Article
Health Care Sciences & Services
Nadine E. Andrew, David Ung, Muideen T. Olaiya, Lachlan L. Dalli, Joosup Kim, Leonid Churilov, Vijaya Sundararajan, Amanda G. Thrift, Dominique A. Cadilhac, Mark R. Nelson, Natasha A. Lannin, Rebecca Barnden, Velandai Srikanth, Monique F. Kilkenny
Summary: This study aims to evaluate the effectiveness of government-funded chronic disease management policies on long-term outcomes (survival, hospital presentations, and preventive medication adherence) in patients with stroke/Transient Ischemic Attack (TIA). The results showed that government-funded chronic disease management policies significantly improved the long-term survival rate of patients with stroke/TIA.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Multidisciplinary Sciences
Michael Falk Hvidberg, Anne Frolich, Sanne Lykke Lundstrom, Nina Kamstrup-Larsen
Summary: This study provides estimates of multimorbidity means and associated prevalence rates using real-world data from the Danish population. The findings highlight the high prevalence of multimorbidity in adults and its importance for future healthcare planning. The data offer essential information for differentiated treatments and research in various areas.
Article
Rheumatology
Mehmet Hocaoglu, Maria O. Valenzuela-Almada, Jesse Y. Dabit, Shirley-Ann Osei-Onomah, Baptiste Chevet, Rachel E. Giblon, Ladan Zand, Fernando C. Fervenza, Charles G. Helmick, Cynthia S. Crowson, Ali Duarte-Garcia
Summary: This study examined the epidemiology of lupus nephritis (LN) in a specific region of the US over a 4-decade period. It found that the incidence and prevalence of LN increased over time, with female and non-Hispanic White individuals being more affected. LN patients had a higher mortality rate and a significant risk of developing end-stage renal disease (ESRD).
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Nader Al-Dewik, Muthanna Samara, Salma Younes, Rana Al-jurf, Gheyath Nasrallah, Sawsan Al-Obaidly, Husam Salama, Tawa Olukade, Sara Hammuda, Neil Marlow, Mohamed Ismail, Taghreed Abu Nada, M. Walid Qoronfleh, Binny Thomas, Ghassan Abdoh, Palli Valapila Abdulrouf, Thomas Farrell, Mai Al Qubaisi, Hilal Al Rifai
Summary: This study aimed to assess the incidence, risk factors, and outcomes of major congenital anomalies (CAs) in Qatar. The study found that the incidence of any CA among live births in Qatar was 1.3%, with cardiovascular system (CVS) anomalies being the most common. Multiple pregnancies, parity, and maternal BMI were associated with specific CAs. CAs were significantly associated with high rates of caesarean deliveries, low Apgar scores, in-hospital mortality, and neonatal intensive care unit admission.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
S. Lofvendahl, J. M. Norlin, M. Schmitt-Egenolf
Summary: The study estimated the prevalence and incidence of palmoplantar pustulosis (PPP) in the Swedish general population, finding that population-based prevalence may be larger than previously estimated, but the estimates were sensitive to the criteria used for PPP cases.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Qiu-Yu Cai, Kun Tan, Xue-Li Zhang, Xu Han, Jing-Ping Pan, Zhi-Yin Huang, Cheng-Wei Tang, Jing Li
Summary: The incidence of CP in Sichuan Province, China is increasing, with an average annual incidence rate of 6.81 per 100000 person-years.The most common comorbidity in CP patients is diabetes. The number of CP-related hospitalizations and the hospitalization costs have been increasing over the years.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Jens Kjeldsen, Jan Nielsen, Torkell Ellingsen, Torben Knudsen, Rasmus Gaardskaer Nielsen, Michael Due Larsen, Ken Lund, Bente Mertz Norgard
Summary: The study found that hospitalized patients with COVID-19 and chronic inflammatory diseases did not have significantly increased length of hospital stay, had the same need for respiratory support devices (such as CPAP and mechanical ventilation), and had similar mortality rates compared to patients hospitalized with COVID-19 and no chronic inflammatory diseases.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Dermatology
Sofia Lofvendahl, Jenny M. Norlin, Marcus Schmitt-Egenolf
Summary: This study estimated the prevalence and incidence of generalized pustular psoriasis (GPP) in the Swedish general population, as well as the prevalence of psoriasis vulgaris within the GPP population. The results indicated that the estimated GPP population in Sweden falls within the range of previous estimates, but the estimates were sensitive to the criteria used to define GPP cases.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Nutrition & Dietetics
Yina Fang, Hwasun Lee, Serhim Son, Sewon Oh, Sang-Kyung Jo, Wonyong Cho, Myung-Gyu Kim
Summary: Despite the global market of dietary supplements, the impact of these supplements on kidney disease remains uncertain. A study in Korea analyzed data from over 13,000 adults and found a significant association between dietary supplements and chronic kidney disease (CKD). Vitamin and mineral intake was the most common type of supplement, followed by omega-3 fatty acids and ginseng. Those who consumed amino acids and proteins, ginseng and red ginseng, and herbal medicine had a higher prevalence of CKD, while probiotic supplement users had a lower prevalence. Further research is needed to understand the specific effects of each supplement on CKD.
