Article
Multidisciplinary Sciences
Chao-Chung Ho, Yi-Sun Yang, Chien-Ning Huang, Shih-Chang Lo, Yu-Hsun Wang, Edy Kornelius
Summary: This study evaluated the renal-protective effects of pioglitazone in diabetic kidney disease patients. The results showed that pioglitazone did not reduce the risk of renal disease progression in these patients. Further randomized controlled studies are needed to establish the effects of pioglitazone definitively.
Review
Biochemistry & Molecular Biology
Emanuel Amezcua-Castillo, Hector Gonzalez-Pacheco, Arturo Saenz-San Martin, Pablo Mendez-Ocampo, Ivan Gutierrez-Moctezuma, Felipe Masso, Daniel Sierra-Lara, Rashidi Springall, Emma Rodriguez, Alexandra Arias-Mendoza, Luis M. Amezcua-Guerra
Summary: Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide, and inflammation plays a crucial role in the pathogenesis of coronary artery disease (CAD). C-reactive protein (CRP), as an inflammatory marker, has been widely used in cardiovascular risk assessment and therapeutic decision-making. Pharmacological interventions with anti-inflammatory properties have also shown promising effects in reducing cardiovascular risks and CRP levels.
Article
Pharmacology & Pharmacy
Zimo Pan, Jiayu Cheng, Wenjia Yang, Lingxia Chen, Jingtong Wang
Summary: This study evaluated the effects of colchicine treatment on hs-CRP and IL-6 levels in patients with coronary artery disease. The results showed that colchicine significantly reduced hs-CRP and IL-6 levels in these patients. Additionally, the effects of colchicine may be influenced by the duration of intervention and baseline hs-CRP levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Chin-Hsiao Tseng
Summary: This study examined the risk of prostate cancer in diabetes patients who had used or never used rosiglitazone in Taiwan. Male patients with a new diagnosis of type 2 diabetes mellitus were selected from the nationwide database of the National Health Insurance and followed up for prostate cancer incidence. The results showed that there was no significant association between rosiglitazone use and prostate cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Harpreet S. Bhatia, Robyn L. McClelland, Susan R. Heckbert, Michael Criqui, Parveen Garg
Summary: Elevated coronary artery calcium (CAC) volume and density are associated with an increased risk of incident atrial fibrillation (AF), with CAC volume showing a stronger association. The association between CAC and AF appears to be independent of plaque density.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Mu-Cyun Wang, Che-Chen Lin, Hsiu-Yin Chiang, Hung-Lin Chen, Hsiu-Chen Tsai, Wen-Yuan Lin, Hung-Chi Ho, Chin-Chi Kuo
Summary: This study investigated the association between coronary artery calcium (CAC) and all-cause mortality in an Asian cohort. The results showed that higher CAC scores were associated with increased risk of death, and age was found to be a moderating variable.
Review
Endocrinology & Metabolism
J. David Spence, Catherine Viscoli, Walter N. Kernan, Lawrence H. Young, Karen Furie, Ralph DeFronzo, Muhammad Abdul-Ghani, Paresh Dandona, Silvio E. Inzucchi
Summary: This study evaluated the effectiveness and risks of lower versus higher doses of pioglitazone in patients with stroke. The results showed that lower doses of pioglitazone had fewer adverse effects while still providing substantial effects in preventing cardiovascular events and new-onset diabetes.
DIABETES OBESITY & METABOLISM
(2022)
Review
Cardiac & Cardiovascular Systems
Cheng Yuan Xue, Meng Qi Zhou, Qi Yan Zheng, Jin Hui Zhang, Wei Ting Cheng, Xue Hui Bai, Fen Zhou, Ai Ming Wu, Bo Nie, Wei Jing Liu, Li Xia Lou
Summary: TZDs drugs have shown inhibiting effects on plaque progression and protective effects on vascular endothelium in diabetic patients with coronary atherosclerosis, potentially contributing to a protective effect on myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Shuangyan Luo, Jin Zhang, Biyan Li, Hui Wu
Summary: This meta-analysis found that elevated baseline CRP level was associated with adverse outcomes in patients with stable CAD, indicating its predictive value.
Article
Multidisciplinary Sciences
Chul-Hyun Park, Yong-Taek Lee, Kyung Jae Yoon
Summary: There is a limited understanding of the relationship between osteosarcopenia and coronary artery disease. This study aimed to investigate the association between osteosarcopenia and coronary artery calcification (CAC) scores in asymptomatic adults. The results showed that osteosarcopenia was independently associated with a higher prevalence of subclinical coronary atherosclerosis.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
Seoyeong Park, Karam Nam, Tae Kyong Kim
Summary: This study found that preoperative FAR is significantly associated with all-cause mortality in patients undergoing OPCAB, with higher FAR indicating increased mortality risk.
