisms (BclI, N363S, and ER22/23EK) on the NR3C1 gene and the development of NODAT in kidney transplant recipients. The results showed that the BclI mutant genotypes were significantly associated with an increased risk of NODAT.
Review
Endocrinology & Metabolism
Ya-Ling Chung, Yi-Chou Hou, I-Kuan Wang, Kuo-Cheng Lu, Tzung-Hai Yen
Summary: Organophosphate is a commonly used pesticide in the agricultural sector, which can lead to hyperglycemia and new-onset diabetes mellitus. Currently, there is no preventive strategy for organophosphate-mediated new-onset diabetes mellitus, but reducing reactive oxygen species levels may help to reduce the risk of developing hyperglycemia.
WORLD JOURNAL OF DIABETES
(2021)
Article
Urology & Nephrology
Takahito Wakamiya, Takuya Fujimoto, Takahito Endo, Shun Nishioka, Naoki Yokoyama, Shimpei Yamashita, Kazuro Kikkawa, Yoji Hyodo, Takeshi Ishimura, Yasuo Kohjimoto, Isao Hara, Masato Fujisawa
Summary: This study evaluated the impact of myosteatosis on new-onset diabetes mellitus after kidney transplantation, and found that skeletal muscle depletion, including sarcopenia and myosteatosis, could be used as a predictor of new-onset diabetes mellitus.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lars Krogvold, Ida Maria Mynarek, Erica Ponzi, Freja Barrett Mork, Trine Witzner Hessel, Trine Roald, Nina Lindblom, Jacob Westman, Peter Barker, Heikki Hyoety, Johnny Ludvigsson, Kristian F. Hanssen, Jesper Johannesen, Knut Dahl-Jorgensen
Summary: The results suggest that antiviral treatment may help preserve insulin production in children and adolescents with new-onset type 1 diabetes.
Article
Pediatrics
Faraz Alizadeh, Amanda O'Halloran, Areej Alghamdi, Charlotte Chen, Maria Trissal, Avram Traum, Danielle DeCourcey
Summary: This is a novel case of a 16-month-old boy with a rare combination of prematurity, intrauterine growth restriction, microcephaly, pachygyria, agenesis of the corpus callosum, postnatal embolic stroke, new-onset diabetes mellitus with diabetic ketoacidosis, severe acute respiratory syndrome coronavirus 2 infection, and atypical hemolytic syndrome (aHUS). The patient showed remarkable insulin resistance before aHUS diagnosis, which improved after eculizumab therapy, suggesting a potential connection between COVID-19 and complement-mediated microangiopathic thrombotic disease. Whole-exome sequencing did not reveal a clear etiology for aHUS, indicating that this could be a case of COVID-19-triggered aHUS rather than an idiopathic one unmasked by the infection.
Article
Biochemistry & Molecular Biology
Raffaele Maio, Edoardo Suraci, Benedetto Caroleo, Cristina Politi, Simona Gigliotti, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone, Maria Perticone
Summary: The study suggests that endothelial dysfunction plays a significant role in the pathways leading to diabetes and cardiovascular events in hypertensive patients. Analysis using an illness-event model indicates that a decrease in forearm blood flow is associated with an increased risk of cardiovascular events and diabetes in these patients.
Article
Surgery
Vidit N. Munshi, Soroush Saghafian, Curtiss B. Cook, Sumhith Veda Aradhyula, Harini A. Chakkera
Summary: The study found that the incidence of NODAT increased when HbA1c and FBG data were collected perfectly. Perfect screening was cost-saving for kidney transplant patients and cost-effective for liver and heart transplant patients.
ANNALS OF TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Yip Han Chin, Hon Qin Marcus Tan, Cheng Han Ng, Darren Jun Hao Tan, Snow Yunni Lin, Daniel Q. Huang, Chin Meng Khoo, Mark Dhinesh Muthiah
Summary: This meta-analysis estimated the incidence of NODAT after liver transplantation, with higher rates found at the three-year, five-year, and ten-year timepoints in sensitivity analysis. Studies with predominantly Asian participants generally had a higher incidence of NODAT, suggesting the need for further research on how ethnicity can affect NODAT incidence.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shinje Moon, Ji-Yong Jang, Yumin Kim, Chang-Myung Oh
Summary: By utilizing machine learning techniques, a novel diabetes index with high accuracy for diabetes risk classification was proposed in this study. A gender-specific diabetes prediction model based on two large-scale population studies showed high sensitivity and selectivity, providing effective classification for individuals at high risk of diabetes.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Tess Montada-Atin, G. V. Ramesh Prasad
Summary: A common challenge in managing kidney transplant recipients is post-transplant diabetes mellitus (PTDM), which may lead to cardiovascular disease. Available therapies for PTDM, including newer drugs, have shown some initial promise in glycemic control, but their effectiveness in reducing cardiovascular events in this high-risk population is still unproven.
WORLD JOURNAL OF DIABETES
(2021)
Review
Oncology
Jan Bures, Darina Kohoutova, Jan Skrha, Bohus Bunganic, Ondrej Ngo, Stepan Suchanek, Pavel Skrha, Miroslav Zavoral
Summary: Pancreatic ductal adenocarcinoma is a serious malignancy and a leading cause of cancer-related deaths worldwide. There are no effective screening methods available so far. Impaired glucose metabolism is present in about 3/4 of patients. This paper proposed a distinct approach to older subjects with new-onset diabetes mellitus with possible pancreatic cancer, aiming to improve the current unsatisfactory situation in diagnostics and subsequent poor outcomes of treatment.
Review
Surgery
Lale A. Ertuglu, Esteban Porrini, Mads Hornum, Atalay Demiray, Baris Afsar, Alberto Ortiz, Adrian Covic, Peter Rossing, Mehmet Kanbay
Summary: PTDM is a common complication of solid organ transplantation with currently no preferred first-line agent for long-term management. GLP-1RA and SGLT2 inhibitors show promise in improving glycemic control, but more data and randomized-controlled trials are needed to confirm their safety and efficacy for PTDM treatment.
TRANSPLANT INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Mancheng Xia, Haosen Yang, Xunan Tong, Hongjie Xie, Fan Cui, Weibing Shuang
Summary: Older age, body mass index, family history of diabetes, tacrolimus use, history of hypertension, polycystic kidney disease, acute rejection, hepatitis B virus infection, and hepatitis C virus infection are risk factors for new-onset diabetes mellitus after kidney transplantation.
JOURNAL OF DIABETES INVESTIGATION
(2021)
