Article
Oncology
Jun Li, Gang Peng, Kuikui Zhu, Xiaohua Jie, Yingzhuo Xu, Xinrui Rao, Yunhong Xu, Yunshang Chen, Biyuan Xing, Gang Wu, Liangliang Shi
Summary: This study found that mast cells are poor prognostic factors associated with resistance to anti-PD-1 immunotherapy. The PD-1 antibody can activate PD-1(+) mast cells to release histamine and cytokines, thereby playing a negative role in the tumor microenvironment. Inhibition of mast cells may provide a new solution to improve the response rate of anti-PD-1 immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Thayse R. Brueggemann, Hadas Pahima, David Mankuta, Bruce D. Levy, Francesca Levi-Schaffer
Summary: The study found that Cromolyn Sodium has immunomodulatory actions in allergic inflammation that go beyond just stabilizing mast cells, indicating broader mechanisms at play.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Parasitology
Marwa A. EL-Dardiry, Amany A. Abdel-Aal, Magda S. A. Abdeltawab, Mona El-Sherbini, Marwa A. Hassan, Asmaa A. Abdel-Aal, Manal Badawi, Shady E. Anis, Bahaa-Eldin A. Khaled, Abeer S. Al-Antably
Summary: Experimental findings showed that mice with a sensitized response to the parasites significantly decreased parasite numbers and exhibited more pronounced inflammatory responses. All treated groups exhibited a significant reduction in parasite count, and MCS demonstrated a reduction in parasite count in both non-sensitized and sensitized groups.
PARASITES & VECTORS
(2021)
Article
Medicine, Research & Experimental
Ziye Huang, Guang Wang, Bowei Yang, Pei Li, Tongxin Yang, Yuyun Wu, Xing Yang, Jianhe Liu, Jiongming Li
Summary: Ketotifen fumarate effectively inhibits the formation of calcium oxalate stones and reduces tissue inflammation by regulating the infiltration and activation of mast cells in renal tissue. It also affects the expression of certain important proteins in renal tubules and renal interstitium, as well as the synthesis of integrins and reactive oxygen species.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Betuel Karayay, Heidi Olze, Agnieszka J. Szczepek
Summary: Our research group discovered resident mast cells in rodents' cochleae and found that adding cisplatin changed their number. We further observed that murine cochlear mast cells degranulate in response to cisplatin and that the mast cell stabilizer cromolyn inhibits this process. Additionally, cromolyn significantly prevented cisplatin-induced loss of auditory hair cells and spiral ganglion neurons, providing evidence for mast cell participation in cisplatin-induced damage to the inner ear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Tomohiro Nizawa, Imran A. Bhutto, Anupama Tiwari, Rhonda R. Grebe, Jesse Alt, Rana Rais, Malia M. Edwards, Gerard A. Lutty
Summary: The study demonstrated that topical KTF eye drops, at both 1% and 0.25 concentrations, effectively reduced choroidal mast cell degranulation, RPE loss, and retinal/choroidal thinning in a rat model of GA, while also preventing the decline in ERG amplitude. These findings suggest that topical KTF may be a promising therapeutic agent for treating GA.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Afton K. Limberg, Christopher G. Salib, Meagan E. Tibbo, Juan S. Vargas-Hernandez, Jacob W. Bettencourt, Banu Bayram, Charlotte E. Berry, Amel Dudakovic, Brad Bolon, Andre J. van Wijnen, Mark E. Morrey, Joaquin Sanchez-Sotelo, Daniel J. Berry, Jodi M. Carter, Matthew P. Abdel
Summary: This study assessed the immune cell microenvironment in arthrofibrosis following total knee arthroplasty, and found increased tissue fibrosis and myofibroblast populations in arthrofibrotic patients compared to non-arthrofibrotic patients. Macrophages were significantly decreased in the fibrotic tissue region of arthrofibrosis patients compared to patients with primary TKA, while CD163 + macrophages were significantly increased in the adipose tissue region of arthrofibrotic specimens compared to non-arthrofibrotic specimens. These findings provide insights into the underlying pathogenetic mechanisms of arthrofibrosis.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
M. Motiur Rahman, Sheuli Afroz, Subha Arthur, Uma Sundaram
Summary: This study demonstrates that mast cell mediators likely inhibit Cl:HCO3 exchange in Inflammatory Bowel Disease (IBD), leading to electrolyte malabsorption and diarrhea. Treatment with a mast cell stabilizer, ketotifen, restores Cl:HCO3 exchange activity in SAMP1 mice, alleviating the symptoms of IBD.
