Article
Public, Environmental & Occupational Health
Himanshu Nayak, Rajendra Gadhavi, Bhavin Solanki, Bhagyalaxmi Aroor, Hemant Gameti, Kalpita S. Shringarpure, Jayun Joshi, Zuveriya Kazi
Summary: This study aimed to implement a community-based screening and awareness-raising project for gestational diabetes in Ahmedabad, India. By training medical personnel to screen pregnant women, a high prevalence of gestational diabetes was found, indicating the need for implementing this project on a larger scale.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2022)
Article
Medicine, General & Internal
Teresa A. Hillier, Kathryn L. Pedula, Keith K. Ogasawara, Kimberly K. Vesco, Caryn E. S. Oshiro, Suzanne L. Lubarsky, Jan Van Marter
Summary: In this study comparing one-step screening with two-step screening for gestational diabetes mellitus, the one-step approach resulted in more diagnoses of gestational diabetes mellitus but did not have a significant impact on the incidence of adverse perinatal and maternal outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Fahimeh Ramezani Tehrani, Samira Behboudi-Gandevani, Farshad Farzadfar, Farhad Hosseinpanah, Farzad Hadaegh, Davood Khalili, Masoud Soleymani-Dodaran, Majid Valizadeh, Mehrandokht Abedini, Maryam Rahmati, Razieh Bidhendi Yarandi, Farahnaz Torkestani, Zahra Abdollahi, Marzieh Bakhshandeh, Mehdi Zokaee, Mina Amiri, Farzam Bidarpour, Mehdi Javanbakht, Iraj Nabipour, Ensieh Nasli Esfahani, Afshin Ostovar, Fereidoun Azizi
Summary: This study compared the impact of different GDM screening criteria on maternal and neonatal outcomes and found that less strict criteria were not inferior to other criteria in terms of adverse outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Karina W. Davidson, Michael J. Barry, Carol M. Mangione, Michael Cabana, Aaron B. Caughey, Esa M. Davis, Katrina E. Donahue, Chyke A. Doubeni, Martha Kubik, Li Li, Gbenga Ogedegbe, Lori Pbert, Michael Silverstein, James Stevermer, Chien-Wen Tseng, John B. Wong
Summary: Gestational diabetes is a common condition during pregnancy in the US, with significant risks for both mothers and infants. The USPSTF recommends screening for gestational diabetes at 24 weeks of gestation or after to improve outcomes for both mother and fetus, but finds insufficient evidence to recommend screening before 24 weeks.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Medicine, General & Internal
Lore Raets, Kaat Beunen, Katrien Benhalima
Summary: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide, and screening and treatment in early pregnancy still lack consensus. Observational studies show varying results in detecting GDM early, with ongoing large RCTs to determine appropriate strategies and benefits. There is also limited evidence on the sensitivity of HbA1c in early pregnancy, requiring further research.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Olga Buerger, Tania Elger, Antonia Varthaliti, Argyro Syngelaki, Alan Wright, Kypros H. Nicolaides
Summary: In this study, we found that maternal characteristics and medical history can be used to predict the risk of Gestational Diabetes Mellitus (GDM), with a higher risk in twin pregnancies. Factors such as maternal age, weight, family history, racial background, and conception method all influence the risk of GDM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Hongying Liu, Aizhong Liu, Atipatsa C. Kaminga, Judy McDonald, Shi Wu Wen, Xiongfeng Pan
Summary: This meta-analysis indicates the presence of abnormal concentrations of various chemokines in patients with GDM, which are closely associated with the development of GDM. Additionally, the subgroup analysis highlights the importance of investigating the potential mechanisms underlying this association to develop individualized clinical and therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Matladi Masete, Stephanie Dias, Nompumelelo Malaza, Sumaiya Adam, Carmen Pheiffer
Summary: Maternal diabetes, especially pregestational type 1 and type 2 diabetes, is associated with more frequent and severe pregnancy complications compared to gestational diabetes. Recent studies have shown the potential role of miRNAs in the pathophysiology of pregnancy-related disorders, including diabetes. However, there is a lack of miRNA profiling studies in pregnancies complicated by pregestational diabetes, highlighting the need for further research in this area.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Bachuki Shashikadze, Florian Flenkenthaler, Jan B. Stoeckl, Libera Valla, Simone Renner, Elisabeth Kemter, Eckhard Wolf, Thomas Froehlich
Summary: Maternal diabetes can have a significant impact on the health of offspring, potentially leading to increased birth weight and metabolic disorders in later life, making early diagnosis and prevention challenging. Omics technologies allow comprehensive investigation of the effects of maternal diabetes on offspring and may help identify diagnostic biomarkers and support the development of preventive and therapeutic strategies.