Article
Endocrinology & Metabolism
Juan P. Gonzalez-Rivas, Jeffrey Mechanick, Maria M. Infante-Garcia, Jose R. Medina-Inojosa, Iuliia Pavlovska, Ota Hlinomaz, Petr Zak, Sarka Kunzova, Ramfis Nieto-Martinez, Maria Skladana, Jan Broz, Jose Pantaleon Hernandez, Francisco Lopez-Jimenez, Gorazd B. Stokin
Summary: The study found that 69.4% of the population had Dysglycemia-Based Chronic Disease (DBCD), with each stage being associated with traditional cardiometabolic risk factors, suggesting common pathophysiologic mechanisms and a potential for early preventive care. Individuals with lower educational levels and income were more likely to develop DBCD.
ENDOCRINE PRACTICE
(2021)
Article
Public, Environmental & Occupational Health
Sophie A. Korenhof, Ellen V. Rouwet, Liset E. M. Elstgeest, Irene N. Fierloos, Siok Swan Tan, Marta M. Pisano-Gonzalez, An L. D. Boone, Yves-Marie Pers, Alberto Pilotto, Monica Lopez-Ventoso, Isabel Diez Valcarce, Xuxi Zhang, Hein EFFICHRONIC Consortium Hein Raat, Hein Raat
Summary: This study evaluated the effects of a 6-week Chronic Disease Self-Management Program (CDSMP) on self-efficacy, mental health, health-related quality of life (HR-QoL), and health responsibilities among vulnerable populations with chronic disease. The results showed that the intervention improved self-efficacy, mental health, HR-QoL, and health responsibilities for patients with chronic conditions, but did not significantly impact dietary habits, physical activity, substance use, and sleep and fatigue. For caregivers without a chronic condition, only doctor visits significantly decreased.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Johanna Kausto, Kia Gluschkoff, Jarno Turunen, Sanna Selinheimo, Laura Peutere, Ari Vaananen
Summary: This study found that starting statutory rehabilitative psychotherapy may decrease the risk of work disability related to depression or anxiety, showing a positive impact on reducing mental health-related work disability. The effect was most significant in the older age group.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Medicine, Research & Experimental
Tobias Kussel, Torben Brenner, Galina Tremper, Josef Schepers, Martin Lablans, Kay Hamacher
Summary: MainSEL is a secure and privacy-preserving record linkage framework that enables statistical feasibility estimations for medical research, especially in the field of rare diseases. It achieves practical runtimes, improved security guarantees, and easy deployment in clinical IT environments. Real-world testing has shown its wide applicability and usefulness for medical researchers.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Esperance A. K. Schaefer
Summary: Despite efforts to improve screening for CHB in high-risk populations and provide care for those with chronic infection in the United States, data shows that a large proportion of at-risk individuals remain untested and only a minority of those with chronic infection receive long-term care. Additionally, even among patients being treated for CHB, only a small minority undergo basic testing and screening for disease staging and complications.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Masanori Ito, Aya Sugiyama, Megumi Mino, Masaomi Kodama, Yuko Nagaoki, Kanon Abe, Hirohito Imada, Serge Ouoba, E. Bunthen, Ko Ko, Tomoyuki Akita, Takayuki Harakawa, Toru Sako, Kazuaki Chayama, Junko Tanaka