ANESTHESIA AND ANALGESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Carlo Andrea Pivato, Davis Jones, Davide Cao, Samantha Sartori, Mauro Chiarito, Johny Nicolas, Zhongjie Zhang, Frans Beerkens, Matteo Nardin, Hanbo Qiu, Victor Razuk, Daniel Feldman, Vaishali Kumaraguru, Giulio G. Stefanini, Joseph Sweeny, Usman Baber, George Dangas, Samin K. Sharma, Annapoorna Kini, Roxana Mehran
Summary: Elevated levels of high sensitivity C-reactive protein (hsCRP) after percutaneous coronary intervention (PCI) is associated with worse ischemic outcomes, including all-cause mortality, in both diabetic and nondiabetic patients. Inflammation, indicated by high hsCRP levels, may increase cardiovascular risk independent of diabetes status.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Si-Si Zhang, Wen-Yi Hu, Yi-Jing Li, Juan Yu, Shang Sang, Zakareya M. Alsalman, Da-Qi Xie
Summary: This study investigates the association between lp(a) variability and mean CRP levels in patients undergoing percutaneous coronary intervention (PCI). The results show that lp(a) variability is positively correlated with mean follow-up CRP level, suggesting that high variability can be considered an independent risk factor for increased post-PCI CRP level.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Endocrinology & Metabolism
Kyeezu Kim, Brian T. Joyce, Yinan Zheng, Pamela J. Schreiner, David R. Jacobs, Janet M. Catov, James M. Shikany, Mercedes R. Carnethon, Philip Greenland, Linda V. Van Horn, Norrina B. Allen, Donald M. Lloyd-Jones, Erica P. Gunderson, Lifang Hou
Summary: The study found that DNA methylation-based biological age is positively associated with the risk of type 2 diabetes, particularly among obese individuals. Additionally, GrimAge partially mediates the association between cumulative obesity and diabetes or prediabetes.
Review
Cardiac & Cardiovascular Systems
Asra Khalid Butt, Brandon Cave, Miguel Maturana, William F. Towers, Rami N. Khouzam
Summary: Inflammation plays a crucial role in atherosclerosis and coronary artery disease, with colchicine being a drug with unique anti-inflammatory properties that shows potential in reducing cardiovascular morbidity and mortality. Studies have shown promising results in using colchicine for the prevention and treatment of atherosclerosis in coronary artery disease.
CURRENT PROBLEMS IN CARDIOLOGY
(2021)
Editorial Material
Engineering, Multidisciplinary
Xiong-Fei Pan, Juan Yang, Ying Wen, Naishi Li, Simiao Chen, An Pan
Article
Cardiac & Cardiovascular Systems
Wann Jia Loh, Xuling Chang, Tar Choon Aw, Soon Kieng Phua, Adrian F. Low, Mark Yan-Yee Chan, Gerald F. Watts, Chew-Kiat Heng
Summary: This study found that plasma Lp(a) concentration is a positive predictor of coronary artery disease (CAD) and acute myocardial infarction (AMI) in a mostly male South East Asian population.
Article
Obstetrics & Gynecology
Zhongwei Huang, Xuling Chang, Ling Wang, Jianjun Liu, Chew-Kiat Heng, Chiea-Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Rajkumar Dorajoo
Summary: This study confirms the existence of genetic variants in East-Asian women that interact with smoking to reduce reproductive lifespan. These findings highlight the importance of both genetic predisposition and lifestyle factors in determining reproductive outcomes in women.
HUMAN REPRODUCTION
(2022)
Article
Oncology
Shiwei Liu, Yuxiang Zhao, Ruixue Duan, Yaru Wu, Xiaoqin Chen, Naishi Li
Summary: This study identified CASP3 and TP53 as core genes associated with type 2 diabetes mellitus and gastric cancer, shedding light on the potential mechanisms underlying the progression of diabetes to gastric cancer. These findings provide valuable information for identifying new biomarkers for gastric cancer and offer a theoretical basis for preventing the occurrence and development of gastric cancer.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Sport Sciences
Xinwen Cui, Jianfang Xu, Xingya Yang, Lifeng Li, Xiao Jia, Jingjing Yu, Naishi Li, Yimin Zhang
Summary: This study compared the effects of high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) on glucose management in type 2 diabetes (T2D) patients. The results showed that both HIIE and MICE had similar effects on plasma glucose control in T2D men aged 30-50 years.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2022)
Biographical-Item
Cell Biology
Xudong Liu, Yuanmeng Li, Naishi Li
Article
Endocrinology & Metabolism
Yuanmeng Li, Long Chang, Xiaofeng Chai, He Liu, Hongbo Yang, Yu Xia, Li Huo, Hui Zhang, Naishi Li, Xiaolan Lian
Summary: Thyroid involvement in Langerhans cell histiocytosis (LCH) is not rare and can be associated with diabetes insipidus and neck swelling. The incidence of thyroid LCH is 14.00% in children and 10.10% in adults. Thyroid LCH often involves the hypothalamic-pituitary axis (HPA) and the lung.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Surgery
Xiaojing Wang, Naishi Li, Yi Xie, Liang Zhu, Ji Li, Feng Gu, Xinhua Xiao
Summary: This article reports a rare case of non-islet cell tumor hypoglycemia (NICTH) concurrent with acromegalic facial features, induced by a retroperitoneal hemangiopericytoma. Similar cases in the literature were also reviewed. The article emphasizes the importance of considering NICTH in non-diabetic patients and identifies fibrous origin as the most common tumor type for NICTH with acromegaly features.