Article
Environmental Sciences
Waleed M. Aldahmash, Saleh H. Alwasel, Khaldoon Aljerian
Summary: Gestational diabetes mellitus poses significant risks to both the developing fetus and the mother, increasing the risk of maternal complications during pregnancy and later development of type 2 diabetes mellitus and cardiovascular disease. The study found that placental vasculopathies on both the maternal and fetal sides were significantly increased in the GDM group, indicating histopathological changes induced by GDM in the full-term placenta.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Olimpia Mora-Janiszewska, Anna Faryniak-Zuzak, Dorota Darmochwal-Kolarz
Summary: Gestational diabetes mellitus (GDM) is a significant global problem that induces diabetogenic and obesogenic changes in an offspring's DNA through epigenetic mechanisms. Alterations in microbiota play a crucial role in this process. Identification of specific epigenetic marks may provide key solutions for personalized medicine. This manuscript summarizes available data on epigenetic changes among women with GDM and their offspring, in relation to microbiome alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Huifeng Shi, Xiaoli Gong, Qing Sheng, Xiang Li, Ying Wang, Tianchen Wu, Yangyu Zhao, Yuan Wei
Summary: This study found an association between vitamin E (VE) levels and gestational diabetes mellitus (GDM) in pregnant women. Low first-trimester VE levels and subsequent decrease in VE during pregnancy were related to increased risk of GDM. These findings suggest the importance of consuming VE-rich foods and appropriate VE supplementation to prevent GDM in pregnant women with low baseline VE levels.
Review
Endocrinology & Metabolism
Caro Minschart, Kaat Beunen, Katrien Benhalima
Summary: Gestational diabetes mellitus (GDM) is a common medical complication during pregnancy, with inconsistent screening and diagnostic practices worldwide. Early pregnancy screening for GDM remains controversial, with conflicting results on its benefits. Implementing the one-step International Association of Diabetes and Pregnancy Study Groups (IADPSG) screening strategy at 24-28 weeks may significantly increase the prevalence of GDM.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Public, Environmental & Occupational Health
Xiuting Mo, Ruoyan Gai Tobe, Yoshimitsu Takahashi, Naoko Arata, Tippawan Liabsuetrakul, Takeo Nakayama, Rintaro Mori
Summary: This study aimed to find evidence of the cost-effectiveness of gestational diabetes mellitus (GDM) screening and assessed the quality of current economic evaluations. Most studies found GDM screening to be cost-effective, though uncertainties remain due to many factors. The quality assessment identified weaknesses in the economic evaluations in terms of integrating existing data, measuring costs and consequences, analyzing perspectives, and adjusting for uncertainties.
JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Medicine, General & Internal
Robert Modzelewski, Magdalena Maria Stefanowicz-Rutkowska, Wojciech Matuszewski, Elzbieta Maria Bandurska-Stankiewicz
Summary: Gestational diabetes mellitus is the most common medical complication in pregnancy, affecting approximately 15% of pregnancies worldwide. It increases the risk of complications and may lead to the development of type 2 diabetes in both the mother and infant. The increasing incidence of GDM also poses a significant economic burden.
JOURNAL OF CLINICAL MEDICINE
(2022)