Summary: This study investigated the prevalence of Helicobacter pylori infection in a Japanese general population using large-scale resident-register-based sampling. The results showed a decrease in the prevalence of H. pylori infection in younger subjects in both rural and urban areas.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Shigeo Shimose, Atsushi Hiraoka, Andrea Casadei-Gardini, Tsubasa Tsutsumi, Dan Nakano, Hideki Iwamoto, Fujimasa Tada, Margherita Rimini, Masatoshi Tanaka, Takuji Torimura, Hideya Suga, Hideko Ohama, Valentina Burgio, Takashi Niizeki, Etsuko Moriyama, Hiroyuki Suzuki, Tomotake Shirono, Yu Noda, Naoki Kamachi, Masahito Nakano, Ryoko Kuromatsu, Hironori Koga, Takumi Kawaguchi
Summary: This study evaluated the impact of MAFLD on the efficacy of lenvatinib in treating HCC. The results showed that MAFLD was a beneficial factor for survival in HCC patients treated with lenvatinib, especially in those with non-viral HCC.
HEPATOLOGY RESEARCH
(2023)
Article
Environmental Sciences
Claudio Gariazzo, Matteo Renzi, Alessandro Marinaccio, Paola Michelozzi, Stefania Massari, Camillo Silibello, Giuseppe Carlino, Paolo Giorgi Rossi, Sara Maio, Giovanni Viegi, Massimo Stafoggia
Summary: This study evaluated the association between daily air pollution and cause-specific mortality in 8092 municipalities in Italy. The results showed a positive association between PM10 and PM2.5 and mortality from natural, cardiovascular, cardiac, respiratory, and nervous system causes. NO2 was positively associated with respiratory and metabolic mortality. These findings highlight the potential health hazards of air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Margherita Rimini, Carles Fabregat-Franco, Mara Persano, Valentina Burgio, Francesca Bergamo, Monica Niger, Mario Scartozzi, Ilario Giovanni Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Summary: This study investigated the prognostic impact of IDH1 mutations in patients with advanced iCCA after progression on first-line therapies. The presence of IDH1 mutations was associated with worse overall survival and worse objective response rate in second-line therapy. IDH1 mutations were confirmed as an independent negative prognostic factor.
Article
Oncology
Mara Persano, Margherita Rimini, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Jaekyung Cheon, Fabian Finkelmeier, Ho Yeong Lim, Jose Presa, Gianluca Masi, Changhoon Yoo, Sara Lonardi, Tiziana Pressiani, Fabio Piscaglia, Takashi Kumada, Lorenza Rimassa, Mario Scartozzi, Stefano Cascinu, Andrea Casadei-Gardini
Summary: This study aimed to establish a novel prognostic index for hepatocellular carcinoma (HCC) patients treated with atezolizumab plus bevacizumab (ABE) in the first-line setting. Using recursive partitioning analysis (RPA), the patients were categorized into high-risk, intermediate-risk, and low-risk groups. The study concluded that the ABE index allows for easy stratification of HCC patients undergoing first-line treatment with ABE.
ANTICANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Alessandro Vanoli, Camilla Guerini, Giovanni Arpa, Catherine Klersy, Federica Grillo, Andrea Casadei Gardini, Gert De Hertogh, Marc Ferrante, Annick Moens, Daniela Furlan, Fausto Sessa, Erica Quaquarini, Marco Vincenzo Lenti, Giuseppe Neri, Maria Cristina Macciomei, Matteo Fassan, Stefano Cascinu, Marco Paulli, Rondell Patrell, Antonio Di Sabatino
Summary: This study suggests that mismatch repair deficiency is associated with a better prognosis in stage III small bowel adenocarcinoma (SBA) patients. Testing for mismatch repair status is important for prognostic stratification in these patients.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Infectious Diseases
Massimo Vicentini, Francesco Venturelli, Pamela Mancuso, Eufemia Bisaccia, Alessandro Zerbini, Marco Massari, Andrea Cossarizza, Sara De Biasi, Patrizio Pezzotti, Emanuela Bedeschi, Paolo Giorgi Rossi
Summary: This study evaluated the risk of SARS-CoV-2 reinfection based on vaccination status, predominant variant, and time after initial infection. The results showed that two doses of vaccine and prior infection could reduce the risk of reinfection, while natural immunity had low protection against the Omicron BA.1 variant. Combined vaccination and natural immunity were more effective in preventing reinfection than either alone.
Review
Oncology
Carlo Bosi, Margherita Rimini, Andrea Casadei-Gardini, Giorgio Ercolani
Summary: Surgical resection and radiofrequency ablation are preferred options for early-stage hepatocellular carcinoma (HCC), and understanding the causes of recurrence and identifying its predictors are priorities in HCC research. Recent insights suggest that vascular invasion and angiogenesis play key roles in HCC recurrence, and agents targeting these hallmarks should be prioritized in early-stage HCC clinical trials. Patient enrollment in clinical trials should also consider the biological characteristics of their inherent disease.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Gastroenterology & Hepatology
Giuseppe Vanella, Giuseppe Dell'Anna, Gabriele Capurso, Patrick Maisonneuve, Michiel Bronswijk, Stefano Crippa, Domenico Tamburrino, Marina Macchini, Giulia Orsi, Andrea Casadei-Gardini, Luca Aldrighetti, Michele Reni, Massimo Falconi, Schalk van der Merwe, Paolo Giorgio Arcidiacono
Summary: This study aimed to report on the clinical outcomes of EUS-GE in a prospective cohort study and compared it with ES. The results showed that EUS-GE demonstrated excellent efficacy in treating mGOO, and had several clinically significant advantages over ES.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Oncology
Margherita Rimini, Mara Persano, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Jaekyung Cheon, Fabian Finkelmeier, Ho Yeong Lim, Jose Presa, Francesca Salani, Sara Lonardi, Fabio Piscaglia, Takashi Kumada, Naoya Sakamoto, Hideki Iwamoto, Tomoko Aoki, Hong Jae Chon, Vera Himmelsbach, Marta Schirripa, Margarida Montes, Caterina Vivaldi, Caterina Solda, Atsushi Hiraoka, Takuya Sho, Takashi Niizeki, Naoshi Nishida, Christoph Steup, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Valentina Burgio, Mario Scartozzi, Stefano Cascinu, Andrea Casadei-Gardini
Summary: This study analyzed the efficacy of atezolizumab plus bevacizumab versus Lenvatinib as first-line treatment for patients with advanced hepatocellular carcinoma (HCC) and Child-Pugh (CP) class B. The results showed that Lenvatinib had a longer overall survival (OS) compared to atezolizumab plus bevacizumab in patients with CP B HCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Carmen B. Visioli, Paolo Giorgi Rossi, Paola Armaroli, Anna Iossa, Raffaella Rizzolo, Luigina A. Bonelli, Ezio Venturino, Francesca M. Carozzi, Simonetta Bisanzi, Laura De Marco, Livia Giordano, Elisa Camussi, Annarosa Del Mistro, Marco Zappa
Summary: This study evaluated the participation in cervical cancer screening at the age of 25 among girls in Italy who were offered human papillomavirus vaccination at the age of 15 to 16 years. The results showed that vaccinated women had higher participation rates in screening, and active policies targeting the unvaccinated and unscreened population, especially non-native women, are needed to accelerate cervical cancer elimination in Italy.
