Article
Pharmacology & Pharmacy
Md. Ashraful Islam, Faris El-Dahiyat, Ahmed Nouri, Qais Alefan, Atta Abbas Naqvi
Summary: This study aimed to validate the Arabic version of the General Medication Adherence Scale in patients with type 2 diabetes in Jordan. The results obtained suggest that the scale is valid and reliable in measuring adherence to medications in the studied sample of patients with diabetes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nursing
Arraji Maryem, Iderdar Younes, Mourajid Yassmine, Guennouni Morad, Boumendil Karima, Korrida Amal, El Khoudri Noureddine, Ifleh Mohamed, Khalis Mohamed, Mohamed Chahboune
Summary: The objective of this study was to cross-culturally adapt and validate the General Medication Adherence Scale (GMAS) in patients with type-2 diabetes in Morocco. The results showed that the adapted version of the GMAS tool has acceptable psychometric values in the Moroccan context. This means that Moroccan researchers and health professionals can use it to measure adherence among individuals with type-2 diabetes.
Article
Medicine, General & Internal
Abelardo Contreras-Vergara, Sonia Sifuentes-Franco, Sally Haack, Omar Graciano-Machuca, Adolfo Daniel Rodriguez-Carrizalez, Ana Karen Lopez-Contreras, Itzel Viridiana Reyes-Perez, Selene G. Huerta-Olvera
Summary: Pharmaceutical education has a significant impact on medication adherence in patients with Type 2 Diabetes and Systemic Arterial Hypertension, improving their blood glucose and blood pressure control, and increasing their medication adherence.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Endocrinology & Metabolism
Guoqiang Hou, Ziwei Fang, Wenjun Cao, Yan Shi, Xinrong Xu, Mei Han, Jiaxin Dong
Summary: The study aimed to develop a Diabetes Mellitus Treatment Adherence Scale (DMTAS) to assess treatment adherence in patients with diabetes mellitus. After generating an initial item pool and conducting expert review and pilot testing, the final DMTAS included 19 items and six dimensions, showing good validity and reliability. The results of the exploratory factor analysis and confirmatory factor analysis supported the adequacy of the scale.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Yasmine Elhenawy, Reham Abdelmageed, Dalia K. Zaafar, Asmaa W. Abdelaziz
Summary: This study evaluated the psychometric properties of the Arabic version of the four-item Morisky Green Levine Medication Adherence Scale (MGLS-4) as a self-reported measure of adherence to insulin among pediatric patients with T1DM. The results showed that the tool had good reliability and validity.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Multidisciplinary Sciences
NaRen QiMuge, Xu Fang, Baocheng Chang, Dong Mei Li, Yuanyuan Li
Summary: In this study, a medication nonadherence risk prediction model for Chinese type 2 diabetes mellitus patients was established and validated. The model incorporates several factors related to nonadherence and can assist clinicians in predicting the risk of medication nonadherence in patients.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Medicine, General & Internal
Atsedemariam Andualem, Tiliksew Liknaw, Afework Edmealem, Mihretie Gedefaw
Summary: This study aimed to assess adherence to antihypertensive medications among adult hypertensive patients in Dessie Referral Hospital. The study revealed that almost half of the hypertensive patients had good adherence to medication, and factors associated with good adherence included sex, occupational status, knowledge, and self-efficacy. Health education on medication compliance importance and monitoring by health extension workers are recommended.
Article
Health Care Sciences & Services
Jorge Caro-Bautista, Carmen Rodriguez-Blazquez, David Perez-Manchon, Eva Timonet-Andreu, Gloria Carvajal-Carrascal, Alejandra Fuentes-Ramirez, Silvia Corchon, Marta Aranda-Gallardo, Leire Ambrosio
Summary: The study validates a Living with Chronic Illness Scale for a Spanish-speaking T2DM population, proving its adequacy in terms of internal consistency, reliability, and precision. The instrument correlates positively with social support, quality of life, and satisfaction, but shows limitations in confirmatory factor analysis. Further research is needed to investigate its structural validity.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Multidisciplinary Sciences
Walid Al-Qerem, Anan S. Jarab, Mohammad Badinjki, Dana Hyassat, Raghda Qarqaz
Summary: This study found that a large proportion of diabetic patients have moderate adherence, with necessity and concerns about medication being important factors influencing adherence, and education level also impacting medication beliefs.
Article
Nutrition & Dietetics
Adele Bossel, Gerard Waeber, Antoine Garnier, Pedro Marques-Vidal, Vanessa Kraege
Summary: There is no association between adherence to the Mediterranean diet and the incidence of type 2 diabetes in a non-Mediterranean population.
