Article
Endocrinology & Metabolism
Sameh Sarray, Meriem Dallel, Laila Ben Lamine, Deeba Jairajpuri, Nejla Sellami, Amira Turki, Zainab Malalla, Roland Brock, Mohamed Ghorbel, Touhami Mahjoub
Summary: The study revealed a consistent association of the rs243865 and rs243866 genotypes with protection against T2D susceptibility.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Biology
Nada Alqadri
Summary: This study investigated the genotyping levels of rs5210 polymorphism in the KCNJ11 gene in the older population with T2DM in Saudi Arabia. The results showed an association between the rs5210 polymorphism and allele frequencies. However, further large-scale studies are needed to determine whether KCNJ11 gene polymorphisms may serve as risk markers for T2DM in the Saudi population.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Maria Trapali, Dimitra Houhoula, Anthimia Batrinou, Anastasia Kanellou, Irini F. Strati, Argyris Siatelis, Panagiotis Halvatsiotis
Summary: The present study found that the TNF-alpha- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms are associated with the risk of developing type 2 diabetes mellitus (T2DM).
Article
Agronomy
Hailiang Zhang, Abdul Sammad, Rui Shi, Yixin Dong, Shanjiang Zhao, Lin Liu, Gang Guo, Qing Xu, Aoxing Liu, Yachun Wang
Summary: In this study, we investigated the polymorphism effects of two metabolic-syndrome pathway genes, IL6R and LEPR, on reproductive performance in dairy cows. Through population-level association analyses and cell-level gene expression analyses, we found that several single nucleotide polymorphisms in IL6R and LEPR were significantly associated with reproductive traits in Chinese Holstein cows. The functional validation of these genes improved our understanding of cattle reproduction and provided molecular markers for genetic selection of reproductive traits in high-yielding dairy cattle.
Article
Multidisciplinary Sciences
Maryam Moazzam-Jazi, Leila Najd-Hassan-Bonab, Sajedeh Masjoudi, Maryam Tohidi, Mehdi Hedayati, Fereidoun Azizi, Maryam S. Daneshpour
Summary: This study investigates the association of common KCNJ11 variants with type 2 diabetes (T2D) in Iranian adults and conducts a meta-analysis. The results show that KCNJ11 variants are not associated with T2D incidence in Iranian adults, but certain variants are significantly associated with increased T2D susceptibility in diverse populations. The meta-analysis also highlights the impact of sample size on the magnitude of pooled genetic effect size.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Yue Li, Zhiyan Yang, Shuyu Ren, Bowen Shen, Yundi Zhang, Huiying Zong, Yan Li
Summary: This study aimed to evaluate the relationship between GLP-1R gene polymorphisms and type 2 diabetes mellitus with and without dyslipidemia in China. The rs3765467 (G/A) variant was found to be associated with the incidence of dyslipidemia, with the G allele possibly being a risk factor for dyslipidemia.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: The study found a negative association between the use of alendronate and the risk of developing type 2 diabetes, with a dose-response relationship observed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Nora A. Kalagi, Rohith N. Thota, Elizabeth Stojanovski, Khalid A. Alburikan, Manohar L. Garg
Summary: This study compared plasma TMAO levels in people with or without T2D and explored the association between TMAO and T2D. The results showed a significant association between higher plasma TMAO levels and T2D, with red meat consumption being a contributing factor. Further research is needed to assess the correlation between TMAO and T2D.
Article
Environmental Sciences
Peiwen Li, Yali Xu, Zhaoyang Li, Xu Cheng, Chengyong Jia, Shiyang Zhang, Jun An, Xin Zhang, Yan Yan, Meian He
Summary: This study investigated the association between polychlorinated biphenyls (PCBs) exposure and incident type 2 diabetes mellitus (T2DM), as well as the relationship between PCBs and 5-year fasting blood glucose (FBG) changes. The results showed significant associations between non-dioxin-like PCBs (NDL-PCBs) and higher T2DM incidence, as well as positive associations between NDL-PCBs and changes in FBG. It was concluded that PCBs increased T2DM incidence through lipid metabolic pathways.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Yishuang Duan, Hongwen Sun, Yiming Yao, Yongcheng Li, Yue Meng, Yuan Lu, Liping Han, Liming Chen
Summary: The study found that exposure to certain PFASs may increase the risk of type 2 diabetes mellitus (T2DM), while most PFASs are inversely associated with T2DM risk. Different PFASs may have non-monotonic dose-response effects on T2DM at varying exposure levels. Further research is needed to clarify the mechanisms of action of different PFASs on T2DM at different exposure levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Fei Wang, Ying Zhang, Shiyang Zhang, Xu Han, Yue Wei, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Summary: This study found a U-shaped association between serum BPA levels and the risk of type 2 diabetes. Additionally, individuals with higher serum BPA levels and a genetic risk for diabetes had higher fasting plasma glucose levels and a higher risk of type 2 diabetes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Endocrinology & Metabolism
Lucas Raphael Bento Silva, Paulo Gentil, Camila Simoes Seguro, Gabriela Teles de Oliveira, Maria Sebastiana Silva, Antonio Roberto Zamuner, Thomas Beltrame, Ana Cristina Silva Rebelo
Summary: Type 2 diabetes (T2D) is associated with cardiac autonomic dysfunction, as evidenced by lower HRV and slower HRR in T2D patients compared to controls. Fasting glycemia is a predictor of impaired cardiac autonomic modulation in T2D patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Sarah Charlier, Janina Vavanikunnel, Claudia Becker, Susan S. Jick, Christian Meier, Christoph R. Meier
Summary: The study found that patients with good glycemic control who were treated with metformin monotherapy had a lower risk of fractures, while glycemic control in patients receiving other antidiabetic medications was not associated with fracture risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Laura del Bosque-Plata, Eduardo Martinez-Martinez, Miguel Angel Espinoza-Camacho, Claudia Gragnoli
Summary: TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and is consistently associated with the disease across diverse populations with different genetic origins. The exact mechanisms by which TCF7L2 affects T2D are still not well understood.