Article
Endocrinology & Metabolism
Qun Yan, Weiting Hu, Yan Tian, Xu Li, Yuan Yu, Xing Li, Bo Feng
Summary: The aim of this study was to assess the incidence of type 2 diabetes mellitus (T2DM) after 6 years in patients with IGT who received early probiotic intervention. The results showed that there was no significant difference in the risk of developing T2DM between the probiotic treatment group and the placebo group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kathryn J. Potter, Quitterie Reynaud, Valerie Boudreau, Florence Racine, Francois Tremblay, Annick Lavoie, Maite Carricart, Genevieve Mailhot, Isabelle Durieu, Peter A. Senior, Remi Rabasa-Lhoret
Summary: Patients meeting both criteria of indeterminate glycemia and impaired glucose tolerance have an increased risk of developing diabetes, suggesting the need for closer monitoring.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Benedikt Dietz, Juergen Machann, Vaibhav Agrawal, Martin Heni, Patrick Schwab, Julia Dienes, Steffen Reichert, Andreas L. Birkenfeld, Hans-Ulrich Haering, Fritz Schick, Norbert Stefan, Andreas Fritsche, Hubert Preissl, Bernhard Schoelkopf, Stefan Bauer, Robert Wagner
Summary: The study indicated that diabetes can be detected through whole-body MRI without additional data, with visceral fat playing a crucial role in diabetes classification. The model identified a high-risk group with increased risk for future diabetes and microalbuminuria.
Article
Nutrition & Dietetics
Bo-Ying Zang, Li-Xia He, Ling Xue
Summary: Obesity and diabetes are significant health issues, and moderate weight loss is important for reducing the risk of metabolic diseases. Intermittent fasting (IF) is a popular weight loss strategy, but more research is needed, especially regarding its application in obese and type 2 diabetic patients.
Article
Medicine, Research & Experimental
Chelsea M. Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, J. Steven Leeder
Summary: An accurate understanding of the changes in height and weight of children with age is crucial for predicting drug concentrations in children. This study extracted data from electronic medical records to develop growth curves for youth with type 2 diabetes. The results showed that these youth deviated from the standard growth patterns in terms of weight and height, highlighting the importance of considering disease-specific growth curves in pediatric drug development models.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Jae-Young Park, Woo Jeng Kim, Yoo Hyun Chung, Bongseong Kim, Yonggyu Park, In Yang Park, Hyun Sun Ko
Summary: This study found that high levels of pregravid GGT and ALT were associated with an increased risk of GDM + IT in women pregnant with twins, regardless of pregravid obesity or metabolic syndrome. However, there were no significant associations between pregravid ALT and GGT levels and risks for the development of GDM - IT.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Procolo Di Bonito, Maria Rosaria Licenziati, Domenico Corica, Malgorzata Gabriela Wasniewska, Anna Di Sessa, Emanuele Miraglia del Giudice, Anita Morandi, Claudio Maffeis, Maria Felicia Faienza, Enza Mozzillo, Valeria Calcaterra, Giulio Maltoni, Francesca Franco, Giuliana Valerio
Summary: The aim of this study was to assess a new formula for improving the screening of isolated impaired glucose tolerance (IGT) in youth with overweight/obesity (OW/OB). A cross-sectional study was performed on 1189 Caucasian youths to develop a simple formula based on metabolic and anamnestic data. The formula showed good performance in screening IGT in both the training set and validation set.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Alessandra Celli, Yoann Barnouin, Bryan Jiang, Dean Blevins, Georgia Colleluori, Sanjay Mediwala, Reina Armamento-Villareal, Clifford Qualls, Dennis T. Villareal
Summary: A lifestyle intervention strategy is highly successful in improving metabolic and functional health of older adults with diabetes.
Article
Endocrinology & Metabolism
Ravi Retnakaran, Chang Ye, Anthony J. Hanley, Philip W. Connelly, Mathew Sermer, Bernard Zinman
Summary: This study compared postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated. The results showed that treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy. Insulin sensitivity and beta-cell function decreased, while fasting and 2-h glucose levels increased progressively across the five groups.
Article
Endocrinology & Metabolism
Yanyan Chen, Ping Zhang, Jinping Wang, Qiuhong Gong, Yali An, Xin Qian, Bo Zhang, Hui Li, Edward W. Gregg, Peter H. Bennett, Guangwei Li
Summary: Chinese adults with impaired glucose tolerance (IGT) who reverted to normal glucose tolerance (NGT) or remained with IGT after a 6-year intervention trial had significantly lower incidences of cardiovascular disease and microvascular disease compared to those who developed diabetes.
Article
Multidisciplinary Sciences
Heng Yaw Yong, Zalilah Mohd Shariff, Barakatun Nisak Mohd Yusof, Zulida Rejali, Yvonne Yee Siang Tee, Jacques Bindels, Eline M. van der Beek
Summary: This study investigates the association between height and the risk of Gestational Diabetes Mellitus (GDM), as well as the moderation effect of early pregnancy body mass index (BMI) and gestational weight gain (GWG) on this association. The findings suggest that there is a significant association between shorter height and GDM risk in overweight/obese women, particularly in those with excessive GWG at the end of the second trimester.
Article
Medicine, General & Internal
Yan Yan, Yuanjie Sun, Xinlu Wang, Lili Zhu, Yu Chen, Zhishun Liu
Summary: This study aims to evaluate the effectiveness and safety of acupuncture treatment for IGT in people who are overweight/obese and provide quantitative clinical evidence.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Amel Rezki, Marinos Fysekidis, Sabrina Chiheb, Eric Vicaut, Emmanuel Cosson, Paul Valensi
Summary: The study demonstrated that saxagliptin has metabolic benefits in glucose-intolerant obese patients by significantly reducing postprandial blood glucose levels, leading to an improvement in glucose tolerance.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Judith Estrada-Meza, Jasmine Videlo, Clara Bron, Cecile Saint-Beat, Marine Silva, Francois Duboeuf, Olivier Peyruchaud, Fabienne Rajas, Gilles Mithieux, Amandine Gautier-Stein
Summary: The neonatal administration of tamoxifen had long-term, sex-dependent effects on energy homeostasis in adult mice, with females showing increased fat mass, food intake, and impaired glucose control, while males had modest improvements in glucose tolerance but decreased lean mass and bone weight. Caution is warranted when using tamoxifen for the development of transgenic mouse models related to energy homeostasis and bone biology.
Article
Endocrinology & Metabolism
Yoshifumi Kasuga, Tomoko Kawai, Kei Miyakoshi, Asuka Hori, Masumi Tamagawa, Keita Hasegawa, Satoru Ikenoue, Daigo Ochiai, Yoshifumi Saisho, Mariko Hida, Mamoru Tanaka, Kenichiro Hata
Summary: This study investigated DNA methylation patterns in neonates born to mothers with E-GDM, and found that there were no significant differences in DNA methylation between the E-GDM group and normal OGTT group. Neonates born to mothers with GDM diagnosed based on Japan Society of Obstetrics and Gynecology criteria may not differ in DNA methylation compared to those born to normal OGTT mothers.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)