Article
Medicine, Research & Experimental
Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sorine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jorgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O. Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C. W. Ma, Juliana C. N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Summary: Diabetic nephropathy (DN) is a polygenic disorder with poorly defined genome-wide methylation patterns. Methylation sequencing using leukocytes from a Finnish diabetes study identified differentially methylated genes associated with DN, which were further validated in independent T1D registries from Denmark, Hong Kong, and Thailand. Reduced DNA methylation at certain sites was connected with DN pathways related to insulin signaling, lipid metabolism, and fibrosis. Experimental observations in human renal cells, macrophages, and vascular endothelial cells supported the findings.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Xiaoya Ren, Ninglin Kang, Xianghui Yu, Xiaolei Li, Yange Tang, Jie Wu
Summary: Diabetes is a chronic disease that exerts significant pressure on patients and the medical system, especially for those with complications such as diabetic nephropathy. Understanding the factors associated with diabetic nephropathy is necessary to improve the quality of life for diabetes patients.
Article
Ophthalmology
Lanhua Wang, Ling Jin, Wei Wang, Xia Gong, Yuting Li, Wangting Li, Xiaoling Liang, Wenyong Huang, Yizhi Liu
Summary: There is a strong association between renal function and vision-threatening diabetic retinopathy (VTDR) and diabetic macular oedema (DMO) in diabetic patients. The association between glomerular filtration rate (GFR) and VTDR is significant, while the association with any DR depends on the presence of microalbuminuria. High microalbuminuria and chronic kidney disease (CKD) are significantly associated with DMO.
Article
Endocrinology & Metabolism
Angier Allen, Zohora Iqbal, Abigail Green-Saxena, Myrna Hurtado, Jana Hoffman, Qingqing Mao, Ritankar Das
Summary: This study aims to develop a machine learning algorithm that predicts the stages of diabetic kidney disease within 5 years after diagnosis of type 2 diabetes mellitus.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Endocrinology & Metabolism
Tadesse Asmamaw Dejenie, Endeshaw Chekol Abebe, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizchew Ambaw Kassie, Amanuel Yosef Gebrekidan, Molalegn Mesele Gesese, Kirubel Dagnaw Tegegne, Denekew Tenaw Anley, Sefineh Fenta Feleke, Melkamu Aderajew Zemene, Anteneh Mengist Dessie, Natnael Moges, Yenealem Solomon Kebede, Berihun Bantie, Dagnew Getnet Adugna
Summary: This study investigated the value of serum cystatin C levels and dyslipidemia in detecting diabetic nephropathy in patients with type 2 diabetes mellitus. The results showed significant lipoprotein abnormalities and increased serum cystatin C levels in type 2 diabetes patients with nephropathy. The study also found a significant correlation between dyslipidemia and serum cystatin C levels. Therefore, serum cystatin C and dyslipidemia may serve as sensitive and non-invasive biomarkers for diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Khalid Siddiqui, Teena P. George, Salini S. Joy, Assim A. Alfadda
Summary: This study investigates the involvement of risk factors in the severity of CKD among participants with longer duration of diabetes. The results suggest that patients with T2DM and duration of ≥ 15 years, hyperlipidemia, hypertension, and diabetic retinopathy have a higher prevalence of advanced CKD. Additionally, an increased number of risk factors may indicate the severity of CKD in T2D.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nihal Halawa, Tamer Wahid Elsaid, Lamia Mohamed El Wakeel, May Ahmed Shawki
Summary: Oral Mg citrate supplementation can improve microalbuminuria in patients with diabetic nephropathy (DN), and also has positive effects on lipid profile, serum osteocalcin, and quality of life.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Urology & Nephrology
