Article
Endocrinology & Metabolism
Lucas H. Armitage, Scott E. Stimpson, Katherine E. Santostefano, Lina Sui, Similoluwa Ogundare, Brittney N. Newby, Roberto Castro-Gutierrez, Mollie K. Huber, Jared P. Taylor, Prerana Sharma, Ilian A. Radichev, Daniel J. Perry, Natalie C. Fredette, Alexei Y. Savinov, Mark A. Wallet, Naohiro Terada, Todd M. Brusko, Holger A. Russ, Jing Chen, Dieter Egli, Clayton E. Mathews
Summary: Type 1 diabetes is a disease caused by complex immunogenetic mechanisms, involving key cell-cell interactions such as activation, migration, interaction, and killing of specific cells, regulated by individual genetic risk variants. An isogenic system from a single donor has been developed to study these critical cellular interactions, providing a proof-of-concept for future research on the role of disease alleles in the pathogenesis of T1D.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Wei Zhang, Qing Ling, Bin Wang, Kai Wang, Jianbo Pang, Jing Lu, Yan Bi, Dalong Zhu
Summary: Both UC-MSCs and BM-MSCs showed comparable therapeutic effects in improving T1D, with similar results in lowering blood glucose levels and preserving beta-cell function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Liem Thanh Nguyen, Duc M. Hoang, Kien T. Nguyen, Duc M. Bui, Hieu T. Nguyen, Hong T. A. Le, Van T. Hoang, Hue T. H. Bui, Phuong T. M. Dam, Xuan T. A. Hoang, Anh T. L. Ngo, Hang M. Le, Nhi Y. Phung, Duc M. Vu, Trung T. Duong, Tu D. Nguyen, Lien T. Ha, Hoa T. P. Bui, Hoa K. Nguyen, Michael Heke, Anh Bui
Summary: The study suggests that autologous administration of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) is safe in patients with type 2 diabetes mellitus (T2DM), with treatment efficacy dependent on the quality of the stem cell population and administration routes. Short-term therapeutic effects were observed in patients with shorter T2DM duration and lower body weight.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Denise Weffort, Leticia F. Adolpho, Alann T. P. Souza, Gileade P. Freitas, Helena B. Lopes, Fabiola S. Oliveira, Rayana L. Bighetti-Trevisan, Leticia Pitol-Palin, Doris H. Matsushita, Roberta Okamoto, Marcio M. Beloti, Adalberto L. Rosa
Summary: Type 1 (T1DM) and type 2 (T2DM) diabetes mellitus affect glucose metabolism and cause bone damage through various mechanisms, including the impact on osteoblasts. This study examined the osteoblast differentiation of mesenchymal stem cells (MSCs) from rats with T1DM or T2DM and the effects of removing hyperglycemia on the osteogenic potential of these cells. The results showed that both T1DM and T2DM inhibited the osteoblast differentiation of MSCs cultured in hyperglycemic media, with T1DM having a more significant effect. Restoring normoglycemic conditions partially recovered the osteogenic potential of MSCs from rats with T1DM but not with T2DM. These findings highlight the need for targeted therapies for T1DM- or T2DM-induced bone loss, as both conditions disrupt osteoblast differentiation at different levels and likely through different mechanisms.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Gulen Guney-Esken, Ozgur Dogus Erol, Burcu Pervin, Gulben Gurhan Sevinc, Tamer Onder, Elif Bilgic, Petek Korkusuz, Aysen Gunel-Ozcan, Duygu Uckan-Cetinkaya, Fatima Aerts-Kaya
Summary: GS-2 is a rare autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene. This study successfully generated iPSC from 3 GS-2 patients using lentiviral vectors, which expressed pluripotency markers and differentiated into cells from all three germ layers. The iPSCs can be used for future studies on novel treatments and the pathophysiology of GS-2 disease.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Medicinal
Osama M. Ahmed, Ablaa S. Saleh, Eman A. Ahmed, Mohammed M. Ghoneim, Hasnaa Ali Ebrahim, Mohamed A. Abdelgawad, Mohammed Abdel-Gabbar
Summary: This study aimed to evaluate the effectiveness of bone marrow-derived mesenchymal stem cells (BM-MSCs) and hesperetin in treating a rat model of Type 1 diabetes mellitus (T1DM). The results showed that the use of hesperetin and BM-MSCs significantly improved glycemic control, insulin secretion, and pancreatic islet architecture, as well as decreased hepatic glucose output in diabetic rats. These effects may be mediated through their antioxidant, anti-inflammatory, and antiapoptotic actions.
Review
Endocrinology & Metabolism
Kriti Joshi, Fergus Cameron, Swasti Tiwari, Stuart I. Mannering, Andrew G. Elefanty, Edouard G. Stanley
Summary: Induced pluripotent stem cell (iPSC) technology is increasingly used to create in vitro models of monogenic human disorders, while complex conditions like autoimmune Type 1 diabetes (T1D) may require consideration of polygenic inheritance and environmental factors. Models for T1D should be aware of the importance of cell interactions and genetic backgrounds for more accurate representation of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zahra Eydian, Alaleh Mohammad Ghasemi, Samira Ansari, Ali Naghi Kamali, Maryam Khosravi, Sima Momtaz, Sanaz Riki, Laleh Rafighdoost, Reza Entezari Heravi
Summary: This study demonstrates the differentiation of mesenchymal stem cells (MSCs) from human adipose tissue and bone marrow into functional beta-islet cells. It suggests that adipose stem cells may be a better choice for the treatment of diabetes mellitus due to their higher potency.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and lower BV/TV. The new BMA parameter Ad.N/BS is correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and with lower BV/TV. A new BMA parameter, Ad.N/BS, is positively correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while that of metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Cell & Tissue Engineering
Helen Jiang, Fang-Xu Jiang
Summary: Insulin remains the main treatment for type 1 diabetes, but it is not a cure. Stem cell-derived beta cells show potential for cell replacement therapy, but more research is needed to fully understand their nature and address technical and ethical challenges.
