Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 98, Issue 3, Pages E32-E35Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2012.09.036
Keywords
Liraglutide; Insulinogenic Index; Early insulin secretion; Glucagon challenge test
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [22790862] Funding Source: KAKEN
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The amelioration of glucose tolerance by liraglutide was associated with a significant improvement of early insulin-response during OGTT. The serum C-peptide response to glucagon challenge strongly correlated with the improvement of the early insulin-response. The C-peptide response to glucagon challenge would be useful to predict therapeutic response to liraglutide. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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