Article
Pediatrics
Seyda Binay Yaz, Derya Cinar
Summary: The study developed and evaluated the psychometric properties of the Parental Quality of Life Scale in Type 1 Diabetes for parents. Data were collected from 201 parents of children with type 1 diabetes between May and July 2021. Descriptive statistics, Cronbach's alpha, item-total score analysis, and factor analysis were used to evaluate the data. A 12-item scale with two sub-dimensions was created, showing 62.7% of the total variance. The scale demonstrated high reliability and validity, making it useful for research on children with type 1 diabetes and their families.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Mohiba Ali Khowaja, Shafquat Rozi, Sobiya Sawani, Asma Ahmed
Summary: This study aimed to investigate the association of medication adherence, self-care behaviors, and diabetes knowledge with Diabetes Empowerment among patients with type II diabetes. The results showed that medication adherence, self-care behaviors, and diabetes knowledge were closely related to Diabetes Empowerment. Enhancing patients' self-management ability is crucial for diabetic control.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Jing Luo, Robert Feldman, Katherine Callaway Kim, Scott Rothenberger, Mary Korytkowski, Inmaculada Hernandez, Walid F. Gellad
Summary: This retrospective cohort study aimed to assess the association between high out-of-pocket costs and the initiation of SGLT2 inhibitors or GLP-1 receptor agonists in adults with type 2 diabetes and established cardiovascular disease. The study found that patients with the highest out-of-pocket costs were 13% less likely to initiate a GLP-1 RA and 20% less likely to initiate an SGLT2 inhibitor compared to those with the lowest out-of-pocket costs.
Review
Endocrinology & Metabolism
Anne-Ditte Termannsen, Annemarie Varming, Christina van Elst, Natasja Bjerre, Ole Norgaard, Nana Folmann Hempler, Kristine Faerch, Jonas Salling Quist
Summary: This systematic scoping review aimed to evaluate the feasibility of time-restricted eating (TRE) in individuals with overweight, obesity, prediabetes, or type 2 diabetes. The results showed that TRE is implementable, acceptable, and safe in these populations, but requires support and options for individual adjustments.
Review
Biochemical Research Methods
Ika Kustiyah Oktaviyanti, Diyar Salahuddin Ali, Sura A. Awadh, Maria Jade Catalan Opulencia, Shukhrat Yusupov, Rui Dias, Fahad Alsaikhan, Mais Mahmood Mohammed, Himanshu Sharma, Yasser Fakri Mustafa, Marwan Mahmood Saleh
Summary: Breast cancer is a common and deadly form of cancer in women, and CA15-3 is an overregulated tumor marker in breast cancer. CA15-3 is also overexpressed in other types of cancers. Immunosensors based on nanomaterials and antibodies show promise in detecting CA15-3 biomarkers and can overcome the limitations of conventional methods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Environmental Sciences
Trias Mahmudiono, Pushpamala Ramaiah, Heydar Maleki, Rumi Iqbal Doewes, Mohammed Nader Shalaby, Fahad Alsaikhan, Mohammad Javad Mohammadi
Summary: This article is a systematic review of relevant literature on the stability of the new coronavirus, different types of disinfectants, and the effects of disinfectants on SARS-CoV-2 and the environment. It highlights the survival time of the virus on various surfaces and the effectiveness of different disinfectants in killing the virus. Additionally, the article mentions the potential negative impacts of prolonged and high-level exposure to disinfectants on human and animal health.
REVIEWS ON ENVIRONMENTAL HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Saade Abdalkareem Jasim, Dmitry Olegovich Bokov, Wanich Suksatan, Fahad Alsaikhan, Mohammed Abed Jawad, Satish Kumar Sharma, Supat Chupradit, Lakshmi Thangavelu
Summary: We are currently in the midst of a revolution in regenerative medicine, with recent advancements in organoid technology offering new possibilities for the study of human biology and diseases. Organoid models have completely transformed the field of in vitro culture tools for biomedical research by accurately replicating the cellular heterogeneity, structure, and functions of primary tissues. This technology allows researchers to recreate human organs and disease models in a laboratory setting, holding great promise for applications in regenerative medicine, drug discovery, and precision medicine.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Xingang Tan, Rasha Fadhel Obaid, Ghassan Fadhil Smaisim, M. H. Malekipour Esfahani, Fahad Alsaikhan, Shaghayegh Baghaei, Salema K. Hadrawi, M. Y. P. M. Yusof, Anupam Yadav
Summary: This study combines the excellent intrinsic properties of polylactic acid (PLA) with the unique properties of 3D printing technique and coating of chitosan-hydroxyapatite (CHI-HA) to develop a microstructural scaffold for the regeneration of hard tissues. The study explores the morphological characteristics of the scaffold using scanning electron microscope (SEM) and investigates the biological reactions in phosphate buffer saline (PBS) and simulated body fluid (SBF). Mechanical analyzes, including compressive strength and porosity, are also performed and the results are evaluated using existing number models. The presence of HA nanoparticles is found to improve the mechanical and biological properties of the scaffold, with the sample containing 10 wt% HA showing the most suitable properties.
