Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 100, Issue 3, Pages E66-E69Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2013.03.034
Keywords
DPP-4 inhibitor; Type 2 diabetes mellitus; Pancreatic amylase; Lipase; Pancreatitis
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Funding
- Grants-in-Aid for Scientific Research [23591297, 24591312] Funding Source: KAKEN
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A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. We evaluated the DPP-4i effects on pancreatic amylase and lipase activity in patients with type 2 diabetes. These enzymes were slightly but significantly increased, suggesting DPP-4i cause a low-grade inflammatory change in the exocrine pancreas. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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