Article
Urology & Nephrology
Kotaro Haruhara, Toru Suzuki, Hiromichi Wakui, Kengo Azushima, Daisuke Kurotaki, Wataru Kawase, Kazushi Uneda, Ryu Kobayashi, Kohji Ohki, Sho Kinguchi, Takahiro Yamaji, Ikuma Kato, Kenichi Ohashi, Akio Yamashita, Tomohiko Tamura, Nobuo Tsuboi, Takashi Yokoo, Kouichi Tamura
Summary: Tubular ATRAP-mediated modulation of angiotensin II type 1 receptor signaling affects glomerular manifestations of diabetic nephropathy.
KIDNEY INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Chang-e Ma, Pei Yu, Wei Wei, Xiao-qin Chen
Summary: The combination of ARB and TGs in the treatment of DN has shown promising results, providing helpful evidence for clinical practice. The meta-analysis aims to enhance existing literature and improve guidance in clinical settings.
Article
Hematology
Julian Kamhieh-Milz, Lei Chen, Claudia Goettsch, Anna Maria Pfefferkorn, Anja Hofmann, Coy Brunssen, Gregor M. Mueller, Thomas Walther, Muhammad Imtiaz Ashraf, Guido Moll, Henning Morawietz, Janusz Witowski, Rusan Catar
Summary: This study analyzed the mechanism by which NOX2 contributes to Ang II-induced ET-1 production in human microvascular endothelial cells. The results showed that high-fat diet increased the expression of Ang II and ET-1 in wild-type mice, but not in Nox2-deficient mice. In vitro experiments revealed that Ang II promoted NOX2 expression through induction of the Oct-1 protein and increased production of superoxide anions. Inhibition of Oct-1 and superoxide attenuated Ang II-induced ET-1 production.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Ralmony de Alcantara Santos, Vinicius Guzzoni, Kleiton Augusto Santos Silva, Danielle Sanches Aragao, Rodolfo de Paula Vieira, Nadia Bertoncello, Nestor Schor, Flavio Aimbire, Dulce Elena Casarini, Tatiana Sousa Cunha
Summary: The study aimed to investigate the effects of resistance training on renal renin-angiotensin system components and inflammatory mediators in diabetic rats. The results showed that resistance training improved kidney function in diabetic rats by modulating intrarenal RAS towards the ACE2/Ang 1-7 axis and reducing inflammatory cytokines levels.
Review
Biochemistry & Molecular Biology
Claudine Moratal, Audrey Laurain, Mourad Naimi, Thibault Florin, Vincent Esnault, Jaap G. Neels, Nicolas Chevalier, Giulia Chinetti, Guillaume Favre
Summary: Diabetic nephropathy is characterized by proteinuria, renal dysfunction, renal fibrosis, and infiltration of macrophages derived from peripheral monocytes. Research focuses on the control of monocyte recruitment and modulation of macrophage polarization in the context of diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Kengo Azushima, Jean -Paul Kovalik, Takahiro Yamaji, Jianhong Ching, Tze Wei Chng, Jing Guo, Jian-Jun Liu, Mien Nguyen, Rashidah Binte Sakban, Simi E. George, Puay Hoon Tan, Su Chi Lim, Susan B. Gurley, Thomas M. Coffman
Summary: This study found that in a mouse model of diabetic nephropathy, there were elevated lactate levels and impaired energy metabolism in the kidneys. Treatment with an angiotensin-receptor blocker (ARB) improved these abnormalities. Increased expression of lactate dehydrogenase isoforms, specifically LdhA in the proximal tubule, was also observed. Urinary lactate levels were found to be predictive of clinical outcomes in diabetic patients with kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Biology
Jin Shu, Jue Shi, Yiwen Gu, Lei Deng, Chen Zhao, Chun Wu, Jiachen Zhao, Haiya Wang, Li Jin
Summary: This study aimed to explore the effects of TIMP-1 on LC-mediated regulation of AngII-induced MF and its underlying mechanisms. AngII treatment upregulated Axl, alpha-SMA, and MMP3 expression and downregulated STAT4 and TIMP1 expression. LC and TIMP-1-OE transfection further suppressed cell viability and migration induced by Ang II and upregulated apoptosis, whereas si-TIMP-1 had the opposite effect. TIMP-1 is therefore a potential therapeutic target for delaying MF progression.