CERAMICS INTERNATIONAL
(2023)
Article
Optics
Sikandar Aftab, Muhammad Zahir Iqbal, Muhammad Waqas Iqbal, Muhammad Arslan Shehzad
Summary: This paper presents the first experimental demonstration of the bulk photovoltaic effect in 1T'-MoTe2 and discovers the strain-enhanced BPVE. These results show a new way to improve the efficiency of turning energy into electricity in new optoelectronic materials.
LASER & PHOTONICS REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Jianping Chen, Bin Liu, Hang Cai, Shude Liu, Yusuke Yamauchi, Seong Chan Jun
Summary: This study develops a covalently interlayer-confined organic-inorganic hybrid for improving the reaction kinetics of supercapacitors. The covalent assembly facilitates cross-layer electron transfer, increases active sites, and enhances the specific capacitance and rate capability of the hybrid material.
Article
Chemistry, Multidisciplinary
Amar M. Patil, Sunil Moon, Youngho Seo, Sanjib B. Roy, Arti A. Jadhav, Deepak P. Dubal, Keonwook Kang, Seong Chan Jun
Summary: This study demonstrates the unique core-shell architecture of metal organic framework derived N-S codoped carbon@CoxSy micropetals decorated with Nb-incorporated cobalt molybdate nanosheets, which significantly improves the electrochemical performance of high-energy-density battery-type materials. The optimized electrode exhibits a high specific capacity and excellent cycle stability. A flexible quasi-solid-state supercapacitor with a layer-by-layer deposited reduced graphene oxide/Ti3C2TX anode also achieves high specific energy and capacity retention over 10,000 charge-discharge cycles.
Review
Oncology
Shunshun Bao, Mohammad Darvishi, Ali Amin, Maysoon T. Al-Haideri, Indrajit Patra, Khadisha Kashikova, Irfan Ahmad, Fahad Alsaikhan, Zahraa Haleem Al-qaim, Moaed E. Al-Gazally, Bahman Abedi Kiasari, Bahareh Tavakoli-Far, Akmal A. Sidikov, Yasser Fakri Mustafa, Reza Akhavan-Sigari
Summary: CXC chemokine receptor type 4 (CXCR4) is a G protein-coupled receptor that interacts with its ligand CXCL12 to trigger downstream signaling pathways. This interaction plays a key role in tumor progression and is involved in processes such as tumor growth, angiogenesis, metastasis, and therapeutic resistance. CXCR4-targeting compounds have shown promising anti-tumor activity and have potential as therapeutic options for cancer treatment. This review focuses on the physiological signaling of the CXCL12/CXCR4 axis, its role in tumor progression, and strategies to block CXCR4.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Physical
Behrouz Notej, Hamidreza Bagheri, Fahad Alsaikhan, Hassan Hashemipour
Summary: This investigation studied the solubility of phenytoin and raloxifene in supercritical CO2 at different temperatures and pressures. The results showed that the solubility of phenytoin and raloxifene varied with pressure and had different effects at different extraction temperatures. Two mathematical approaches were used to model the experimental results, and it was found that the Peng-Robinson equations of state with the Kwak-Mansoori mixing rule predicted the solubilities more accurately. Furthermore, three density-based correlations were used to model the solubilities, and the Bartle et al. model showed better performance for both drugs.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pathology
Jitendra Gupta, Waleed K. Abdulsahib, Abduladheem Turki Jalil, Doaa Saadi Kareem, Zafar Aminov, Fahad Alsaikhan, Andres Alexis Ramirez-Coronel, Pushpamala Ramaiah, Bagher Farhood
Summary: Prostate cancer is a highly prevalent malignancy with no cure due to its progressive nature. Genetic and epigenetic alterations play important roles in its development. Apoptosis disruption is a common mechanism in malignancy, and recent evidence suggests that microRNAs have crucial roles in regulating apoptosis in prostate cancer. Understanding the mechanisms by which microRNAs affect apoptosis pathways in prostate cancer can provide new targets for treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Cell & Tissue Engineering
