Article
Multidisciplinary Sciences
William H. Hoffman, Stephen A. Whelan, Norman Lee
Summary: Diabetic ketoacidosis (DKA) is a serious complication of Type 1 diabetes (T1D) caused by insulin deficiency and insulin resistance. The metabolic and immunologic dysregulation in DKA leads to oxidative stress, inflammation, and the development of brain edema (BE). Changes in the tryptophan (TRP)/kynurenine pathway (KP) metabolites may play a role in the pathogenesis of DKA/BE.
Article
Endocrinology & Metabolism
Nicole K. Gibbings, Paul A. Kurdyak, Patricia A. Colton, Baiju R. Shah
Summary: Adolescents and young adults with type 1 diabetes and eating disorders have more than triple the risk of DKA and nearly sixfold increased risk of death compared with their peers without eating disorders.
Article
Endocrinology & Metabolism
Yan Fu, Xue Liu, Beichen Cui, Cong Wang, Zhiwei Liu, Bin Zhao
Summary: This retrospective study aims to evaluate the clinical characteristics of diabetic ketoacidosis (DKA) in type 2 diabetes mellitus (T2DM) patients with acute pancreatitis (AP) in a Chinese cohort and identify simple laboratory parameters to discriminate high-risk patients. The study found that patients with concurrent DKA tend to be younger, more obese, and have higher blood glucose and triglyceride levels on admission. Blood glucose >21.75mmol/L could potentially be used as a simple laboratory parameter to identify high-risk patients.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Elizabeth S. Keiner, James C. Slaughter, Karishma A. Datye, Alan D. Cherrington, Daniel J. Moore, Justin M. Gregory
Summary: COVID-19 infection in pediatric patients with type 1 diabetes is associated with lower tissue glucose disposal during standardized therapy for diabetic ketoacidosis (DKA), suggesting a metabolic derangement caused by COVID-19.
Article
Endocrinology & Metabolism
Charlotte Loh, Paul Weihe, Nicole Kuplin, Kerstin Placzek, Susann Weihrauch-Blueher
Summary: The study analyzed the impact of the COVID-19 lockdown on children with diabetes mellitus, showing that the lockdown resulted in younger age and more severe DKA symptoms in children with new-onset diabetes, leading to longer hospital stays.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Pediatrics
Clemens Kamrath, Joachim Rosenbauer, Alexander J. Eckert, Angeliki Pappa, Felix Reschke, Tilman R. Rohrer, Kirsten Moenkemoeller, Michael Wurm, Kathrin Hake, Klemens Raile, Reinhard W. Holl
Summary: This study aimed to quantify the relative risk of diabetic ketoacidosis in children with newly diagnosed type 1 diabetes in 2020 and examine its association with regional COVID-19 incidence. The findings indicate a significant increase in ketoacidosis frequency compared to expected rates during certain months in 2020, with a positive association between regional COVID-19 incidence and ketoacidosis risk in the first half of the year. However, this association was not observed in the second half of 2020.
Article
Endocrinology & Metabolism
Angela Ibald-Mulli, Jochen Seufert, Julia M. Grimsmann, Markus Laimer, Peter Bramlage, Alexandre Civet, Margot Blanchon, Simon Gosset, Alexandre Templier, W. Dieter Paar, Fang Liz Zhou, Stefanie Lanzinger
Summary: This study aimed to identify predictive factors for diabetic ketoacidosis (DKA) by analyzing registry data and using a subgroup discovery algorithm. The findings showed several clinical characteristics associated with an increased risk of DKA, including low body mass index standard deviation score, DKA at diagnosis, specific age groups, higher HbA1c levels, no fast-acting insulin intake, certain age groups not using a continuous glucose monitoring system, physician diagnosis of nephrotic kidney disease, severe hypoglycemia, hypoglycemic coma, and autoimmune thyroiditis. The risk of DKA increased with the number of risk profiles matching the patients' characteristics.
DIABETES OBESITY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Aila J. Ahola, Valma Harjutsalo, Merlin C. Thomas, Carol Forsblom, Per-Henrik Groop
Summary: The study investigated the relationship between diet and hospitalization risk for DKA or hypoglycemia in type 1 diabetes patients. Alcohol intake was associated with increased risk of DKA hospitalization, while higher fiber intake seemed to be protective. Substituting carbohydrates for fats increased the risk of hypoglycemia hospitalization.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Hugo Segerer, Michael Wurm, Julia M. Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W. Holl
Summary: The study found that the incidence of DKA at the time of T1D diagnosis in children and adolescents did not decrease between 2000 and 2019. Patients with MiH, children under 6, and girls were at a higher risk of DKA.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Janet Snell-Bergeon, Gregory L. Kinney, Anagha Champakanath, Andrew Monte, Viral N. Shah
Summary: The study found that cannabis users had significantly higher pH and bicarbonate levels compared to non-users, and the accuracy of predicting HK-CHS with a positive cannabis urine test result was high.