Article
Gastroenterology & Hepatology
Hanife Yurdakul Ertan, Gunnur Ozbakis Dengiz, Figen Barut, Yonca Yilmaz Urun, Murat Can, Shemsu Umer Hussen, Yucel Ustundag
Summary: The study aimed to compare the effects of cromolyn sodium and other medications on cholestatic pruritus and related parameters in an experimental cholestasis model. Cromolyn sodium showed significant improvements in serum histamine and autotaxin levels, total bile acids, bilirubin, and biliary enzymes compared to the control group. Furthermore, it demonstrated promising antipruritic efficacy and histopathological recovery. Peribiliary mast cells were found to produce autotaxin, an important pruritogenic signal in cholestasis.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Instruments & Instrumentation
Shereen Kesserwan, Li Mao, Roshanak Sharafieh, Donald L. Kreutzer, Ulrike Klueh
Summary: The study focused on stabilizing mast cells to mitigate the inflammatory response caused by insulin phenolic preservatives, using Cromolyn sodium (CS). Results showed that CS can reduce inflammation triggered by insulin phenolic preservatives, potentially extending the longevity of insulin infusion sets. Further research may confirm the importance of mast cells in insulin infusion therapy through different models.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
David Lopez-Perez, Anais Redruello-Romero, Jesus Garcia-Rubio, Carlos Arana, Luis A. Garcia-Escudero, Francisco Tamayo, Jose D. Puentes-Pardo, Sara Moreno-SanJuan, Javier Salmeron, Armando Blanco, Julio Galvez, Josefa Leon, Angel Carazo
Summary: Type 2 diabetes is a global health issue caused by obesity and sedentary lifestyle. Inflammation significantly impacts white adipose tissue function, leading to reduced mast cell numbers in T2D patients, especially in omental white adipose tissue.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Inga Kavazovic, Mia Krapic, Ammarina Beumer-Chuwonpad, Bojan Polic, Tamara Turk Wensveen, Niels A. Lemmermann, Klaas P. J. M. van Gisbergen, Felix M. Wensveen
Summary: Type 2 diabetes leads to impaired antiviral and anticancer capacity of memory CD8 T cells due to hyperglycemia, rather than hyperinsulinemia, in the context of obesity.
Article
Endocrinology & Metabolism
David Lopez-Perez, Anais Redruello-Romero, Jesus Garcia-Rubio, Carlos Arana, Luis A. Garcia-Escudero, Francisco Tamayo, Javier Salmeron, Julio Galvez, Josefa Leon, Angel Carazo
Summary: The paradigm of mast cells in type 2 diabetes is changing. Research has found that mast cells, once considered harmful inflammatory cells, play important roles in adipose tissue homeostasis. A study measuring the surface expression of four proteins on mast cells in the adipose tissue of obese patients with different stages of diabetes found that type 2 diabetes affects mast cells more severely in omental adipose tissue than in subcutaneous adipose tissue.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maho Tsuchiya, Kensuke Fukushima, Ken Takata, Yoshihisa Ohashi, Katsufumi Uchiyama, Naonobu Takahira, Hiroki Saito, Ayumi Tsukada, Gen Inoue, Masashi Takaso, Kentaro Uchida
Summary: Research investigated the expression of tryptase genes in the synovium of overweight hip osteoarthritis (HOA) patients. It was found that the expression of TPSB2 and TPSD1 was increased in the synovium of overweight HOA patients compared to normal weight patients. However, there was no significant difference in the expression of these genes between the MC-RF of the two groups. This study highlights the need for further investigation into the role of tryptase in the relationship between increasing BMI and HOA pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Guido H. Falduto, Annika Pfeiffer, Andrea Luker, Dean D. Metcalfe, Ana Olivera
Summary: Mast cells are tissue-resident immune cells that play important roles in allergic inflammation through IgE-mediated mechanisms, but also have antibody-independent biological functions. Recent research has shed light on the diverse roles of mast cells in health and disease, as well as potential novel therapeutic approaches targeting mast cell activity.
PHARMACOLOGY & THERAPEUTICS
(2021)