FRONTIERS IN SURGERY
(2022)
Article
Endocrinology & Metabolism
Xuling Chang, Kevin Yiqiang Chua, Fang Lin Ng, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, Rajkumar Dorajoo, Woon-Puay Koh
Summary: This study investigated the relationship between body mass index (BMI) in midlife and functional mobility in late life. The results showed a causal effect of obesity on mobility dysfunction, with high BMI leading to poorer performance in the Timed Up-and-Go test (TUG). Genetic analyses also indicated potential neuronal dysfunctions in regulating the link between obesity and mobility dysfunction.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Pharmacology & Pharmacy
Qing Wang, Qinlei Zhu, Naishi Li
Summary: This study provides a comprehensive analysis of scientific research and technological innovation in needle-free insulin injection. It reveals that patent innovation is more active than clinical research and identifies the growth stage of needle-free injection technology.
CLINICAL THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Zhu, Shitian Wang, Zhaoyong Sun, Jingyi Liu, Menghua Dai, Xianlin Han, Qiang Xu, Naishi Li, Marcel Dominik Nickel, Huadan Xue, Zhengyu Jin
Summary: This study evaluates the ability of native T1 value and ECV of the pancreas in predicting postoperative NODM and worsened glucose tolerance in patients undergoing major pancreatic surgeries. The results show that native pancreatic T1 value and ECV are significantly higher in diabetic patients compared to prediabetic/non-diabetic patients, and ECV is also significantly higher in pre-diabetic patients compared to nondiabetic patients. Pancreatic ECV predicts the risk of postoperative NODM and worsened glucose tolerance in patients undergoing major pancreatic surgeries.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuanmeng Li, Juan Sun, Yang Jiao, Naishi Li, Weigang Zhao
Summary: This study explores the relationship between vitamin D levels and thyroid hormone sensitivity among euthyroid individuals. The results suggest that impaired thyroid hormone sensitivity correlates with decreased vitamin D levels, with associations varying by age, sex, race, and BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yuanmeng Li, Yue Chi, Xiaofeng Chai, He Liu, Naishi Li, Xiaolan Lian
Summary: Greater focus on FDH is critical when investigating the causes of inappropriate secretion of thyroid-stimulating hormone (IST), especially in cases with concurrent FDH and primary thyroid diseases. This case report highlights the challenges in recognising and managing FDH, as well as the importance of correctly evaluating thyroid function status to avoid inappropriate treatment.
BMC ENDOCRINE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Lingge Wu, Yan Xu, Xiang Wang, Xinqi Cheng, Yuelun Zhang, Yingyi Wang, Xinrong Fan, Haitao Zhao, He Liu, Xiaofeng Chai, Li Zhang, Mengzhao Wang, Naishi Li, Hui Pan, Xiaolan Lian
Summary: This study retrospectively analyzed Chinese patients who received ICI therapy and found that approximately 44% of patients developed immune-related thyroid dysfunction. The most common thyroid irAE was overt hypothyroidism, followed by subclinical thyrotoxicosis and subclinical hypothyroidism. Thyroid dysfunction was associated with better progression-free survival and overall survival.
Article
Gastroenterology & Hepatology
Claire E. Thomas, Brenda Diergaarde, Allison L. Kuipers, Jennifer J. Adibi, Hung N. Luu, Xuling Chang, Rajkumar Dorajoo, Chew-Kiat Heng, Chiea-Chuen Khor, Renwei Wang, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan
Summary: Using data from the Singapore Chinese Health Study (SCHS), researchers found a strong correlation between a polygenic risk score (PRS) for hepatic fat (HFC-PRS) and nonalcoholic fatty liver disease (NAFLD), as well as an increased risk of hepatocellular carcinoma (HCC).
HEPATOLOGY COMMUNICATIONS
(2022)