Article
Endocrinology & Metabolism
Guy Todd Alonso, Osagie Ebekozien, Mary Pat Gallagher, Saketh Rompicherla, Sarah K. Lyons, Abha Choudhary, Shideh Majidi, Catherina T. Pinnaro, Sadana Balachandar, Mariam Gangat, Alissa Jeanne Curda Roberts, Brynn E. Marks, Ana Creo, Janine Sanchez, Tossaporn Seeherunvong, Jose Jimenez-Vega, Neha S. Patel, Jamie R. Wood, Liana Gabriel, Kathryn M. Sumpter, Meredith Wilkes, Robert Rapaport, Anna Cymbaluk, Jenise C. Wong, Srinath Sanda, Anastasia Albanese-O'neill
Summary: Analysis of data from pediatric patients under 19 years old with type 1 diabetes and COVID-19 found that higher A1c levels were the only predictor for hospitalization, with diabetic ketoacidosis being the primary concern in this group.
JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Janet Snell-Bergeon, Gregory L. Kinney, Anagha Champakanath, Andrew Monte, Viral N. Shah
Summary: The study aimed to differentiate between diabetic ketoacidosis (DKA) and hyperglycemic ketosis due to cannabis hyperemesis syndrome (HK-CHS) in adults with type 1 diabetes. It was found that cannabis users had higher levels of pH and bicarbonate compared to non-users. A positive urine test result for cannabis could be used to predict the occurrence of HK-CHS.
Article
Cardiac & Cardiovascular Systems
Huan Chen, Yochai Birnbaum, Regina Ye, Hsiu-Chiung Yang, Mandeep Bajaj, Yumei Ye
Summary: SGLT2 inhibitors increase plasma ketone concentrations and may induce ketoacidosis in diabetes patients. Dehydration can precipitate SGLT2 inhibitor-induced ketoacidosis in type-2 diabetes. Dapagliflozin attenuated the development of ketoacidosis and associated signaling pathways in T1DM mice.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Hafeez Shaka, Maria Aguilera, Maria Aucar, Zain El-Amir, Farah Wani, Chukwudi Charles Muojieje, Asim Kichloo
Summary: This study analyzed the 2018 Nationwide Readmission Database to describe rates and characteristics of nonelective 30-day readmission among adult patients with T1DM hospitalized for DKA, as well as identify predictors of readmission. The study found a high readmission rate for DKA in T1DM patients, with most patients having DKA as the principal diagnosis on readmission. Predictors of readmission included a Charlson Comorbidity Index (CCI) score of 3 or greater, hypertension, female sex, and being discharged against medical advice.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Blake E. Nichols, Jessica S. Hook, Kayson Weng, Chul Ahn, Jessica G. Moreland
Summary: A study found a unique primed phenotype in circulating leukocytes of T1D patients, regardless of DKA status. This phenotype is associated with a hyperinflammatory state and may be linked to a single nucleotide polymorphism in the TLR-1 gene.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Avivit Brener, Itai Peleg, Talya Rosenfeld, Sharona Kern, Adi Uretzky, Erella Elkon-Tamir, Gil Rosen, Hila Levinson, Galit Israeli, Hagar Interator, Yael Lebenthal
Summary: This real-life observational study aimed to explore the body composition of pediatric patients referred for endocrine evaluation. The results showed that boys had lower fat percentage and higher muscle mass compared to girls. The study suggests that MFR may be a better marker of blood pressure levels than BMI-SDS in pediatric patients.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Sari Krepel Volsky, Shlomit Shalitin, Elena Fridman, Michal Yackobovitch-Gavan, Liora Lazar, Rachel Bello, Tal Oron, Ariel Tenenbaum, Liat de Vries, Yael Lebenthal
Summary: The study found that 79.5% of young T1D patients had at least one additional CVD risk factor, and 41.6% had multiple CVD risk factors. A positive family history of CVD was associated with elevated lipid profiles, highlighting the importance of early diagnosis and control of blood pressure and genetic factors in preventing and managing dyslipidemia.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Marianna Rachmiel, Yael Lebenthal, Kineret Mazor-Aronovitch, Avivit Brener, Noa Levek, Neria Levran, Efrat Chorna, Michal Dekel, Galia Barash, Zohar Landau, Orit Pinhas-Hamiel
Summary: The study showed that telehealth visits benefited pediatric and young adult patients with T1D during COVID-19, but this modality is not suitable for a significant proportion of patients.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Shiran Abargil Loochi, Sharon Demol, Nessia Nagelberg, Yael Lebenthal, Moshe Phillip, Michal Yackobovitch-Gavan
Summary: The impact of GnRHa treatment on girls with central precocious/early-fast puberty (CPP/EFP) includes gradual increases in adiposity, decreases in muscle mass, and a decline in psychosocial functioning. Nutrition and physical activity levels did not fully explain the changes in body composition, calling for tailored counseling to prevent obesity.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pediatrics
Avivit Brener, Yarden Waksman, Talya Rosenfeld, Sigal Levy, Itai Peleg, Adi Raviv, Hagar Interator, Yael Lebenthal
Summary: This study found heritable body composition traits in childhood but not in adolescence, indicating that environmental factors have a stronger impact during teenage years. There were sex differences in body composition parameters, with boys generally having lower fat percentage and higher muscle-to-fat ratio than girls in both prepubertal and pubertal subjects.