WORLD JOURNAL OF STEM CELLS
(2023)
Review
Endocrinology & Metabolism
Xin-Xing Wan, Dan-Yi Zhang, Md. Asaduzzaman Khan, Sheng-Yuan Zheng, Xi-Min Hu, Qi Zhang, Rong-Hua Yang, Kun Xiong
Summary: This review article discusses the application of stem cell transplantation in the treatment of type 1 diabetes mellitus (T1DM). Stem cells have the potential to reestablish immunotolerance and preserve islet beta-cell function, providing a promising alternative for T1DM treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Jonathan Ribot, Cyprien Denoeud, Guilhem Frescaline, Rebecca Landon, Herve Petite, Graciela Pavon-Djavid, Morad Bensidhoum, Fani Anagnostou
Summary: This study highlights the impact of the T2DM environment on the properties and functions of BMMSCs, showing impaired expansion, adipogenic differentiation, and angiogenesis-related gene expression.
Article
Biochemistry & Molecular Biology
Michiko Horiguchi, Yuko Okada, Yuya Turudome, Kentaro Ushijima
Summary: Type 1 diabetes mellitus leads to degeneration of organelles in adipose-derived stem cells, with the main characteristic being prominent enlarged spherical vesicles. The exosomes of T1DM ADSCs are found to be enlarged, reduced in number, and increased in the percentage positive for tetraspanin CD9, providing insight into the characteristics of stem cells in patients with type 1 diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julie C. Bulman, Marwan Moussa, Trevor K. Lewis, Seth Berkowitz, Ammar Sarwar, Salomao Faintuch, Muneeb Ahmed
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julie C. Bulman, Omar Zurkiya, Vincent Wu, Eric Wehrenberg-Klee, Edwin Palmer, David Chow, Alexander Brook, Suvranu Ganguli
Summary: In patients undergoing repeat radioembolization treatments, there was no significant difference in LSF between different time points and arterial distributions. Patients with lung doses well under 30 Gy for the initial treatment and a cumulative dose of 50 Gy may not require a repeat LSF calculation.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Julie C. Bulman, Jeffrey L. Weinstein, Marwan Moussa, Muneeb Ahmed
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey L. Weinstein, Fady El-Gabalawy, Ammar Sarwar, Sarah Schroeppel DeBacker, Salomao Faintuch, Seth J. Berkowitz, Julie C. Bulman, Matthew R. Palmer, Robina Matyal, Feroze Mahmood, Muneeb Ahmed
Summary: Electromagnetic hand motion tracking can effectively differentiate between expert and trainee operators in simulated interventional tasks, with experts outperforming trainees.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah E. Schroeppel DeBacker, Julie C. Bulman, Jeffrey L. Weinstein
Summary: Venous leg ulcers (VLUs) affect 20% of patients with chronic venous insufficiency, requiring careful clinical examination and ultrasound evaluation for diagnosis and treatment success; Treatment should focus on reducing edema and venous hypertension through compression therapy, local wound care, and addressing venous reflux or obstruction. Interventional radiologists should be familiar with disease classification, scoring systems, and guidelines for venous ulcers.
SEMINARS IN INTERVENTIONAL RADIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Animan Randhawa, Julie C. Bulman, Olga R. Brook, Sahil V. Mehta, Salomao Faintuch, Muneeb Ahmed, Jeffrey L. Weinstein
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Julie C. Bulman, Ammar Sarwar
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Hamza Ali, Julie C. Bulman, Ammar Sarwar, Jeffrey Weinstein
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Julie C. Bulman, Jeffrey L. Weinstein
Article
Medicine, General & Internal
Benjamin A. Wagner, Dwight D. Harris, Matthew R. Shalvoy, Julie C. Bulman
Summary: A male in his 70s presented to the emergency department with sudden-onset abdominal pain and syncope. He was diagnosed with abdominal apoplexy and successfully treated with embolisation of the bleeding vessels. The patient made an excellent recovery.
Article
Radiology, Nuclear Medicine & Medical Imaging
Julie C. Bulman, Fady El-Gabalawy, Luz A. Martinez, Ammar Sarwar, Jeffrey L. Weinstein, Salomao Faintuch, Muneeb Ahmed
Summary: The study assessed patient and provider satisfaction with interventional radiology (IR) outpatient telehealth and in-person clinic. The findings showed high satisfaction among patients with telehealth visits, similar to in-person visits. Both patients and providers reported time-saving and greater efficiency with telehealth, suggesting its importance in outpatient IR clinic care.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
J. C. Bulman, S. A. McQuiston, H. S. Bedi, J. Rawson
ACADEMIC RADIOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Harika Dabbara, Julie C. Bulman, Vijay Ramalingam, Jeffrey L. Weinstein
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Clinical Neurology
Dimitrios Mathios, Ernest J. Bobeff, Davide Longo, Abtin Tabaee, Vijay K. Anand, Kyle J. Godfrey, Theodore H. Schwartz
Summary: The lateral transorbital approach (LTOA) can be used as an alternative method for repairing lateral sphenoid sinus encephaloceles, avoiding the potential morbidity associated with the endonasal endoscopic approach (EEA). It provides a shorter distance to target and better visualization of the V2 nerve compared to the EEA.
OPERATIVE NEUROSURGERY
(2023)
Article
Ophthalmology
Aliaa H. Abdelhakim, Kristen E. Dunbar, Kyle J. Godfrey, Cristina Abascal Ananza, David N. Silvers, Michael Kazim
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2019)