Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT) are differently associated with the prevalence of metabolic syndrome (MS) and its components. IVAT area index was independently associated with MS and its components, while RVAT area index was only associated with the blood pressure component.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Lucia Baila-Rueda, Ana Cenarro, Itziar Lamiquiz-Moneo, Victoria Marco-Benedi, Irene Gracia-Rubio, Maria Carmen Casamayor-Franco, Jose M. Arbones-Mainar, Fernando Civeira, Martin Laclaustra
Summary: This study found that cholesterol and oxidized metabolites in adipose tissue are associated with metabolic characteristics. Insulin is positively correlated with hydroxycholesterol, and leptin is also positively correlated with hydroxycholesterol. There is a positive correlation between tissue cholesterol and hydroxycholesterol.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Adriana Fodor, Andrada Luciana Lazar, Cristina Buchman, Brandusa Tiperciuc, Olga Hilda Orasan, Angela Cozma
Summary: MetS is a complex entity that increases the risk of various diseases, including type two diabetes, cardiovascular diseases, and certain types of cancer. miRNAs play an important role in cancer genesis, progression, and metastasis, and the altered secretion of miRs in adipose tissue may explain their involvement in oncogenesis. The interaction between miRs expressed in adipose tissue, their dysregulation, and cancer pathogenesis are still intriguing, as miRNAs exhibit both carcinogenic and tumor suppressor effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hang-Long Li, Xiaoping Wu, Aimin Xu, Ruby Lai-Chong Hoo
Summary: A-FABP functions as a fatty acid chaperone and hormone, regulating lipid homeostasis and inflammation. It plays crucial roles in metabolic syndrome and cardiometabolic diseases, making it a promising therapeutic target with diagnostic and prognostic significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Agnieszka Miklosz, Barbara Emilia Nikitiuk, Adrian Chabowski
Summary: Obesity is a critical risk factor for metabolic diseases, but adipose-derived mesenchymal stem cells (ADMSCs) have shown potential in improving pancreatic islet cell function and reducing inflammation and oxidative stress in experimental studies. However, there is a lack of clinical studies using ADMSCs for treating metabolic complications, and further research is needed to establish their safety and efficacy in humans.
Article
Medicine, Research & Experimental
Yi-Hsuan Chien, Yu-Hsiang Yu, Yue-Wen Chen
Summary: Excessive energy intake leads to dysbiosis of gut microbiota, oxidative stress, and inflammation, which contribute to metabolic syndrome. Taiwanese green propolis (TGP) has various beneficial properties, including antibacterial, anti-inflammatory, and antioxidant effects. This study investigated the preventive effects of TGP on obesity induced by a high-fat diet. The results showed that TGP supplementation improved various conditions associated with obesity, such as hyperlipidemia, fat accumulation, liver steatosis, and whitening of brown adipose tissue. TGP also improved glucose intolerance and insulin insensitivity, restructured gut microbiota composition, promoted healthy white adipose tissue remodeling, and balanced glucose and lipid homeostasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Nellie Y. Loh, Raymond Noordam, Constantinos Christodoulides
Summary: Genetically instrumented longer leukocyte telomere length is associated with higher waist-to-hip ratio, raised blood pressure, and increased risk of Metabolic Syndrome.
Article
Biochemistry & Molecular Biology
Yuki Kitamura, Shinji Oikawa, Jie Chang, Yurie Mori, Gaku Ichihara, Sahoko Ichihara
Summary: This study used 2D-Oxyblot and 2D-DIGE techniques to analyze carbonylated proteins induced by oxidative stress in a metabolic syndrome animal model, as well as changes in protein expression levels in adipose tissue at different stages of the syndrome. The results showed that up-regulated proteins at the pre-symptomatic stage were mainly involved in ATP production and redox reactions, while down-regulated proteins at the symptomatic stage were associated with antioxidant activity and the TCA cycle. Increased levels of carbonylated proteins, including gelsolin, may contribute to the oxidative stress state and progression of metabolic syndrome.
Review
Cardiac & Cardiovascular Systems
Cheukyau Luk, Natalie J. Haywood, Katherine I. Bridge, Mark T. Kearney
Summary: The vascular endothelium plays a crucial role in maintaining whole organism homeostasis by secreting a variety of anti-inflammatory and pro-inflammatory vasoactive molecules. Dysfunction of the endothelium, characterized by imbalanced secretion of regulatory factors, may contribute to the progression of cardiometabolic syndromes. Understanding and targeting the crosstalk between the endothelium and adipose tissue could lead to novel therapeutic opportunities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hongyan Wang, Lan Wang, Huijun Cheng, Huifang Ge, Zhongwen Xie, Daxiang Li
Summary: This study found that large yellow tea polysaccharides (LYPs) can improve obesity-related metabolic syndrome, including weight gain, dyslipidemia, glucose intolerance, and insulin resistance. Furthermore, LYPs can also improve obesity-related complications by reshaping M2 polarization of adipose tissue macrophages, making it a potential novel therapeutic agent for treating metabolic disorders.
Article
Nutrition & Dietetics
Adela Kabelova, Hana Malinska, Irena Markova, Olena Oliyarnyk, Blanka Chylikova, Ondrej Seda
Summary: Ellagic acid, a natural substance found in fruits and nuts, has beneficial effects on metabolic syndrome by lowering oxidative stress levels and improving characteristics of brown adipose tissue.
Article
Nutrition & Dietetics
Aimee L. Dordevic, Susan L. Coort, Chris T. Evelo, Chiara Murgia, Andrew J. Sinclair, Maxine P. Bonham, Amy E. Larsen, Petra Gran, David Cameron-Smith
Summary: In middle-aged males with MetS, a widespread suppression of the subcutaneous adipose tissue nutrient responsive gene expression suggests an inflexibility in the transcriptomic responsiveness to both high-fat meals.
CLINICAL NUTRITION
(2021)
Review
Physiology
Simon T. Bond, Anna C. Calkin, Brian G. Drew
Summary: Adipose tissue, through the secretion of extracellular vesicles, plays a crucial role in endocrine regulation and disease occurrence.
FRONTIERS IN PHYSIOLOGY
(2022)