Sarah J. Schrauben, Haochang Shou, Xiaoming Zhang, Amanda Hyre Anderson, Joseph V. Bonventre, Jing Chen, Steven Coca, Susan L. Furth, Jason H. Greenberg, Orlando M. Gutierrez, Joachim H. Ix, James P. Lash, Chirag R. Parikh, Casey M. Rebholz, Venkata Sabbisetti, Mark J. Sarnak, Michael G. Shlipak, Sushrut S. Waikar, Paul L. Kimmel, Ramachandran S. Vasan, Harold I. Feldman, Jeffrey R. Schelling
Summary: Higher plasma levels of KIM-1, TNFR-1, TNFR-2, MCP-1, suPAR, and YKL-40 were associated with increased risk of progression of diabetic kidney disease. TNFR-2 had the highest risk after accounting for other biomarkers. These findings validate previous literature on TNFR-1, TNFR-2, and KIM-1 and provide new insights into the influence of suPAR and YKL-40 as plasma biomarkers that require validation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Cong Li, Honghua Yu, Zhuoting Zhu, Xianwen Shang, Yu Huang, Charumathi Sabanayagam, Xiaohong Yang, Lei Liu
Summary: This study aimed to explore the association between blood pressure and the risk of diabetic microvascular complications (DMCs). The results showed that participants with higher systolic blood pressure had a lower risk of DMCs, and hypertension defined by the 2017 ACC/AHA guidelines may not have a significant impact on the incidence of DMCs compared to the JNC 7 criteria.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Urology & Nephrology
Joseph Stavas, David Gerber, Steven G. Coca, Arnold L. Silva, Ashley Johns, Deepak Jain, Tim Bertram, Maria Diaz-Gonzalez de Ferris, George Bakris
Summary: This study aims to investigate the efficacy and safety of renal autologous cell therapy (REACT) in improving or stabilizing renal function among patients with type 2 diabetic kidney disease (T2DKD). By directly injecting REACT into the renal cortex, this therapy has the potential to delay or avoid renal replacement therapy. This is a multicenter phase II clinical trial that enrolled 83 adult patients for observation.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Guido Gembillo, Vincenzo Labbozzetta, Alfio Edoardo Giuffrida, Luigi Peritore, Vincenzo Calabrese, Claudia Spinella, Maria Rita Stancanelli, Eugenia Spallino, Luca Visconti, Domenico Santoro
Summary: Copper is a crucial element for body homeostasis and its imbalances can lead to various diseases. Both copper deficiency and excessive exposure can cause harm to multiple organs. Particularly, the influence of copper on diabetes and its complications, such as Diabetic Kidney Disease, has been studied extensively.
Article
Urology & Nephrology
Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki, Kana Miyake, Masaomi Nangaku, Yasuo Ohashi, Mitsuhiko Noda, Takashi Kadowaki
Summary: The study evaluated the effects of intensified multifactorial intervention on diabetic kidney disease in patients with type 2 diabetes. Results showed a significant reduction in kidney events and progression compared to standard care, indicating the effectiveness of intensified intervention in preventing diabetic kidney disease.
KIDNEY INTERNATIONAL
(2021)
Review
Medical Laboratory Technology
Zhaohui Cao, Di Huang, Cifei Tang, Yang Lu, Shuangxiang Huang, Cuiying Peng, Xiaobo Hu
Summary: This mini-review discusses the molecular mechanisms of inflammasome activation and pyroptosis, highlighting their crucial role in diabetic nephropathy (DN). Natural plant compounds show therapeutic potential in regulating inflammasomes and pyroptosis.
CLINICA CHIMICA ACTA
(2022)
Article
Medicine, General & Internal
Shovna Dash, Abhilash Chougule, Soumyakanta Mohanty
Summary: This study found a definite association between urinary albumin excretion and severe diabetic retinopathy in patients with type-II diabetes. Microalbuminuria was associated with all grades of retinopathy, with a higher proportion in lower grade retinopathy, while macroalbuminuria was associated with severe non-proliferative diabetic retinopathy, proliferative diabetic retinopathy, and very severe non-proliferative diabetic retinopathy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)