Article
Medicine, General & Internal
Jingjing Zhu, Min Chen, Yuzi Pang, Shumin Li
Summary: This study aims to explore the influence of lifestyle education on T2DM patients with microalbuminuria. By conducting clinical examinations and recording daily dietary intake, it was found that lifestyle education is effective in controlling T2DM and reducing microalbuminuria.
Article
Urology & Nephrology
Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki, Kana Miyake, Masaomi Nangaku, Yasuo Ohashi, Mitsuhiko Noda, Takashi Kadowaki
Summary: The study evaluated the effects of intensified multifactorial intervention on diabetic kidney disease in patients with type 2 diabetes. Results showed a significant reduction in kidney events and progression compared to standard care, indicating the effectiveness of intensified intervention in preventing diabetic kidney disease.
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Mohamed Hassanein, Mick John Kumwenda, Kamel Hemida, Kirstin Clark, Julie Roberts, Carol Pritchard Jones, Sri Gandham, Ahmed Swidan, Hemakumar Mallappa, Peter Hobson
Summary: The study showed that a structured hypertension education program led to a significantly higher percentage of participants achieving the blood pressure target with a reduction in the number of antihypertensive pills needed.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Abdullah Alibrahim, Dalal AlRamadhan, Susmy Johny, Mahdi Alhashemi, Huda Alduwaisan, Maryam Al-Hilal
Summary: The study evaluated the impact of DSME on T2DM patients in Kuwait, showing significant improvement in HbA1c levels over 12 months for patients receiving DSME sessions, especially for young, male, expatriate patients, and those with HbA1c above 7%.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Health Care Sciences & Services
Shiryn D. Sukhram, Gustavo G. Zarini, Lemia H. Shaban, Joan A. Vaccaro, Fatma G. Huffman
Summary: The study found that 21% of Turkish immigrants with type 2 diabetes had microalbuminuria, and the odds of having microalbuminuria were 6.6 times higher in hypertensive individuals compared to normotensive individuals.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Robert Wagner, Martin Heni, Adam G. Tabak, Juergen Machann, Fritz Schick, Elko Randrianarisoa, Martin Hrabe de Angelis, Andreas L. Birkenfeld, Norbert Stefan, Andreas Peter, Hans-Ulrich Haering, Andreas Fritsche
Summary: Analysis of high-risk individuals revealed six distinct subphenotypes of type 2 diabetes, among which three had elevated glycemia levels, with clusters 3 and 5 having imminent diabetes risks.
Article
Health Care Sciences & Services
Filiz Selen, Ulku Polat
Summary: This study demonstrates that web-based education has a significant effect on improving diabetes self-management skills and reducing HbA1c levels in individuals with type 2 diabetes. The results show significant differences between the intervention and control groups.
Article
Endocrinology & Metabolism
Sengul Aydin Yoldemir, Yucel Arman, Murat Akarsu, Ozgur Altun, Mustafa Ozcan, Tufan Tukek
Summary: This study found that changes in blood glucose levels can affect the secretion of endotrophin by adipose tissue, thereby impacting diabetes. The decrease in endotrophin levels was significantly correlated with the decrease in HbA1c levels, and closely related to the decrease in UACR levels. Studies targeting endotrophin may contribute to the diagnosis, treatment, and follow-up of diabetic nephropathy in the future.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Lixia Huo, Hui Li, Ming Zhu, Yang Liu, Lingyan Ren, Jia Hu, Xiaoyi Wang
Summary: This study found that dysbiosis of gut microbiota occurs in early-stage DKD patients, and the reduction of short-chain fatty acid-producing bacteria is associated with the accumulation of TMA and UACR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Endocrinology & Metabolism
Angier Allen, Zohora Iqbal, Abigail Green-Saxena, Myrna Hurtado, Jana Hoffman, Qingqing Mao, Ritankar Das
Summary: This study aims to develop a machine learning algorithm that predicts the stages of diabetic kidney disease within 5 years after diagnosis of type 2 diabetes mellitus.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Public, Environmental & Occupational Health
Xinjun Jiang, Hua Jiang, Libo Tao, Mingzi Li
Summary: The study found that the self-efficacy-focused structured education program is more cost-effective than routine education for patients with type 2 diabetes mellitus in mainland China, as it can increase life expectancy and quality-adjusted life-years, lower cumulative incidences of complications, and save more direct medical costs. Sensitivity analysis showed a 100% probability of the program being cost-effective.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Mardin Rashid, Adrie J. M. Verhoeven, Monique T. Mulder, Reinier Timman, Behiye Ozcan, Yvonne Van Beek-Nieuwland, Lei M. Chow, Roel J. J. M. van de Laar, Willem A. Dik, Eric J. G. Sijbrands, Kirsten A. Berk
Summary: The study did not find that daily intake of 200 mg MOFs for three months had a significant effect on reducing AER and plasma markers of endothelial dysfunction in type 2 diabetes patients with microalbuminuria compared to placebo.