Ghaidaa Raheem Lateef Al-Awsi, Fahad Alsaikhan, Ria Margiana, Irfan Ahmad, Indrajit Patra, Mazin A. A. Najm, Ghulam Yasin, Iroda Rasulova, Ali Thaeer Hammid, Hamzah H. Kzar, Moaed E. Al-Gazally, Homayoon Siahmansouri
Summary: Breast cancer is the second most frequently diagnosed cancer and the leading cause of cancer death in women. Mesenchymal stem cells (MSCs) are a subgroup of cells that can differentiate into multiple cell types and have been found to have various effects on tumor growth and development. Recent studies have shown that MSCs can both promote and inhibit tumor development. Exosomes (Exo) have emerged as a new mechanism of cell communication, and MSC-derived exosomes (MSCs-Exo) have been found to carry molecules that can affect the proliferation, metastasis, and drug response of breast cancer cells.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Pharmacology & Pharmacy
Ali G. G. Alkhathami, Mustafa Ryadh Abdullah, Muhjaha Ahmed, Hanan Hassan Ahmed, Sarab W. W. Alwash, Zahra Muhammed Mahdi, Fahad Alsaikhan, Ayed A. A. Dera
Summary: BMP-9, a member of the TGF-beta superfamily, plays a dual role in cancer development by activating both tumor-suppressive and tumor-supportive signaling pathways. Modulating BMP9 expression and functions could be a promising strategy for cancer treatment, and evaluating BMP9 expression might serve as a biomarker for predicting cancer prognosis.
JOURNAL OF DRUG TARGETING
(2023)
Article
Chemistry, Physical
Jun Huang, Shaimaa M. Mohammed, Fahad Alsaikhan, Mohammed H. Mahdi, Mohaned Adil, Shaymaa Abdulhameed Khudair, Ahmed Ghaleb AbdalSalam, Rahman S. Zabibah, Ali Hashim Abbas, Hashem O. Alsaab, Anastasia Andreevna Rushchitc
Summary: This study computationally investigated the adsorption of penicillamine (PCA) drug molecule onto Al- and Ga-doped B12N12 nanoclusters in different environments. The results showed that the PCA molecule interacts effectively with the doped clusters through its nucleophilic sites and forms stable adsorption complexes. The adsorption of PCA molecule decreases the HOMO-LUMO gaps and increases the reactivity of the doped clusters, suggesting an improved drug delivery capacity.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Nanoscience & Nanotechnology
Nguyen Dinh Trung, Dinh Tran Ngoc Huy, Dmitry Olegovich Bokov, Maria Jade Catalan Opulencia, Fahad Alsaikhan, Irfan Ahmad, Guljakhan Karlibaeva
Summary: A new type of steel fiber with a rounded-end shape is proposed to enhance the bonding behavior with Carbon Nanotubes (CNT)-reinforced Ultra-High Performance Concrete (UHPC) matrix. Through a parametric study and nonlinear finite element method, the impact of fiber end characteristics on its bonding behavior is investigated. The novel fibers significantly improve bond strength compared to straight steel fibers, increasing it by 1.1 times for the same diameter. By creating fillet at the contact area, the maximum fiber capacity is achieved and the desired bonding mode is achieved.
ADVANCES IN NANO RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Muhammad Shahid Iqbal, Yaman Walid Kassab, Ahmed Alaa Al-Temimi, Abdullah K. Alahmari, Faisal K. Alkholifi, Fahad I. Al-Saikhan, Yahya Mansour Shafie, Ganesh Sritheran Paneerselvam, Saad Aldosari, Mohd Faiyaz Khan, Ziyad S. Almalki, Mohammed Abdulrahman Alhajri, Faisal Ayed Alanazi, Fayez Ayedh Al Yami, Roaa Mustafa Sagga, Ahlam Zarea Aljohani
Summary: This study aimed to assess knowledge, attitude, and pattern of use of Coenzyme Q10 supplements (CoQ10) among chronic cardiac patients. A cross-sectional study was conducted using a pre-validated, self-administered questionnaire. The study found that patients had poor knowledge about CoQ10 usage and majority had negative attitude towards CoQ10 usage. Elderly and high incomed patients had higher knowledge and positive attitude scores compared to the rest. The study highlights the role of healthcare providers, especially pharmacists, in increasing awareness about the benefits of CoQ10 among chronic cardiac patients.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)