Article
Pediatrics
Inbar Gilboa, Galit Israeli, Avivit Brener, Michal Yackobovitch-Gavan, Uri Kramer, Shimrit Uliel-Sibony, Yael Lebenthal
Summary: Children with West syndrome have a higher prevalence of cardiometabolic derangements, especially in infancy and in patients treated with ACTH. Although these metabolic abnormalities are transient, further investigation is needed to understand their impact on growth and development.
Article
Pediatrics
Noga Salton, Sharona Kern, Hagar Interator, Adar Lopez, Hadar Moran-Lev, Yael Lebenthal, Avivit Brener
Summary: The study suggests an interaction between muscle-to-fat ratio (MFR) and metabolic syndrome (MetS) components in overweight or obese children. Children with lower MFR tend to have higher risks of developing MetS components, with a stronger correlation between BMI and MFR in obese subjects.
Article
Pediatrics
Erez Azoulay, Michal Yackobovitch-Gavan, Hadar Yaacov, Inbar Gilboa, Adar Lopez, Tamar Sheppes, Yarden Waksman, Yael Lebenthal, Avivit Brener
Summary: During the pandemic, children and adolescents with underweight and normal weight showed improvement in body composition parameters, while those with overweight/obesity remained stable. Engagement in physical activity during the pandemic was a predictor for improvement, while lower socioeconomic position was predictive of deterioration.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Avivit Brener, Leonid Zeitlin, Yael Wilnai, Ohad S. Birk, Talya Rosenfeld, Efrat Chorna, Yael Lebenthal
Summary: This study describes three unique cases of childhood-onset diabetes where skeletal manifestations led to the identification of rare types of diabetes. The results demonstrate that understanding the precise genetic cause for the clinical manifestations can predict phenotypic presentations and enhance clinical outcomes.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Marie Mouler, Yael Lebenthal, Liat de Vries, Michal Yackobovitch-Gavan, Noa Sheffer Averbuch, Anne Laure Fauret-Amsellem, Helene Cave, Jacques Beltrand, Michel Polak, Moshe Phillip, Revital Nimri
Summary: Neonatal diabetes mellitus (NDM) patients have specific genetic and treatment characteristics, with some developing chronic diabetes complications after long-term illness. Patients with transient neonatal diabetes have higher height and weight and catch-up growth rapidly to reach normal growth parameters.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Gil Rosen, Anat Lavie, Michal Yackobovitch-Gavan, Shlomo Almashanu, Meital Priel, Ariel Many, Yael Lebenthal, Avivit Brener
Summary: This study investigated the characteristics of term infants detected as having congenital hypothyroidism (CH) and found that CH infants required more medical interventions during labor and delivery, such as vacuum assistance, cesarean section, and oxytocin administration. The study also revealed a correlation between the severity of hypothyroidism in CH infants and an increased demand for oxytocin during labor, with a threefold risk associated with permanent CH.
Article
Endocrinology & Metabolism
Marianna Rachmiel, Yael Lebenthal, Kineret Mazor-Aronovitch, Avivit Brener, Noah Levek, Talia Jacobi-Polishook, Tal Ben Ari, Shirli Abiri, Zohar Landau, Orit Pinhas-Hamiel
Summary: This study assessed glycemic control in adolescents with T1D switching to the MiniMed 780G system and found that it can improve glycemic outcomes. However, more advanced pubertal stage, longer disease duration, and lower compliance were associated with less improvement, highlighting the need for continuous support and re-education in this age group.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Hussein Zaitoon, Gabi Shefer, Anat Segev-Becker, Ori Eyal, Yael Lebenthal, Avivit Brener
Summary: This study investigates the practical application of PEG-TSH testing in cases of discrepancies between elevated TSH and normal FT4 levels. The results show that PEG-TSH results have an impact on clinical decisions in nearly one-half of the cases.
Meeting Abstract
Endocrinology & Metabolism
S. Goldman, O. Pinhas-Hamiel, A. Weinberg, A. Auerbach, A. German, A. Haim, A. Zung, A. Brener, D. Strich, E. Azoulay, F. Levy-Khademi, H. Ludar, I. Koren, M. Rachmiel, M. Yackobovitch-Gavan, N. Zuckerman-Levin, O. David, R. Halloun, R. Cahn, T. Ben-Ari, Y. Yeshayahu, Z. Landau, M. Phillip, Y. Lebenthal
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Avivit Brener, Yael Lebenthal, Roxana Cleper, Livia Kapusta, Leonid Zeitlin
Summary: In this study, the body composition and cardiometabolic health of pediatric patients with X-linked hypophosphatemia (XLH) treated with burosumab were explored. It was found that there was an improvement in body composition, particularly in muscle mass indices, in XLH patients after treatment.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)