OPEN LIFE SCIENCES
(2023)
Article
Immunology
Sijia Li, Chenguang Zhou, Yinghui Zhu, Zhiwen Chao, Zhiyuan Sheng, Yongxin Zhang, Yuanzheng Zhao
Summary: The study shows that Ferrostatin-1 can effectively protect astrocytes from ferroptosis induced by Angiotensin II, reduce the production of inflammatory factors, and exert protective effects by activating the Nrf2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tilman Pfeffer, Charlotte Wetzel, Philip Kirschner, Maria Bartosova, Tanja Poth, Constantin Schwab, Gernot Poschet, Johanna Zemva, Ruben Bulkescher, Ivan Damgov, Christian Thiel, Sven F. F. Garbade, Kristina Klingbeil, Verena Peters, Claus Peter Schmitt
Summary: Supplementation of carnosine and anserine can effectively reduce diabetic nephropathy in rodents. However, the exact mechanism of their nephroprotective action in diabetes, whether it is through local protection or improved systemic glucose homeostasis, remains uncertain.
Article
Environmental Sciences
Cihan Gul, Mustafa Kelle, Mukadder Baylan, Beran Yokus, Ezel Tasdemir
Summary: Ghrelin is an appetite-enhancing anabolic hormone secreted from the stomach, while Angiotensin II plays an important role in maintaining sodium and potassium levels in body fluids and regulating arterial blood pressure. The study investigated the time-dependent changes in plasma ghrelin and angiotensin II levels during the development and progression of diabetic nephropathy in an experimental rat model, finding that plasma angiotensin and serum creatinine levels increased over time while plasma ghrelin levels decreased during the progression of diabetes and the development of diabetes-related nephropathy.
FRESENIUS ENVIRONMENTAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Mona K. Tawfik, Mohammed M. Keshawy, Samy Makary
Summary: The study demonstrates that the intervention of valsartan in diabetic nephropathy shows renoprotective effects in both early and late stages, reducing the expression of various related factors, improving pathological indicators, and slowing down the progression of renal damage.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Physiology
Haru Nomura, Sanjaya Kuruppu, Niwanthi W. Rajapakse
Summary: Diabetic nephropathy is a common disease leading to end-stage renal disease. Chronic activation of the RAAS contributes to kidney inflammation and fibrosis, resulting in kidney disease. Targeting the reno-protective arm of the RAAS provides potential therapeutic options for improving kidney inflammation and fibrosis in diabetic nephropathy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal
Summary: Angiotensin II (Ang II) is a key component of the renin-angiotensin-aldosterone system and is associated with cardiopathology. High levels of Ang II have been linked to inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. This study evaluated the cellular effects of Ang II on THP-1-derived macrophages, showing that it stimulates differentiation markers and proinflammatory markers while decreasing an M2 marker. Ang II also induces calcium overload, increases reactive oxygen species, and arrests cells in the G1 phase, primarily through the angiotensin II type 1 receptor (AT1R).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Peng Zhou, Chao Yang, Shan Zhang, Zun-Xiang Ke, Dian-Xi Chen, Yi-Qing Li, Qin Li
Summary: The importance of early diagnosis and treatment of diabetes and its cutaneous complications is increasingly recognized. High glucose affects collagen gene expression in human dermal fibroblasts, leading to an imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Inhibiting MMP-2 and MMP-9 can alleviate collagen deposition disorder in the skin of diabetic mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Neha Dagar, Pamelika Das, Priya Bisht, Amit Kumar Taraphdar, Ravichandiran Velayutham, Somasundaram Arumugam
Summary: Diabetic nephropathy is a persistent microvascular problem of diabetes mellitus characterized by elevated albumin excretion in urine and impaired renal function. The pathogenesis is multifactorial and requires novel treatment approaches beyond glucose and blood pressure control.
