Animal modelling for inherited central vision loss

Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis

(2015) Najate Aït-Ali et al.   CELL

Gene Therapy Fully Restores Vision to the All-ConeNrl−/−Gucy2e−/−Mouse Model of Leber Congenital Amaurosis-1

(2015) Sanford L. Boye et al.   HUMAN GENE THERAPY

Gene Augmentation Therapy Restores Retinal Function and Visual Behavior in a Sheep Model of CNGA3 Achromatopsia

(2015) Eyal Banin et al.   MOLECULAR THERAPY

Cellular strategies for retinal repair by photoreceptor replacement

(2015) Sujatha A. Jayakody et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies

(2015) Ralph W.N. Slijkerman et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Dog Models for Blinding Inherited Retinal Dystrophies

(2015) Simon M. Petersen-Jones et al.   Human Gene Therapy Clinical Development

Myosin VIIA is a Marker for the Cone Accessory Outer Segment in Zebrafish

(2014) Corinne Hodel et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Canine Retina Has a Primate Fovea-Like Bouquet of Cone Photoreceptors Which Is Affected by Inherited Macular Degenerations

(2014) William A. Beltran et al.   PLoS One

Causes and consequences of inherited cone disorders

(2014) Susanne Roosing et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Secondary Analyses of the Effects of Lutein/Zeaxanthin on Age-Related Macular Degeneration Progression

(2014) Emily Y. Chew et al.   JAMA Ophthalmology

Derivation of Traceable and Transplantable Photoreceptors from Mouse Embryonic Stem Cells

(2014) Sarah Decembrini et al.   Stem Cell Reports

Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology

(2013) Ross F. Collery et al.   EXPERIMENTAL EYE RESEARCH

Successful Gene Therapy in the RPGRIP1-deficient Dog: a Large Model of Cone–Rod Dystrophy

(2013) Elsa Lhériteau et al.   MOLECULAR THERAPY

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

(2013) Anai Gonzalez-Cordero et al.   NATURE BIOTECHNOLOGY

Rapid Cohort Generation and Analysis of Disease Spectrum of Large Animal Model of Cone Dystrophy

(2013) Corinne Kostic et al.   PLoS One

Action Spectra of Zebrafish Cone Photoreceptors

(2013) Duco Endeman et al.   PLoS One

Characterization of Light Lesion Paradigms and Optical Coherence Tomography as Tools to Study Adult Retina Regeneration in Zebrafish

(2013) Anke Weber et al.   PLoS One

The zebrafish as a model for complex tissue regeneration

(2013) Matthew Gemberling et al.   TRENDS IN GENETICS

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Characterization of multiple light damage paradigms reveals regional differences in photoreceptor loss

(2012) Jennifer L. Thomas et al.   EXPERIMENTAL EYE RESEARCH

AAV-Mediated Gene Therapy in the Guanylate Cyclase (RetGC1/RetGC2) Double Knockout Mouse Model of Leber Congenital Amaurosis

(2012) Sanford L. Boye et al.   HUMAN GENE THERAPY

Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice

(2012) Iman Sahly et al.   JOURNAL OF CELL BIOLOGY

Preservation of Cone Photoreceptors after a Rapid yet Transient Degeneration and Remodeling in Cone-Only Nrl-/- Mouse Retina

(2012) J. E. Roger et al.   JOURNAL OF NEUROSCIENCE

Rediscovering the chick embryo as a model to study retinal development

(2012) M Natalia Vergara et al.   Neural Development

A Chick Model of Retinal Detachment: Cone Rich and Novel

(2012) Colleen M. Cebulla et al.   PLoS One

Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration

(2011) J. R. Sommer et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

The visual system of zebrafish and its use to model human ocular Diseases

(2011) Gaia Gestri et al.   Developmental Neurobiology

Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration

(2011) Debarshi Mustafi et al.   FASEB JOURNAL

AAV-mediated photoreceptor transduction of the pig cone-enriched retina

(2011) C Mussolino et al.   GENE THERAPY

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Bicistronic Lentiviruses Containing a Viral 2A Cleavage Sequence Reliably Co-Express Two Proteins and Restore Vision to an Animal Model of LCA1

(2011) Jonathan D. Verrier et al.   PLoS One

Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration

(2011) Jeffrey R. Sommer et al.   TRANSGENIC RESEARCH

Ophthalmic and cone derived electrodiagnostic findings in outbred Miniature Long-haired Dachshunds homozygous for a RPGRIP1 mutation

(2011) Claudia Busse et al.   VETERINARY OPHTHALMOLOGY

Topography of ganglion cells and photoreceptors in the sheep retina

(2010) Aya Shinozaki et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina

(2010) Anand Swaroop et al.   NATURE REVIEWS NEUROSCIENCE

Cone loss is delayed relative to rod loss during induced retinal degeneration in the diurnal cone-rich rodent Arvicanthis ansorgei

(2010) D.L. Boudard et al.   NEUROSCIENCE

Avian Cone Photoreceptors Tile the Retina as Five Independent, Self-Organizing Mosaics

(2010) Yoseph A. Kram et al.   PLoS One

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

(2010) Shannon E. Boye et al.   PLoS One

Loss of the Metalloprotease ADAM9 Leads to Cone-Rod Dystrophy in Humans and Retinal Degeneration in Mice

(2009) David A. Parry et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A mutation in gene CNGA3 is associated with day blindness in sheep

(2009) Shay Reicher et al.   GENOMICS

In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death

(2009) M. Samardzija et al.   HUMAN MOLECULAR GENETICS

Gene therapy for red–green colour blindness in adult primates

(2009) Katherine Mancuso et al.   NATURE

Generation of retinal cells from mouse and human induced pluripotent stem cells

(2009) Yasuhiko Hirami et al.   NEUROSCIENCE LETTERS

Evolution and spectral tuning of visual pigments in birds and mammals

(2009) D. M. Hunt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies

(2009) Merav H. Shamir et al.   VETERINARY JOURNAL

A deletion in nephronophthisis 4 (NPHP4) is associated with recessive cone-rod dystrophy in standard wire-haired dachshund

(2008) A. C. Wiik et al.   GENOME RESEARCH

Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

(2008) Fumitaka Osakada et al.   NATURE BIOTECHNOLOGY

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE

Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

(2008) M.-P. Agbaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photoreceptor organisation and phenotypic characterization in retinas of two diurnal rodent species: Potential use as experimental animal models for human vision research

(2007) Corina Bobu et al.   VISION RESEARCH