CLINICAL NUTRITION
(2021)
Article
Physiology
Yasufumi Seki, Satoshi Morimoto, Shihori Kimura, Noriyoshi Takano, Kaoru Yamashita, Kanako Bokuda, Nobukazu Sasaki, Daisuke Watanabe, Atsuhiro Ichihara
Summary: Aliskiren monotherapy did not show any superiority to amlodipine monotherapy on VFA, estimated glomerular filtration rates, or urinary albumin excretion in obese or type 2 diabetic hypertensive patients.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Medicine, General & Internal
Emer M. Brady, Catherine Bamuya, David Beran, Jorge Correia, Amelia Crampin, Albertino Damasceno, Melanie J. Davies, M. Hadjiconstantinou, Deirdre Harrington, Kamlesh Khunti, Naomi Levitt, Ana Magaia, Jayna Mistry, Hazel Namadingo, Anne Rodgers, Sally Schreder, Leopoldo Simango, Bernie Stribling, Cheryl Taylor, Ghazala Waheed
Summary: The study showed that delivering a culturally, contextually and linguistically adapted diabetes self-management education program (EXTEND) for type 2 diabetes patients in Malawi and Mozambique is feasible and yielded positive results. Despite challenges in training and program delivery, the approach was found to be effective in similar settings.
Article
Rehabilitation
Vicki L. Johnson, Lindsay Apps, Michelle Hadjiconstantinou, Marian E. Carey, Elizabeth Kreit, Ricky Mullis, Jonathan Mant, Melanie J. Davies
Summary: This study aimed to develop a structured self-management programme to address the unmet long-term needs of stroke survivors. The programme was developed through a systematic process based on evidence and theory, and involved three phases.
DISABILITY AND REHABILITATION
(2023)
Article
Public, Environmental & Occupational Health
Ash Routen, Sophia Abner, Louis S. Levene, Clare L. L. Gillies, Melanie Davies, Samuel Seidu, G. Andre Ng, Kamlesh Khunti
Summary: This study used published data to describe differences in documented and estimated atrial fibrillation (AF) prevalence in general practices in England, and explored predictors of variations in AF prevalence. The results showed that documented AF prevalence was lower than estimated. Practice and population characteristics were found to be associated with variations in AF documentation.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Meeriam Kadicheeni, Jatinder S. Minhas, Briana Coles, Shazia T. Hussain, Kamlesh Khunti, Thompson G. Robinson, David J. Eveson, Amit K. Mistri
Summary: This study aims to assess the mortality rate of TIA patients in a rapid-access clinic. The results showed that the mortality rate was higher following a CV diagnosis, and it was associated with males, older individuals, white ethnicity, and orthostatic hypotension.
CEREBROVASCULAR DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Laura Doblas, Per M. Hagglund, Eduardo Fuentes-Lemus, Michael J. Davies
Summary: This study investigates the modifications of proteins during milk processing and storage, with a focus on oxidation and crosslinking. The research reveals the formation and stability of crosslinks generated by the addition of Cys residues to quinones produced from the oxidation of Tyr residues. The findings provide insights into a novel mechanism of protein crosslink formation and information on the stability of these species, which could serve as markers for protein quality.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Endocrinology & Metabolism
Brenda Bongaerts, Oliver Kuss, Fabrice Bonnet, Hungta Chen, Andrew Cooper, Peter Fenici, Marilia B. Gomes, Niklas Hammar, Linong Ji, Kamlesh Khunti, Jesus Medina, Antonio Nicolucci, Marina V. Shestakova, Hirotaka Watada, Wolfgang Rathmann
Summary: This study aimed to identify different HbA1c trajectories in T2D patients starting second-line glucose-lowering therapy. Four distinct trajectories were found, with most patients achieving stable good or highly improved long-term glycaemic control. However, one-fifth of participants showed moderate or poor glycaemic control during follow-up.