JOURNAL OF MEDICAL SCREENING
(2023)
Article
Environmental Sciences
Silvia Panunzi, Pierpaolo Marchetti, Massimo Stafoggia, Chiara Badaloni, Nicola Caranci, Kees de Hoogh, Paolo Giorgi Rossi, Linda Guarda, Francesca Locatelli, Marta Ottone, Caterina Silocchi, Paolo Ricci, Alessandro Marcon
Summary: In this cohort study, it was found that exposure to pollutants such as nitrogen dioxide, formaldehyde, and particulate matter is associated with adverse respiratory and allergic outcomes among residents in the Viadana district in northern Italy. These findings highlight the importance of taking preventive measures to improve air quality, particularly targeting emissions from industrial activities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Rheumatology
Luigi Boiardi, Elena Galli, Pierluigi Macchioni, Francesco Muratore, Giulia Klinowski, Gene G. Hunder, Massimiliano Casali, Giulia Besutti, Lucia Spaggiari, Annibale Versari, Stefania Croci, Pamela Mancuso, Paolo Giorgi Rossi, Chiara Marvisi, Carlo Salvarani
Summary: This study compared the clinical and imaging characteristics of Italian patients with Takayasu arteritis (TAK) and large vessel-giant cell arteritis (LV-GCA). The results showed that LV-GCA patients had a higher prevalence of males and more frequently presented with cranial symptoms, fever, polymyalgia rheumatica, and hypertension. TAK patients had longer delay to diagnosis and presented more frequently with loss of pulses of large arteries, vascular bruits, limb claudication, myocardial infarction/angina, and hypertension induced by renal artery stenosis. In terms of treatment, TAK patients received higher doses of prednisone, had longer duration of prednisone therapy, and received traditional immunosuppressants and biological agents more frequently. Flares were more frequent in TAK patients, while no differences were observed for long-term remission. New vascular procedures were more frequently performed in TAK patients. Imaging at diagnosis showed that TAK patients had more frequent vascular stenosis/occlusion and a higher number of vessels with structural damage, while LV-GCA patients had a higher number of inflamed vessels.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Hematology
Chiara Marraccini, Davide Schiroli, Pamela Mancuso, Giuseppe Molinari, Agnese Razzoli, Gaia Gavioli, Tommaso Fasano, Roberto Baricchi, Paolo Giorgi Rossi, Lucia Merolle
Summary: Plasmapheresis donation is generally safe, but its long-term effects remain unclear. The amount of anticoagulant used in the process varies, and it is influenced by factors such as hematocrit, total blood processed, plasma collected, and donor characteristics. This study found that the unit weight setting and sex have an impact on anticoagulant distribution and post-donation citrate metabolism.
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2023)
Article
Environmental Sciences
Francesco Venturelli, Pamela Mancuso, Massimo Vicentini, Marta Ottone, Cinzia Storchi, Francesca Roncaglia, Eufemia Bisaccia, Chiara Ferrarini, Patrizio Pezzotti, Paolo Giorgi Rossi
Summary: This study aimed to assess whether the effect of high temperature on mortality differed in COVID-19 survivors and naive individuals. Data from summer mortality and COVID-19 surveillances were used. The results showed a 3.8% excess risk in summer 2022 compared to 2015-2019, with a 20% increase in the last fortnight of July, the period with the highest temperature. The increase in mortality rates during this period was higher among naive individuals compared to COVID-19 survivors. Time series analysis confirmed the association between temperatures and mortality in naive individuals but not in COVID-19 survivors.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Olivera Djuric, Paolo Giorgi Rossi, Elena Camelia Ivanciu, Salvatore Cardellicchio, Chiara Cresci, Laura Carozzi, Francesco Pistelli, Valentina Bessi, Patrizia Gai, Valentina Galli, Giacomo Lavacchini, Claudia Bricci, Giuseppe Gorini, Sandra Bosi, Eugenio Paci, Working Grp
Summary: This study aimed to assess the motivation to quit smoking and the acceptability of a lung cancer screening program among people attending smoking cessation programs. A survey involving 197 participants was conducted, and questionnaires and information sheets about the benefits and harms of the screening program were distributed during the courses. The majority of participants expressed a favorable perception of the screening program, despite concerns about potential harms.
PREVENTIVE MEDICINE REPORTS
(2023)