DIABETES OBESITY & METABOLISM
(2023)
Article
Sport Sciences
Alex V. Rowlands, Paddy C. Dempsey, Benjamin Maylor, Cameron Razieh, Francesco Zaccardi, Melanie J. Davies, Kamlesh Khunti, Thomas Yates
Summary: This study examined the association between self-reported walking pace and all-cause mortality (ACM), and found that the association persisted across different categories of accelerometer-assessed physical activity status. The results showed that a higher walking pace was associated with higher physical activity levels and lower risk of all-cause mortality. The findings highlight the importance of both self-reported walking pace and accelerometer-assessed physical activity in predicting mortality risk.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Multidisciplinary Sciences
Murray D. D. Smith, Colin Ridyard, Vanessa Botan, Amanda Brewster, Sally Dunmore, June James, Kamlesh Khunti, Despina Laparidou, Graham Law, Pauline Mountain, Leon Roberts, Elise Rowan, Robert Spaight, Keith Spurr, Aloysius N. N. Siriwardena
Summary: 'Hypos' can strike twice (HS2) is a leaflet-based referral intervention aimed at encouraging patients treated for hypoglycemia to engage with their healthcare providers for better medical management of diabetes, reducing the risk of recurrent hypoglycemia. An economic model comparing HS2 to standard care showed that HS2 resulted in slightly higher NHS costs (average £49.79) compared to standard care (average £40.50) in the two weeks following the initial attack. The probability of no recurrence of hypoglycemia was slightly higher under HS2 (42.4%) compared to standard care (39.4%), indicating a 7.6% reduction in relative risk. The study concludes that, in its current form, HS2 is not cost-effective compared to standard NHS care in reducing the risk of recurrent hypoglycemia within two weeks of an initial attack.
Letter
Medicine, General & Internal
Lauren L. O'Mahoney, Ash Routen, Clare Gillies, Kamlesh Khuntia
Review
Biochemistry & Molecular Biology
Joao M. Anghinoni, Paloma T. Birmann, Marcia J. da Rocha, Caroline S. Gomes, Michael J. Davies, Cesar A. Bruening, Lucielli Savegnago, Eder J. Lenardao
Summary: In this review, the synthesis and bioassays of organic selenium compounds with antioxidant activity in the past five years are discussed, presenting the most active compounds in each series.
Article
Biochemistry & Molecular Biology
Barry A. Borlaug, Dalane W. Kitzman, Melanie J. Davies, Soren Rasmussen, Eric Barros, Javed Butler, Mette Nygaard Einfeldt, G. Kees Hovingh, Daniel Vega Moller, Mark C. Petrie, Sanjiv J. Shah, Subodh Verma, Walter Abhayaratna, Fozia Z. Ahmed, Vijay Chopra, Justin Ezekowitz, Michael Fu, Hiroshi Ito, Malgorzata Lelonek, Vojtech Melenovsky, Julio Nunez, Eduardo Perna, Morten Schou, Michele Senni, Peter van der Meer, Dirk Von Lewinski, Dennis Wolf, Mikhail N. Kosiborod
Summary: In the STEP-HFpEF trial, semaglutide demonstrated positive treatment effects on symptoms, physical limitations, exercise function, and body weight in patients with the obesity phenotype of heart failure with preserved ejection fraction (HFpEF). The results showed that semaglutide consistently improved outcomes across different obesity categories and the magnitude of benefit was directly related to the extent of weight loss.
Article
Health Care Sciences & Services
Sharleen L. O'Reilly, Rachel Laws, Helle Terkildsen Maindal, Helena Teede, Cheryce Harrison, Fionnuala M. McAuliffe, Aisling Geraghty, Cristina Campoy, Mercedes G. Bermudez, Laura Pirhonen, Christy Burden, Anna Davies, Ditte Hjorth Laursen, Timothy Skinner
Summary: This study aims to explore the feasibility and implementation of the B2B&Me intervention and investigate its effectiveness in women at risk of gestational diabetes.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Medicine, Research & Experimental
Edith E. Holloway, Shikha Gray, Jennifer Halliday, Benjamin Harrap, Carolyn Hines, Timothy C. Skinner, Jane Speight, Christel Hendrieckx
Summary: This study examined the feasibility and acceptability of the LISTEN intervention, which provides low-intensity mental health support for adults with diabetes via telehealth. The training for healthcare professionals was successful, and the pilot study showed that LISTEN was acceptable and had potential benefits for adults with diabetes. The findings suggest that adaptations could enhance the delivery and satisfaction of LISTEN.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Obstetrics & Gynecology
Lauren A. Booker, Cheree Fitzgibbon, Jo Spong, Melissa Deacon-Crouch, Danielle L. Wilson, Timothy C. Skinner
Summary: This study found that both rapid and slow cooling pasteurization processes resulted in a significant reduction in melatonin levels in breast milk. Melatonin was still present after pasteurization, suggesting that donor banks should consider circadian timing hormones like melatonin and the time of day breast milk is expressed.
BREASTFEEDING MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Lauren A. Booker, Jo Spong, Brad Hodge, Melissa Deacon-Crouch, Melanie Bish, Jane Mills, Timothy C. Skinner
Summary: This study compared the differences in shift patterns and work-related factors between metropolitan and regional/rural healthcare shift workers and their associations with poor sleep and mental health. The findings revealed that shift workers in metropolitan areas had longer commute times, higher anxiety levels, more workplace accidents, and a higher likelihood of car accidents. Furthermore, work-related factors and sleep quality were related to workplace accidents and medical errors.
AUSTRALIAN JOURNAL OF RURAL HEALTH
(2023)
